KEGG   PATHWAY: fch04060
Entry
fch04060                    Pathway                                
Name
Cytokine-cytokine receptor interaction - Falco cherrug (Saker falcon)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
fch04060  Cytokine-cytokine receptor interaction
fch04060

Organism
Falco cherrug (Saker falcon) [GN:fch]
Gene
102045713  IL1RL1; interleukin-1 receptor-like 1 isoform X1 [KO:K05171]
102045730  IL17RC; LOW QUALITY PROTEIN: interleukin-17 receptor C [KO:K05166]
102045945  BMPR1A; bone morphogenetic protein receptor type-1A [KO:K04673] [EC:2.7.11.30]
102045996  BMP7; bone morphogenetic protein 7 [KO:K16621]
102046018  ACVR1B; LOW QUALITY PROTEIN: activin receptor type-1B [KO:K13567] [EC:2.7.11.30]
102046032  [KO:K12964]
102046188  ACVRL1; serine/threonine-protein kinase receptor R3 [KO:K13594] [EC:2.7.11.30]
102046204  [KO:K12964]
102046369  [KO:K12499]
102046415  BMPR2; bone morphogenetic protein receptor type-2 isoform X1 [KO:K04671] [EC:2.7.11.30]
102046556  GDF1; embryonic growth/differentiation factor 1 [KO:K05495]
102046734  IL34; interleukin-34 [KO:K22633]
102046752  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
102046968  IL12B; interleukin-12 subunit beta [KO:K05425]
102047170  TNFRSF4; tumor necrosis factor receptor superfamily member 4 isoform X1 [KO:K05142]
102047171  BMP4; bone morphogenetic protein 4 isoform X2 [KO:K04662]
102047185  TNFRSF13C; tumor necrosis factor receptor superfamily member 13C [KO:K05151]
102047265  IFNLR1; interferon lambda receptor 1 [KO:K05140]
102047279  IL16; pro-interleukin-16 [KO:K22628]
102047345  NODAL; nodal homolog [KO:K04666]
102047473  EDA; ectodysplasin-A [KO:K05480]
102047657  IL6; interleukin-6 [KO:K05405]
102047662  IFNG; interferon gamma [KO:K04687]
102047690  IL12A; interleukin-12 subunit alpha [KO:K05406]
102047699  TNFSF10; tumor necrosis factor ligand superfamily member 10 isoform X1 [KO:K04721]
102047707  [KO:K05439]
102047745  IL15; interleukin-15 isoform X3 [KO:K05433]
102047778  TGFB2; transforming growth factor beta-2 proprotein [KO:K13376]
102047797  EDAR; tumor necrosis factor receptor superfamily member EDAR isoform X1 [KO:K05162]
102047809  BMP5; bone morphogenetic protein 5 isoform X1 [KO:K04663]
102047829  IL22; interleukin-22 [KO:K05445]
102047882  GDF2; LOW QUALITY PROTEIN: growth/differentiation factor 2 [KO:K05503]
102047942  PRLR; prolactin receptor isoform X1 [KO:K05081]
102048009  IL13RA1; interleukin-13 receptor subunit alpha-1 [KO:K05076]
102048246  MPL; thrombopoietin receptor [KO:K05082]
102048403  [KO:K05507]
102048414  IFNGR1; LOW QUALITY PROTEIN: interferon gamma receptor 1 [KO:K05132]
102048434  ACVR2B; activin receptor type-2B [KO:K13596] [EC:2.7.11.30]
102048632  [KO:K04388] [EC:2.7.11.30]
102048640  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
102048793  BMP2; bone morphogenetic protein 2 [KO:K21283]
102048813  CXCL12; stromal cell-derived factor 1 [KO:K10031]
102048823  IL11RA; interleukin-11 receptor subunit alpha isoform X3 [KO:K05056]
102048906  [KO:K04181]
102048973  [KO:K12964]
102048997  EBI3; interleukin-27 subunit beta isoform X2 [KO:K24476]
102049000  CCL19; C-C motif chemokine 19 [KO:K05512]
102049003  LEPR; leptin receptor isoform X8 [KO:K05062]
102049070  GDF9; growth/differentiation factor 9 [KO:K22673]
102049106  GDF5; growth/differentiation factor 5 [KO:K04664]
102049176  CCL21; C-C motif chemokine 21 [KO:K16062]
102049228  IL13RA2; interleukin-13 receptor subunit alpha-2 [KO:K05077]
102049358  [KO:K05509]
102049472  CCR10; C-C chemokine receptor type 10 [KO:K04185]
102049561  LIFR; leukemia inhibitory factor receptor [KO:K05058]
102049613  [KO:K04183]
102049736  [KO:K05057]
102049741  [KO:K05068]
102049775  TNFRSF17; tumor necrosis factor receptor superfamily member 17 [KO:K05153]
