KEGG   PATHWAY: mcoc04142
Entry
mcoc04142                   Pathway                                
Name
Lysosome biogenesis - Mastomys coucha (southern multimammate mouse)
Description
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class
Cellular Processes; Transport and catabolism
Pathway map
mcoc04142  Lysosome biogenesis
mcoc04142

Other DBs
GO: 0005764
Organism
Mastomys coucha (southern multimammate mouse) [GN:mcoc]
Gene
116067878  Pla2g15; group XV phospholipase A2 [KO:K06129] [EC:3.1.1.5]
116067922  [KO:K08515]
116068105  Idua; alpha-L-iduronidase isoform X1 [KO:K01217] [EC:3.2.1.76]
116068106  Tmem175; endosomal/lysosomal potassium channel TMEM175 isoform X1 [KO:K24915]
116068318  Tpcn1; two pore calcium channel protein 1 [KO:K16896]
116068360  Vps29; vacuolar protein sorting-associated protein 29 isoform X1 [KO:K18467]
116068397  Vps33a; vacuolar protein sorting-associated protein 33A [KO:K20182]
116068417  Abcb9; ATP-binding cassette sub-family B member 9 [KO:K05656]
116068441  Atp6v0a2; V-type proton ATPase 116 kDa subunit a [KO:K02154]
116068463  Slc15a4; solute carrier family 15 member 4 isoform X1 [KO:K14638]
116068489  Gusb; beta-glucuronidase isoform X1 [KO:K01195] [EC:3.2.1.31]
116068577  Ap1s1; AP-1 complex subunit sigma-1A [KO:K12394]
116068625  Ap4m1; AP-4 complex subunit mu-1 isoform X1 [KO:K12402]
116068633  Lamtor4; ragulator complex protein LAMTOR4 isoform X1 [KO:K20399]
116068688  Ap5z1; AP-5 complex subunit zeta-1 isoform X1 [KO:K19025]
116068831  Mcoln1; mucolipin-1 [KO:K04992]
116068931  Lamp1; lysosome-associated membrane glycoprotein 1 isoform X1 [KO:K06528]
116068962  Cln8; protein CLN8 [KO:K12360]
116069018  Ap3m2; AP-3 complex subunit mu-2 [KO:K12398]
116069071  Hgsnat; heparan-alpha-glucosaminide N-acetyltransferase isoform X1 [KO:K10532] [EC:2.3.1.78]
116069197  Asah1; acid ceramidase [KO:K12348] [EC:3.5.1.23]
116069217  Tlr3; toll-like receptor 3 isoform X1 [KO:K05401]
116069274  Aga; N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase [KO:K01444] [EC:3.5.1.26]
116069344  Ap1b1; AP-1 complex subunit beta-1 [KO:K12392]
116069414  Atp6v1b2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
116069449  Borcs8; BLOC-1-related complex subunit 8 [KO:K20822]
116069471  Kxd1; kxDL motif-containing protein 1 isoform X1 [KO:K20818]
116069547  Ap1m1; AP-1 complex subunit mu-1 [KO:K12393]
116069661  Arl8a; ADP-ribosylation factor-like protein 8A [KO:K07955]
116069736  Dnase2; deoxyribonuclease-2-alpha [KO:K01158] [EC:3.1.22.1]
116069755  Man2b1; lysosomal alpha-mannosidase isoform X1 [KO:K12311] [EC:3.2.1.24]
116069760  Vps35; vacuolar protein sorting-associated protein 35 [KO:K18468]
116070056  Atp6v0d1; V-type proton ATPase subunit d 1 [KO:K02146]
116070158  Ap1g1; AP-1 complex subunit gamma-1 isoform X1 [KO:K12391]
116070279  Meak7; MTOR-associated protein MEAK7 [KO:K27947]
116070337  Galns; N-acetylgalactosamine-6-sulfatase isoform X1 [KO:K01132] [EC:3.1.6.4]
116070370  Atp6v1g3; V-type proton ATPase subunit G 3 [KO:K02152]
116070413  Psapl1; proactivator polypeptide-like 1 [KO:K12382]
