KEGG   PATHWAY: mcf04630
Entry
mcf04630                    Pathway                                
Name
JAK-STAT signaling pathway - Macaca fascicularis (crab-eating macaque)
Description
The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors.
Class
Environmental Information Processing; Signal transduction
Pathway map
mcf04630  JAK-STAT signaling pathway
mcf04630

Other DBs
GO: 0007259
Organism
Macaca fascicularis (crab-eating macaque) [GN:mcf]
Gene
102129830  IL2; interleukin-2 [KO:K05429]
107130068  IL4; interleukin-4 [KO:K05430]
102135001  IL7; interleukin-7 isoform X1 [KO:K05431]
102131911  IL9; interleukin-9 [KO:K05432]
102119613  IL15; interleukin-15 [KO:K05433]
102130762  IL21; interleukin-21 [KO:K05434]
102119254  TSLP; thymic stromal lymphopoietin [KO:K05436]
102123605  IL2RA; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068]
102138714  IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
102144912  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
102133649  IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
102143679  IL7R; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072]
102136616  IL9R; interleukin-9 receptor isoform X2 [KO:K05073]
102121571  IL15RA; interleukin-15 receptor subunit alpha isoform X2 [KO:K05074]
102135042  IL21R; interleukin-21 receptor isoform X1 [KO:K05075]
123571109  CRLF2; cytokine receptor-like factor 2 isoform X1 [KO:K05078]
102118362  IL3; interleukin-3 [KO:K04736]
102125522  IL5; interleukin-5 [KO:K05428]
102118747  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
102145538  IL3RA; interleukin-3 receptor subunit alpha isoform X1 [KO:K04737]
102115323  IL5RA; interleukin-5 receptor subunit alpha [KO:K05067]
102139775  CSF2RA; granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X4 [KO:K05066]
102143353  CSF2RB; cytokine receptor common subunit beta isoform X2 [KO:K04738]
102138971  IL6; interleukin-6 precursor [KO:K05405]
102128313  IL11; interleukin-11 isoform X1 [KO:K05417]
102125887  IL13; interleukin-13 [KO:K05435]
102145935  IL27; interleukin-27 subunit alpha isoform X2 [KO:K22629]
102128264  OSM; oncostatin-M isoform X1 [KO:K05418]
102129162  LIF; leukemia inhibitory factor [KO:K05419]
102115528  CNTF; ciliary neurotrophic factor [KO:K05420]
102130856  CTF1; cardiotrophin-1 isoform X1 [KO:K05422]
102118445  LOW QUALITY PROTEIN: cardiotrophin-2 [KO:K24382]
102136357  CLCF1; cardiotrophin-like cytokine factor 1 isoform X2 [KO:K05421]
102117292  LOW QUALITY PROTEIN: interleukin-6 receptor subunit alpha [KO:K05055]
101926138  IL6ST; interleukin-6 receptor subunit beta isoform X1 [KO:K05060]
102133459  IL11RA; interleukin-11 receptor subunit alpha isoform X4 [KO:K05056]
102135058  IL13RA1; interleukin-13 receptor subunit alpha-1 [KO:K05076]
102121264  IL13RA2; interleukin-13 receptor subunit alpha-2 [KO:K05077]
102139216  IL27RA; interleukin-27 receptor subunit alpha isoform X1 [KO:K19598]
102117994  IL31RA; interleukin-31 receptor subunit alpha [KO:K22630]
102135082  OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
102131906  LIFR; leukemia inhibitory factor receptor isoform X1 [KO:K05058]
102140176  CNTFR; ciliary neurotrophic factor receptor subunit alpha isoform X5 [KO:K05059]
102133450  IL10; interleukin-10 [KO:K05443]
102133068  IL19; interleukin-19 isoform X2 [KO:K05444]
102129310  IL22; interleukin-22 [KO:K05445]
102131684  IL20; interleukin-20 [KO:K22667]
102135102  IL24; interleukin-24 [KO:K22668]
102128691  IL26; interleukin-26 [KO:K05446]
102127536  IL10RA; interleukin-10 receptor subunit alpha [KO:K05134]
102139461  IL10RB; interleukin-10 receptor subunit beta isoform X1 [KO:K05135]
102141570  IL20RA; interleukin-20 receptor subunit alpha isoform X2 [KO:K05136]
102119675  IL20RB; interleukin-20 receptor subunit beta isoform X2 [KO:K05137]
102117911  IL22RA1; interleukin-22 receptor subunit alpha-1 isoform X3 [KO:K05138]
102143120  IL22RA2; interleukin-22 receptor subunit alpha-2 [KO:K05139]
102115316  IL12A; interleukin-12 subunit alpha [KO:K05406]
102124858  IL12B; interleukin-12 subunit beta [KO:K05425]
102128555  IL23A; interleukin-23 subunit alpha [KO:K05426]
