KEGG   PATHWAY: cabi04820
Entry
cabi04820                   Pathway                                
Name
Cytoskeleton in muscle cells - Chelonoidis abingdonii (Abingdon island giant tortoise)
Class
Cellular Processes; Cell motility
Pathway map
cabi04820  Cytoskeleton in muscle cells
cabi04820

Organism
Chelonoidis abingdonii (Abingdon island giant tortoise) [GN:cabi]
Gene
116814706  FHL2; four and a half LIM domains protein 2 isoform X1 [KO:K14380]
116814723  SYNPO2; synaptopodin-2 isoform X1 [KO:K24066]
116814738  MYOZ2; myozenin-2 isoform X1 [KO:K26050]
116814756  PDLIM5; LOW QUALITY PROTEIN: PDZ and LIM domain protein 5 [KO:K19867]
116814941  FBN1; fibrillin-1 [KO:K06825]
116814966  [KO:K01689] [EC:4.2.1.11]
116815006  FBLN1; LOW QUALITY PROTEIN: fibulin-1 [KO:K17307]
116815096  MYL7; myosin regulatory light chain 2, atrial isoform isoform X1 [KO:K12754]
116815248  VCAN; versican core protein isoform X1 [KO:K06793]
116815490  SDC2; syndecan-2 [KO:K16336]
116815537  ZYX; zyxin isoform X1 [KO:K06273]
116815674  FBLN2; fibulin-2 [KO:K17307]
116815751  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
116816058  LMOD1; leiomodin-1 isoform X1 [KO:K22030]
116816073  THBS4; thrombospondin-4 [KO:K04659]
116816088  DCN; decorin [KO:K04660]
116816108  MYL1; myosin light chain 1/3, skeletal muscle isoform isoform X1 [KO:K05738]
116816311  TPM1; tropomyosin alpha-1 chain isoform X1 [KO:K10373]
116816441  ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 isoform X1 [KO:K01540]
116816595  NID2; nidogen-2 [KO:K06826]
116816772  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
116816837  [KO:K10654]
116816929  AMPD1; AMP deaminase 1 isoform X1 [KO:K01490] [EC:3.5.4.6]
116816958  CUNH10orf71; cardiac-enriched FHL2-interacting protein [KO:K28413]
116816963  DIAPH2; protein diaphanous homolog 2 isoform X1 [KO:K05741]
116816995  TMOD1; tropomodulin-1 isoform X1 [KO:K10370]
116817193  ATP1B4; protein ATP1B4 [KO:K01540]
116817239  THBS3; LOW QUALITY PROTEIN: thrombospondin-3 [KO:K04659]
116817309  SSPN; sarcospan isoform X1 [KO:K22194]
116817371  SDC4; syndecan-4 [KO:K16338]
116817436  COL5A1; collagen alpha-1(V) chain [KO:K19721]
116817560  ACTB; actin, cytoplasmic 1 [KO:K05692]
116817943  [KO:K12567] [EC:2.7.11.1]
116818023  DSP; desmoplakin isoform X1 [KO:K10381]
116818075  MYOZ1; myozenin-1 [KO:K26050]
116818110  ANKRD1; ankyrin repeat domain-containing protein 1 [KO:K21433]
116818141  LMOD2; leiomodin-2 [KO:K22030]
116818349  PDLIM4; PDZ and LIM domain protein 4 isoform X1 [KO:K23353]
116818500  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
116818513  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
116818593  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
116818744  ELN; elastin [KO:K14211]
116818867  CSRP3; cysteine and glycine-rich protein 3 [KO:K09377]
116818909  [KO:K12569]
116819068  TNNT3; troponin T, fast skeletal muscle isoform X1 [KO:K12046]
116819142  TNNI2; troponin I, fast skeletal muscle [KO:K12043]
116819298  XIRP2; xin actin-binding repeat-containing protein 2 [KO:K27381]
116819324  [KO:K12564]
116819331  SUN1; SUN domain-containing protein 1 isoform X1 [KO:K19347]
116819532  VCL; LOW QUALITY PROTEIN: vinculin [KO:K05700]
116819553  SNTB2; beta-2-syntrophin isoform X1 [KO:K24064]
116819599  [KO:K05692]
116819656  [KO:K23958]
116819691  SGCD; delta-sarcoglycan [KO:K12563]
116819760  SPTBN1; spectrin beta chain, non-erythrocytic 1 isoform X1 [KO:K06115]
116819843  [KO:K01539] [EC:7.2.2.13]