116070688  Bloc1s4; biogenesis of lysosome-related organelles complex 1 subunit 4 [KO:K08366]
116072061  Hyal1; hyaluronidase-1 [KO:K01197] [EC:3.2.1.35]
116072064  Hyal3; hyaluronidase-3 [KO:K01197] [EC:3.2.1.35]
116072223  Glb1; beta-galactosidase isoform X1 [KO:K12309] [EC:3.2.1.23]
116072341  Slc36a4; proton-coupled amino acid transporter 4 isoform X1 [KO:K14209]
116072512  Hexa; beta-hexosaminidase subunit alpha [KO:K12373] [EC:3.2.1.52]
116072784  Vps11; vacuolar protein sorting-associated protein 11 homolog isoform X1 [KO:K20179]
116072927  Ctsh; pro-cathepsin H [KO:K01366] [EC:3.4.22.16]
116073152  Cln6; ceroid-lipofuscinosis neuronal protein 6 [KO:K12359]
116073297  Hyal2; hyaluronidase-2 [KO:K01197] [EC:3.2.1.35]
116073359  Acp5; tartrate-resistant acid phosphatase type 5 [KO:K14379] [EC:3.1.3.2]
116073430  Ap1m2; LOW QUALITY PROTEIN: AP-1 complex subunit mu-2 [KO:K12393]
116073433  Tlr9; toll-like receptor 9 [KO:K10161]
116073464  Vps26b; vacuolar protein sorting-associated protein 26B [KO:K18466]
116073848  Vps13c; vacuolar protein sorting-associated protein 13C isoform X1 [KO:K19525]
116073899  Slc17a5; sialin [KO:K12301]
116073927  Dmxl2; dmX-like protein 2 isoform X1 [KO:K24155]
116074208  [KO:K16344]
116074224  Vamp7; vesicle-associated membrane protein 7 isoform X1 [KO:K08515]
116074353  Vps26a; vacuolar protein sorting-associated protein 26A isoform X1 [KO:K18466]
116074538  Tfeb; transcription factor EB isoform X1 [KO:K15590]
116074659  Atp6v1g2; V-type proton ATPase subunit G 2 [KO:K02152]
116074802  Cd164; sialomucin core protein 24 isoform X1 [KO:K06546]
116074914  Slc29a3; equilibrative nucleoside transporter 3 [KO:K15014]
116074946  Ostm1; osteopetrosis-associated transmembrane protein 1 isoform X1 [KO:K23863]
116074956  Slc29a1; equilibrative nucleoside transporter 1 [KO:K15014]
116075056  Psap; prosaposin isoform X1 [KO:K12382]
116075127  Neu1; sialidase-1 [KO:K01186] [EC:3.2.1.18]
116075331  Ppt2; lysosomal thioesterase PPT2 isoform X1 [KO:K01074] [EC:3.1.2.22]
116075343  Fig4; polyphosphoinositide phosphatase [KO:K22913] [EC:3.1.3.-]
116075662  Gga1; ADP-ribosylation factor-binding protein GGA1 isoform X1 [KO:K12404]
116075767  Gnptab; N-acetylglucosamine-1-phosphotransferase subunits alpha/beta isoform X1 [KO:K08239] [EC:2.7.8.17]
116075787  Gns; N-acetylglucosamine-6-sulfatase isoform X1 [KO:K01137] [EC:3.1.6.14]
116075833  Ap3d1; AP-3 complex subunit delta-1 isoform X1 [KO:K12396]
116075886  Bloc1s1; biogenesis of lysosome-related organelles complex 1 subunit 1 [KO:K20185]
116075967  Atp6ap1; V-type proton ATPase subunit S1 [KO:K03662]
116076272  Cd63; CD63 antigen [KO:K06497]
116076661  Naga; alpha-N-acetylgalactosaminidase isoform X1 [KO:K01204] [EC:3.2.1.49]
116076679  Plekhm1; pleckstrin homology domain-containing family M member 1 [KO:K23282]
116076821  Gnptg; N-acetylglucosamine-1-phosphotransferase subunit gamma isoform X1 [KO:K10087]
116076834  Igf2r; cation-independent mannose-6-phosphate receptor [KO:K06564]
116076896  Abca5; ATP-binding cassette sub-family A member 5 isoform X1 [KO:K05648]
