KEGG   PATHWAY: acat04060
Entry
acat04060                   Pathway                                
Name
Cytokine-cytokine receptor interaction - Aquarana catesbeiana (American bullfrog)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
acat04060  Cytokine-cytokine receptor interaction
acat04060

Organism
Aquarana catesbeiana (American bullfrog) [GN:acat]
Gene
141101803  [KO:K05495]
141101890  [KO:K22672]
141102620  IL5RA; interleukin-5 receptor subunit alpha [KO:K05067]
141102925  IL17RC; interleukin-17 receptor C [KO:K05166]
141102927  IL17RE; LOW QUALITY PROTEIN: interleukin-17 receptor E [KO:K05168]
141103167  IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
141103173  CSF2RB; cytokine receptor common subunit beta isoform X1 [KO:K04738]
141103536  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
141103791  IL12RB2; interleukin-12 receptor subunit beta-2 [KO:K05064]
141103801  LEPR; leptin receptor isoform X1 [KO:K05062]
141103860  MPL; thrombopoietin receptor [KO:K05082]
141104171  [KO:K21283]
141105310  [KO:K04666]
141105511  TNFRSF1A; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 1A [KO:K03158]
141105520  [KO:K06454]
141105521  CD4; T-cell surface glycoprotein CD4 [KO:K06454]
141105540  GDF15; growth/differentiation factor 15 [KO:K05504]
141105712  [KO:K04191]
141106022  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
141106186  BMPR1A; bone morphogenetic protein receptor type-1A [KO:K04673] [EC:2.7.11.30]
141106187  AMH; muellerian-inhibiting factor [KO:K04665]
141106296  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
141106350  CNTF; ciliary neurotrophic factor [KO:K05420]
141106362  CLCF1; cardiotrophin-like cytokine factor 1 [KO:K05421]
141106484  GDF10; growth/differentiation factor 10 [KO:K22674]
141106485  [KO:K05503]
141106532  [KO:K10032]
141106549  [KO:K10032]
141107175  [KO:K22669]
141107203  BMP3; bone morphogenetic protein 3 [KO:K05496]
141107316  BMP15; bone morphogenetic protein 15 [KO:K05498]
141107612  LTB; lymphotoxin-beta [KO:K03157]
141107613  [KO:K03156]
141107614  [KO:K05468]
141107742  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
141107989  IL13RA2; interleukin-13 receptor subunit alpha-2 isoform X1 [KO:K05077]
141108005  [KO:K05076]
141108006  [KO:K05076]
141108007  [KO:K05076]
141108040  CD40LG; CD40 ligand [KO:K03161]
141108255  IL12RB1; interleukin-12 receptor subunit beta-1 isoform X1 [KO:K05063]
141108533  EDA2R; tumor necrosis factor receptor superfamily member 27 [KO:K05163]
141108585  [KO:K10030]
141108599  [KO:K10030]
141108767  TNFSF15; tumor necrosis factor ligand superfamily member 15 [KO:K05478]
141108769  TNFSF8; tumor necrosis factor ligand superfamily member 8 isoform X1 [KO:K05471]
141108816  EDA; ectodysplasin-A isoform X1 [KO:K05480]
141108841  [KO:K05070]
141109068  [KO:K12671]
141109084  [KO:K12671]
141109100  [KO:K12671]
141109116  [KO:K12671]
141109132  [KO:K12671]
141109847  BMPR1B; bone morphogenetic protein receptor type-1B isoform X1 [KO:K13578] [EC:2.7.11.30]
141109870  [KO:K12671]
141110029  [KO:K04188]
141110668  [KO:K04188]
141110759  [KO:K05439]
141110809  CXCR5; C-X-C chemokine receptor type 5 isoform X1 [KO:K04190]
141110834  IL10RA; interleukin-10 receptor subunit alpha [KO:K05134]
141110900  IL11; interleukin-11 [KO:K05417]
141110999  [KO:K05142]
141111056  TNFRSF14; tumor necrosis factor receptor superfamily member 14 isoform X1 [KO:K05152]
141111081  [KO:K05154]
141111120  IL18; interleukin-18 [KO:K05482]
141111328  [KO:K05145]
141111425  TNFRSF9; tumor necrosis factor receptor superfamily member 9 [KO:K05146]