116819897  MYOZ3; myozenin-3 [KO:K26050]
116819948  SYNE3; nesprin-3 isoform X1 [KO:K21761]
116820213  DIAPH1; protein diaphanous homolog 1 [KO:K05740]
116820407  LMOD3; leiomodin-3 [KO:K22030]
116820544  SYNE1; nesprin-1 isoform X1 [KO:K19326]
116820582  FHL1; four and a half LIM domains protein 1 isoform X1 [KO:K14365]
116820630  SGCB; beta-sarcoglycan isoform X1 [KO:K12566]
116820837  [KO:K05692]
116821048  ENO2; gamma-enolase [KO:K01689] [EC:4.2.1.11]
116821174  SDC1; syndecan-1 [KO:K06257]
116821205  ACTG2; actin, gamma-enteric smooth muscle [KO:K12315]
116821237  [KO:K02184]
116821595  [KO:K06238]
116821596  COL6A6; collagen alpha-6(VI) chain isoform X1 [KO:K06238]
116821643  ACTC1; actin, alpha cardiac muscle 1 [KO:K12314]
116821675  ACTN2; alpha-actinin-2 isoform X1 [KO:K21073]
116821681  NID1; nidogen-1 [KO:K06826]
116821741  NRAP; nebulin-related-anchoring protein isoform X1 [KO:K24421]
116821805  TRIM54; tripartite motif-containing protein 54 [KO:K10653]
116821952  ENO1; alpha-enolase isoform X1 [KO:K01689] [EC:4.2.1.11]
116822688  LDB3; LIM domain-binding protein 3 isoform X1 [KO:K19867]
116822807  ANKRD2; ankyrin repeat domain-containing protein 2 isoform X1 [KO:K21434]
116822866  TRIM55; tripartite motif-containing protein 55 isoform X1 [KO:K10654]
116822884  MYOM2; myomesin-2 [KO:K24495]
116822980  SNTB1; LOW QUALITY PROTEIN: beta-1-syntrophin [KO:K24064]
116823152  TPM4; tropomyosin alpha-4 chain isoform X1 [KO:K10375]
116823237  [KO:K07611]
116823425  MYOT; myotilin isoform X1 [KO:K19875]
116823772  MYL5; myosin light chain 5 [KO:K12753]
116823786  [KO:K10370]
116823789  [KO:K10370]
116823959  MYL3; myosin light chain 3 [KO:K12749]
116824003  [KO:K07601]
116824177  COL24A1; collagen alpha-1(XXIV) chain [KO:K19721]
116824339  CAPZB; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
116824442  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
116824443  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
116824593  AGRN; agrin isoform X1 [KO:K06254]
116824739  MYH15; myosin-15 isoform X1 [KO:K24220]
116824857  [KO:K07610]
116825033  [KO:K06271]
116825189  NEB; nebulin [KO:K18267]
116825195  THBS2; thrombospondin-2 [KO:K04659]
116825210  [KO:K12314]
116825344  TMOD4; tropomodulin-4 [KO:K10370]
116825465  CAPN3; calpain-3 [KO:K08573] [EC:3.4.22.54]
116825607  MYH9; myosin-9 isoform X1 [KO:K10352]
116825690  PKP2; plakophilin-2 [KO:K12642]
116825730  MYBPC1; myosin-binding protein C, slow-type isoform X1 [KO:K12557]
116825796  ITGB6; integrin beta-6 [KO:K06589]
116825881  MYBPC3; myosin-binding protein C, cardiac-type [KO:K12568]
116825944  DAAM1; disheveled-associated activator of morphogenesis 1 isoform X1 [KO:K04512]
116826211  COMP; cartilage oligomeric matrix protein isoform X1 [KO:K04659]
116826302  [KO:K08118]
116826353  [KO:K10364]
116826806  ITGA4; integrin alpha-4 [KO:K06483]
116826835  ACTA1; actin, alpha skeletal muscle [KO:K10354]
116826964  [KO:K27381]
116826979  [KO:K09255]
116827088  TMEM43; transmembrane protein 43 [KO:K27488]
116827438  [KO:K12564]
116827483  [KO:K24220]
116827484  [KO:K24220]
116827620  DSG2; desmoglein-2 [KO:K07597]
116827641  SGCE; epsilon-sarcoglycan isoform X1 [KO:K27061]
116827643  COL1A2; collagen alpha-2(I) chain [KO:K06236]
116827775  ITGA7; LOW QUALITY PROTEIN: integrin alpha-7 [KO:K06583]
116827801  FMNL3; formin-like protein 3 isoform X1 [KO:K23957]
116827849  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
