KEGG   PATHWAY: slal04621
Entry
slal04621                   Pathway                                
Name
NOD-like receptor signaling pathway - Seriola lalandi dorsalis (Yellowtail amberjack)
Description
Specific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains more than 20 members in mammals and plays a pivotal role in the recognition of intracellular ligands. NOD1 and NOD2, two prototypic NLRs, sense the cytosolic presence of the bacterial peptidoglycan fragments that escaped from endosomal compartments, driving the activation of NF-{kappa}B and MAPK, cytokine production and apoptosis. On the other hand, a different set of NLRs induces caspase-1 activation through the assembly of multiprotein complexes called inflammasomes. The activated of caspase-1 regulates maturation of the pro-inflammatory cytokines IL-1B, IL-18 and drives pyroptosis.
Class
Organismal Systems; Immune system
Pathway map
slal04621  NOD-like receptor signaling pathway
slal04621

Organism
Seriola lalandi dorsalis (Yellowtail amberjack) [GN:slal]
Gene
111664422  nod1; nucleotide-binding oligomerization domain-containing protein 1 [KO:K08727]
111661295  ripk2; receptor-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K08846] [EC:2.7.11.1]
111659926  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
111655428  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
111658207  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
111665990  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
111672507  NF-kappa-B inhibitor alpha-like [KO:K04734]
111673714  nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
111665614  LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p105 subunit-like [KO:K02580]
111670446  rela; transcription factor p65 isoform X1 [KO:K04735]
111659489  interleukin-1 beta-like [KO:K04519]
111660942  interleukin-1 beta-like [KO:K04519]
111660964  interleukin-1 beta-like [KO:K04519]
111666074  interleukin-1 beta-like [KO:K04519]
111659317  interleukin-6-like [KO:K05405]
111645657  tumor necrosis factor-like [KO:K03156]
111655660  tumor necrosis factor-like isoform X1 [KO:K03156]
111664504  interleukin-8-like isoform X1 [KO:K10030]
111664505  interleukin-8-like [KO:K10030]
111647131  permeability factor 2-like [KO:K10030]
111651623  nucleotide-binding oligomerization domain-containing protein 2-like [KO:K10165]
111672267  nod2; nucleotide-binding oligomerization domain-containing protein 2 isoform X1 [KO:K10165]
111645547  mitogen-activated protein kinase kinase kinase 7-like [KO:K04427] [EC:2.7.11.25]
111661524  map3k7; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
111671826  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
111645234  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
111650181  tab3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1 [KO:K12793]
111657703  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
111660943  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
111656807  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
111658196  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
111664771  mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
111646556  mitogen-activated protein kinase 9-like [KO:K04440] [EC:2.7.11.24]
111650024  mitogen-activated protein kinase 13-like [KO:K04441] [EC:2.7.11.24]
111670673  mitogen-activated protein kinase 14A-like isoform X1 [KO:K04441] [EC:2.7.11.24]
111667674  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
111667284  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
111653210  mitogen-activated protein kinase 14A-like [KO:K04441] [EC:2.7.11.24]
111661800  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
111667336  mitogen-activated protein kinase 11-like [KO:K04441] [EC:2.7.11.24]
111666541  jun; transcription factor AP-1 [KO:K04448]
111671973  transcription factor AP-1-like isoform X1 [KO:K04448]
111648134  transcription factor AP-1-like [KO:K04448]
111646703  atg16l1; autophagy-related protein 16-1 isoform X1 [KO:K17890]
111669231  atg5; autophagy protein 5 [KO:K08339]
111669827  atg12; ubiquitin-like protein ATG12 [KO:K08336]
111656635  gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
111650701  gabarap; gamma-aminobutyric acid receptor-associated protein [KO:K08341]
111669946  gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
111647741  gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
111655733  microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
