KEGG   PATHWAY: hcg04060
Entry
hcg04060                    Pathway                                
Name
Cytokine-cytokine receptor interaction - Hemicordylus capensis (graceful crag lizard)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
hcg04060  Cytokine-cytokine receptor interaction
hcg04060

Organism
Hemicordylus capensis (graceful crag lizard) [GN:hcg]
Gene
128321963  NGF; beta-nerve growth factor isoform X1 [KO:K02582]
128322032  TNFRSF11B; tumor necrosis factor receptor superfamily member 11B isoform X1 [KO:K05148]
128322156  CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
128323135  IL20; interleukin-20 [KO:K22667]
128323136  [KO:K22667]
128323146  IL23R; interleukin-23 receptor [KO:K05064]
128323669  [KO:K04388] [EC:2.7.11.30]
128323750  IL12RB2; interleukin-12 receptor subunit beta-2 isoform X1 [KO:K05064]
128323964  [KO:K05469]
128323970  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
128323984  MPL; thrombopoietin receptor isoform X1 [KO:K05082]
128324170  PRL; prolactin [KO:K05439]
128324336  IL10; interleukin-10 [KO:K05443]
128324521  GDF5; growth/differentiation factor 5 [KO:K04664]
128324876  [KO:K22667]
128324890  BMP7; bone morphogenetic protein 7 [KO:K16621]
128324982  RELL2; RELT-like protein 2 isoform X1 [KO:K26541]
128325063  TNFRSF6B; tumor necrosis factor receptor superfamily member 6B [KO:K05143]
128325100  LEPR; leptin receptor isoform X1 [KO:K05062]
128325218  GDF6; growth/differentiation factor 6 [KO:K20012]
128325824  RELL1; RELT-like protein 1 [KO:K26541]
128325832  CSF2RB; cytokine receptor common subunit beta isoform X1 [KO:K04738]
128325836  [KO:K12672]
128326346  [KO:K12671]
128326717  BMPR1B; bone morphogenetic protein receptor type-1B isoform X1 [KO:K13578] [EC:2.7.11.30]
128326987  IL17RA; interleukin-17 receptor A isoform X1 [KO:K05164]
128327225  BMP3; bone morphogenetic protein 3 [KO:K05496]
128327334  IFNG; interferon gamma isoform X1 [KO:K04687]
128327429  IL22; interleukin-22 [KO:K05445]
128327445  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
128327520  IL15; interleukin-15 isoform X1 [KO:K05433]
128327556  [KO:K05439]
128327798  [KO:K12672]
128328021  LEP; leptin [KO:K05424]
128328217  IL15RA; interleukin-15 receptor subunit alpha isoform X1 [KO:K05074]
128328709  [KO:K05422]
128328711  [KO:K02583]
128328894  [KO:K10030]
128328904  [KO:K05423]
128328985  [KO:K05050]
128329030  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
128329031  [KO:K05050]
128329065  [KO:K10035]
128329096  [KO:K04180]
128329097  [KO:K04180]
128329098  CXCR6; C-X-C chemokine receptor type 6 [KO:K04191]
128329099  [KO:K04180]
128329100  XCR1; chemokine XC receptor 1 [KO:K04193]
128329136  ACVR1; activin receptor type-1 isoform X1 [KO:K04675] [EC:2.7.11.30]
128329154  ACVR1C; activin receptor type-1C isoform X1 [KO:K13568] [EC:2.7.11.30]
128329227  ACVR2B; activin receptor type-2B isoform X1 [KO:K13596] [EC:2.7.11.30]
128329294  CCR9; C-C chemokine receptor type 9 isoform X1 [KO:K04184]
128329517  TNFSF12; tumor necrosis factor ligand superfamily member 12 [KO:K05474]
128330226  TGFB3; transforming growth factor beta-3 proprotein isoform X1 [KO:K13377]
128330329  CCR10; C-C chemokine receptor type 10 [KO:K04185]
128330376  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
128330442  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
128330595  ACVR2A; activin receptor type-2A isoform X1 [KO:K04670] [EC:2.7.11.30]
128330617  [KO:K22629]
128330764  INHBA; inhibin beta A chain [KO:K04667]
128330794  CCR7; C-C chemokine receptor type 7 isoform X1 [KO:K04182]
128330933  [KO:K24382]
128330939  IL11; interleukin-11 [KO:K05417]
128331321  [KO:K05438]
128331359  IL6; interleukin-6 [KO:K05405]
128331449  [KO:K04192]
128331571  IL25; interleukin-25 isoform X1 [KO:K05493]
128331843  [KO:K04179]
128331905  [KO:K04180]