116827868  DES; desmin [KO:K07610]
116828387  ANK3; ankyrin-3 isoform X1 [KO:K09259]
116828451  ITGA5; integrin alpha-5 isoform X1 [KO:K06484]
116828497  ITGB7; integrin beta-7 [KO:K06590]
116828998  ACTL8; actin-like protein 8 [KO:K05692]
116829354  AMPD3; AMP deaminase 3 isoform X1 [KO:K01490] [EC:3.5.4.6]
116829396  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
116829410  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
116829506  COL11A2; collagen alpha-2(XI) chain [KO:K19721]
116829824  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
116829825  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
116829881  JUP; junction plakoglobin [KO:K10056]
116830075  MYH7B; LOW QUALITY PROTEIN: myosin-7B [KO:K24220]
116830210  MYOM3; myomesin-3 [KO:K24495]
116830358  [KO:K25865]
116830365  [KO:K24220]
116830455  FMNL2; LOW QUALITY PROTEIN: formin-like protein 2 [KO:K23957]
116830615  DAAM2; disheveled-associated activator of morphogenesis 2 isoform X1 [KO:K04512]
116830663  MYOM1; myomesin-1 [KO:K24495]
116830714  ANKRD23; ankyrin repeat domain-containing protein 23 [KO:K21438]
116830729  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
116830849  [KO:K05745]
116830943  [KO:K07611]
116831169  ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
116831198  TNNC2; troponin C, skeletal muscle isoform X1 [KO:K12042]
116831350  ITGAV; integrin alpha-V [KO:K06487]
116831364  MYL4; myosin light chain 4 [KO:K12750]
116831384  [KO:K19879]
116831385  [KO:K19879]
116831476  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
116831481  SGCA; alpha-sarcoglycan isoform X1 [KO:K12565]
116831482  COL1A1; collagen alpha-1(I) chain [KO:K06236]
116831708  CSRP1; cysteine and glycine-rich protein 1 [KO:K09377]
116831709  TNNI1; troponin I, slow skeletal muscle [KO:K10371]
116831719  TNNT2; troponin T, cardiac muscle isoform X1 [KO:K12045]
116831807  SUN2; SUN domain-containing protein 2 [KO:K19347]
116831825  LMNA; lamin [KO:K12641]
116831844  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
116831941  DAG1; dystroglycan [KO:K06265]
116831998  PDLIM1; PDZ and LIM domain protein 1 isoform X1 [KO:K23353]
116832254  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
116832354  [KO:K10352]
116832443  COL5A3; collagen alpha-3(V) chain [KO:K19721]
116832467  [KO:K06585]
116832538  SNTA1; alpha-1-syntrophin isoform X1 [KO:K24063]
116832588  MYH11; myosin-11 isoform X1 [KO:K10352]
116832615  [KO:K19346]
116832688  LBR; delta(14)-sterol reductase LBR [KO:K19532] [EC:1.3.1.70]
116832729  TPM3; tropomyosin alpha-3 chain isoform X1 [KO:K09290]
116832807  SPTBN5; spectrin beta chain, non-erythrocytic 5 isoform X1 [KO:K06115]
116832872  VIM; vimentin [KO:K07606]
116833194  ATP1B2; sodium/potassium-transporting ATPase subunit beta-2 [KO:K01540]
116833203  ITGB5; integrin beta-5 [KO:K06588]
116833311  [KO:K19867]
116833623  MYPN; myopalladin isoform X1 [KO:K22028]
116833834  SPTBN4; LOW QUALITY PROTEIN: spectrin beta chain, non-erythrocytic 4 [KO:K06115]
116834118  ITGA2B; LOW QUALITY PROTEIN: integrin alpha-IIb [KO:K06476]
116834152  CAPZA3; F-actin-capping protein subunit alpha-3 [KO:K10364]
116834154  [KO:K12753]
116834284  FHL3; four and a half LIM domains protein 3 [KO:K24414]
116834317  [KO:K01539] [EC:7.2.2.13]
116834666  FMNL1; formin-like protein 1 isoform X1 [KO:K23957]
116834744  COL11A1; collagen alpha-1(XI) chain [KO:K19721]
116834747  [KO:K05692]
116834818  ACTG1; actin, cytoplasmic 2 [KO:K05692]
116834920  [KO:K10372]