111655782  microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]
111670232  microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]
111644392  map1lc3a; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
111666584  sugt1; protein SGT1 homolog isoform X1 [KO:K12795]
111661091  ranBP-type and C3HC4-type zinc finger-containing protein 1-like [KO:K20894]
111669673  rbck1; ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform X1 [KO:K10630] [EC:2.3.2.31]
111662905  ranBP-type and C3HC4-type zinc finger-containing protein 1 [KO:K10630] [EC:2.3.2.31]
111648339  E3 ubiquitin-protein ligase RNF31-like isoform X1 [KO:K11974] [EC:2.3.2.31]
111657059  E3 ubiquitin-protein ligase RNF31-like [KO:K11974] [EC:2.3.2.31]
111647268  E3 ubiquitin-protein ligase RNF31-like [KO:K11974] [EC:2.3.2.31]
111646416  xiap; E3 ubiquitin-protein ligase XIAP isoform X1 [KO:K04725] [EC:2.3.2.27]
111665751  thyroid receptor-interacting protein 6-like isoform X1 [KO:K12792]
111666781  erbin; erbin [KO:K12796]
111666176  inhibitor of apoptosis protein-like [KO:K16060]
111647918  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
111666015  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
111664872  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
111649752  TNF receptor-associated factor 5-like [KO:K09849]
111644323  traf6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
111649131  card9; caspase recruitment domain-containing protein 9 [KO:K12794]
111645308  tnfaip3; tumor necrosis factor alpha-induced protein 3 [KO:K11859] [EC:3.4.19.12]
111672858  mavs; mitochondrial antiviral-signaling protein [KO:K12648]
111659505  traf3; TNF receptor-associated factor 3 [KO:K03174]
111671054  tbk1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
111667666  ikbke; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
111654506  tank; TRAF family member-associated NF-kappa-B activator [KO:K12650]
111658714  interferon regulatory factor 3-like [KO:K05411]
111661782  irf7; interferon regulatory factor 7 [KO:K09447]
111656186  interferon a3-like [KO:K05414]
111662555  nlrx1; NLR family member X1 isoform X1 [KO:K12653]
111646149  anthrax toxin receptor 1-like [KO:K20909]
111655192  anthrax toxin receptor 1-like [KO:K20909]
111657298  anthrax toxin receptor 1-like [KO:K20909]
111660933  antxr2; anthrax toxin receptor 2 [KO:K20909]
111655753  anthrax toxin receptor 2-like [KO:K20909]
111645012  anthrax toxin receptor 1-like [KO:K20909]
111654143  caspase-1-A-like isoform X1 [KO:K01370] [EC:3.4.22.36]
111649666  apoptosis regulator Bcl-2-like [KO:K02161]
111666676  apoptosis regulator Bcl-2-like [KO:K02161]
111670485  bcl2; apoptosis regulator Bcl-2 [KO:K02161]
111649248  bcl-2-like protein 1 [KO:K04570]
111661912  bcl2l1; bcl-2-like protein 1 [KO:K04570]
111653030  cathepsin B-like [KO:K01363] [EC:3.4.22.1]
111668865  cathepsin B-like [KO:K01363] [EC:3.4.22.1]
111666650  panx1; pannexin-1 [KO:K03443]
111647557  pannexin-1-like isoform X1 [KO:K03443]
111645663  p2rx7; P2X purinoceptor 7 [KO:K05220]
111671500  trpm2; transient receptor potential cation channel subfamily M member 2 [KO:K04977] [EC:3.6.1.13]
111659123  trpm7; transient receptor potential cation channel subfamily M member 7 isoform X1 [KO:K04982] [EC:2.7.11.1]
111666288  casr; extracellular calcium-sensing receptor [KO:K04612]
111664131  gprc6a; G-protein coupled receptor family C group 6 member A [KO:K04622]
111645524  G-protein coupled receptor family C group 6 member A-like [KO:K04622]
111657998  G-protein coupled receptor family C group 6 member A-like [KO:K04622]
111672617  G-protein coupled receptor family C group 6 member A-like isoform X1 [KO:K04622]
111672675  plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
111672676  plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
111644585  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like [KO:K05858] [EC:3.1.4.11]
111652449  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
111653469  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
111653189  LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 1-like [KO:K04958]
111667746  inositol 1,4,5-trisphosphate receptor type 1-like [KO:K04958]
111655344  itpr2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
111673377  itpr3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
111659977  vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
111670041  voltage-dependent anion-selective channel protein 2 [KO:K15040]