141111775  IL17C; interleukin-17C [KO:K05491]
141111931  [KO:K04722]
141111961  IL15; interleukin-15 isoform X1 [KO:K05433]
141112662  IL34; interleukin-34 isoform X1 [KO:K22633]
141113246  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
141113499  EBI3; interleukin-27 subunit beta [KO:K24476]
141113749  [KO:K05438]
141113884  BMP7; bone morphogenetic protein 7 [KO:K16621]
141113980  TNFRSF6B; tumor necrosis factor receptor superfamily member 6B [KO:K05143]
141114235  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
141114346  CCR7; C-C chemokine receptor type 7 [KO:K04182]
141114515  GDF5; growth/differentiation factor 5 [KO:K04664]
141114532  CCR10; C-C chemokine receptor type 10 [KO:K04182]
141116539  RELL1; RELT-like protein 1 [KO:K26541]
141116796  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
141116861  [KO:K04178]
141117488  BMP4; bone morphogenetic protein 4 [KO:K04662]
141121837  [KO:K16062]
141121840  [KO:K16062]
141121855  CCL27; C-C motif chemokine 27 [KO:K05513]
141121862  IL11RA; interleukin-11 receptor subunit alpha [KO:K05056]
141121888  CNTFR; ciliary neurotrophic factor receptor subunit alpha [KO:K05059]
141126882  RELT; tumor necrosis factor receptor superfamily member 19L isoform X1 [KO:K05156]
141127193  TNFRSF19; tumor necrosis factor receptor superfamily member 19 [KO:K05155]
141127207  IL17D; interleukin-17D isoform X1 [KO:K05492]
141127407  [KO:K22688]
141127409  [KO:K22688]
141127418  [KO:K12671]
141127464  GDF11; growth/differentiation factor 11 [KO:K22679]
141127543  ACVR1B; activin receptor type-1B [KO:K13567] [EC:2.7.11.30]
141127544  ACVRL1; activin receptor type-1-like [KO:K04675] [EC:2.7.11.30]
141127589  TNFSF11; tumor necrosis factor ligand superfamily member 11 isoform X1 [KO:K05473]
141127731  TNFSF13B; tumor necrosis factor ligand superfamily member 13B [KO:K05476]
141127894  IL18RAP; interleukin-18 receptor accessory protein isoform X1 [KO:K05174]
141127895  IL18R1; interleukin-18 receptor 1 [KO:K05173]
141127897  [KO:K04386]
141127898  [KO:K04386]
141127901  IL1R2; interleukin-1 receptor type 2 isoform X1 [KO:K04387]
141127924  EDAR; tumor necrosis factor receptor superfamily member EDAR isoform X1 [KO:K05162]
141128165  [KO:K16622]
141128282  IFNLR1; interferon lambda receptor 1 [KO:K05140]
141128368  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
141128397  NGF; beta-nerve growth factor isoform X1 [KO:K02582]
141128850  [KO:K05066]
141128851  [KO:K05066]
141129240  [KO:K05131]
141129243  [KO:K05135]
141129244  [KO:K05133]
141129245  [KO:K05130]
141129384  [KO:K05066]
141129818  AMHR2; anti-Muellerian hormone type-2 receptor [KO:K04672] [EC:2.7.11.30]
141129840  IL23A; interleukin-23 subunit alpha [KO:K05426]
141129994  [KO:K22667]
141129996  [KO:K22667]
141129997  IL10; interleukin-10 [KO:K05443]
141131377  IL16; pro-interleukin-16 [KO:K22628]
141132305  IL17B; interleukin-17B isoform X1 [KO:K05490]
141132443  CXCL14; C-X-C motif chemokine 14 [KO:K10033]
141132500  RELL2; RELT-like protein 2 [KO:K26541]
141132519  PRLR; prolactin receptor [KO:K05081]
141132531  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
141132601  IL12B; interleukin-12 subunit beta isoform X1 [KO:K05425]
141132721  [KO:K05058]
141132743  [KO:K05057]
141132764  IL17RA; interleukin-17 receptor A isoform X1 [KO:K05164]
141132867  GHR; growth hormone receptor [KO:K05080]
141132950  CCL28; C-C motif chemokine 28 isoform X1 [KO:K05513]
141132985  BMP10; bone morphogenetic protein 10 [KO:K22670]
141133035  [KO:K04519]
141133038  [KO:K04519]
141133039  [KO:K04519]
141133258  [KO:K04738]