102143359  IL12RB1; interleukin-12 receptor subunit beta-1 isoform X1 [KO:K05063]
102131165  IL12RB2; interleukin-12 receptor subunit beta-2 isoform X1 [KO:K05064]
102133210  IL23R; interleukin-23 receptor [KO:K05065]
101925524  EPO; erythropoietin precursor [KO:K05437]
135967886  somatotropin-like [KO:K05438]
135967887  growth hormone variant-like isoform X2 [KO:K05438]
135967741  somatotropin-like isoform X2 [KO:K05438]
135967888  growth hormone variant-like isoform X2 [KO:K05438]
135967819  growth hormone variant [KO:K05438]
135967742  somatotropin-like isoform X2 [KO:K05438]
102139443  CSH2; somatotropin isoform X1 [KO:K05438]
102973054  CSH3; LOW QUALITY PROTEIN: somatotropin [KO:K05438]
102141100  CSH4; somatotropin [KO:K05438]
102973055  GHV; growth hormone variant [KO:K05438]
102143728  GH1; somatotropin [KO:K05438]
123571569  somatotropin-like isoform X1 [KO:K05438]
102133150  PRL; prolactin [KO:K05439]
102144240  THPO; thrombopoietin isoform X1 [KO:K06854]
102123087  CSF3; granulocyte colony-stimulating factor isoform X1 [KO:K05423]
102136844  LEP; leptin isoform X1 [KO:K05424]
102138718  EPOR; erythropoietin receptor [KO:K05079]
102121279  GHR; growth hormone receptor isoform X1 [KO:K05080]
102139140  PRLR; prolactin receptor isoform X1 [KO:K05081]
101864977  MPL; thrombopoietin receptor isoform X1 [KO:K05082]
102132219  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
102115046  LEPR; leptin receptor isoform X3 [KO:K05062]
135967426  LOW QUALITY PROTEIN: interferon alpha-6-like [KO:K05414]
102146717  interferon alpha-17 [KO:K05414]
102140303  interferon alpha-1/13 [KO:K05414]
102140954  IFNA8; interferon alpha-8 [KO:K05414]
102141744  interferon alpha-1/13 [KO:K05414]
102141352  interferon alpha-1/13 [KO:K05414]
102143043  interferon alpha-6 [KO:K05414]
102144479  interferon alpha-14 [KO:K05414]
102144833  interferon alpha-16 [KO:K05414]
102145208  interferon alpha-10 [KO:K05414]
102145962  interferon alpha-17 [KO:K05414]
102115289  interferon alpha-10 [KO:K05414]
102142148  interferon alpha-2 [KO:K05414]
123569038  interferon alpha-17-like [KO:K05414]
102146344  interferon alpha-21 [KO:K05414]
102147079  interferon alpha-4-like [KO:K05414]
102115670  IFNB1; interferon beta [KO:K05415]
102139283  IFNE; interferon epsilon [KO:K05442]
102117773  IFNK; interferon kappa [KO:K05441]
102139603  IFNL1; interferon lambda-1 isoform X2 [KO:K05447]
102138968  interferon lambda-3 [KO:K22669]
102137836  interferon lambda-2-like [KO:K22669]
102130733  LOW QUALITY PROTEIN: interferon lambda-3 [KO:K22669]
102114910  IFNW1; interferon omega-1 [KO:K05440]
101926190  IFNAR1; interferon alpha/beta receptor 1 isoform X3 [KO:K05130]
102140083  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
102116826  IFNLR1; interferon lambda receptor 1 isoform X1 [KO:K05140]
102128291  IFNG; interferon gamma [KO:K04687]
101866179  IFNGR1; interferon gamma receptor 1 isoform X4 [KO:K05132]
102138221  IFNGR2; interferon gamma receptor 2 isoform X2 [KO:K05133]
102123415  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
102126620  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
102125183  PDGFB; platelet-derived growth factor subunit B isoform X2 [KO:K17386]
102138724  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
102138392  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
101867161  PDGFRB; platelet-derived growth factor receptor beta isoform X2 [KO:K05089] [EC:2.7.10.1]
102123983  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
102119008  JAK2; tyrosine-protein kinase JAK2 isoform X2 [KO:K04447] [EC:2.7.10.2]
102134669  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
102143094  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
101925134  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X2 [KO:K11220]
102133020  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
102118402  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
101925110  STAT4; signal transducer and activator of transcription 4 isoform X1 [KO:K11222]
102120556  signal transducer and activator of transcription 5A [KO:K11223]
102127060  STAT5B; signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
