KEGG   PATHWAY: ely04082
Entry
ely04082                    Pathway                                
Name
Neuroactive ligand signaling - Epinephelus lanceolatus (giant grouper)
Description
Neuroactive ligand signaling is a process where receptors and ligands on the cell membrane initiate intracellular signaling pathways. It plays a crucial role in the development of various brain disorders.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
ely04082  Neuroactive ligand signaling
ely04082

Organism
Epinephelus lanceolatus (giant grouper) [GN:ely]
Gene
117245775  ache; acetylcholinesterase [KO:K01049] [EC:3.1.1.7]
117245782  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
117246020  hrh2b; histamine receptor H2b [KO:K04150]
117246147  slc1a1; excitatory amino acid transporter 3 isoform X1 [KO:K05612]
117246265  htr2cl1; 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled-like 1 [KO:K04157]
117246416  si:dkey-6n21.13; P2Y purinoceptor 3 [KO:K04271]
117246681  [KO:K05211]
117246700  [KO:K00623] [EC:2.3.1.6]
117246720  [KO:K04819]
117246752  [KO:K12302]
117246878  slc18a3b; probable vesicular acetylcholine transporter-B [KO:K14636]
117246910  adrb1; beta-1 adrenergic receptor [KO:K04141]
117246969  [KO:K14387]
117246982  [KO:K04819]
117247128  gnb2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
117247260  p2rx1; P2X purinoceptor 1 isoform X1 [KO:K05215]
117247302  [KO:K05858] [EC:3.1.4.11]
117247439  gabrr3a; gamma-aminobutyric acid receptor subunit rho-3a isoform X1 [KO:K05190]
117247471  [KO:K04131]
117247511  [KO:K05241]
117247538  [KO:K04819]
117247539  [KO:K04819]
117247540  [KO:K04819]
117247542  [KO:K04819]
117247547  [KO:K04819]
117247562  gngt2b; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2b [KO:K04549]
117247622  [KO:K04819]
117247635  [KO:K04819]
117247637  [KO:K05840]
117247870  [KO:K04541]
117247916  ogfrl1; opioid growth factor receptor-like protein 1 [KO:K27951]
117247947  slc18a3a; probable vesicular acetylcholine transporter-A [KO:K14636]
117247960  [KO:K04163]
117247961  [KO:K04163]
117248120  [KO:K14387]
117248160  chrm3a; muscarinic acetylcholine receptor M3 [KO:K04131]
117248398  slc18a2; synaptic vesicular amine transporter [KO:K08155]
117248513  oprm1; mu-type opioid receptor [KO:K04215]
117248687  [KO:K05840]
117248700  [KO:K14387]
117248723  [KO:K04138]
117248754  [KO:K14387]
117248757  [KO:K05189]
117248790  chata; choline O-acetyltransferase isoform X1 [KO:K00623] [EC:2.3.1.6]
117248918  [KO:K14387]
117248993  chrna3; neuronal acetylcholine receptor subunit alpha-3 [KO:K04805]
117249107  chrm2a; muscarinic acetylcholine receptor M2a [KO:K04130]
117249363  gnai1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
117249384  [KO:K05046]
117249385  slc6a1l; sodium- and chloride-dependent GABA transporter 1 [KO:K05034]
117249428  drd4-rs; dopamine receptor D4 related sequence [KO:K04147]
117249433  [KO:K01049] [EC:3.1.1.7]
117249487  grm8a; glutamate receptor, metabotropic 8a isoform X1 [KO:K04610]
117249515  [KO:K05046]
117249719  [KO:K14387]
117249720  [KO:K14387]
117249783  [KO:K05181]
117249785  [KO:K05175]
117249801  [KO:K14387]
117249879  chrm4a; muscarinic acetylcholine receptor M4 [KO:K04132]
117249986  [KO:K05228]
117250016  [KO:K08048] [EC:4.6.1.1]
117250136  [KO:K05046]
117250207  [KO:K14387]
117250239  [KO:K05186]
117250345  [KO:K04147]
117250356  [KO:K14387]
117250357  [KO:K14387]
117250861  [KO:K04542]
117250888  [KO:K04270]
117251058  [KO:K04157]
117251125  htr1fa; 5-hydroxytryptamine receptor 1F [KO:K04153]
117251142  pnoca; prepronociceptin [KO:K25696]