116077002  Slc36a2; proton-coupled amino acid transporter 2 [KO:K14209]
116077050  Clcn7; H(+)/Cl(-) exchange transporter 7 isoform X1 [KO:K05016]
116077213  Sgsh; N-sulphoglucosamine sulphohydrolase isoform X1 [KO:K01565] [EC:3.10.1.1]
116077227  Gaa; lysosomal alpha-glucosidase [KO:K12316] [EC:3.2.1.20]
116077504  Rptor; regulatory-associated protein of mTOR [KO:K07204]
116077533  Telo2; telomere length regulation protein TEL2 homolog isoform X1 [KO:K11137]
116077751  Slc36a1; proton-coupled amino acid transporter 1 [KO:K14209]
116077943  Atp6v0e1; V-type proton ATPase subunit e 1 isoform X1 [KO:K02153]
116078052  Arsa; arylsulfatase A [KO:K01134] [EC:3.1.6.8]
116078084  Osbpl7; oxysterol-binding protein-related protein 7 isoform X1 [KO:K20463]
116078164  Naglu; alpha-N-acetylglucosaminidase [KO:K01205] [EC:3.2.1.50]
116078194  Atp6v0c; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
116078256  Gm2a; ganglioside GM2 activator [KO:K12383]
116078307  Borcs6; BLOC-1-related complex subunit 6 [KO:K20820]
116078319  Slc36a3; proton-coupled amino acid transporter 3 isoform X1 [KO:K14209]
116078351  Lamp2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
116078499  Mlst8; target of rapamycin complex subunit LST8 [KO:K08266]
116078714  Ap2b1; AP-2 complex subunit beta [KO:K11825]
116079009  Arsg; arylsulfatase G isoform X1 [KO:K12381] [EC:3.1.6.-]
116079092  Cd68; macrosialin [KO:K06501]
116079113  Cltc; clathrin heavy chain 1 isoform X1 [KO:K04646]
116079123  Gga3; ADP-ribosylation factor-binding protein GGA3 isoform X1 [KO:K12404]
116079228  Atp6v0a1; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
116079272  Ctns; cystinosin isoform X1 [KO:K12386]
116079609  Galc; galactocerebrosidase isoform X1 [KO:K01202] [EC:3.2.1.46]
116079681  Tmem251; transmembrane protein 251 isoform X1 [KO:K26747]
116079697  Zfyve26; zinc finger FYVE domain-containing protein 26 isoform X1 [KO:K19027]
116079784  Slc11a2; natural resistance-associated macrophage protein 2 isoform X1 [KO:K21398]
116079860  Atp6v1e2; V-type proton ATPase subunit E 2 [KO:K02150]
116080017  Laptm4a; lysosomal-associated transmembrane protein 4A [KO:K12387]
116080061  Atp6v1d; V-type proton ATPase subunit D [KO:K02149]
116080085  Npc2; NPC intracellular cholesterol transporter 2 [KO:K13443]
116080304  Ap4s1; AP-4 complex subunit sigma-1 [KO:K12403]
116080803  Atp6v1c2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
116080851  Lgmn; legumain [KO:K01369] [EC:3.4.22.34]
116081555  Atp6v1c1; V-type proton ATPase subunit C 1 [KO:K02148]
116081595  Deptor; DEP domain-containing mTOR-interacting protein [KO:K20402]
116081794  Laptm4b; lysosomal-associated transmembrane protein 4B [KO:K12387]
116081909  Bloc1s5; biogenesis of lysosome-related organelles complex 1 subunit 5 isoform X1 [KO:K20187]
116082154  Cltb; clathrin light chain B isoform X1 [KO:K04645]
116082227  [KO:K01365] [EC:3.4.22.15]
116082696  Dtnbp1; dysbindin isoform X1 [KO:K20189]
116082714  Vps41; vacuolar protein sorting-associated protein 41 homolog [KO:K20184]