102117594  STAT6; signal transducer and activator of transcription 6 isoform X1 [KO:K11225]
102142271  IRF9; interferon regulatory factor 9 isoform X1 [KO:K04693]
102119548  CISH; cytokine-inducible SH2-containing protein isoform X2 [KO:K04701]
102135411  SOCS1; suppressor of cytokine signaling 1 [KO:K04694]
102125352  SOCS2; suppressor of cytokine signaling 2 [KO:K04695]
102121569  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
102141350  SOCS4; suppressor of cytokine signaling 4 [KO:K04697]
135964340  SOCS5; suppressor of cytokine signaling 5 [KO:K04698]
107126398  uncharacterized protein LOC107126398 [KO:K04698]
102146000  SOCS6; suppressor of cytokine signaling 6 [KO:K04699]
102116074  SOCS7; suppressor of cytokine signaling 7 isoform X1 [KO:K04699]
102138212  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
101925224  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 isoform X2 [KO:K02539]
102135814  PIM1; serine/threonine-protein kinase pim-1 [KO:K04702] [EC:2.7.11.1]
102127966  MYC; myc proto-oncogene protein [KO:K04377]
102135329  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
102119572  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
101865999  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
102136063  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
102134825  AOX4; aldehyde oxidase 4 [KO:K00157] [EC:1.2.3.1]
102131116  aldehyde oxidase 1 isoform X1 [KO:K00157] [EC:1.2.3.1]
102134468  AOX2; aldehyde oxidase 2 [KO:K00157] [EC:1.2.3.1]
101926850  GFAP; glial fibrillary acidic protein isoform X2 [KO:K05640]
102127970  STAM; signal transducing adapter molecule 1 isoform X1 [KO:K04705]
102117972  STAM2; signal transducing adapter molecule 2 isoform X1 [KO:K04705]
101866630  PTPN2; tyrosine-protein phosphatase non-receptor type 2 isoform X1 [KO:K18026] [EC:3.1.3.48]
102133910  PTPN6; tyrosine-protein phosphatase non-receptor type 6 isoform X2 [KO:K05697] [EC:3.1.3.48]
102131731  EP300; histone acetyltransferase p300 isoform X2 [KO:K04498] [EC:2.3.1.48]
102135037  CREBBP; CREB-binding protein isoform X2 [KO:K04498] [EC:2.3.1.48]
101926817  PIAS1; E3 SUMO-protein ligase PIAS1 isoform X1 [KO:K04706] [EC:2.3.2.-]
102146750  PIAS2; E3 SUMO-protein ligase PIAS2 isoform X1 [KO:K16063] [EC:2.3.2.-]
101866567  PIAS3; E3 SUMO-protein ligase PIAS3 isoform X1 [KO:K16064] [EC:2.3.2.-]
102139847  PIAS4; E3 SUMO-protein ligase PIAS4 isoform X6 [KO:K16065] [EC:2.3.2.27]
101926241  FHL1; four and a half LIM domains protein 1 isoform X1 [KO:K14365]
102129572  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X2 [KO:K07293] [EC:3.1.3.48]
102118276  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
102135079  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
102138313  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
102118744  HRAS; GTPase HRas [KO:K02833]
102125312  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
102143464  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102142026  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
102122725  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102137291  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
101866246  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
102124804  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
102144461  AKT3; RAC-gamma serine/threonine-protein kinase isoform X4 [KO:K04456] [EC:2.7.11.1]
102142406  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102132744  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102128371  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
Reference
PMID:22383755
  Authors
Harrison DA
  Title
The Jak/STAT pathway.
  Journal
Cold Spring Harb Perspect Biol 4:a011205 (2012)
DOI:10.1101/cshperspect.a011205
Reference
PMID:22339650
  Authors
Kiu H, Nicholson SE
  Title
Biology and significance of the JAK/STAT signalling pathways.
  Journal
Growth Factors 30:88-106 (2012)
DOI:10.3109/08977194.2012.660936
Reference
PMID:21372217
  Authors
Hervas-Stubbs S, Perez-Gracia JL, Rouzaut A, Sanmamed MF, Le Bon A, Melero I
  Title
Direct effects of type I interferons on cells of the immune system.
