KEGG   PATHWAY: dnm04082
Entry
dnm04082                    Pathway                                
Name
Neuroactive ligand signaling - Dasypus novemcinctus (nine-banded armadillo)
Description
Neuroactive ligand signaling is a process where receptors and ligands on the cell membrane initiate intracellular signaling pathways. It plays a crucial role in the development of various brain disorders.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
dnm04082  Neuroactive ligand signaling
dnm04082

Organism
Dasypus novemcinctus (nine-banded armadillo) [GN:dnm]
Gene
101410636  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
101410956  GABRG3; gamma-aminobutyric acid receptor subunit gamma-3 [KO:K05186]
101411559  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
101411573  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
101411584  SLC6A12; sodium- and chloride-dependent betaine transporter [KO:K05045]
101411610  [KO:K04634]
101411627  TAC1; protachykinin-1 isoform X1 [KO:K05239]
101411900  GABRQ; gamma-aminobutyric acid receptor subunit theta [KO:K05192]
101412265  GABRA6; gamma-aminobutyric acid receptor subunit alpha-6 [KO:K05175]
101412334  PDYN; proenkephalin-B [KO:K15840]
101412492  SLC1A6; LOW QUALITY PROTEIN: excitatory amino acid transporter 4 [KO:K05617]
101412982  SLC6A1; sodium- and chloride-dependent GABA transporter 1 [KO:K05034]
101413154  POMC; pro-opiomelanocortin [KO:K05228]
101413194  [KO:K04539]
101413297  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
101413339  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
101413654  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X2 [KO:K05858] [EC:3.1.4.11]
101413759  CHRNA4; neuronal acetylcholine receptor subunit alpha-4 [KO:K04806]
101413767  P2RX4; P2X purinoceptor 4 [KO:K05218]
101413770  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
101413809  [KO:K04345] [EC:2.7.11.11]
101413839  HRH1; histamine H1 receptor [KO:K04149]
101414060  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
101414190  GABBR2; gamma-aminobutyric acid type B receptor subunit 2 [KO:K04615]
101414215  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
101414490  [KO:K04161]
101414723  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
101415152  P2RY2; P2Y purinoceptor 2 [KO:K04269]
101415315  HTR1A; LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 1A [KO:K04153]
101415580  P2RY6; P2Y purinoceptor 6 [KO:K04272]
101415818  CHRM4; muscarinic acetylcholine receptor M4 [KO:K04132]
101415897  PNOC; prepronociceptin [KO:K25696]
101416895  HTR1F; 5-hydroxytryptamine receptor 1F [KO:K04153]
101416949  OPRD1; delta-type opioid receptor [KO:K04213]
101417178  HTR3A; 5-hydroxytryptamine receptor 3A [KO:K04819]
101417345  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
101417837  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
101418064  GABBR1; gamma-aminobutyric acid type B receptor subunit 1 [KO:K04615]
101418132  ADRA2B; alpha-2B adrenergic receptor [KO:K04139]
101418542  GABRA4; LOW QUALITY PROTEIN: gamma-aminobutyric acid receptor subunit alpha-4 [KO:K05175]
101418577  SLC1A1; excitatory amino acid transporter 3 [KO:K05612]
101418686  HTR2B; 5-hydroxytryptamine receptor 2B isoform X1 [KO:K04157]
101418727  HRH3; histamine H3 receptor [KO:K04151]
101418780  SLC1A2; excitatory amino acid transporter 2 isoform X1 [KO:K05613]
101419177  TACR1; substance-P receptor [KO:K04222]
101419239  CHRNA3; neuronal acetylcholine receptor subunit alpha-3 [KO:K04805]
101419243  [KO:K04819]
101419332  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
101419674  CHRNB4; neuronal acetylcholine receptor subunit beta-4 [KO:K04815]
