KEGG   PATHWAY: aam04010
Entry
aam04010                    Pathway                                
Name
MAPK signaling pathway - Apteryx mantelli mantelli (North Island brown kiwi)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
aam04010  MAPK signaling pathway
aam04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Apteryx mantelli mantelli (North Island brown kiwi) [GN:aam]
Gene
106482299  CACNB4; calcium voltage-gated channel auxiliary subunit beta 4 [KO:K04865]
106482375  MAPK8IP3; mitogen-activated protein kinase 8 interacting protein 3 [KO:K04436]
106482869  [KO:K16859]
106482877  TGFB3; transforming growth factor beta 3 [KO:K13377]
106482922  RPS6KA5; ribosomal protein S6 kinase A5 [KO:K04445] [EC:2.7.11.1]
106482997  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
106483025  RASGRP1; RAS guanyl releasing protein 1 [KO:K04350]
106483053  [KO:K16859]
106483057  FOS; Fos proto-oncogene, AP-1 transcription factor subunit [KO:K04379]
106483176  TRADD; TNFRSF1A associated via death domain [KO:K03171]
106483280  NFATC3; nuclear factor of activated T-cells 3 [KO:K17333]
106483715  EFNA4; ephrin A4 [KO:K05462]
106483864  STK3; serine/threonine kinase 3 [KO:K04412]
106483939  GNA12; G protein subunit alpha 12 [KO:K04346]
106483968  [KO:K04402]
106484003  VEGFC; vascular endothelial growth factor C [KO:K05449]
106484082  CASP3; caspase 3 [KO:K02187] [EC:3.4.22.56]
106484232  [KO:K04454]
106484561  ELK4; ELK4, ETS transcription factor [KO:K04376]
106484839  RELB; RELB proto-oncogene, NF-kB subunit [KO:K09253]
106485142  CACNA1G; calcium voltage-gated channel subunit alpha1 G [KO:K04854]
106485254  NGF; nerve growth factor [KO:K02582]
106485263  RAP1A; RAP1A, member of RAS oncogene family [KO:K04353]
106485268  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
106485327  IGF1R; insulin like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
106485436  VEGFA; vascular endothelial growth factor A [KO:K05448]
106485481  RASGRP3; RAS guanyl releasing protein 3 [KO:K12362]
106485509  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
106485595  RPS6KA1; ribosomal protein S6 kinase A1 [KO:K04373] [EC:2.7.11.1]
106485602  HGF; hepatocyte growth factor [KO:K05460]
106485676  GRB2; growth factor receptor bound protein 2 [KO:K04364]
106485853  RASA2; RAS p21 protein activator 2 [KO:K08053]
106485955  CACNA2D2; calcium voltage-gated channel auxiliary subunit alpha2delta 2 [KO:K04859]
106486026  PLA2G4A; phospholipase A2 group IVA [KO:K16342] [EC:3.1.1.4]
106486055  [KO:K04439]
106486085  MKNK1; MAP kinase interacting serine/threonine kinase 1 [KO:K04372] [EC:2.7.11.1]
106486146  [KO:K03283]
106486153  ERBB2; erb-b2 receptor tyrosine kinase 2 [KO:K05083] [EC:2.7.10.1]
106486190  PRKCB; protein kinase C beta [KO:K19662] [EC:2.7.11.13]
106486192  CACNG3; calcium voltage-gated channel auxiliary subunit gamma 3 [KO:K04868]
106486247  CRKL; CRK like proto-oncogene, adaptor protein [KO:K04438]
106486519  GNG12; G protein subunit gamma 12 [KO:K04347]
106486591  [KO:K04462] [EC:2.1.1.367]
106486780  RPS6KA2; ribosomal protein S6 kinase A2 [KO:K04373] [EC:2.7.11.1]
106486799  MAP3K4; mitogen-activated protein kinase kinase kinase 4 [KO:K04428] [EC:2.7.11.25]
106486816  TAB2; TGF-beta activated kinase 1/MAP3K7 binding protein 2 [KO:K04404]
106486833  [KO:K04432] [EC:2.7.12.2]
106486864  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
106486993  [KO:K05121] [EC:2.7.10.1]
106487036  RASGRF1; Ras protein specific guanine nucleotide releasing factor 1 [KO:K04349]
106487045  DUSP7; dual specificity phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
106487128  [KO:K07861]
106487129  [KO:K07861]
106487164  FGF1; fibroblast growth factor 1 [KO:K18496]
106487372  MAP3K21; mitogen-activated protein kinase kinase kinase 21 [KO:K17534] [EC:2.7.11.25]
106487442  CACNA1H; calcium voltage-gated channel subunit alpha1 H [KO:K04855]
106487512  [KO:K05866] [EC:3.1.3.48]
106487528  NRK; Nik related kinase [KO:K04407] [EC:2.7.11.1]
106487663  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
106487715  CRK; CRK proto-oncogene, adaptor protein [KO:K04438]
106487776  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
106487830  FAS; Fas cell surface death receptor [KO:K04390]
106487858  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