128331985  [KO:K10030]
128331986  [KO:K10030]
128332037  [KO:K05438]
128332058  TNFRSF12A; tumor necrosis factor receptor superfamily member 12A isoform X1 [KO:K05149]
128332125  EPO; erythropoietin [KO:K05437]
128332133  ACKR4; atypical chemokine receptor 4 [KO:K04186]
128332546  [KO:K22669]
128332607  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
128332804  IL20RB; interleukin-20 receptor subunit beta [KO:K05137]
128332886  [KO:K04188]
128333011  BMP8A; bone morphogenetic protein 8A [KO:K16622]
128333038  CXCR3; C-X-C chemokine receptor type 3 isoform X1 [KO:K04188]
128333105  IL22RA1; interleukin-22 receptor subunit alpha-1 [KO:K05138]
128333307  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
128333393  [KO:K04662]
128333513  [KO:K04722]
128333534  BMP10; bone morphogenetic protein 10 [KO:K22670]
128333619  [KO:K05482]
128333668  CXCR5; C-X-C chemokine receptor type 5 isoform X1 [KO:K04190]
128333697  [KO:K05481]
128333860  IL1B; interleukin-1 beta [KO:K04519]
128333880  [KO:K04666]
128333934  IL10RA; interleukin-10 receptor subunit alpha [KO:K05134]
128333936  [KO:K05483]
128334151  IL17C; interleukin-17C [KO:K05491]
128334526  CCL22; C-C motif chemokine 22 [KO:K21083]
128335070  IL16; pro-interleukin-16 isoform X1 [KO:K22628]
128335148  [KO:K05494]
128335174  MSTN; growth/differentiation factor 8 [KO:K05497]
128335325  BMP15; bone morphogenetic protein 15 [KO:K05498]
128335441  EDA2R; tumor necrosis factor receptor superfamily member 27 isoform X1 [KO:K05163]
128335534  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
128335562  EDA; ectodysplasin-A [KO:K05480]
128335656  CD40LG; CD40 ligand [KO:K03161]
128335703  IL13RA1; interleukin-13 receptor subunit alpha-1 [KO:K05076]
128336680  TNFRSF13B; tumor necrosis factor receptor superfamily member 13B isoform X1 [KO:K05150]
128336690  IL21R; interleukin-21 receptor isoform X1 [KO:K05075]
128336691  [KO:K05073]
128336909  [KO:K13376]
128337682  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
128337832  LIF; leukemia inhibitory factor [KO:K05419]
128338017  [KO:K05419]
128338352  TNFRSF8; tumor necrosis factor receptor superfamily member 8 isoform X1 [KO:K05145]
128338354  TNFRSF18; tumor necrosis factor receptor superfamily member 18 [KO:K05154]
128338359  BMPR2; bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
128338487  TNFRSF14; tumor necrosis factor receptor superfamily member 14 [KO:K05152]
128338608  TNFRSF25; tumor necrosis factor receptor superfamily member 25 [KO:K05160]
128338645  TNFRSF4; tumor necrosis factor receptor superfamily member 4 [KO:K05142]
128338672  TNFRSF1B; tumor necrosis factor receptor superfamily member 1B isoform X1 [KO:K05141]
128338738  TNFRSF9; tumor necrosis factor receptor superfamily member 9 isoform X1 [KO:K05146]
128339047  TNFSF8; tumor necrosis factor ligand superfamily member 8 [KO:K05471]
128339101  TNFSF15; tumor necrosis factor ligand superfamily member 15 [KO:K05478]
128339230  BMP2; bone morphogenetic protein 2 [KO:K21283]
128339420  CLCF1; cardiotrophin-like cytokine factor 1 isoform X1 [KO:K05421]
128339449  [KO:K05050]
128339609  TNFSF13B; tumor necrosis factor ligand superfamily member 13B isoform X1 [KO:K05476]
128339914  BMP4; bone morphogenetic protein 4 [KO:K04662]
128339949  BMP5; bone morphogenetic protein 5 [KO:K04663]
128340110  TNFRSF21; tumor necrosis factor receptor superfamily member 21 isoform X1 [KO:K05157]
128340245  CCR6; C-C chemokine receptor type 6 [KO:K04181]
128340257  GDF7; growth/differentiation factor 7 [KO:K20013]
128340281  CNTF; ciliary neurotrophic factor isoform X1 [KO:K05420]
128340609  INHBB; inhibin beta B chain [KO:K22687]
128340730  INHA; inhibin alpha chain [KO:K05500]
128340731  [KO:K04722]
128341052  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
128341099  ACKR3; atypical chemokine receptor 3 [KO:K04304]