101419679  [KO:K04819]
101419849  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
101419875  GRIA4; glutamate receptor 4 isoform X1 [KO:K05200]
101419878  PLCB4; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
101420027  SLC6A11; sodium- and chloride-dependent GABA transporter 3 [KO:K05044]
101420116  [KO:K04819]
101420315  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
101420476  SLC17A7; LOW QUALITY PROTEIN: vesicular glutamate transporter 1 [KO:K12302]
101420741  [KO:K04536]
101421581  SLC17A6; vesicular glutamate transporter 2 [KO:K12302]
101421680  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
101421763  SLC17A9; solute carrier family 17 member 9 isoform X1 [KO:K12303]
101422000  SLC1A3; excitatory amino acid transporter 1 isoform X1 [KO:K05614]
101422732  [KO:K08048] [EC:4.6.1.1]
101422824  TACR3; neuromedin-K receptor [KO:K04224]
101423121  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
101423562  GABRD; gamma-aminobutyric acid receptor subunit delta [KO:K05184]
101423692  PRKACB; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
101424077  MC4R; melanocortin receptor 4 [KO:K04202]
101424155  GABRA2; gamma-aminobutyric acid receptor subunit alpha-2 isoform X1 [KO:K05175]
101424319  GRIK4; glutamate receptor ionotropic, kainate 4 isoform X1 [KO:K05204]
101424413  GRM8; LOW QUALITY PROTEIN: metabotropic glutamate receptor 8 [KO:K04610]
101424528  HTR7; 5-hydroxytryptamine receptor 7 isoform X1 [KO:K04163]
101424600  GABRG1; gamma-aminobutyric acid receptor subunit gamma-1 isoform X2 [KO:K05186]
101424835  OGFR; LOW QUALITY PROTEIN: opioid growth factor receptor [KO:K27951]
101425794  CHRNB2; neuronal acetylcholine receptor subunit beta-2 [KO:K04813]
101426538  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
101426588  TAC4; tachykinin-4 [KO:K05241]
101426647  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630]
101426937  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha [KO:K04633]
101427179  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X2 [KO:K05858] [EC:3.1.4.11]
101427185  P2RY14; P2Y purinoceptor 14 [KO:K04299]
101427192  DRD1; D(1A) dopamine receptor [KO:K04144]
101427206  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
101427610  GRIN2C; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2C [KO:K05211]
101427927  ADCY7; LOW QUALITY PROTEIN: adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
101427975  GABRP; gamma-aminobutyric acid receptor subunit pi [KO:K05189]
101428152  [KO:K04632]
101428255  SLC18A2; synaptic vesicular amine transporter [KO:K08155]
101428860  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
101428942  P2RY13; P2Y purinoceptor 13 [KO:K08388]
101429338  DRD3; D(3) dopamine receptor isoform X1 [KO:K04146]
101429663  P2RY12; P2Y purinoceptor 12 [KO:K04298]
101429799  P2RY1; P2Y purinoceptor 1 [KO:K04270]
101429893  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
101430150  ADORA2A; adenosine receptor A2a [KO:K04266]
101430245  GRM3; metabotropic glutamate receptor 3 isoform X1 [KO:K04606]
101430250  GRIA3; glutamate receptor 3 isoform X1 [KO:K05199]
101430276  ACHE; acetylcholinesterase isoform X1 [KO:K01049] [EC:3.1.1.7]
101430279  SLC32A1; vesicular inhibitory amino acid transporter [KO:K15015]
101430977  DRD2; D(2) dopamine receptor isoform X1 [KO:K04145]
101430989  SLC18A3; vesicular acetylcholine transporter [KO:K14636]
101431326  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
101431384  ADRB2; beta-2 adrenergic receptor [KO:K04142]
101431397  SLC5A7; high affinity choline transporter 1 [KO:K14387]
101431586  HTR1D; 5-hydroxytryptamine receptor 1D [KO:K04153]
101431703  SLC18A1; chromaffin granule amine transporter [KO:K08155]