106487877  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
106487885  TEK; TEK receptor tyrosine kinase [KO:K05121] [EC:2.7.10.1]
106487921  MAX; MYC associated factor X [KO:K04453]
106488061  FGF18; fibroblast growth factor 18 [KO:K04358]
106488157  PTPRR; protein tyrosine phosphatase, receptor type R [KO:K04458] [EC:3.1.3.48]
106488178  KITLG; KIT ligand [KO:K05461]
106488179  DUSP6; dual specificity phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
106488320  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
106488354  RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [KO:K07860]
106488357  CACNA1I; calcium voltage-gated channel subunit alpha1 I [KO:K04856]
106488360  CACNA2D4; calcium voltage-gated channel auxiliary subunit alpha2delta 4 [KO:K04861]
106488364  CACNA1C; calcium voltage-gated channel subunit alpha1 C [KO:K04850]
106488383  IGF1; insulin like growth factor 1 [KO:K05459]
106488398  NTF3; neurotrophin 3 [KO:K04356]
106488469  PDGFB; platelet derived growth factor subunit B [KO:K17386]
106488478  [KO:K17386]
106488487  CACNG2; calcium voltage-gated channel auxiliary subunit gamma 2 [KO:K04867]
106488605  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
106488627  CACNA1D; calcium voltage-gated channel subunit alpha1 D [KO:K04851]
106488632  RAP1B; RAP1B, member of RAS oncogene family [KO:K07836]
106488640  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
106488645  TAB1; TGF-beta activated kinase 1 (MAP3K7) binding protein 1 [KO:K04403]
106488703  ATF4; activating transcription factor 4 [KO:K04374]
106488808  MET; MET proto-oncogene, receptor tyrosine kinase [KO:K05099] [EC:2.7.10.1]
106488826  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
106488842  BRAF; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
106488895  IRAK4; interleukin 1 receptor associated kinase 4 [KO:K04733] [EC:2.7.11.1]
106489062  [KO:K04360] [EC:2.7.10.1]
106489303  [KO:K05462]
106489310  FGF16; fibroblast growth factor 16 [KO:K04358]
106489560  FGF6; fibroblast growth factor 6 [KO:K04358]
106489568  FGF23; fibroblast growth factor 23 [KO:K22428]
106489690  MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
106489768  [KO:K04373] [EC:2.7.11.1]
106489849  [KO:K05096] [EC:2.7.10.1]
106489927  CACNB2; calcium voltage-gated channel auxiliary subunit beta 2 [KO:K04863]
106489958  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
106490079  FGF20; fibroblast growth factor 20 [KO:K04358]
106490087  KIT; KIT proto-oncogene receptor tyrosine kinase [KO:K05091] [EC:2.7.10.1]
106490172  PDGFRA; platelet derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
106490175  [KO:K05098] [EC:2.7.10.1]
106490233  MAP2K6; mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
106490234  HSPA8; heat shock protein family A (Hsp70) member 8 [KO:K03283]
106490250  TGFA; transforming growth factor alpha [KO:K08774]
106490262  [KO:K04729]
106490397  PPM1B; protein phosphatase, Mg2+/Mn2+ dependent 1B [KO:K04461] [EC:3.1.3.16]
106490440  TGFB2; transforming growth factor beta 2 [KO:K13376]
106490450  DUSP10; dual specificity phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
106491015  TGFBR1; transforming growth factor beta receptor 1 [KO:K04674] [EC:2.7.11.30]
106491249  TGFBR2; transforming growth factor beta receptor 2 [KO:K04388] [EC:2.7.11.30]
106491269  [KO:K05467]
106491345  RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
106491390  EPHA2; EPH receptor A2 [KO:K05103] [EC:2.7.10.1]
106491594  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
106491762  DUSP3; dual specificity phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
106491797  AREG; amphiregulin [KO:K09782]
106491798  EREG; epiregulin [KO:K09784]
106491825  LAMTOR3; late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 [KO:K04370]
106491847  FGF2; fibroblast growth factor 2 [KO:K18497]
106491870  VEGFD; vascular endothelial growth factor D [KO:K05449]
106491877  PDGFC; platelet derived growth factor C [KO:K05450]
106491937  EGF; epidermal growth factor [KO:K04357]
106491974  [KO:K08018]
106491979  NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
106492052  PPP3CA; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
106492073  RPS6KA3; ribosomal protein S6 kinase A3 [KO:K04373] [EC:2.7.11.1]
106492166  MAPKAPK3; mitogen-activated protein kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