111657081  voltage-dependent anion-selective channel protein 2-like [KO:K15040]
111665991  vdac3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
111666020  voltage-dependent anion-selective channel protein 2-like isoform X1 [KO:K15041]
111658957  mcu; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
111663961  dhx33; putative ATP-dependent RNA helicase DHX33 [KO:K17820] [EC:5.6.2.6]
111670228  mitofusin-1-like [KO:K21356] [EC:3.6.5.-]
111650203  mfn1; mitofusin-1 isoform X1 [KO:K21356] [EC:3.6.5.-]
111670657  mfn2; mitofusin-2 [KO:K06030] [EC:3.6.5.-]
111670509  ripk1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
111653316  receptor-interacting serine/threonine-protein kinase 3-like isoform X1 [KO:K08847] [EC:2.7.11.1]
111661685  receptor-interacting serine/threonine-protein kinase 3-like [KO:K08847] [EC:2.7.11.1]
111663968  dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
111651990  dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
111651509  dnm1l; dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
111668643  nicotinamide phosphoribosyltransferase-like [KO:K03462] [EC:2.4.2.12]
111663698  nampt; nicotinamide phosphoribosyltransferase [KO:K03462] [EC:2.4.2.12]
111672373  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
111646239  cytochrome b-245 light chain [KO:K08009]
111644699  thioredoxin-interacting protein-like [KO:K20910]
111669199  txnip; thioredoxin-interacting protein [KO:K20910]
111647209  thioredoxin-like [KO:K03671]
111662494  txn2; thioredoxin, mitochondrial [KO:K03671]
111654858  serine/threonine-protein kinase Nek7 [KO:K20876] [EC:2.7.11.34]
111669344  brcc3; lys-63-specific deubiquitinase BRCC36 [KO:K11864] [EC:3.4.19.-]
111672729  heat shock protein HSP 90-alpha [KO:K04079]
111672730  heat shock protein HSP 90-alpha 1 [KO:K04079]
111661412  hsp90ab1; heat shock protein HSP 90-beta isoform X1 [KO:K04079]
111650471  NACHT, LRR and PYD domains-containing protein 1b allele 2-like [KO:K12801]
111648936  uncharacterized protein LOC111648936 [KO:K12801]
111652826  NACHT, LRR and PYD domains-containing protein 1-like [KO:K12801]
111667008  pstpip1; proline-serine-threonine phosphatase-interacting protein 1 [KO:K12804]
111659169  proline-serine-threonine phosphatase-interacting protein 1-like [KO:K12804]
111666542  casp8; caspase-8 [KO:K04398] [EC:3.4.22.61]
111648895  caspase-8-like isoform X1 [KO:K04398] [EC:3.4.22.61]
111644206  FAS-associated death domain protein-like [KO:K02373]
111669290  FAS-associated death domain protein-like [KO:K02373]
111667849  prkcd; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
111670988  protein kinase C delta type-like [KO:K06068] [EC:2.7.11.13]
111656612  tp53bp1; TP53-binding protein 1 [KO:K20915]
111669019  rho-related GTP-binding protein RhoA-C-like [KO:K04513]
111666387  rho-related GTP-binding protein RhoA-B-like [KO:K04513]
111660814  transforming protein RhoA [KO:K04513]
111658866  rho-related GTP-binding protein RhoA-C [KO:K04513]
111662517  serine/threonine-protein kinase N1-like isoform X1 [KO:K06071] [EC:2.7.11.13]
111659773  pkn1; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
111661242  pkn2; serine/threonine-protein kinase N2 isoform X1 [KO:K23691] [EC:2.7.11.13]
111671290  14-3-3 protein epsilon-like isoform X1 [KO:K06630]
111656080  14-3-3 protein epsilon [KO:K06630]
111663409  uncharacterized protein LOC111663409 [KO:K05131]
111645354  jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
111660573  tyk2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
111672441  signal transducer and activator of transcription 1-alpha/beta-like isoform X1 [KO:K11220]
111667430  signal transducer and activator of transcription 1-alpha/beta-like [KO:K11220]
111667811  signal transducer and activator of transcription 1-alpha/beta-like [KO:K11221]
111660116  interferon regulatory factor 9-like isoform X1 [KO:K04693]
111654777  TIR domain-containing adapter molecule 1-like [KO:K05842]
111656280  myeloid differentiation primary response protein MyD88-like [KO:K04729]
111650410  irak4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
111646434  tmem173; stimulator of interferon genes protein [KO:K12654]
Compound
C00002  ATP
C00076  Calcium cation
C00155  L-Homocysteine
C00238  Potassium cation
C00533  Nitric oxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:23124073
  Authors
Vandenabeele P, Bertrand MJ
  Title
The role of the IAP E3 ubiquitin ligases in regulating pattern-recognition receptor signalling.