101431937  GRM7; metabotropic glutamate receptor 7 [KO:K04609]
101432303  HRH2; histamine H2 receptor [KO:K04150]
101432614  CHAT; LOW QUALITY PROTEIN: choline O-acetyltransferase [KO:K00623] [EC:2.3.1.6]
101432615  ADORA1; adenosine receptor A1 [KO:K04265]
101432953  GRIA1; glutamate receptor 1 [KO:K05197]
101433543  P2RX3; P2X purinoceptor 3 [KO:K05217]
101433830  HTR1E; 5-hydroxytryptamine receptor 1E [KO:K04153]
101434213  HTR1B; 5-hydroxytryptamine receptor 1B [KO:K04153]
101434630  OPRL1; nociceptin receptor isoform X1 [KO:K04216]
101434916  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
101434986  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
101435031  CHRNA6; neuronal acetylcholine receptor subunit alpha-6 isoform X1 [KO:K04808]
101435246  GRIA2; glutamate receptor 2 isoform X7 [KO:K05198]
101435311  [KO:K05210]
101435314  ADRA1A; alpha-1A adrenergic receptor isoform X1 [KO:K04135]
101435354  HTR3B; 5-hydroxytryptamine receptor 3B [KO:K04819]
101435683  DRD5; D(1B) dopamine receptor [KO:K05840]
101436023  GRM6; metabotropic glutamate receptor 6 [KO:K04608]
101436226  [KO:K04607]
101436602  [KO:K04819]
101436856  HTR4; 5-hydroxytryptamine receptor 4 [KO:K04160]
101436934  SLC17A8; vesicular glutamate transporter 3 [KO:K12302]
101437466  P2RX6; P2X purinoceptor 6 isoform X4 [KO:K05221]
101437569  GRIN3B; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
101437672  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
101437817  GRIK3; glutamate receptor ionotropic, kainate 3 [KO:K05203]
101437988  OPRM1; mu-type opioid receptor isoform X2 [KO:K04215]
101438048  SLC6A9; LOW QUALITY PROTEIN: sodium- and chloride-dependent glycine transporter 1 [KO:K05038]
101438079  SLC1A7; LOW QUALITY PROTEIN: excitatory amino acid transporter 5 [KO:K05618]
101438580  SLC6A5; sodium- and chloride-dependent glycine transporter 2 [KO:K05038]
101438608  OPRK1; kappa-type opioid receptor [KO:K04214]
101439009  P2RX1; P2X purinoceptor 1 isoform X2 [KO:K05215]
101439024  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
101439694  GLRA3; glycine receptor subunit alpha-3 isoform X1 [KO:K05195]
101439895  MC3R; melanocortin receptor 3 [KO:K04201]
101439924  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
101439953  GLRA1; glycine receptor subunit alpha-1 isoform X1 [KO:K05193]
101440009  ADORA2B; adenosine receptor A2b [KO:K04267]
101440356  OGFRL1; opioid growth factor receptor-like protein 1 [KO:K27951]
101440579  P2RX5; P2X purinoceptor 5 isoform X1 [KO:K05219]
101440779  GRIK5; glutamate receptor ionotropic, kainate 5 [KO:K05205]
101440883  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
101441262  TACR2; substance-K receptor [KO:K04223]
101441349  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
101441501  P2RY4; P2Y purinoceptor 4 [KO:K04271]
101441767  GRIK2; glutamate receptor ionotropic, kainate 2 [KO:K05202]
101441846  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
101442415  [KO:K05190]
101442734  SLC6A2; sodium-dependent noradrenaline transporter [KO:K05035]
101442901  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
101442950  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
101442974  TAC3; tachykinin-3 [KO:K05240]
101442978  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
101443500  ADRB1; LOW QUALITY PROTEIN: beta-1 adrenergic receptor [KO:K04141]
101444486  GABRG2; gamma-aminobutyric acid receptor subunit gamma-2 isoform X1 [KO:K05186]
101444730  GRM2; LOW QUALITY PROTEIN: metabotropic glutamate receptor 2 [KO:K04605]
101444811  GABRB1; gamma-aminobutyric acid receptor subunit beta-1 [KO:K05181]