116083091  Slc38a9; sodium-coupled neutral amino acid transporter 9 isoform X1 [KO:K14995]
116083254  Ap3b1; AP-3 complex subunit beta-1 [KO:K12397]
116083371  Hexb; beta-hexosaminidase subunit beta [KO:K12373] [EC:3.2.1.52]
116083781  Arsb; arylsulfatase B isoform X1 [KO:K01135] [EC:3.1.6.12]
116084459  Rogdi; protein rogdi homolog [KO:K24628]
116084518  Entpd4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
116084542  Nagpa; N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [KO:K01125] [EC:3.1.4.45]
116084579  [KO:K20002]
116084819  [KO:K01319] [EC:3.4.21.20]
116084920  Litafd; LITAF domain-containing protein isoform X1 [KO:K19363]
116085237  Litaf; lipopolysaccharide-induced tumor necrosis factor-alpha factor [KO:K19363]
116085276  Ap3m1; AP-3 complex subunit mu-1 isoform X1 [KO:K12398]
116085308  Cln5; ceroid-lipofuscinosis neuronal protein 5 [KO:K12390]
116085316  Ap5m1; AP-5 complex subunit mu-1 [KO:K19023]
116085343  Ap1g2; AP-1 complex subunit gamma-like 2 isoform X1 [KO:K12391]
116085396  Ctsb; cathepsin B isoform X1 [KO:K01363] [EC:3.4.22.1]
116085655  Snap29; synaptosomal-associated protein 29 [KO:K08509]
116085689  Ids; iduronate 2-sulfatase [KO:K01136] [EC:3.1.6.13]
116085721  Ap2m1; AP-2 complex subunit mu [KO:K11826]
116085932  Atp6v1a; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
116086325  Lamp3; lysosome-associated membrane glycoprotein 3 [KO:K06562]
116086849  Npc1; LOW QUALITY PROTEIN: NPC intracellular cholesterol transporter 1 [KO:K12385]
116086854  Osbpl1a; oxysterol-binding protein-related protein 1 isoform X1 [KO:K20174]
116087136  Ap3s1; AP-3 complex subunit sigma-1 isoform X1 [KO:K12399]
116087146  Dmxl1; dmX-like protein 1 isoform X1 [KO:K24155]
116087261  Wdr7; WD repeat-containing protein 7 isoform X1 [KO:K24738]
116087990  Rragd; ras-related GTP-binding protein D isoform X1 [KO:K16186]
116088138  Atp6v1h; V-type proton ATPase subunit H isoform X1 [KO:K02144]
116088520  Pikfyve; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
116088567  Slc11a1; natural resistance-associated macrophage protein 1 [KO:K12347]
116088633  Ap1s3; AP-1 complex subunit sigma-3 [KO:K12395]
116088640  Gla; alpha-galactosidase A [KO:K01189] [EC:3.2.1.22]
116088998  Atp6v0d2; V-type proton ATPase subunit d 2 [KO:K02146]
116089818  Abca2; ATP-binding cassette sub-family A member 2 isoform X1 [KO:K05642]
116089878  Slc2a6; solute carrier family 2, facilitated glucose transporter member 6 isoform X1 [KO:K08144]
116090000  Rragb; ras-related GTP-binding protein B isoform X1 [KO:K16185]
116090317  Gpr155; integral membrane protein GPR155 isoform X1 [KO:K28455]
116090344  Osbpl6; oxysterol-binding protein-related protein 6 isoform X1 [KO:K20463]
116090393  Ap1s2; AP-1 complex subunit sigma-2 isoform X1 [KO:K12394]
116090463  Acp2; lysosomal acid phosphatase [KO:K14410] [EC:3.1.3.2]
116090566  Tlr8; toll-like receptor 8 [KO:K10170]
116090574  Tlr7; toll-like receptor 7 isoform X1 [KO:K05404]
116090719  Vps18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
116090757  Vps39; vam6/Vps39-like protein isoform X1 [KO:K20183]