117251213  chrnb4; neuronal acetylcholine receptor subunit beta-4 [KO:K04815]
117251312  adcy5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
117251643  [KO:K14387]
117252139  tacr1a; tachykinin receptor 1a [KO:K04222]
117252208  drd4b; dopamine receptor D4b [KO:K04147]
117252277  slc6a4b; solute carrier family 6 member 4b [KO:K05037]
117252327  htr7c; 5-hydroxytryptamine receptor 7 [KO:K04163]
117252355  htr1aa; 5-hydroxytryptamine (serotonin) receptor 1A a [KO:K04153]
117252356  adra1aa; adrenoceptor alpha 1Aa [KO:K04135]
117252381  adora2aa; adenosine A2a receptor a [KO:K04266]
117252436  [KO:K04140]
117252448  [KO:K04634]
117252566  [KO:K08155]
117252569  grin1b; glutamate receptor ionotropic, NMDA 1b [KO:K05208]
117252760  gnao1b; guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, b [KO:K04534]
117252859  slc1a3a; solute carrier family 1 member 3a [KO:K05614]
117253027  p2rx2; P2X purinoceptor 2 [KO:K05216]
117253092  adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
117253110  p2rx4b; P2X purinoceptor 4b [KO:K05218]
117253207  adra2b; alpha-2B adrenergic receptor [KO:K04139]
117253291  si:dkey-44g17.6; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04347]
117253309  glra1; glycine receptor subunit alphaZ1 isoform X1 [KO:K05193]
117253564  [KO:K04635]
117253586  slc1a7b; solute carrier family 1 member 7b [KO:K05618]
117253632  [KO:K05186]
117253744  [KO:K04538]
117253765  gabrb3; gamma-aminobutyric acid receptor subunit beta-3 isoform X1 [KO:K05181]
117253766  gabra5; gamma-aminobutyric acid receptor subunit alpha-5 [KO:K05175]
117253831  slc1a8a; excitatory amino acid transporter 5 [KO:K05618]
117253964  [KO:K04542]
117254003  [KO:K04819]
117254004  [KO:K04819]
117254005  [KO:K04819]
117254040  [KO:K04819]
117254041  [KO:K04819]
117254042  [KO:K04819]
117254043  [KO:K04819]
117254044  [KO:K04819]
117254045  [KO:K04819]
117254046  [KO:K04819]
117254075  grin3bb; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
117254086  [KO:K04151]
117254159  htr2b; 5-hydroxytryptamine receptor 2B [KO:K04157]
117254244  [KO:K08041] [EC:4.6.1.1]
117254297  [KO:K04819]
117254444  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
117254479  slc1a6; excitatory amino acid transporter 4 [KO:K05617]
117254644  [KO:K04299]
117254745  si:ch211-286b5.5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
117254873  [KO:K05196]
117254889  chrnb5a; neuronal acetylcholine receptor subunit beta-2 [KO:K04813]
117254906  adra2a; alpha-2A adrenergic receptor [KO:K04138]
117254945  [KO:K19662] [EC:2.7.11.13]
117254990  adra2c; alpha-2C adrenergic receptor [KO:K04140]
117255024  adra1d; alpha-1D adrenergic receptor [KO:K04137]
117255112  tacr2; substance-K receptor [KO:K04223]
117255130  adcy9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
117255140  [KO:K04144]
117255184  glra3; glycine receptor subunit alpha-3 [KO:K05195]
117255275  slc6a5; sodium- and chloride-dependent glycine transporter 2 isoform X1 [KO:K05038]
117255397  prkacab; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
117255414  prkcaa; protein kinase C, alpha, a isoform X1 [KO:K02677] [EC:2.7.11.13]
117255465  grin2bb; glutamate receptor, ionotropic, N-methyl D-aspartate 2B, genome duplicate b isoform X1 [KO:K05210]
117255589  chrna8; neuronal acetylcholine receptor subunit alpha-7 isoform X1 [KO:K04809]
117255744  [KO:K14387]
117255767  tacr3l; tachykinin receptor 3-like [KO:K04224]
117255805  p2rx3b; P2X purinoceptor 3b [KO:K05217]
117255814  tacr3a; tachykinin receptor 3a [KO:K04224]
117255824  chrna6; neuronal acetylcholine receptor subunit alpha-6 [KO:K04808]