101445211  PENK; proenkephalin-A [KO:K18832]
101445239  GABRA1; gamma-aminobutyric acid receptor subunit alpha-1 [KO:K05175]
101445594  GRM5; metabotropic glutamate receptor 5 [KO:K04604]
101445596  [KO:K04345] [EC:2.7.11.11]
101445685  GABRB2; gamma-aminobutyric acid receptor subunit beta-2 [KO:K05181]
101445686  GABRA5; gamma-aminobutyric acid receptor subunit alpha-5 [KO:K05175]
101446448  GRIK1; glutamate receptor ionotropic, kainate 1 isoform X1 [KO:K05201]
101446475  GABRR1; gamma-aminobutyric acid receptor subunit rho-1 [KO:K05190]
101446505  SLC6A13; sodium- and chloride-dependent GABA transporter 2 isoform X1 [KO:K05046]
101446603  GABRB3; gamma-aminobutyric acid receptor subunit beta-3 [KO:K05181]
101446663  CHRNA7; CHRNA7-FAM7A fusion protein [KO:K04809]
101446893  GLRB; glycine receptor subunit beta [KO:K05196]
101447107  GABRA3; gamma-aminobutyric acid receptor subunit alpha-3 isoform X2 [KO:K05175]
101447207  GABRR2; gamma-aminobutyric acid receptor subunit rho-2 [KO:K05190]
101447216  ADRA2A; alpha-2A adrenergic receptor [KO:K04138]
101447287  [KO:K04603]
101447351  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
101447407  AGRP; agouti-related protein [KO:K05231]
101447543  GABRE; LOW QUALITY PROTEIN: gamma-aminobutyric acid receptor subunit epsilon [KO:K05185]
101447616  SLC6A4; sodium-dependent serotonin transporter [KO:K05037]
101447838  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
101447951  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X2 [KO:K04630]
111760787  [KO:K07826]
111763551  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
111764136  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
111764630  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
111765858  [KO:K04634]
Compound
C00002  ATP
C00008  ADP
C00015  UDP
C00025  L-Glutamate
C00029  UDP-glucose
C00037  Glycine
C00075  UTP
C00076  Calcium cation
C00114  Choline
C00165  Diacylglycerol
C00212  Adenosine
C00334  4-Aminobutanoate
C00388  Histamine
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00698  Cl-
C00780  Serotonin
C00788  L-Adrenaline
C01330  Sodium cation
C01996  Acetylcholine
C02210  beta-Endorphin
C02758  alpha-Melanotropin
C03758  Dopamine
C11684  MET-enkephalin
C15871  Nocistatin
C16039  alpha-Neoendorphin
C16040  beta-Neoendorphin
C16041  Leu-enkephalin
C16044  Nociceptin
C16094  Substance P
C16095  Neuropeptide K
C16096  Neuropeptide gamma
C16097  Neurokinin A
C16098  Neurokinin B
C16099  Endokinin A/B
C16100  Endokinin C
C16101  Endokinin D
C16103  Agouti related protein (87-132)
C16136  beta-Melanotropin
C16137  gamma-Melanotropin
Reference
  Authors
Nimgampalle M, Chakravarthy H, Sharma S, Shree S, Bhat AR, Pradeepkiran JA, Devanathan V
  Title
Neurotransmitter systems in the etiology of major neurological disorders: Emerging insights and therapeutic implications.
  Journal
Ageing Res Rev 89:101994 (2023)
DOI:10.1016/j.arr.2023.101994
Reference
  Authors
Malik AR, Willnow TE
  Title
Excitatory Amino Acid Transporters in Physiology and Disorders of the Central Nervous System.
  Journal
Int J Mol Sci 20:ijms20225671 (2019)
DOI:10.3390/ijms20225671
Reference
  Authors
Higley MJ
  Title
Localized GABAergic inhibition of dendritic Ca(2+) signalling.
  Journal
Nat Rev Neurosci 15:567-72 (2014)
DOI:10.1038/nrn3803
Reference
  Authors
Brambilla P, Perez J, Barale F, Schettini G, Soares JC
  Title
GABAergic dysfunction in mood disorders.
  Journal
Mol Psychiatry 8:721-37, 715 (2003)
DOI:10.1038/sj.mp.4001362
Reference
  Authors
Shimizu-Okabe C, Kobayashi S, Kim J, Kosaka Y, Sunagawa M, Okabe A, Takayama C
  Title
Developmental Formation of the GABAergic and Glycinergic Networks in the Mouse Spinal Cord.
