Entry Name JAK-STAT signaling pathway - Macaca fascicularis (crab-eating macaque)
Description The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors.
Class Environmental Information Processing; Signal transductionBRITE hierarchy
Pathway map Other DBs Organism Macaca fascicularis (crab-eating macaque) [GN:
mcf ]
Gene 101866246 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649 ]
101866567 PIAS3; E3 SUMO-protein ligase PIAS3 isoform X1 [KO:K16064 ] [EC:2.3.2.-]
101925110 STAT4; signal transducer and activator of transcription 4 isoform X1 [KO:K11222 ]
101925134 STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X2 [KO:K11220 ]
101925224 MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 isoform X2 [KO:K02539 ]
101926138 IL6ST; interleukin-6 receptor subunit beta isoform X2 [KO:K05060 ]
101926241 FHL1; four and a half LIM domains protein 1 isoform X1 [KO:K14365 ]
101926817 PIAS1; E3 SUMO-protein ligase PIAS1 isoform X1 [KO:K04706 ] [EC:2.3.2.-]
102117594 STAT6; signal transducer and activator of transcription 6 isoform X1 [KO:K11225 ]
102117911 IL22RA1; interleukin-22 receptor subunit alpha-1 isoform X3 [KO:K05138 ]
102117972 STAM2; signal transducing adapter molecule 2 isoform X1 [KO:K04705 ]
102118276 GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364 ]
102118402 STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692 ]
102118747 CSF2; granulocyte-macrophage colony-stimulating factor isoform X1 [KO:K05427 ]
102119548 CISH; cytokine-inducible SH2-containing protein isoform X3 [KO:K04701 ]
102119675 IL20RB; interleukin-20 receptor subunit beta isoform X2 [KO:K05137 ]
102121571 IL15RA; interleukin-15 receptor subunit alpha isoform X2 [KO:K05074 ]
102122725 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
102123087 CSF3; granulocyte colony-stimulating factor isoform X1 [KO:K05423 ]
102123605 IL2RA; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068 ]
102124804 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
102125183 PDGFB; platelet-derived growth factor subunit B isoform X2 [KO:K17386 ]
102126620 PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359 ]
102127060 STAT5B; signal transducer and activator of transcription 5B isoform X1 [KO:K11224 ]
102127970 STAM; signal transducing adapter molecule 1 isoform X1 [KO:K04705 ]
102131165 IL12RB2; interleukin-12 receptor subunit beta-2 isoform X1 [KO:K05064 ]
102132219 CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061 ]
102133020 STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221 ]
102133459 IL11RA; interleukin-11 receptor subunit alpha isoform X12 [KO:K05056 ]
102133649 IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071 ]
102135082 OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057 ]
102136357 CLCF1; cardiotrophin-like cytokine factor 1 isoform X2 [KO:K05421 ]
102137291 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
102138714 IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069 ]
102139216 IL27RA; interleukin-27 receptor subunit alpha isoform X1 [KO:K19598 ]
102139461 IL10RB; interleukin-10 receptor subunit beta isoform X1 [KO:K05135 ]
102140176 CNTFR; ciliary neurotrophic factor receptor subunit alpha isoform X6 [KO:K05059 ]
102141570 IL20RA; interleukin-20 receptor subunit alpha isoform X2 [KO:K05136 ]
102142026 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
102143353 CSF2RB; cytokine receptor common subunit beta isoform X2 [KO:K04738 ]
102143359 IL12RB1; interleukin-12 receptor subunit beta-1 isoform X1 [KO:K05063 ]
102143464 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
102143679 IL7R; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072 ]
102144912 IL2RG; cytokine receptor common subunit gamma isoform X1 [KO:K05070 ]
102145538 IL3RA; interleukin-3 receptor subunit alpha isoform X1 [KO:K04737 ]
102146750 PIAS2; E3 SUMO-protein ligase PIAS2 isoform X1 [KO:K16063 ] [EC:2.3.2.-]
Reference Authors Harrison DA
Title The Jak/STAT pathway.
Journal Reference Authors Kiu H, Nicholson SE
Title Biology and significance of the JAK/STAT signalling pathways.
Journal Reference Authors Hervas-Stubbs S, Perez-Gracia JL, Rouzaut A, Sanmamed MF, Le Bon A, Melero I
Title Direct effects of type I interferons on cells of the immune system.
Journal Reference Authors Fish EN, Platanias LC
Title Interferon receptor signaling in malignancy: a network of cellular pathways defining biological outcomes.
Journal Reference Authors Ivanenkov YA, Balakin KV, Lavrovsky Y
Title Small molecule inhibitors of NF-kB and JAK/STAT signal transduction pathways as promising anti-inflammatory therapeutics.
Journal Reference Authors O'Shea JJ, Schwartz DM, Villarino AV, Gadina M, McInnes IB, Laurence A
Title The JAK-STAT pathway: impact on human disease and therapeutic intervention.
Journal Reference Authors Zoranovic T, Grmai L, Bach EA
Title Regulation of proliferation, cell competition, and cellular growth by the Drosophila JAK-STAT pathway.
Journal Reference Authors Ungureanu D, Silvennoinen O
Title SLIM trims STATs: ubiquitin E3 ligases provide insights for specificity in the regulation of cytokine signaling.
Journal Reference Authors Richard AJ, Stephens JM
Title The role of JAK-STAT signaling in adipose tissue function.
Journal Reference Authors Sun Y, Lehmbecker A, Kalkuhl A, Deschl U, Sun W, Rohn K, Tzvetanova ID, Nave KA, Baumgartner W, Ulrich R
Title STAT3 represents a molecular switch possibly inducing astroglial instead of oligodendroglial differentiation of oligodendroglial progenitor cells in Theiler's murine encephalomyelitis.
Journal Reference Authors Hirano T, Ishihara K, Hibi M
Title Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors.
Journal Reference Authors Rane SG, Reddy EP
Title Janus kinases: components of multiple signaling pathways.
Journal Reference Authors Heim MH
Title The Jak-STAT pathway: specific signal transduction from the cell membrane to the nucleus.
Journal Reference Authors Morris R, Kershaw NJ, Babon JJ
Title The molecular details of cytokine signaling via the JAK/STAT pathway.
Journal Reference Authors Tzeng HT, Chyuan IT, Lai JH
Title Targeting the JAK-STAT pathway in autoimmune diseases and cancers: A focus on molecular mechanisms and therapeutic potential.
Journal Reference Authors Salas A, Hernandez-Rocha C, Duijvestein M, Faubion W, McGovern D, Vermeire S, Vetrano S, Vande Casteele N
Title JAK-STAT pathway targeting for the treatment of inflammatory bowel disease.
Journal Related mcf04060 Cytokine-cytokine receptor interaction
KO pathway