106492199  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
106492330  ERBB4; erb-b2 receptor tyrosine kinase 4 [KO:K05085] [EC:2.7.10.1]
106492613  PAK2; p21 (RAC1) activated kinase 2 [KO:K04410] [EC:2.7.11.1]
106492977  MAPKAPK5; mitogen-activated protein kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
106492992  FGFR1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
106493092  PRKCA; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
106493108  CACNG1; calcium voltage-gated channel auxiliary subunit gamma 1 [KO:K04866]
106493158  CACNG5; calcium voltage-gated channel auxiliary subunit gamma 5 [KO:K04870]
106493178  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
106493240  ANGPT2; angiopoietin 2 [KO:K05466]
106493440  CSF1R; colony stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
106493441  PDGFRB; platelet derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
106493457  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
106493463  FLT4; fms related tyrosine kinase 4 [KO:K05097] [EC:2.7.10.1]
106493726  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
106493757  TAOK1; TAO kinase 1 [KO:K04429] [EC:2.7.11.1]
106493905  CACNA1F; calcium voltage-gated channel subunit alpha1 F [KO:K04853]
106493934  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 [KO:K04407] [EC:2.7.11.1]
106493955  CACNA1E; calcium voltage-gated channel subunit alpha1 E [KO:K04852]
106494064  IL1R1; interleukin 1 receptor type 1 [KO:K04386]
106494171  SRF; serum response factor [KO:K04378]
106494252  TRAF2; TNF receptor associated factor 2 [KO:K03173] [EC:2.3.2.27]
106494282  FGF5; fibroblast growth factor 5 [KO:K04358]
106494324  EFNA1; ephrin A1 [KO:K05462]
106494465  ANGPT1; angiopoietin 1 [KO:K05465]
106494500  JUN; Jun proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
106494573  MAP2K5; mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
106494843  [KO:K05462]
106494862  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
106495087  NTRK1; neurotrophic receptor tyrosine kinase 1 [KO:K03176] [EC:2.7.10.1]
106495130  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
106495161  CACNA2D3; calcium voltage-gated channel auxiliary subunit alpha2delta 3 [KO:K04860]
106495234  PPM1A; protein phosphatase, Mg2+/Mn2+ dependent 1A [KO:K04457] [EC:3.1.3.16]
106495273  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
106495295  CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
106495321  FGF17; fibroblast growth factor 17 [KO:K04358]
106495371  PAK1; p21 (RAC1) activated kinase 1 [KO:K04409] [EC:2.7.11.1]
106495394  DUSP5; dual specificity phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
106495523  PDGFD; platelet derived growth factor D [KO:K05450]
106495607  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
106495649  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
106495796  MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
106495837  DUSP4; dual specificity phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
106495909  PPP3R1; protein phosphatase 3 regulatory subunit B, alpha [KO:K06268]
106495922  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
106495935  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
106496220  MYC; v-myc avian myelocytomatosis viral oncogene homolog [KO:K04377]
106496232  TAOK3; TAO kinase 3 [KO:K04429] [EC:2.7.11.1]
106496545  FGF7; fibroblast growth factor 7 [KO:K04358]
106496655  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
106496868  MAP2K4; mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
106496881  FGF8; fibroblast growth factor 8 [KO:K04358]
106496994  IGF2; insulin like growth factor 2 [KO:K13769]
106497062  INS; insulin [KO:K04526]
106497121  PTPN5; protein tyrosine phosphatase, non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
106497122  RRAS2; related RAS viral (r-ras) oncogene homolog 2 [KO:K07830]
106497152  DUSP8; dual specificity phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
106497278  TNFRSF1A; TNF receptor superfamily member 1A [KO:K03158]
106497316  HSPB1; heat shock protein family B (small) member 1 [KO:K04455]
106497395  [KO:K04372] [EC:2.7.11.1]
106497424  MAPT; microtubule associated protein tau [KO:K04380]
106497426  MAP3K3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