128341164  [KO:K05408]
128341549  [KO:K05057]
128341554  CXCL14; C-X-C motif chemokine 14 [KO:K10033]
128341591  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
128342003  [KO:K05136]
128342052  IFNGR1; interferon gamma receptor 1 isoform X1 [KO:K05132]
128342449  GDF1; embryonic growth/differentiation factor 1 [KO:K05495]
128342825  [KO:K06454]
128343216  AMH; muellerian-inhibiting factor [KO:K04665]
128343282  PRLR; prolactin receptor isoform X1 [KO:K05081]
128343357  GHR; growth hormone receptor isoform X1 [KO:K05080]
128343433  EBI3; interleukin-27 subunit beta isoform X1 [KO:K24476]
128343650  [KO:K05414]
128343651  [KO:K05414]
128343652  [KO:K05441]
128343653  [KO:K05441]
128343656  IFNK; interferon kappa [KO:K05414]
128343758  IL12RB1; interleukin-12 receptor subunit beta-1 [KO:K05063]
128343787  [KO:K21283]
128344008  IL12B; interleukin-12 subunit beta [KO:K05425]
128344874  CCL28; C-C motif chemokine 28 [KO:K05513]
128344904  IL6ST; interleukin-6 receptor subunit beta isoform X1 [KO:K05060]
128345042  [KO:K05058]
128345411  [KO:K04179]
128345464  IL11RA; interleukin-11 receptor subunit alpha isoform X1 [KO:K05056]
128345731  ACVR1B; activin receptor type-1B isoform X1 [KO:K13567] [EC:2.7.11.30]
128345732  ACVRL1; LOW QUALITY PROTEIN: serine/threonine-protein kinase receptor R3 [KO:K13594] [EC:2.7.11.30]
128345861  IL17RB; interleukin-17 receptor B isoform X1 [KO:K05165]
128346024  [KO:K03156]
128346030  [KO:K03158]
128346085  [KO:K22689]
128346304  IL17B; interleukin-17B [KO:K05490]
128346390  [KO:K05472]
128346436  IL27RA; interleukin-27 receptor subunit alpha isoform X1 [KO:K19598]
128346474  IL17RE; interleukin-17 receptor E isoform X1 [KO:K05168]
128346484  [KO:K05441]
128346500  GDF9; growth/differentiation factor 9 isoform X1 [KO:K22673]
128346563  TNFSF14; tumor necrosis factor ligand superfamily member 14 isoform X1 [KO:K05477]
128346647  EPOR; erythropoietin receptor [KO:K05079]
128347297  CNTFR; ciliary neurotrophic factor receptor subunit alpha isoform X1 [KO:K05059]
128347677  AMHR2; anti-Muellerian hormone type-2 receptor isoform X1 [KO:K04672] [EC:2.7.11.30]
128347865  GDF11; growth/differentiation factor 11 [KO:K22679]
128347999  [KO:K05408]
128348063  IL31RA; interleukin-31 receptor subunit alpha isoform X1 [KO:K22630]
128348140  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
128348267  IL17RC; interleukin-17 receptor C isoform X1 [KO:K05166]
128348817  GDF2; growth/differentiation factor 2 [KO:K05503]
128348822  [KO:K05408]
128348862  EDAR; tumor necrosis factor receptor superfamily member EDAR [KO:K05162]
128348987  CRLF2; cytokine receptor-like factor 2 [KO:K05078]
128348998  CCL20; C-C motif chemokine 20 isoform X1 [KO:K14625]
128349113  IFNGR2; interferon gamma receptor 2 isoform X1 [KO:K05133]
128349198  [KO:K05066]
128349750  IL1R2; interleukin-1 receptor type 2 isoform X1 [KO:K04387]
128350146  IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
128350163  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
128350164  IL10RB; interleukin-10 receptor subunit beta isoform X1 [KO:K05135]
128350512  IL1RL1; interleukin-1 receptor-like 1 [KO:K05171]
128350566  TGFB2; transforming growth factor beta-2 proprotein [KO:K13376]
128350792  BMPR1A; bone morphogenetic protein receptor type-1A [KO:K04673] [EC:2.7.11.30]
128350855  [KO:K04386]
128350884  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
128350897  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
128350984  [KO:K05507]
128351015  [KO:K05172]
128351071  IL17D; interleukin-17D isoform X1 [KO:K05492]
128351073  [KO:K06854]
128351121  TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473]
128351132  [KO:K05171]
128351224  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
128351259  TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