102049789  CCR9; C-C chemokine receptor type 9 [KO:K04184]
102049860  GHR; growth hormone receptor isoform X3 [KO:K05080]
102049975  BMP15; bone morphogenetic protein 15 [KO:K05498]
102050149  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
102050341  GH1; somatotropin [KO:K05438]
102050446  ACKR3; atypical chemokine receptor 3 [KO:K04304]
102050580  TNFSF13B; tumor necrosis factor ligand superfamily member 13B [KO:K05476]
102050665  TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473]
102050671  [KO:K21283]
102050776  [KO:K04519]
102050985  GDF7; LOW QUALITY PROTEIN: growth/differentiation factor 7 [KO:K20013]
102051023  [KO:K06854]
102051109  IL10; interleukin-10 [KO:K05443]
102051174  INHBB; LOW QUALITY PROTEIN: inhibin beta B chain [KO:K22687]
102051181  IL31RA; interleukin-31 receptor subunit alpha isoform X1 [KO:K22630]
102051282  [KO:K22667]
102051332  IL12RB1; LOW QUALITY PROTEIN: interleukin-12 receptor subunit beta-1 [KO:K05063]
102051343  IL17C; interleukin-17C [KO:K05491]
102051353  IL6ST; interleukin-6 receptor subunit beta isoform X1 [KO:K05060]
102051374  [KO:K05494]
102051397  [KO:K05508]
102051544  IL17A; interleukin-17A [KO:K05489]
102051566  CCL17; LOW QUALITY PROTEIN: C-C motif chemokine 17 [KO:K21083]
102051634  [KO:K10030]
102051915  PRL; prolactin [KO:K05439]
102052025  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
102052126  GDF10; growth/differentiation factor 10 [KO:K22674]
102052415  BMP3; bone morphogenetic protein 3 [KO:K05496]
102052578  [KO:K16622]
102052691  ACVR1C; activin receptor type-1C isoform X1 [KO:K13568] [EC:2.7.11.30]
102052757  [KO:K22688]
102052830  CLCF1; cardiotrophin-like cytokine factor 1 [KO:K05421]
102052886  IL12RB2; interleukin-12 receptor subunit beta-2 [KO:K05064]
102052893  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
102052925  AMH; muellerian-inhibiting factor [KO:K04665]
102052930  [KO:K22688]
102052979  IL7R; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072]
102053092  ACVR1; activin receptor type-1 isoform X1 [KO:K04675] [EC:2.7.11.30]
102053169  [KO:K04722]
102053209  [KO:K04180]
102053215  RELL2; RELT-like protein 2 isoform X1 [KO:K26541]
102053225  [KO:K22669]
102053325  ACVR2A; activin receptor type-2A isoform X2 [KO:K04670] [EC:2.7.11.30]
102053336  TNFRSF13B; tumor necrosis factor receptor superfamily member 13B [KO:K05150]
102053362  [KO:K05050]
102053376  RELT; tumor necrosis factor receptor superfamily member 19L [KO:K05156]
102053457  IL20RB; interleukin-20 receptor subunit beta [KO:K05137]
102053466  IL17B; interleukin-17B [KO:K05490]
102053489  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
102053581  MSTN; growth/differentiation factor 8 [KO:K05497]
102053683  [KO:K10032]
102053690  TNFRSF18; tumor necrosis factor receptor superfamily member 18 isoform X1 [KO:K05154]
102053724  GDF6; growth/differentiation factor 6 [KO:K20012]
102053856  [KO:K10032]
102053918  TNFRSF11A; tumor necrosis factor receptor superfamily member 11A [KO:K05147]
102053988  CCR7; C-C chemokine receptor type 7 [KO:K04182]
102054291  BMPR1B; bone morphogenetic protein receptor type-1B [KO:K13578] [EC:2.7.11.30]
102054375  TNFRSF11B; tumor necrosis factor receptor superfamily member 11B [KO:K05148]
102054400  IL17RA; interleukin-17 receptor A isoform X1 [KO:K05164]
102054449  IL18; interleukin-18 [KO:K05482]
102054469  TNFRSF6B; tumor necrosis factor receptor superfamily member 6B isoform X1 [KO:K05143]
102054470  LIF; leukemia inhibitory factor [KO:K05419]
102054509  NGFR; tumor necrosis factor receptor superfamily member 16 isoform X1 [KO:K02583]
102054741  IFNGR2; interferon gamma receptor 2 [KO:K05133]
102054800  TNFRSF21; tumor necrosis factor receptor superfamily member 21 isoform X2 [KO:K05157]