141133352  EPOR; erythropoietin receptor [KO:K05079]
141133392  IL27RA; interleukin-27 receptor subunit alpha [KO:K19598]
141133446  TNFSF14; tumor necrosis factor ligand superfamily member 14 [KO:K05477]
141133448  [KO:K10035]
141133454  IL6ST; interleukin-6 receptor subunit beta isoform X1 [KO:K05060]
141133469  IL31RA; interleukin-31 receptor subunit alpha isoform X1 [KO:K22630]
141134031  [KO:K04666]
141134032  [KO:K04666]
141134035  [KO:K04666]
141134036  [KO:K04666]
141134037  [KO:K04666]
141134038  [KO:K04666]
141134039  [KO:K04666]
141134040  [KO:K04666]
141134136  [KO:K05474]
141134453  [KO:K16621]
141134477  LEP; leptin [KO:K05424]
141134516  IL26; interleukin-26 [KO:K05446]
141134517  IFNG; interferon gamma [KO:K04687]
141134567  GDF9; growth/differentiation factor 9 [KO:K22673]
141134662  [KO:K04519]
141134675  [KO:K04666]
141134676  [KO:K04666]
141134677  [KO:K04666]
141134678  [KO:K04666]
141134679  [KO:K04666]
141134680  [KO:K04666]
141134681  [KO:K04666]
141134682  [KO:K04666]
141134683  [KO:K04666]
141134684  [KO:K04666]
141134685  [KO:K04666]
141134687  [KO:K04666]
141134688  [KO:K04666]
141134689  [KO:K04666]
141134690  [KO:K04666]
141134691  [KO:K04666]
141134692  [KO:K04666]
141134693  [KO:K04666]
141134698  [KO:K04666]
141134899  EPO; erythropoietin [KO:K05437]
141139299  TNFRSF21; tumor necrosis factor receptor superfamily member 21 [KO:K05157]
141139326  GDF7; growth/differentiation factor 7 [KO:K20013]
141139414  [KO:K05507]
141139417  [KO:K16062]
141139418  [KO:K14625]
141139426  IL20RB; interleukin-20 receptor subunit beta [KO:K05137]
141139768  TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
141139861  IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
141140000  BMP5; bone morphogenetic protein 5 isoform X1 [KO:K04663]
141140312  [KO:K05136]
141140313  [KO:K05136]
141140315  IFNGR1; interferon gamma receptor 1 [KO:K05132]
141140387  CCR6; C-C chemokine receptor type 6 [KO:K04181]
141140852  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
141140997  BMP2; bone morphogenetic protein 2 [KO:K21283]
141141196  [KO:K04666]
141141363  [KO:K05494]
141141367  [KO:K05494]
141141368  [KO:K05494]
141141369  [KO:K05494]
141141370  [KO:K05494]
141141371  [KO:K05494]
141141373  [KO:K05489]
141141404  [KO:K14625]
141144411  IL6; interleukin-6 [KO:K05405]
141144513  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
141144571  ACKR4; atypical chemokine receptor 4 [KO:K04186]
141144645  INHBA; inhibin beta A chain [KO:K04667]
141144741  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
141144757  [KO:K04178]
141144798  LIF; leukemia inhibitory factor [KO:K05419]
141144841  TNFRSF11A; tumor necrosis factor receptor superfamily member 11A [KO:K05147]
141144915  BMP6; bone morphogenetic protein 6 isoform X1 [KO:K16620]
141145379  GDF6; growth/differentiation factor 6 [KO:K20012]
141145459  TNFRSF11B; tumor necrosis factor receptor superfamily member 11B [KO:K05148]
141145630  [KO:K02583]
141145880  [KO:K04193]
141145913  PRL; prolactin [KO:K05439]
141145949  ACVR2B; activin receptor type-2B [KO:K13596] [EC:2.7.11.30]
141146705  [KO:K05497]
141146706  [KO:K05497]
141146750  BMPR2; bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
141146879  ACKR3; atypical chemokine receptor 3 [KO:K04304]
141147070  ACVR1; activin receptor type-1 isoform X1 [KO:K04675] [EC:2.7.11.30]
141147071  ACVR1C; activin receptor type-1C isoform X1 [KO:K13568] [EC:2.7.11.30]
141147111  ACVR2A; activin receptor type-2A isoform X1 [KO:K04670] [EC:2.7.11.30]
141147126  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
141147230  [KO:K05050]