117255842  [KO:K14387]
117255941  [KO:K14387]
117255943  [KO:K05198]
117256029  [KO:K04160]
117256064  [KO:K04547]
117256221  slc32a1; vesicular inhibitory amino acid transporter [KO:K15015]
117256385  [KO:K04265]
117256394  slc6a11a; solute carrier family 6 member 11a [KO:K05045]
117256618  [KO:K27951]
117256628  drd5a; D(1B) dopamine receptor [KO:K05840]
117256656  [KO:K04265]
117256884  grm6b; glutamate receptor, metabotropic 6b [KO:K04608]
117256915  slc1a2a; excitatory amino acid transporter 2a [KO:K05613]
117256933  [KO:K14387]
117256978  gnb1b; guanine nucleotide binding protein (G protein), beta polypeptide 1b [KO:K04536]
117257002  [KO:K04609]
117257011  [KO:K04630]
117257069  [KO:K04632]
117257127  [KO:K05046]
117257143  slc6a11b; sodium- and chloride-dependent GABA transporter 3 [KO:K05044]
117257144  slc6a1b; sodium- and chloride-dependent GABA transporter 1b [KO:K05034]
117257351  gnai2b; guanine nucleotide-binding protein G(i) subunit alpha-2b [KO:K04630]
117257370  slc17a6b; vesicular glutamate transporter 2.1 [KO:K12302]
117257381  [KO:K04270]
117257399  grm2a; glutamate receptor, metabotropic 2a [KO:K04605]
117257406  [KO:K04265]
117257421  hrh1; histamine H1 receptor [KO:K04149]
117257486  [KO:K04607]
117257502  grm2b; glutamate receptor, metabotropic 2b [KO:K04605]
117257628  htr6; 5-hydroxytryptamine receptor 6 [KO:K04162]
117257812  chrna4b; neuronal acetylcholine receptor subunit alpha-4b isoform X1 [KO:K04806]
117257846  [KO:K12303]
117257850  adora1b; adenosine receptor A1b [KO:K04265]
117257914  [KO:K04265]
117257989  [KO:K04608]
117258025  [KO:K04270]
117258098  [KO:K04145]
117258139  ogfr; opioid growth factor receptor [KO:K27951]
117258192  adcy6b; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
117258226  [KO:K08046] [EC:4.6.1.1]
117258276  slc6a1a; sodium- and chloride-dependent GABA transporter 1a [KO:K05034]
117258303  gnb1a; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
117258332  [KO:K04609]
117258383  gnas; guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632]
117258408  gabrd; gamma-aminobutyric acid receptor subunit delta [KO:K05184]
117258430  gnai3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630]
117258616  [KO:K15015]
117258649  [KO:K04607]
117258658  oprl1; nociceptin receptor [KO:K04216]
117258690  [KO:K04270]
117258691  [KO:K04270]
117258692  [KO:K04270]
117258754  tac3a; tachykinin-3a isoform X1 [KO:K05240]
117258771  [KO:K04270]
117258831  [KO:K04270]
117258833  [KO:K04270]
117258870  pdyn; proenkephalin-B [KO:K15840]
117258907  slc17a9b; solute carrier family 17 member 9b [KO:K12303]
117259077  [KO:K04299]
117259081  [KO:K05219]
117259111  grm5b; metabotropic glutamate receptor 5b [KO:K04604]
117259200  [KO:K08388]
117259201  [KO:K08388]
117259226  [KO:K05045]
117259314  p2ry1; P2Y purinoceptor 1 [KO:K04270]
117259378  slc6a4a; solute carrier family 6 member 4a isoform X1 [KO:K05037]
117259565  p2ry2.1; P2Y purinoceptor 2 isoform X1 [KO:K04269]
117259615  agrp; agouti-related protein [KO:K05231]
117259812  [KO:K08388]
117259828  [KO:K05045]
117260124  p2ry12; P2Y purinoceptor 12 [KO:K04298]
117260160  [KO:K05045]
117260190  [KO:K04299]
117260199  gria4a; glutamate receptor 4a isoform X1 [KO:K05200]
117260215  [KO:K05201]
117260238  drd2a; dopamine receptor D2a [KO:K04145]
117260288  grik4; glutamate receptor ionotropic, kainate 4 isoform X1 [KO:K05204]
117260335  [KO:K04272]
117260459  p2ry4; P2Y purinoceptor 4 [KO:K04271]
117260524  gria1a; glutamate receptor 1a isoform X1 [KO:K05197]
117260568  gabra4; gamma-aminobutyric acid receptor subunit alpha-4 [KO:K05175]