102054913  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
102055038  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
102055084  IL10RB; interleukin-10 receptor subunit beta [KO:K05135]
102055105  [KO:K05172]
102055258  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
102055279  IL18R1; interleukin-18 receptor 1 [KO:K05173]
102055349  IL22RA1; interleukin-22 receptor subunit alpha-1 [KO:K05138]
102055350  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
102055356  RELL1; RELT-like protein 1 [KO:K26541]
102055360  IL23A; interleukin-23 subunit alpha [KO:K05426]
102055386  CCL20; C-C motif chemokine 20 [KO:K14625]
102055453  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
102055457  IL18RAP; LOW QUALITY PROTEIN: interleukin-18 receptor accessory protein [KO:K05174]
102055637  NGF; beta-nerve growth factor [KO:K02582]
102055672  IL5RA; LOW QUALITY PROTEIN: interleukin-5 receptor subunit alpha [KO:K05067]
102056039  BMP10; bone morphogenetic protein 10 [KO:K22670]
102056138  [KO:K06454]
102056177  TNFRSF19; tumor necrosis factor receptor superfamily member 19 isoform X1 [KO:K05155]
102056382  CSF3; granulocyte colony-stimulating factor [KO:K05423]
102056445  TNFSF8; tumor necrosis factor ligand superfamily member 8 [KO:K05471]
102056524  IL20RA; interleukin-20 receptor subunit alpha isoform X1 [KO:K05136]
102056618  TNFSF15; tumor necrosis factor ligand superfamily member 15 [KO:K05478]
102056731  INHA; inhibin alpha chain [KO:K05500]
102056819  BMP6; bone morphogenetic protein 6 [KO:K16620]
102056940  [KO:K10030]
102056981  CSF1; LOW QUALITY PROTEIN: macrophage colony-stimulating factor 1 [KO:K05453]
102057089  ACKR4; atypical chemokine receptor 4 [KO:K04186]
102057173  IL10RA; interleukin-10 receptor subunit alpha [KO:K05134]
102057300  [KO:K05066]
102057310  EDA2R; tumor necrosis factor receptor superfamily member 27 [KO:K05163]
102057469  [KO:K05066]
102057560  GDF11; growth/differentiation factor 11 [KO:K22679]
102057636  CRLF2; cytokine receptor-like factor 2 isoform X1 [KO:K05078]
102057894  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
102057935  CNTF; ciliary neurotrophic factor [KO:K05420]
102058061  [KO:K04180]
102058084  [KO:K05481]
102058116  CSF2RB; LOW QUALITY PROTEIN: cytokine receptor common subunit beta [KO:K04738]
102058144  CNTFR; ciliary neurotrophic factor receptor subunit alpha isoform X1 [KO:K05059]
102058179  INHBA; inhibin beta A chain [KO:K04667]
102058232  [KO:K04180]
102058400  XCR1; chemokine XC receptor 1 [KO:K04193]
102058541  TNFRSF8; tumor necrosis factor receptor superfamily member 8 isoform X1 [KO:K05145]
102058714  [KO:K05141]
102058748  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
102058923  [KO:K04179]
102059090  CX3CR1; CX3C chemokine receptor 1 [KO:K04192]
102059260  [KO:K04183]
102059509  CD40LG; CD40 ligand [KO:K03161]
102059533  CXCL14; C-X-C motif chemokine 14 [KO:K10033]
102059582  [KO:K05430]
102059593  [KO:K05414]
102059601  CXCR6; C-X-C chemokine receptor type 6 [KO:K04191]
102059759  IL21R; interleukin-21 receptor isoform X1 [KO:K05075]
102059925  IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
102059926  IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
102059985  IL1R2; interleukin-1 receptor type 2 [KO:K04387]
102059987  CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
102060042  GDF15; growth/differentiation factor 15 [KO:K05504]
102060155  [KO:K04386]
102060188  CXCR5; C-X-C chemokine receptor type 5 [KO:K04190]
106630793  CSF3R; granulocyte colony-stimulating factor receptor [KO:K05061]
106630798  [KO:K05073]
106630898  IL15RA; interleukin-15 receptor subunit alpha [KO:K05074]
106630936  TNFSF4; tumor necrosis factor ligand superfamily member 4 [KO:K05469]