116090813  Spg11; spatacsin isoform X1 [KO:K19026]
116090832  Bloc1s6; biogenesis of lysosome-related organelles complex 1 subunit 6 [KO:K20188]
116090866  Ap4e1; AP-4 complex subunit epsilon-1 isoform X1 [KO:K12400]
116090929  Vps16; vacuolar protein sorting-associated protein 16 homolog isoform X1 [KO:K20180]
116090958  Ap5s1; AP-5 complex subunit sigma-1 isoform X1 [KO:K19024]
116091003  Lamp5; lysosome-associated membrane glycoprotein 5 [KO:K28774]
116091297  Tti1; TELO2-interacting protein 1 homolog [KO:K20403]
116091373  Ctsa; lysosomal protective protein [KO:K13289] [EC:3.4.16.5]
116091501  Ctsz; cathepsin Z [KO:K08568] [EC:3.4.18.1]
116091523  Osbpl2; oxysterol-binding protein-related protein 2 [KO:K20174]
116093027  Ctso; cathepsin O [KO:K01374] [EC:3.4.22.42]
116093135  Lamtor2; ragulator complex protein LAMTOR2 [KO:K20398]
116093158  Gba; lysosomal acid glucosylceramidase [KO:K01201] [EC:3.2.1.45]
116093414  Ctsk; cathepsin K [KO:K01371] [EC:3.4.22.38]
116093415  Ctss; cathepsin S isoform X1 [KO:K01368] [EC:3.4.22.27]
116093539  Ap4b1; AP-4 complex subunit beta-1 isoform X1 [KO:K12401]
116093591  Lamtor5; ragulator complex protein LAMTOR5 [KO:K16344]
116093623  Sort1; sortilin isoform X1 [KO:K12388]
116093824  Manba; beta-mannosidase isoform X1 [KO:K01192] [EC:3.2.1.25]
116093838  Lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
116093914  Mcoln3; mucolipin-3 [KO:K04994]
116093915  Mcoln2; mucolipin-2 isoform X1 [KO:K04993]
116093920  Ctbs; di-N-acetylchitobiase [KO:K12310] [EC:3.2.1.-]
116094117  Snapin; SNARE-associated protein Snapin [KO:K20002]
116094385  Dnase2b; deoxyribonuclease-2-beta [KO:K01158] [EC:3.1.22.1]
116095131  Mfsd8; major facilitator superfamily domain-containing protein 8 isoform X1 [KO:K12307]
116095766  Rragc; ras-related GTP-binding protein C [KO:K16186]
116095922  Clta; clathrin light chain A isoform X1 [KO:K04644]
116095991  Stx17; syntaxin-17 [KO:K08491]
116096127  Atp6v1g1; V-type proton ATPase subunit G 1 [KO:K02152]
116096204  Rraga; ras-related GTP-binding protein A [KO:K16185]
116096509  Atp6v0b; V-type proton ATPase 21 kDa proteolipid subunit isoform X1 [KO:K03661]
116096567  Ppt1; palmitoyl-protein thioesterase 1 isoform X1 [KO:K01074] [EC:3.1.2.22]
116096736  Laptm5; lysosomal-associated transmembrane protein 5 [KO:K12387]
116096852  Fuca1; tissue alpha-L-fucosidase [KO:K01206] [EC:3.2.1.51]
116097015  Mtor; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
116097778  Fuca2; plasma alpha-L-fucosidase isoform X1 [KO:K01206] [EC:3.2.1.51]
116097878  Ncoa7; nuclear receptor coactivator 7 isoform X1 [KO:K25442]
116098025  [KO:K01197] [EC:3.2.1.35]
116098026  Hyal4; hyaluronidase-4 [KO:K01197] [EC:3.2.1.35]
116098027  [KO:K01197] [EC:3.2.1.35]
116098028  [KO:K01197] [EC:3.2.1.35]
116098665  Atp6v1f; V-type proton ATPase subunit F [KO:K02151]
116098742  Atp6v0a4; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
116098857  Atp6v0e2; V-type proton ATPase subunit e 2 isoform X1 [KO:K02153]
116098893  Osbpl3; oxysterol-binding protein-related protein 3 isoform X1 [KO:K20463]