117260595  [KO:K04813]
117260634  adra2db; alpha-2Db adrenergic receptor [KO:K04140]
117260637  gria2b; glutamate receptor 2b isoform X1 [KO:K05198]
117260654  [KO:K04136]
117260719  drd1a; D(1) dopamine receptor [KO:K04144]
117260876  gabrb2a; gamma-aminobutyric acid receptor subunit beta-2a isoform X1 [KO:K05181]
117260878  gabra6a; gamma-aminobutyric acid receptor subunit alpha-6a isoform X1 [KO:K05175]
117260884  p2rx3a; P2X purinoceptor 3a [KO:K05217]
117261001  slc5a7a; high-affinity choline transporter 1 [KO:K14387]
117261107  [KO:K04809]
117261117  [KO:K05199]
117261181  gabrp; gamma-aminobutyric acid receptor subunit pi [KO:K05189]
117261280  htr4; 5-hydroxytryptamine receptor 4 [KO:K04160]
117261287  [KO:K05175]
117261289  hrh2a; histamine receptor H2a [KO:K04150]
117261318  glrbb; glycine receptor, beta b isoform X1 [KO:K05196]
117261434  [KO:K05045]
117261449  adrb2a; adrenoceptor beta 2, surface a [KO:K04142]
117261485  [KO:K04808]
117261553  grik1a; glutamate receptor ionotropic, kainate 1 isoform X1 [KO:K05201]
117261580  [KO:K14387]
117261793  [KO:K12302]
117261801  gnb5a; guanine nucleotide-binding protein subunit beta-5a [KO:K04539]
117261802  [KO:K04270]
117262028  [KO:K04130]
117262030  drd4a; dopamine receptor D4a [KO:K04147]
117262067  slc1a2b; excitatory amino acid transporter 2b isoform X1 [KO:K05613]
117262337  [KO:K04630]
117262340  [KO:K04142]
117262436  [KO:K04610]
117262546  slc17a8; vesicular glutamate transporter 3 [KO:K12302]
117262630  [KO:K04809]
117262688  chrm4b; muscarinic acetylcholine receptor M4 [KO:K04132]
117262721  grm3; metabotropic glutamate receptor 3 [KO:K04606]
117262761  slc6a13; sodium- and chloride-dependent GABA transporter 2 [KO:K05046]
117262875  gnao1a; guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, a isoform X1 [KO:K04534]
117262989  gnb3b; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3b [KO:K07825]
117263024  grin2da; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
117263064  [KO:K04615]
117263235  drd1b; dopamine receptor D1b [KO:K04144]
117263253  chrna11; cholinergic receptor, nicotinic, alpha 11 isoform X1 [KO:K04809]
117263293  gngt1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
117263394  [KO:K04809]
117263687  [KO:K05205]
117263807  p2rx5; P2X purinoceptor 5 [KO:K05219]
117263849  [KO:K14387]
117263859  [KO:K14387]
117263864  gabbr2; gamma-aminobutyric acid type B receptor subunit 2 [KO:K04615]
117263948  adcy2b; adenylate cyclase type 2b isoform X1 [KO:K08042] [EC:4.6.1.1]
117264040  tac1; protachykinin-1 [KO:K05239]
117264082  [KO:K04151]
117264099  [KO:K05228]
117264200  oprd1a; opioid receptor, delta 1a [KO:K04213]
117264352  [KO:K04214]
117264462  drd3; D(3) dopamine receptor [KO:K04146]
117264484  mc4r; melanocortin receptor 4 [KO:K04202]
117264527  [KO:K05190]
117264538  htr5ab; 5-hydroxytryptamine (serotonin) receptor 5A, genome duplicate b [KO:K04161]
117264652  htr3a; 5-hydroxytryptamine receptor 3A [KO:K04819]
117264741  adcy3a; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
117264975  gng3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
117265048  [KO:K04633]
117265068  [KO:K04819]
117265296  gnb3a; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3a [KO:K07825]
117265547  slc6a3; sodium-dependent dopamine transporter [KO:K05036]
117265556  drd2l; dopamine receptor D2 like [KO:K04145]
117265585  [KO:K04809]
117265672  adcy2a; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
117265709  prkcg; protein kinase C alpha type [KO:K19663] [EC:2.7.11.13]
117265788  grik2; glutamate receptor ionotropic, kainate 2 isoform X1 [KO:K05202]
