Entry
Name
Neuroactive ligand signaling - Dasypus novemcinctus (nine-banded armadillo)
Description
Neuroactive ligand signaling is a process where receptors and ligands on the cell membrane initiate intracellular signaling pathways. It plays a crucial role in the development of various brain disorders.
Class
Environmental Information Processing; Signaling molecules and interaction
BRITE hierarchy
Pathway map
Organism
Dasypus novemcinctus (nine-banded armadillo) [GN:
dnm ]
Gene
101410636 GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825 ]
101410956 GABRG3; gamma-aminobutyric acid receptor subunit gamma-3 [KO:K05186 ]
101411584 SLC6A12; sodium- and chloride-dependent betaine transporter [KO:K05045 ]
101411900 GABRQ; gamma-aminobutyric acid receptor subunit theta [KO:K05192 ]
101412265 GABRA6; gamma-aminobutyric acid receptor subunit alpha-6 [KO:K05175 ]
101412492 SLC1A6; LOW QUALITY PROTEIN: excitatory amino acid transporter 4 [KO:K05617 ]
101412982 SLC6A1; sodium- and chloride-dependent GABA transporter 1 [KO:K05034 ]
101413297 GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826 ]
101413654 PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X2 [KO:K05858 ] [EC:3.1.4.11 ]
101413759 CHRNA4; neuronal acetylcholine receptor subunit alpha-4 [KO:K04806 ]
101413770 GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546 ]
101414190 GABBR2; gamma-aminobutyric acid type B receptor subunit 2 [KO:K04615 ]
101414215 GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548 ]
101415315 HTR1A; LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 1A [KO:K04153 ]
101418064 GABBR1; gamma-aminobutyric acid type B receptor subunit 1 [KO:K04615 ]
101418542 GABRA4; LOW QUALITY PROTEIN: gamma-aminobutyric acid receptor subunit alpha-4 [KO:K05175 ]
101418780 SLC1A2; excitatory amino acid transporter 2 isoform X1 [KO:K05613 ]
101419239 CHRNA3; neuronal acetylcholine receptor subunit alpha-3 [KO:K04805 ]
101419674 CHRNB4; neuronal acetylcholine receptor subunit beta-4 [KO:K04815 ]
101419849 GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347 ]
101419878 PLCB4; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858 ] [EC:3.1.4.11 ]
101420027 SLC6A11; sodium- and chloride-dependent GABA transporter 3 [KO:K05044 ]
101420315 PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858 ] [EC:3.1.4.11 ]
101420476 SLC17A7; LOW QUALITY PROTEIN: vesicular glutamate transporter 1 [KO:K12302 ]
101421763 SLC17A9; solute carrier family 17 member 9 isoform X1 [KO:K12303 ]
101422000 SLC1A3; excitatory amino acid transporter 1 isoform X1 [KO:K05614 ]
101423121 GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534 ]
101423562 GABRD; gamma-aminobutyric acid receptor subunit delta [KO:K05184 ]
101424155 GABRA2; gamma-aminobutyric acid receptor subunit alpha-2 isoform X1 [KO:K05175 ]
101424319 GRIK4; glutamate receptor ionotropic, kainate 4 isoform X1 [KO:K05204 ]
101424413 GRM8; LOW QUALITY PROTEIN: metabotropic glutamate receptor 8 [KO:K04610 ]
101424600 GABRG1; gamma-aminobutyric acid receptor subunit gamma-1 isoform X2 [KO:K05186 ]
101424835 OGFR; LOW QUALITY PROTEIN: opioid growth factor receptor [KO:K27951 ]
101425794 CHRNB2; neuronal acetylcholine receptor subunit beta-2 [KO:K04813 ]
101426538 GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537 ]
101426647 GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630 ]
101426937 GNAL; guanine nucleotide-binding protein G(olf) subunit alpha [KO:K04633 ]
101427179 PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X2 [KO:K05858 ] [EC:3.1.4.11 ]
101427206 GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547 ]
101427610 GRIN2C; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2C [KO:K05211 ]
101428860 GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541 ]
101431326 GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543 ]
101435031 CHRNA6; neuronal acetylcholine receptor subunit alpha-6 isoform X1 [KO:K04808 ]
101438048 SLC6A9; LOW QUALITY PROTEIN: sodium- and chloride-dependent glycine transporter 1 [KO:K05038 ]
101438079 SLC1A7; LOW QUALITY PROTEIN: excitatory amino acid transporter 5 [KO:K05618 ]
101438580 SLC6A5; sodium- and chloride-dependent glycine transporter 2 [KO:K05038 ]
101440883 GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538 ]
101441349 GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630 ]