128351537  IL18RAP; interleukin-18 receptor accessory protein isoform X1 [KO:K05174]
128351538  IL18R1; interleukin-18 receptor 1 [KO:K05173]
128351851  TNFRSF19; tumor necrosis factor receptor superfamily member 19 isoform X1 [KO:K05155]
128352433  NODAL; nodal homolog isoform X1 [KO:K04666]
128352443  RELT; tumor necrosis factor receptor superfamily member 19L isoform X1 [KO:K05156]
128352498  IL12A; interleukin-12 subunit alpha isoform X1 [KO:K05406]
128352845  BMP6; bone morphogenetic protein 6 [KO:K16620]
128352962  TNFRSF11A; tumor necrosis factor receptor superfamily member 11A [KO:K05147]
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Reference
PMID:21106488
  Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
  Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
  Journal
Hum Genomics 5:30-55 (2010)
DOI:10.1186/1479-7364-5-1-30
Reference
PMID:27577879
  Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
  Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
  Journal
J Allergy Clin Immunol 138:984-1010 (2016)
DOI:10.1016/j.jaci.2016.06.033
Reference
PMID:15500860
  Authors
Boulanger MJ, Garcia KC
  Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
  Journal
Adv Protein Chem 68:107-46 (2004)
DOI:10.1016/S0065-3233(04)68004-1
Reference
PMID:16034365
  Authors
Allan SM, Tyrrell PJ, Rothwell NJ
  Title
Interleukin-1 and neuronal injury.
  Journal
Nat Rev Immunol 5:629-40 (2005)
DOI:10.1038/nri1664
Reference
PMID:23847622
  Authors
Lopetuso LR, Chowdhry S, Pizarro TT
  Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
  Journal
Front Immunol 4:181 (2013)
DOI:10.3389/fimmu.2013.00181
Reference
PMID:21349428
  Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
  Title
Functional specialization of interleukin-17 family members.
  Journal
Immunity 34:149-62 (2011)
DOI:10.1016/j.immuni.2011.02.012
Reference
PMID:17530315
  Authors
Fischer P, Hilfiker-Kleiner D
  Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
  Journal
Basic Res Cardiol 102:279-97 (2007)
DOI:10.1007/s00395-007-0658-z
Reference
PMID:24381786
  Authors
Richards CD
  Title
The enigmatic cytokine oncostatin m and roles in disease.
  Journal
ISRN Inflamm 2013:512103 (2013)
DOI:10.1155/2013/512103
Reference
PMID:18926762
  Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
  Title
Structures and biological functions of IL-31 and IL-31 receptors.
  Journal
Cytokine Growth Factor Rev 19:347-56 (2008)
DOI:10.1016/j.cytogfr.2008.08.003
Reference
PMID:21155715
  Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
  Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
  Journal
Biochem J 434:343-51 (2011)
DOI:10.1042/BJ20101628
Reference
PMID:22410872
  Authors
de Weerd NA, Nguyen T
  Title
The interferons and their receptors--distribution and regulation.
  Journal
Immunol Cell Biol 90:483-91 (2012)
DOI:10.1038/icb.2012.9
Reference
PMID:12949498
  Authors
Aggarwal BB
  Title
Signalling pathways of the TNF superfamily: a double-edged sword.
  Journal
Nat Rev Immunol 3:745-56 (2003)
DOI:10.1038/nri1184
Reference
PMID:12189384
  Authors
Ashkenazi A
  Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
  Journal
Nat Rev Cancer 2:420-30 (2002)
DOI:10.1038/nrc821
Reference
PMID:26115564
  Authors
Seeger P, Musso T, Sozzani S
  Title
The TGF-beta superfamily in dendritic cell biology.
  Journal
Cytokine Growth Factor Rev 26:647-57 (2015)
DOI:10.1016/j.cytogfr.2015.06.002
Reference
PMID:23612460
  Authors
Wakefield LM, Hill CS
  Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
  Journal
Nat Rev Cancer 13:328-41 (2013)
DOI:10.1038/nrc3500
Reference
PMID:22710174
  Authors
Mueller TD, Nickel J
  Title
Promiscuity and specificity in BMP receptor activation.
  Journal
FEBS Lett 586:1846-59 (2012)
DOI:10.1016/j.febslet.2012.02.043
KO pathway
ko04060   

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