141147262  INHBB; inhibin beta B chain [KO:K22687]
141147306  [KO:K04388] [EC:2.7.11.30]
141147810  INHA; inhibin alpha chain [KO:K05500]
141147950  CTF1; cardiotrophin-1 [KO:K24382]
141148365  [KO:K05422]
141148430  TNFRSF12A; tumor necrosis factor receptor superfamily member 12A [KO:K05149]
141148910  IL21R; interleukin-21 receptor [KO:K05075]
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Reference
PMID:21106488
  Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
  Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
  Journal
Hum Genomics 5:30-55 (2010)
DOI:10.1186/1479-7364-5-1-30
Reference
PMID:27577879
  Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
  Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
  Journal
J Allergy Clin Immunol 138:984-1010 (2016)
DOI:10.1016/j.jaci.2016.06.033
Reference
PMID:15500860
  Authors
Boulanger MJ, Garcia KC
  Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
  Journal
Adv Protein Chem 68:107-46 (2004)
DOI:10.1016/S0065-3233(04)68004-1
Reference
PMID:16034365
  Authors
Allan SM, Tyrrell PJ, Rothwell NJ
  Title
Interleukin-1 and neuronal injury.
  Journal
Nat Rev Immunol 5:629-40 (2005)
DOI:10.1038/nri1664
Reference
PMID:23847622
  Authors
Lopetuso LR, Chowdhry S, Pizarro TT
  Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
  Journal
Front Immunol 4:181 (2013)
DOI:10.3389/fimmu.2013.00181
Reference
PMID:21349428
  Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
  Title
Functional specialization of interleukin-17 family members.
  Journal
Immunity 34:149-62 (2011)
DOI:10.1016/j.immuni.2011.02.012
Reference
PMID:17530315
  Authors
Fischer P, Hilfiker-Kleiner D
  Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
  Journal
Basic Res Cardiol 102:279-97 (2007)
DOI:10.1007/s00395-007-0658-z
Reference
PMID:24381786
  Authors
Richards CD
  Title
The enigmatic cytokine oncostatin m and roles in disease.
  Journal
ISRN Inflamm 2013:512103 (2013)
DOI:10.1155/2013/512103
Reference
PMID:18926762
  Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
  Title
Structures and biological functions of IL-31 and IL-31 receptors.
  Journal
Cytokine Growth Factor Rev 19:347-56 (2008)
DOI:10.1016/j.cytogfr.2008.08.003
Reference
PMID:21155715
  Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
  Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
  Journal
Biochem J 434:343-51 (2011)
DOI:10.1042/BJ20101628
Reference
PMID:22410872
  Authors
de Weerd NA, Nguyen T
  Title
The interferons and their receptors--distribution and regulation.
  Journal
Immunol Cell Biol 90:483-91 (2012)
DOI:10.1038/icb.2012.9
Reference
PMID:12949498
  Authors
Aggarwal BB
  Title
Signalling pathways of the TNF superfamily: a double-edged sword.
  Journal
Nat Rev Immunol 3:745-56 (2003)
DOI:10.1038/nri1184
Reference
PMID:12189384
  Authors
Ashkenazi A
  Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
  Journal
Nat Rev Cancer 2:420-30 (2002)
DOI:10.1038/nrc821
Reference
PMID:26115564
  Authors
Seeger P, Musso T, Sozzani S
  Title
The TGF-beta superfamily in dendritic cell biology.
  Journal
Cytokine Growth Factor Rev 26:647-57 (2015)
DOI:10.1016/j.cytogfr.2015.06.002
Reference
PMID:23612460
  Authors
Wakefield LM, Hill CS
  Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
  Journal
Nat Rev Cancer 13:328-41 (2013)
DOI:10.1038/nrc3500
Reference
PMID:22710174
  Authors
Mueller TD, Nickel J
  Title
Promiscuity and specificity in BMP receptor activation.
  Journal
FEBS Lett 586:1846-59 (2012)
DOI:10.1016/j.febslet.2012.02.043
KO pathway
ko04060   

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