  Journal
Nat Rev Immunol 12:833-44 (2012)
DOI:10.1038/nri3325
Reference
PMID:16493424
  Authors
Strober W, Murray PJ, Kitani A, Watanabe T
  Title
Signalling pathways and molecular interactions of NOD1 and NOD2.
  Journal
Nat Rev Immunol 6:9-20 (2006)
DOI:10.1038/nri1747
Reference
PMID:24718315
  Authors
Estornes Y, Bertrand MJ
  Title
IAPs, regulators of innate immunity and inflammation.
  Journal
Semin Cell Dev Biol 39:106-14 (2015)
DOI:10.1016/j.semcdb.2014.03.035
Reference
PMID:24707857
  Authors
Jakopin Z
  Title
Nucleotide-binding oligomerization domain (NOD) inhibitors: a rational approach toward inhibition of NOD signaling pathway.
  Journal
J Med Chem 57:6897-918 (2014)
DOI:10.1021/jm401841p
Reference
PMID:25526305
  Authors
Caruso R, Warner N, Inohara N, Nunez G
  Title
NOD1 and NOD2: signaling, host defense, and inflammatory disease.
  Journal
Immunity 41:898-908 (2014)
DOI:10.1016/j.immuni.2014.12.010
Reference
PMID:19767725
  Authors
Murray PJ
  Title
Beyond peptidoglycan for Nod2.
  Journal
Nat Immunol 10:1053-4 (2009)
DOI:10.1038/ni1009-1053
Reference
PMID:20643110
  Authors
Lecat A, Piette J, Legrand-Poels S
  Title
The protein Nod2: an innate receptor more complex than previously assumed.
  Journal
Biochem Pharmacol 80:2021-31 (2010)
DOI:10.1016/j.bcp.2010.07.016
Reference
PMID:26655628
  Authors
Man SM, Kanneganti TD
  Title
Converging roles of caspases in inflammasome activation, cell death and innate immunity.
  Journal
Nat Rev Immunol 16:7-21 (2016)
DOI:10.1038/nri.2015.7
Reference
PMID:27291964
  Authors
Broz P, Dixit VM
  Title
Inflammasomes: mechanism of assembly, regulation and signalling.
  Journal
Nat Rev Immunol 16:407-20 (2016)
DOI:10.1038/nri.2016.58
Reference
PMID:25879280
  Authors
Man SM, Kanneganti TD
  Title
Regulation of inflammasome activation.
  Journal
Immunol Rev 265:6-21 (2015)
DOI:10.1111/imr.12296
Reference
PMID:26549800
  Authors
Jo EK, Kim JK, Shin DM, Sasakawa C
  Title
Molecular mechanisms regulating NLRP3 inflammasome activation.
  Journal
Cell Mol Immunol 13:148-59 (2016)
DOI:10.1038/cmi.2015.95
Reference
PMID:23846113
  Authors
Broz P, Monack DM
  Title
Newly described pattern recognition receptors team up against intracellular pathogens.