116098912  Ctse; cathepsin E [KO:K01382] [EC:3.4.23.34]
116099080  Vamp8; vesicle-associated membrane protein 8 [KO:K08512]
116099215  Rab7a; ras-related protein Rab-7a [KO:K07897]
116099319  Mitf; microphthalmia-associated transcription factor isoform X1 [KO:K09455]
116099360  Sumf1; formylglycine-generating enzyme [KO:K13444] [EC:1.8.3.7]
116099367  Arl8b; ADP-ribosylation factor-like protein 8B [KO:K07955]
116099516  Atp6v1e1; V-type proton ATPase subunit E 1 [KO:K02150]
116099535  M6pr; cation-dependent mannose-6-phosphate receptor [KO:K10089]
116099695  Borcs5; BLOC-1-related complex subunit 5 isoform X1 [KO:K20819]
116099943  Atp6v1b1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
116100285  Ap2s1; AP-2 complex subunit sigma [KO:K11827]
116101756  Bloc1s3; biogenesis of lysosome-related organelles complex 1 subunit 3 isoform X1 [KO:K20186]
116102140  Napsa; napsin-A [KO:K08565] [EC:3.4.23.-]
116102150  Akt1s1; proline-rich AKT1 substrate 1 isoform X1 [KO:K16184]
116102154  Ap2a1; AP-2 complex subunit alpha-1 isoform X1 [KO:K11824]
116102447  Ap3s2; AP-3 complex subunit sigma-2 [KO:K12399]
116102485  Ap3b2; AP-3 complex subunit beta-2 isoform X1 [KO:K12397]
116102536  Ctsc; dipeptidyl peptidase 1 isoform X1 [KO:K01275] [EC:3.4.14.1]
116102684  Lamtor1; ragulator complex protein LAMTOR1 [KO:K20397]
116102729  Smpd1; sphingomyelin phosphodiesterase [KO:K12350] [EC:3.1.4.12]
116102738  Tpp1; tripeptidyl-peptidase 1 [KO:K01279] [EC:3.4.14.9]
116102906  Gga2; ADP-ribosylation factor-binding protein GGA2 [KO:K12404]
116102959  Cln3; battenin isoform X1 [KO:K12389]
116103044  Tfe3; transcription factor E3 isoform X1 [KO:K09105]
116103231  Ap2a2; AP-2 complex subunit alpha-2 isoform X1 [KO:K11824]
116103240  Ctsd; cathepsin D [KO:K01379] [EC:3.4.23.5]
116103271  Osbpl5; oxysterol-binding protein-related protein 5 [KO:K20464]
116103286  Tpcn2; two pore calcium channel protein 2 isoform X1 [KO:K14077]
116103300  Tcirg1; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
116103352  Ctsf; cathepsin F [KO:K01373] [EC:3.4.22.41]
116103361  Slc29a2; equilibrative nucleoside transporter 2 [KO:K15014]
116103390  Ctsw; cathepsin W isoform X1 [KO:K08569] [EC:3.4.22.-]
116103399  Ap5b1; AP-5 complex subunit beta-1 [KO:K19022]
116103567  Slc15a3; solute carrier family 15 member 3 isoform X1 [KO:K14638]
116103599  Osbp; oxysterol-binding protein 1 isoform X1 [KO:K20456]
116103626  Vps13a; vacuolar protein sorting-associated protein 13A isoform X1 [KO:K19525]
116103762  Lipa; lysosomal acid lipase/cholesteryl ester hydrolase isoform X1 [KO:K01052] [EC:3.1.1.13]
116103886  Bloc1s2; biogenesis of lysosome-related organelles complex 1 subunit 2 isoform X1 [KO:K16750]
116103957  Borcs7; BLOC-1-related complex subunit 7 [KO:K20821]
116104007  [KO:K11827]
116104499  Scarb2; lysosome membrane protein 2 [KO:K12384]
Compound
C00002  ATP
C00008  ADP
Reference
PMID:12628346
  Authors
Eskelinen EL, Tanaka Y, Saftig P
  Title
At the acidic edge: emerging functions for lysosomal membrane proteins.