  Journal
Int J Mol Sci 23:ijms23020834 (2022)
DOI:10.3390/ijms23020834
Reference
  Authors
Wang Y, Tan B, Wang Y, Chen Z
  Title
Cholinergic Signaling, Neural Excitability, and Epilepsy.
  Journal
Molecules 26:molecules26082258 (2021)
DOI:10.3390/molecules26082258
Reference
  Authors
Channer B, Matt SM, Nickoloff-Bybel EA, Pappa V, Agarwal Y, Wickman J, Gaskill PJ
  Title
Dopamine, Immunity, and Disease.
  Journal
Pharmacol Rev 75:62-158 (2023)
DOI:10.1124/pharmrev.122.000618
Reference
  Authors
Savica R, Benarroch EE
  Title
Dopamine receptor signaling in the forebrain: recent insights and clinical implications.
  Journal
Neurology 83:758-67 (2014)
DOI:10.1212/WNL.0000000000000719
Reference
  Authors
Pourhamzeh M, Moravej FG, Arabi M, Shahriari E, Mehrabi S, Ward R, Ahadi R, Joghataei MT
  Title
The Roles of Serotonin in Neuropsychiatric Disorders.
  Journal
Cell Mol Neurobiol 42:1671-1692 (2022)
DOI:10.1007/s10571-021-01064-9
Reference
  Authors
Chhatar S, Lal G
  Title
Role of adrenergic receptor signalling in neuroimmune communication.
  Journal
Curr Res Immunol 2:202-217 (2021)
DOI:10.1016/j.crimmu.2021.11.001
Reference
  Authors
Szukiewicz D
  Title
Histaminergic System Activity in the Central Nervous System: The Role in Neurodevelopmental and Neurodegenerative Disorders.
  Journal
Int J Mol Sci 25:ijms25189859 (2024)
DOI:10.3390/ijms25189859
Reference
  Authors
Huang Z, Xie N, Illes P, Di Virgilio F, Ulrich H, Semyanov A, Verkhratsky A, Sperlagh B, Yu SG, Huang C, Tang Y
  Title
From purines to purinergic signalling: molecular functions and human diseases.
  Journal
Signal Transduct Target Ther 6:162 (2021)
DOI:10.1038/s41392-021-00553-z
Reference
  Authors
Fields RD, Burnstock G
  Title
Purinergic signalling in neuron-glia interactions.
  Journal
Nat Rev Neurosci 7:423-36 (2006)
DOI:10.1038/nrn1928
Reference
  Authors
Cawley NX, Li Z, Loh YP
  Title
60 YEARS OF POMC: Biosynthesis, trafficking, and secretion of pro-opiomelanocortin-derived peptides.
  Journal
J Mol Endocrinol 56:T77-97 (2016)
DOI:10.1530/JME-15-0323
Reference
  Authors
Butler AA, Girardet C, Mavrikaki M, Trevaskis JL, Macarthur H, Marks DL, Farr SA
  Title
A Life without Hunger: The Ups (and Downs) to Modulating Melanocortin-3 Receptor Signaling.
  Journal
Front Neurosci 11:128 (2017)
DOI:10.3389/fnins.2017.00128
Reference
  Authors
Toll L, Bruchas MR, Calo' G, Cox BM, Zaveri NT
  Title
Nociceptin/Orphanin FQ Receptor Structure, Signaling, Ligands, Functions, and Interactions with Opioid Systems.
  Journal
Pharmacol Rev 68:419-57 (2016)
DOI:10.1124/pr.114.009209
Reference
  Authors
Campo A, Dufour S, Rousseau K
  Title
Tachykinins, new players in the control of reproduction and food intake: A comparative review in mammals and teleosts.
  Journal
Front Endocrinol (Lausanne) 13:1056939 (2022)
DOI:10.3389/fendo.2022.1056939
Related
pathway
dnm04080  Neuroactive ligand-receptor interaction
dnm04724  Glutamatergic synapse
dnm04725  Cholinergic synapse
dnm04726  Serotonergic synapse
dnm04727  GABAergic synapse
dnm04728  Dopaminergic synapse
KO pathway
ko04082   

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