  Journal
Clin Cancer Res 17:2619-27 (2011)
DOI:10.1158/1078-0432.CCR-10-1114
Reference
PMID:25217450
  Authors
Fish EN, Platanias LC
  Title
Interferon receptor signaling in malignancy: a network of cellular pathways defining biological outcomes.
  Journal
Mol Cancer Res 12:1691-703 (2014)
DOI:10.1158/1541-7786.MCR-14-0450
Reference
PMID:21034406
  Authors
Ivanenkov YA, Balakin KV, Lavrovsky Y
  Title
Small molecule inhibitors of NF-kB and JAK/STAT signal transduction pathways as promising anti-inflammatory therapeutics.
  Journal
Mini Rev Med Chem 11:55-78 (2011)
DOI:10.2174/138955711793564079
Reference
PMID:25587654
  Authors
O'Shea JJ, Schwartz DM, Villarino AV, Gadina M, McInnes IB, Laurence A
  Title
The JAK-STAT pathway: impact on human disease and therapeutic intervention.
  Journal
Annu Rev Med 66:311-28 (2015)
DOI:10.1146/annurev-med-051113-024537
Reference
PMID:24069565
  Authors
Zoranovic T, Grmai L, Bach EA
  Title
Regulation of proliferation, cell competition, and cellular growth by the Drosophila JAK-STAT pathway.
  Journal
JAKSTAT 2:e25408 (2013)
DOI:10.4161/jkst.25408
Reference
PMID:16204702
  Authors
Ungureanu D, Silvennoinen O
  Title
SLIM trims STATs: ubiquitin E3 ligases provide insights for specificity in the regulation of cytokine signaling.
  Journal
Sci STKE 2005:pe49 (2005)
DOI:10.1126/stke.3042005pe49
Reference
PMID:23735217
  Authors
Richard AJ, Stephens JM
  Title
The role of JAK-STAT signaling in adipose tissue function.
  Journal
Biochim Biophys Acta 1842:431-9 (2014)
DOI:10.1016/j.bbadis.2013.05.030
Reference
PMID:24606160
  Authors
Sun Y, Lehmbecker A, Kalkuhl A, Deschl U, Sun W, Rohn K, Tzvetanova ID, Nave KA, Baumgartner W, Ulrich R
  Title
STAT3 represents a molecular switch possibly inducing astroglial instead of oligodendroglial differentiation of oligodendroglial progenitor cells in Theiler's murine encephalomyelitis.
  Journal
Neuropathol Appl Neurobiol 41:347-70 (2015)
DOI:10.1111/nan.12133
Reference
PMID:10851053
  Authors
Hirano T, Ishihara K, Hibi M
  Title
Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors.
  Journal
Oncogene 19:2548-56 (2000)
DOI:10.1038/sj.onc.1203551
Reference
PMID:11114747
  Authors
Rane SG, Reddy EP
  Title
Janus kinases: components of multiple signaling pathways.
  Journal
Oncogene 19:5662-79 (2000)
DOI:10.1038/sj.onc.1203925
Reference
PMID:8682149
  Authors
Heim MH
  Title
The Jak-STAT pathway: specific signal transduction from the cell membrane to the nucleus.
  Journal
Eur J Clin Invest 26:1-12 (1996)
DOI:10.1046/j.1365-2362.1996.103248.x
Reference
PMID:30267440
  Authors
Morris R, Kershaw NJ, Babon JJ
  Title
The molecular details of cytokine signaling via the JAK/STAT pathway.
  Journal
Protein Sci 27:1984-2009 (2018)
DOI:10.1002/pro.3519
Reference
PMID:34492272
  Authors
Tzeng HT, Chyuan IT, Lai JH
  Title
Targeting the JAK-STAT pathway in autoimmune diseases and cancers: A focus on molecular mechanisms and therapeutic potential.
  Journal
Biochem Pharmacol 193:114760 (2021)
DOI:10.1016/j.bcp.2021.114760
Reference
PMID:32203403
  Authors
Salas A, Hernandez-Rocha C, Duijvestein M, Faubion W, McGovern D, Vermeire S, Vetrano S, Vande Casteele N
  Title
JAK-STAT pathway targeting for the treatment of inflammatory bowel disease.
  Journal
Nat Rev Gastroenterol Hepatol 17:323-337 (2020)
DOI:10.1038/s41575-020-0273-0
Related
pathway
mcf04010  MAPK signaling pathway
mcf04060  Cytokine-cytokine receptor interaction
mcf04110  Cell cycle
mcf04120  Ubiquitin mediated proteolysis
mcf04151  PI3K-Akt signaling pathway
mcf04210  Apoptosis
KO pathway
ko04630   
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