106631073  TNFRSF14; tumor necrosis factor receptor superfamily member 14 [KO:K05152]
106631115  IL23R; interleukin-23 receptor isoform X1 [KO:K05065]
106631140  [KO:K05066]
106631443  LEP; leptin [KO:K05424]
106631726  [KO:K21283]
114014285  CCL28; C-C motif chemokine 28 [KO:K05513]
114015476  TNFRSF9; tumor necrosis factor receptor superfamily member 9 [KO:K05146]
114016185  IL17RE; interleukin-17 receptor E [KO:K05168]
114016258  [KO:K05432]
114016448  IFNK; interferon kappa [KO:K05414]
114017616  [KO:K05431]
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Reference
PMID:21106488
  Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
  Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
  Journal
Hum Genomics 5:30-55 (2010)
DOI:10.1186/1479-7364-5-1-30
Reference
PMID:27577879
  Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
  Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
  Journal
J Allergy Clin Immunol 138:984-1010 (2016)
DOI:10.1016/j.jaci.2016.06.033
Reference
PMID:15500860
  Authors
Boulanger MJ, Garcia KC
  Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
  Journal
Adv Protein Chem 68:107-46 (2004)
DOI:10.1016/S0065-3233(04)68004-1
Reference
PMID:16034365
  Authors
Allan SM, Tyrrell PJ, Rothwell NJ
  Title
Interleukin-1 and neuronal injury.
  Journal
Nat Rev Immunol 5:629-40 (2005)
DOI:10.1038/nri1664
Reference
PMID:23847622
  Authors
Lopetuso LR, Chowdhry S, Pizarro TT
  Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
  Journal
Front Immunol 4:181 (2013)
DOI:10.3389/fimmu.2013.00181
Reference
PMID:21349428
  Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
  Title
Functional specialization of interleukin-17 family members.
  Journal
Immunity 34:149-62 (2011)
DOI:10.1016/j.immuni.2011.02.012
Reference
PMID:17530315
  Authors
Fischer P, Hilfiker-Kleiner D
  Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
  Journal
Basic Res Cardiol 102:279-97 (2007)
DOI:10.1007/s00395-007-0658-z
Reference
PMID:24381786
  Authors
Richards CD
  Title
The enigmatic cytokine oncostatin m and roles in disease.
  Journal
ISRN Inflamm 2013:512103 (2013)
DOI:10.1155/2013/512103
Reference
PMID:18926762
  Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
  Title
Structures and biological functions of IL-31 and IL-31 receptors.
  Journal
Cytokine Growth Factor Rev 19:347-56 (2008)
DOI:10.1016/j.cytogfr.2008.08.003
Reference
PMID:21155715
  Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
  Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
  Journal
Biochem J 434:343-51 (2011)
DOI:10.1042/BJ20101628
Reference
PMID:22410872
  Authors
de Weerd NA, Nguyen T
  Title
The interferons and their receptors--distribution and regulation.
  Journal
Immunol Cell Biol 90:483-91 (2012)
DOI:10.1038/icb.2012.9
Reference
PMID:12949498
  Authors
Aggarwal BB
  Title
Signalling pathways of the TNF superfamily: a double-edged sword.
  Journal
Nat Rev Immunol 3:745-56 (2003)
DOI:10.1038/nri1184
Reference
PMID:12189384
  Authors
Ashkenazi A
  Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
  Journal
Nat Rev Cancer 2:420-30 (2002)
DOI:10.1038/nrc821
Reference
PMID:26115564
  Authors
Seeger P, Musso T, Sozzani S
  Title
The TGF-beta superfamily in dendritic cell biology.
  Journal
Cytokine Growth Factor Rev 26:647-57 (2015)
DOI:10.1016/j.cytogfr.2015.06.002
Reference
PMID:23612460
  Authors
Wakefield LM, Hill CS
  Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
  Journal
Nat Rev Cancer 13:328-41 (2013)
DOI:10.1038/nrc3500
Reference
PMID:22710174
  Authors
Mueller TD, Nickel J
  Title
Promiscuity and specificity in BMP receptor activation.
  Journal
FEBS Lett 586:1846-59 (2012)
DOI:10.1016/j.febslet.2012.02.043
KO pathway
ko04060   

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