117265937  [KO:K05203]
117266036  [KO:K05212]
117266053  chrnb2; neuronal acetylcholine receptor subunit beta-2 [KO:K04813]
117266060  gabbr1a; gamma-aminobutyric acid type B receptor subunit 1 [KO:K04615]
117266087  grik5; glutamate receptor ionotropic, kainate 5 [KO:K05205]
117266208  oprd1b; opioid receptor, delta 1b [KO:K04213]
117266359  [KO:K04615]
117266581  [KO:K04809]
117266622  gabrg2; gamma-aminobutyric acid receptor subunit gamma-2 isoform X1 [KO:K05186]
117266658  gabrg1; gamma-aminobutyric acid receptor subunit gamma-1 [KO:K05186]
117266676  gabra2a; gamma-aminobutyric acid receptor subunit alpha-2 [KO:K05175]
117266694  [KO:K05190]
117266706  gng2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
117266757  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
117266776  htr1d; 5-hydroxytryptamine receptor 1D [KO:K04153]
117266904  chrm5a; muscarinic acetylcholine receptor M5a [KO:K04133]
117266906  htr1b; 5-hydroxytryptamine receptor 1B [KO:K04153]
117266940  slc1a8b; solute carrier family 1 member 8b [KO:K05618]
117267042  gng7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
117267053  gnb5b; guanine nucleotide-binding protein subunit beta-5b [KO:K04539]
117267075  [KO:K04268]
117267243  gna11b; guanine nucleotide-binding protein subunit alpha-11b isoform X1 [KO:K04635]
117267309  grin3ba; glutamate receptor ionotropic, NMDA 3B isoform X1 [KO:K05214]
117267488  gabrb1; gamma-aminobutyric acid receptor subunit beta-1 [KO:K05181]
117267636  gabrr2a; gamma-aminobutyric acid receptor subunit rho-2a [KO:K05190]
117267639  grm1b; metabotropic glutamate receptor 1b isoform X1 [KO:K04603]
117267785  slc1a9; solute carrier family 1 member 9 isoform X1 [KO:K05613]
117267857  gabrb4; gamma-aminobutyric acid receptor subunit beta-4 isoform X1 [KO:K05192]
117267988  gng13b; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13b [KO:K04547]
117267994  [KO:K04347]
117268022  gabra1; gamma-aminobutyric acid receptor subunit alpha-1 isoform X1 [KO:K05175]
117268039  [KO:K04819]
117268101  gabra3; gamma-aminobutyric acid receptor subunit alpha-3 isoform X1 [KO:K05175]
117268140  [KO:K19662] [EC:2.7.11.13]
117268170  grin2ca; glutamate receptor, ionotropic, N-methyl D-aspartate 2Ca [KO:K05211]
117268289  [KO:K05210]
117268316  [KO:K08155]
117268354  si:ch73-374l24.1; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
117268372  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a isoform X1 [KO:K04345] [EC:2.7.11.11]
117268589  slc17a7a; solute carrier family 17 member 7a [KO:K12302]
117268595  grin2aa; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
117268678  [KO:K04819]
117268794  [KO:K08049] [EC:4.6.1.1]
117269244  adora2ab; adenosine A2a receptor b [KO:K04266]
117269255  [KO:K05197]
117269298  grin3a; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
117269299  [KO:K04222]
117269356  [KO:K05614]
117269425  si:dkey-247m21.3; 5-hydroxytryptamine receptor 4 [KO:K04160]
117269430  [KO:K04139]
117269515  adra1ab; alpha-1A adrenergic receptor isoform X1 [KO:K04135]
117269641  [KO:K04634]
117269746  grin1a; glutamate receptor ionotropic, NMDA 1a isoform X1 [KO:K05208]
117269805  gria4b; glutamate receptor 4b isoform X1 [KO:K05200]
117270008  htr1ab; 5-hydroxytryptamine (serotonin) receptor 1A b isoform X1 [KO:K04153]
117270039  gng10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
117270114  [KO:K05199]
117270178  grm5a; glutamate receptor, metabotropic 5a isoform X1 [KO:K04604]
117270347  [KO:K05190]
117270361  [KO:K04136]
117270489  si:dkey-206f10.1; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