116835206  SPTAN1; spectrin alpha chain, non-erythrocytic 1 isoform X1 [KO:K06114]
116835207  [KO:K19721]
116835318  CKM; LOW QUALITY PROTEIN: creatine kinase M-type [KO:K27382]
116835606  LMNB1; lamin-B1 [KO:K07611]
116835661  SPTBN2; spectrin beta chain, non-erythrocytic 2 isoform X1 [KO:K23932]
116835710  ACTN3; alpha-actinin-3 [KO:K21073]
116835793  ITGA2; LOW QUALITY PROTEIN: integrin alpha-2 [KO:K06481]
116835794  ITGA1; integrin alpha-1 [KO:K06480]
116835830  SGCZ; zeta-sarcoglycan isoform X1 [KO:K27062]
116835873  ITGB1; integrin beta-1 [KO:K05719]
116835923  [KO:K23342]
116835956  [KO:K12758]
116836184  AMPD2; LOW QUALITY PROTEIN: AMP deaminase 2 [KO:K01490] [EC:3.5.4.6]
116836264  [KO:K05692]
116836306  [KO:K05692]
116836361  [KO:K01539] [EC:7.2.2.13]
116836456  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
116836642  PDLIM3; PDZ and LIM domain protein 3 isoform X1 [KO:K23353]
116836760  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
116836924  PDLIM2; PDZ and LIM domain protein 2 isoform X1 [KO:K23353]
116836948  TLN1; talin-1 isoform X1 [KO:K06271]
116836953  TPM2; tropomyosin beta chain isoform X1 [KO:K10374]
116837315  MYBPH; myosin-binding protein H isoform X1 [KO:K24494]
116837341  MYH10; myosin-10 isoform X1 [KO:K10352]
116837622  ITGA8; integrin alpha-8 [KO:K06584]
116837626  FLNC; LOW QUALITY PROTEIN: filamin-C [KO:K27393]
116837642  SDC3; syndecan-3 [KO:K16337]
116837699  COL9A3; collagen alpha-3(IX) chain isoform X1 [KO:K08131]
116837790  CAPZA1; F-actin-capping protein subunit alpha-1 [KO:K10364]
116837806  THBS1; thrombospondin-1 [KO:K16857]
116837836  COL5A2; collagen alpha-2(V) chain [KO:K19721]
116837837  COL3A1; collagen alpha-1(III) chain [KO:K19720]
116837879  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
116837994  TRIM63; E3 ubiquitin-protein ligase TRIM63 [KO:K10655] [EC:2.3.2.27]
116838311  [KO:K17751]
116838315  [KO:K17751]
116838357  LAMA2; laminin subunit alpha-2 [KO:K05637]
116838515  PLEC; plectin [KO:K10388]
116838618  CAPZA2; F-actin-capping protein subunit alpha-2 isoform X1 [KO:K10364]
116839348  LAMA1; laminin subunit alpha-1 [KO:K05637]
116839406  FN1; fibronectin isoform X1 [KO:K05717]
116839424  [KO:K05692]
116839435  CSRP2; cysteine and glycine-rich protein 2 [KO:K09377]
116839510  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
116839704  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
116839970  DTNA; dystrobrevin alpha isoform X1 [KO:K26998]
116840096  TNNI3; LOW QUALITY PROTEIN: troponin I, cardiac muscle [KO:K12044]
116840202  [KO:K17531] [EC:2.7.11.1]
Reference
PMID:12142273
  Authors
Clark KA, McElhinny AS, Beckerle MC, Gregorio CC
  Title
Striated muscle cytoarchitecture: an intricate web of form and function.
  Journal
Annu Rev Cell Dev Biol 18:637-706 (2002)
DOI:10.1146/annurev.cellbio.18.012502.105840
Reference
PMID:31407867
  Authors
Mukund K, Subramaniam S
  Title
Skeletal muscle: A review of molecular structure and function, in health and disease.
  Journal
Wiley Interdiscip Rev Syst Biol Med 12:e1462 (2020)
DOI:10.1002/wsbm.1462
Reference
PMID:24481844
  Authors
Stroud MJ, Banerjee I, Veevers J, Chen J
  Title
Linker of nucleoskeleton and cytoskeleton complex proteins in cardiac structure, function, and disease.
  Journal
Circ Res 114:538-48 (2014)
DOI:10.1161/CIRCRESAHA.114.301236
Reference
PMID:28640448
  Authors
Henderson CA, Gomez CG, Novak SM, Mi-Mi L, Gregorio CC
  Title
Overview of the Muscle Cytoskeleton.