101442978 GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540 ]
101443500 ADRB1; LOW QUALITY PROTEIN: beta-1 adrenergic receptor [KO:K04141 ]
101444486 GABRG2; gamma-aminobutyric acid receptor subunit gamma-2 isoform X1 [KO:K05186 ]
101444730 GRM2; LOW QUALITY PROTEIN: metabotropic glutamate receptor 2 [KO:K04605 ]
101444811 GABRB1; gamma-aminobutyric acid receptor subunit beta-1 [KO:K05181 ]
101445239 GABRA1; gamma-aminobutyric acid receptor subunit alpha-1 [KO:K05175 ]
101445685 GABRB2; gamma-aminobutyric acid receptor subunit beta-2 [KO:K05181 ]
101445686 GABRA5; gamma-aminobutyric acid receptor subunit alpha-5 [KO:K05175 ]
101446448 GRIK1; glutamate receptor ionotropic, kainate 1 isoform X1 [KO:K05201 ]
101446475 GABRR1; gamma-aminobutyric acid receptor subunit rho-1 [KO:K05190 ]
101446505 SLC6A13; sodium- and chloride-dependent GABA transporter 2 isoform X1 [KO:K05046 ]
101446603 GABRB3; gamma-aminobutyric acid receptor subunit beta-3 [KO:K05181 ]
101447107 GABRA3; gamma-aminobutyric acid receptor subunit alpha-3 isoform X2 [KO:K05175 ]
101447207 GABRR2; gamma-aminobutyric acid receptor subunit rho-2 [KO:K05190 ]
101447543 GABRE; LOW QUALITY PROTEIN: gamma-aminobutyric acid receptor subunit epsilon [KO:K05185 ]
101447951 GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X2 [KO:K04630 ]
111763551 GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544 ]
111764136 GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545 ]
111764630 GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542 ]
Compound
C16103 Agouti related protein (87-132)
Reference
Authors
Nimgampalle M, Chakravarthy H, Sharma S, Shree S, Bhat AR, Pradeepkiran JA, Devanathan V
Title
Neurotransmitter systems in the etiology of major neurological disorders: Emerging insights and therapeutic implications.
Journal
Reference
Authors
Malik AR, Willnow TE
Title
Excitatory Amino Acid Transporters in Physiology and Disorders of the Central Nervous System.
Journal
Reference
Authors
Higley MJ
Title
Localized GABAergic inhibition of dendritic Ca(2+) signalling.
Journal
Reference
Authors
Brambilla P, Perez J, Barale F, Schettini G, Soares JC
Title
GABAergic dysfunction in mood disorders.
Journal
Reference
Authors
Shimizu-Okabe C, Kobayashi S, Kim J, Kosaka Y, Sunagawa M, Okabe A, Takayama C
Title
Developmental Formation of the GABAergic and Glycinergic Networks in the Mouse Spinal Cord.
Journal
Reference
Authors
Wang Y, Tan B, Wang Y, Chen Z
Title
Cholinergic Signaling, Neural Excitability, and Epilepsy.
Journal
Reference
Authors
Channer B, Matt SM, Nickoloff-Bybel EA, Pappa V, Agarwal Y, Wickman J, Gaskill PJ
Title
Dopamine, Immunity, and Disease.
Journal
Reference
Authors
Savica R, Benarroch EE
Title
Dopamine receptor signaling in the forebrain: recent insights and clinical implications.
Journal
Reference
Authors
Pourhamzeh M, Moravej FG, Arabi M, Shahriari E, Mehrabi S, Ward R, Ahadi R, Joghataei MT
Title
The Roles of Serotonin in Neuropsychiatric Disorders.
Journal
Reference
Authors
Chhatar S, Lal G
Title
Role of adrenergic receptor signalling in neuroimmune communication.
Journal
Reference
Authors
Szukiewicz D
Title
Histaminergic System Activity in the Central Nervous System: The Role in Neurodevelopmental and Neurodegenerative Disorders.
Journal
Reference
Authors
Huang Z, Xie N, Illes P, Di Virgilio F, Ulrich H, Semyanov A, Verkhratsky A, Sperlagh B, Yu SG, Huang C, Tang Y
Title
From purines to purinergic signalling: molecular functions and human diseases.
Journal
Reference
Authors
Fields RD, Burnstock G
Title
Purinergic signalling in neuron-glia interactions.
Journal
Reference
Authors
Cawley NX, Li Z, Loh YP
Title
60 YEARS OF POMC: Biosynthesis, trafficking, and secretion of pro-opiomelanocortin-derived peptides.
Journal
Reference
Authors
Butler AA, Girardet C, Mavrikaki M, Trevaskis JL, Macarthur H, Marks DL, Farr SA
Title
A Life without Hunger: The Ups (and Downs) to Modulating Melanocortin-3 Receptor Signaling.
Journal
Reference
Authors
Toll L, Bruchas MR, Calo' G, Cox BM, Zaveri NT
Title
Nociceptin/Orphanin FQ Receptor Structure, Signaling, Ligands, Functions, and Interactions with Opioid Systems.
Journal
Reference
Authors
Campo A, Dufour S, Rousseau K
Title
Tachykinins, new players in the control of reproduction and food intake: A comparative review in mammals and teleosts.
Journal
Related pathway
dnm04080 Neuroactive ligand-receptor interaction
KO pathway