117270585  [KO:K05228]
117270696  [KO:K04133]
117270700  [KO:K05202]
117270813  pnocb; prepronociceptin b [KO:K25696]
117270860  [KO:K05858] [EC:3.1.4.11]
117270879  adora2b; adenosine receptor A2b [KO:K04267]
117270911  gabra6b; gamma-aminobutyric acid receptor subunit alpha-6 isoform X1 [KO:K05175]
117270969  [KO:K05190]
117271013  [KO:K04153]
117271061  [KO:K05858] [EC:3.1.4.11]
117271141  [KO:K08043] [EC:4.6.1.1]
117271197  grm1a; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
117271278  [KO:K15015]
117271546  slc6a9; sodium- and chloride-dependent glycine transporter 1 isoform X1 [KO:K05038]
117271593  [KO:K18832]
117271602  oprk1; kappa-type opioid receptor [KO:K04214]
117271607  [KO:K04542]
117271635  slc6a2; sodium-dependent noradrenaline transporter [KO:K05035]
117271669  slc1a7a; solute carrier family 1 member 7a [KO:K05618]
117271681  asip2b; agouti-signaling protein 2b [KO:K05231]
117271818  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b isoform X1 [KO:K04345] [EC:2.7.11.11]
117272022  [KO:K05045]
117272061  adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
117272080  [KO:K05046]
117272123  [KO:K05046]
117272153  [KO:K04633]
117272154  [KO:K05045]
117272159  [KO:K05617]
117272176  gng12a; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12a isoform X1 [KO:K04347]
117272185  [KO:K05046]
117272186  [KO:K05046]
117272349  gng8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
117272452  [KO:K08041] [EC:4.6.1.1]
117272629  htr3b; 5-hydroxytryptamine receptor 3B [KO:K04819]
117272642  [KO:K05181]
117272884  [KO:K04140]
Compound
C00002  ATP
C00008  ADP
C00015  UDP
C00025  L-Glutamate
C00029  UDP-glucose
C00037  Glycine
C00075  UTP
C00076  Calcium cation
C00114  Choline
C00165  Diacylglycerol
C00212  Adenosine
C00334  4-Aminobutanoate
C00388  Histamine
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00698  Cl-
C00780  Serotonin
C00788  L-Adrenaline
C01330  Sodium cation
C01996  Acetylcholine
C02210  beta-Endorphin
C02758  alpha-Melanotropin
C03758  Dopamine
C11684  MET-enkephalin
C15871  Nocistatin
C16039  alpha-Neoendorphin
C16040  beta-Neoendorphin
C16041  Leu-enkephalin
C16044  Nociceptin
C16094  Substance P
C16095  Neuropeptide K
C16096  Neuropeptide gamma
C16097  Neurokinin A
C16098  Neurokinin B
C16099  Endokinin A/B
C16100  Endokinin C
C16101  Endokinin D
C16103  Agouti related protein (87-132)
C16136  beta-Melanotropin
C16137  gamma-Melanotropin
Reference
PMID:37385351
  Authors
Nimgampalle M, Chakravarthy H, Sharma S, Shree S, Bhat AR, Pradeepkiran JA, Devanathan V
  Title
Neurotransmitter systems in the etiology of major neurological disorders: Emerging insights and therapeutic implications.
  Journal
Ageing Res Rev 89:101994 (2023)
DOI:10.1016/j.arr.2023.101994
Reference
PMID:31726793
  Authors
Malik AR, Willnow TE
  Title
Excitatory Amino Acid Transporters in Physiology and Disorders of the Central Nervous System.
  Journal
Int J Mol Sci 20:ijms20225671 (2019)
DOI:10.3390/ijms20225671
Reference
PMID:25116141
  Authors
Higley MJ
  Title
Localized GABAergic inhibition of dendritic Ca(2+) signalling.
  Journal
Nat Rev Neurosci 15:567-72 (2014)
DOI:10.1038/nrn3803
Reference
PMID:12888801
  Authors
Brambilla P, Perez J, Barale F, Schettini G, Soares JC
  Title
GABAergic dysfunction in mood disorders.
  Journal
Mol Psychiatry 8:721-37, 715 (2003)
DOI:10.1038/sj.mp.4001362
Reference
PMID:35055019
  Authors
Shimizu-Okabe C, Kobayashi S, Kim J, Kosaka Y, Sunagawa M, Okabe A, Takayama C
  Title
Developmental Formation of the GABAergic and Glycinergic Networks in the Mouse Spinal Cord.