  Journal
Compr Physiol 7:891-944 (2017)
DOI:10.1002/cphy.c160033
Reference
PMID:32265741
  Authors
Csapo R, Gumpenberger M, Wessner B
  Title
Skeletal Muscle Extracellular Matrix - What Do We Know About Its Composition, Regulation, and Physiological Roles? A Narrative Review.
  Journal
Front Physiol 11:253 (2020)
DOI:10.3389/fphys.2020.00253
Reference
PMID:27114860
  Authors
Pinch M, Guth R, Samanta MP, Chaidez A, Unguez GA
  Title
The myogenic electric organ of Sternopygus macrurus: a non-contractile tissue with a skeletal muscle transcriptome.
  Journal
PeerJ 4:e1828 (2016)
DOI:10.7717/peerj.1828
Reference
PMID:23860255
  Authors
Sequeira V, Nijenkamp LL, Regan JA, van der Velden J
  Title
The physiological role of cardiac cytoskeleton and its alterations in heart failure.
  Journal
Biochim Biophys Acta 1838:700-22 (2014)
DOI:10.1016/j.bbamem.2013.07.011
Reference
PMID:36960155
  Authors
Zhang B, Powers JD, McCulloch AD, Chi NC
  Title
Nuclear mechanosignaling in striated muscle diseases.
  Journal
Front Physiol 14:1126111 (2023)
DOI:10.3389/fphys.2023.1126111
Reference
PMID:21464301
  Authors
Al-Amoudi A, Castano-Diez D, Devos DP, Russell RB, Johnson GT, Frangakis AS
  Title
The three-dimensional molecular structure of the desmosomal plaque.
  Journal
Proc Natl Acad Sci U S A 108:6480-5 (2011)
DOI:10.1073/pnas.1019469108
Reference
PMID:33067392
  Authors
Sikora M, Ermel UH, Seybold A, Kunz M, Calloni G, Reitz J, Vabulas RM, Hummer G, Frangakis AS
  Title
Desmosome architecture derived from molecular dynamics simulations and cryo-electron tomography.
  Journal
Proc Natl Acad Sci U S A 117:27132-27140 (2020)
DOI:10.1073/pnas.2004563117
Reference
PMID:26910421
  Authors
Xu XP, Kim E, Swift M, Smith JW, Volkmann N, Hanein D
  Title
Three-Dimensional Structures of Full-Length, Membrane-Embedded Human alpha(IIb)beta(3) Integrin Complexes.
  Journal
Biophys J 110:798-809 (2016)
DOI:10.1016/j.bpj.2016.01.016
Reference
PMID:22945352
  Authors
Wang W, Shi Z, Jiao S, Chen C, Wang H, Liu G, Wang Q, Zhao Y, Greene MI, Zhou Z
  Title
Structural insights into SUN-KASH complexes across the nuclear envelope.
  Journal
Cell Res 22:1440-52 (2012)
DOI:10.1038/cr.2012.126
Reference
PMID:23597672
  Authors
Sosa BA, Kutay U, Schwartz TU
  Title
Structural insights into LINC complexes.
  Journal
Curr Opin Struct Biol 23:285-91 (2013)
DOI:10.1016/j.sbi.2013.03.005
Reference
PMID:33058875
  Authors
Cruz VE, Esra Demircioglu F, Schwartz TU
  Title
Structural Analysis of Different LINC Complexes Reveals Distinct Binding Modes.
  Journal
J Mol Biol 432:6028-6041 (2020)
DOI:10.1016/j.jmb.2020.09.019
Reference
PMID:36523505
  Authors
Schuler SC, Liu Y, Dumontier S, Grandbois M, Le Moal E, Cornelison D, Bentzinger CF
  Title
Extracellular matrix: Brick and mortar in the skeletal muscle stem cell niche.
  Journal
Front Cell Dev Biol 10:1056523 (2022)
DOI:10.3389/fcell.2022.1056523
Reference
PMID:30425656
  Authors
Brull A, Morales Rodriguez B, Bonne G, Muchir A, Bertrand AT
  Title
The Pathogenesis and Therapies of Striated Muscle Laminopathies.
  Journal
Front Physiol 9:1533 (2018)
DOI:10.3389/fphys.2018.01533
Reference
PMID:36552829
  Authors
Storey EC, Fuller HR
  Title
Genotype-Phenotype Correlations in Human Diseases Caused by Mutations of LINC Complex-Associated Genes: A Systematic Review and Meta-Summary.
  Journal
Cells 11:cells11244065 (2022)
DOI:10.3390/cells11244065
Related
pathway
cabi04512  ECM-receptor interaction
cabi04814  Motor proteins
KO pathway
ko04820   

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