106497478  CACNA1B; calcium voltage-gated channel subunit alpha1 B [KO:K04849]
106497521  DUSP1; dual specificity phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
106497779  NFKB2; nuclear factor kappa B subunit 2 [KO:K04469]
106497812  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
106497979  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
106498093  MAP3K9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
106498104  [KO:K16342] [EC:3.1.1.4]
106498106  [KO:K16342] [EC:3.1.1.4]
106498116  MAPK8IP1; mitogen-activated protein kinase 8 interacting protein 1 [KO:K04434]
106498135  FGF3; fibroblast growth factor 3 [KO:K04358]
106498136  FGF19; fibroblast growth factor 19 [KO:K22603]
106498151  [KO:K16342] [EC:3.1.1.4]
106498152  [KO:K16342] [EC:3.1.1.4]
106498154  PLA2G4F; phospholipase A2 group IVF [KO:K16342] [EC:3.1.1.4]
106498156  BDNF; brain derived neurotrophic factor [KO:K04355]
106498170  [KO:K16342] [EC:3.1.1.4]
106498179  PLA2G4E; phospholipase A2 group IVE [KO:K16342] [EC:3.1.1.4]
106498182  [KO:K16342] [EC:3.1.1.4]
106498193  IL1RAP; interleukin 1 receptor accessory protein [KO:K04723]
106498213  [KO:K16342] [EC:3.1.1.4]
106498355  TRAF6; TNF receptor associated factor 6 [KO:K03175] [EC:2.3.2.27]
106498480  [KO:K04388] [EC:2.7.11.30]
106498596  CDC42; cell division cycle 42 [KO:K04393]
106498627  NF1; neurofibromin 1 [KO:K08052]
106498756  NLK; nemo like kinase [KO:K04468] [EC:2.7.11.24]
106498761  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
106498889  RET; ret proto-oncogene [KO:K05126] [EC:2.7.10.1]
106498910  PPP3CB; protein phosphatase 3 catalytic subunit beta [KO:K04348] [EC:3.1.3.16]
106499024  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
106499141  MRAS; muscle RAS oncogene homolog [KO:K07831]
106499205  ATF2; activating transcription factor 2 [KO:K04450]
106499249  MAP3K20; mitogen-activated protein kinase kinase kinase 20 [KO:K04424] [EC:2.7.11.25]
106499278  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
106499359  GADD45G; growth arrest and DNA damage inducible gamma [KO:K04402]
106499515  FGF10; fibroblast growth factor 10 [KO:K04358]
106499573  GDNF; glial cell derived neurotrophic factor [KO:K05452]
106499683  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 [KO:K04406] [EC:2.7.11.1]
106499697  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
106499698  FASLG; Fas ligand [KO:K04389]
106499821  PRKACB; protein kinase cAMP-activated catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
106499981  PPP3CC; protein phosphatase 3 catalytic subunit gamma [KO:K04348] [EC:3.1.3.16]
106500122  STK4; serine/threonine kinase 4 [KO:K04411]
106500154  [KO:K04402]
106500234  NFATC1; nuclear factor of activated T-cells 1 [KO:K04446]
106500235  CACNA1S; calcium voltage-gated channel subunit alpha1 S [KO:K04857]
106500252  PTPN7; protein tyrosine phosphatase, non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
106500348  [KO:K04360] [EC:2.7.10.1]
106500410  FGF9; fibroblast growth factor 9 [KO:K04358]
106500427  FLT1; fms related tyrosine kinase 1 [KO:K05096] [EC:2.7.10.1]
106500428  FLT3; fms related tyrosine kinase 3 [KO:K05092] [EC:2.7.10.1]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
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Cell Signal 13:299-310 (2001)
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Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
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Genes Cells 7:1099-111 (2002)
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Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
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Cancer Lett 328:222-5 (2013)
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Signaling in innate immunity and inflammation.
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Cold Spring Harb Perspect Biol 4:a006049 (2012)
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Nat Rev Drug Discov 8:480-99 (2009)
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Trends Immunol 34:307-16 (2013)
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pathway
aam04070  Phosphatidylinositol signaling system
aam04110  Cell cycle
aam04115  p53 signaling pathway
aam04210  Apoptosis
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KO pathway
ko04010   

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