  Journal
Nat Rev Immunol 13:551-65 (2013)
DOI:10.1038/nri3479
Reference
PMID:22430786
  Authors
Rathinam VA, Vanaja SK, Fitzgerald KA
  Title
Regulation of inflammasome signaling.
  Journal
Nat Immunol 13:333-42 (2012)
DOI:10.1038/ni.2237
Reference
PMID:24840700
  Authors
Sutterwala FS, Haasken S, Cassel SL
  Title
Mechanism of NLRP3 inflammasome activation.
  Journal
Ann N Y Acad Sci 1319:82-95 (2014)
DOI:10.1111/nyas.12458
Reference
PMID:23702978
  Authors
Latz E, Xiao TS, Stutz A
  Title
Activation and regulation of the inflammasomes.
  Journal
Nat Rev Immunol 13:397-411 (2013)
DOI:10.1038/nri3452
Reference
PMID:25145756
  Authors
Blander JM
  Title
A long-awaited merger of the pathways mediating host defence and programmed cell death.
  Journal
Nat Rev Immunol 14:601-18 (2014)
DOI:10.1038/nri3720
Reference
PMID:23215645
  Authors
von Moltke J, Ayres JS, Kofoed EM, Chavarria-Smith J, Vance RE
  Title
Recognition of bacteria by inflammasomes.
  Journal
Annu Rev Immunol 31:73-106 (2013)
DOI:10.1146/annurev-immunol-032712-095944
Reference
PMID:25330206
  Authors
Abais JM, Xia M, Zhang Y, Boini KM, Li PL
  Title
Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector?
  Journal
Antioxid Redox Signal 22:1111-29 (2015)
DOI:10.1089/ars.2014.5994
Reference
PMID:25879288
  Authors
Storek KM, Monack DM
  Title
Bacterial recognition pathways that lead to inflammasome activation.
  Journal
Immunol Rev 265:112-29 (2015)
DOI:10.1111/imr.12289
Reference
PMID:27012466
  Authors
Hu H, Sun SC
  Title
Ubiquitin signaling in immune responses.
  Journal
Cell Res 26:457-83 (2016)
DOI:10.1038/cr.2016.40
Reference
PMID:26121197
  Authors
Guo H, Callaway JB, Ting JP
  Title
Inflammasomes: mechanism of action, role in disease, and therapeutics.
  Journal
Nat Med 21:677-87 (2015)
DOI:10.1038/nm.3893
Reference
PMID:26482951
  Authors
Man SM, Kanneganti TD
  Title
Gasdermin D: the long-awaited executioner of pyroptosis.
  Journal
Cell Res 25:1183-4 (2015)
DOI:10.1038/cr.2015.124
Reference
PMID:22819539
  Authors
Rathinam VA, Vanaja SK, Waggoner L, Sokolovska A, Becker C, Stuart LM, Leong JM, Fitzgerald KA
  Title
TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria.
  Journal
Cell 150:606-19 (2012)
DOI:10.1016/j.cell.2012.07.007
Reference
PMID:21575908
  Authors
Kerur N, Veettil MV, Sharma-Walia N, Bottero V, Sadagopan S, Otageri P, Chandran B
  Title
IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection.
  Journal
Cell Host Microbe 9:363-75 (2011)
DOI:10.1016/j.chom.2011.04.008
Reference
PMID:29148036
  Authors
Heilig R, Broz P
  Title
Function and mechanism of the pyrin inflammasome.
  Journal
Eur J Immunol 48:230-238 (2018)
DOI:10.1002/eji.201746947
Reference
PMID:25816776
  Authors
Chakrabarti A, Banerjee S, Franchi L, Loo YM, Gale M Jr, Nunez G, Silverman RH
  Title
RNase L activates the NLRP3 inflammasome during viral infections.
  Journal
Cell Host Microbe 17:466-77 (2015)
DOI:10.1016/j.chom.2015.02.010
Related
pathway
slal04010  MAPK signaling pathway
slal04140  Autophagy - animal
slal04620  Toll-like receptor signaling pathway
KO pathway
ko04621   
LinkDB

DBGET integrated database retrieval system