  Journal
Int J Mol Sci 23:ijms23020834 (2022)
DOI:10.3390/ijms23020834
Reference
PMID:33924731
  Authors
Wang Y, Tan B, Wang Y, Chen Z
  Title
Cholinergic Signaling, Neural Excitability, and Epilepsy.
  Journal
Molecules 26:molecules26082258 (2021)
DOI:10.3390/molecules26082258
Reference
PMID:36757901
  Authors
Channer B, Matt SM, Nickoloff-Bybel EA, Pappa V, Agarwal Y, Wickman J, Gaskill PJ
  Title
Dopamine, Immunity, and Disease.
  Journal
Pharmacol Rev 75:62-158 (2023)
DOI:10.1124/pharmrev.122.000618
Reference
PMID:25037203
  Authors
Savica R, Benarroch EE
  Title
Dopamine receptor signaling in the forebrain: recent insights and clinical implications.
  Journal
Neurology 83:758-67 (2014)
DOI:10.1212/WNL.0000000000000719
Reference
PMID:33651238
  Authors
Pourhamzeh M, Moravej FG, Arabi M, Shahriari E, Mehrabi S, Ward R, Ahadi R, Joghataei MT
  Title
The Roles of Serotonin in Neuropsychiatric Disorders.
  Journal
Cell Mol Neurobiol 42:1671-1692 (2022)
DOI:10.1007/s10571-021-01064-9
Reference
PMID:35492402
  Authors
Chhatar S, Lal G
  Title
Role of adrenergic receptor signalling in neuroimmune communication.
  Journal
Curr Res Immunol 2:202-217 (2021)
DOI:10.1016/j.crimmu.2021.11.001
Reference
PMID:39337347
  Authors
Szukiewicz D
  Title
Histaminergic System Activity in the Central Nervous System: The Role in Neurodevelopmental and Neurodegenerative Disorders.
  Journal
Int J Mol Sci 25:ijms25189859 (2024)
DOI:10.3390/ijms25189859
Reference
PMID:33907179
  Authors
Huang Z, Xie N, Illes P, Di Virgilio F, Ulrich H, Semyanov A, Verkhratsky A, Sperlagh B, Yu SG, Huang C, Tang Y
  Title
From purines to purinergic signalling: molecular functions and human diseases.
  Journal
Signal Transduct Target Ther 6:162 (2021)
DOI:10.1038/s41392-021-00553-z
Reference
PMID:16715052
  Authors
Fields RD, Burnstock G
  Title
Purinergic signalling in neuron-glia interactions.
  Journal
Nat Rev Neurosci 7:423-36 (2006)
DOI:10.1038/nrn1928
Reference
PMID:26880796
  Authors
Cawley NX, Li Z, Loh YP
  Title
60 YEARS OF POMC: Biosynthesis, trafficking, and secretion of pro-opiomelanocortin-derived peptides.
  Journal
J Mol Endocrinol 56:T77-97 (2016)
DOI:10.1530/JME-15-0323
Reference
PMID:28360832
  Authors
Butler AA, Girardet C, Mavrikaki M, Trevaskis JL, Macarthur H, Marks DL, Farr SA
  Title
A Life without Hunger: The Ups (and Downs) to Modulating Melanocortin-3 Receptor Signaling.
  Journal
Front Neurosci 11:128 (2017)
DOI:10.3389/fnins.2017.00128
Reference
PMID:26956246
  Authors
Toll L, Bruchas MR, Calo' G, Cox BM, Zaveri NT
  Title
Nociceptin/Orphanin FQ Receptor Structure, Signaling, Ligands, Functions, and Interactions with Opioid Systems.
  Journal
Pharmacol Rev 68:419-57 (2016)
DOI:10.1124/pr.114.009209
Reference
PMID:36589829
  Authors
Campo A, Dufour S, Rousseau K
  Title
Tachykinins, new players in the control of reproduction and food intake: A comparative review in mammals and teleosts.
  Journal
Front Endocrinol (Lausanne) 13:1056939 (2022)
DOI:10.3389/fendo.2022.1056939
Related
pathway
ely04080  Neuroactive ligand-receptor interaction
KO pathway
ko04082   

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