  Journal
Trends Cell Biol 13:137-45 (2003)
DOI:10.1016/S0962-8924(03)00005-9
Reference
PMID:1883197
  Authors
Neufeld EF
  Title
Lysosomal storage diseases.
  Journal
Annu Rev Biochem 60:257-80 (1991)
DOI:10.1146/annurev.bi.60.070191.001353
Reference
PMID:2943218
  Authors
von Figura K, Hasilik A
  Title
Lysosomal enzymes and their receptors.
  Journal
Annu Rev Biochem 55:167-93 (1986)
DOI:10.1146/annurev.bi.55.070186.001123
Reference
PMID:15987739
  Authors
Janvier K, Bonifacino JS
  Title
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
  Journal
Mol Biol Cell 16:4231-42 (2005)
DOI:10.1091/mbc.E05-03-0213
Reference
PMID:18635948
  Authors
Vergarajauregui S, Puertollano R
  Title
Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
  Journal
Autophagy 4:832-4 (2008)
DOI:10.4161/auto.6567
Reference
PMID:34249946
  Authors
Jaskolka MC, Winkley SR, Kane PM
  Title
RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification.
  Journal
Front Cell Dev Biol 9:698190 (2021)
DOI:10.3389/fcell.2021.698190
Reference
PMID:34646033
  Authors
Majdoul S, Compton AA
  Title
Lessons in self-defence: inhibition of virus entry by intrinsic immunity.
  Journal
Nat Rev Immunol 22:339-352 (2022)
DOI:10.1038/s41577-021-00626-8
Reference
PMID:19672277
  Authors
Saftig P, Klumperman J
  Title
Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function.
  Journal
Nat Rev Mol Cell Biol 10:623-35 (2009)
DOI:10.1038/nrm2745
Reference
PMID:31611045
  Authors
Savini M, Zhao Q, Wang MC
  Title
Lysosomes: Signaling Hubs for Metabolic Sensing and Longevity.
  Journal
Trends Cell Biol 29:876-887 (2019)
DOI:10.1016/j.tcb.2019.08.008
Reference
PMID:33433692
  Authors
Meyer-Schwesinger C
  Title
Lysosome function in glomerular health and disease.
  Journal
Cell Tissue Res 385:371-392 (2021)
DOI:10.1007/s00441-020-03375-7
Reference
PMID:34345172
  Authors
Allemailem KS, Almatroudi A, Alrumaihi F, Almatroodi SA, Alkurbi MO, Basfar GT, Rahmani AH, Khan AA
  Title
Novel Approaches of Dysregulating Lysosome Functions in Cancer Cells by Specific Drugs and Its Nanoformulations: A Smart Approach of Modern Therapeutics.
  Journal
Int J Nanomedicine 16:5065-5098 (2021)
DOI:10.2147/IJN.S321343
Reference
PMID:36096887
  Authors
Zhang W, Yang X, Li Y, Yu L, Zhang B, Zhang J, Cho WJ, Venkatarangan V, Chen L, Burugula BB, Bui S, Wang Y, Duan C, Kitzman JO, Li M
  Title
GCAF(TMEM251) regulates lysosome biogenesis by activating the mannose-6-phosphate pathway.
  Journal
Nat Commun 13:5351 (2022)
DOI:10.1038/s41467-022-33025-1
Reference
PMID:38357444
  Authors
Liu Q, Wang W, Xu L, Zhang Q, Wang H
  Title
The host mannose-6-phosphate pathway and viral infection.
  Journal
Front Cell Infect Microbiol 14:1349221 (2024)
DOI:10.3389/fcimb.2024.1349221
Reference
PMID:38711187
  Authors
He Y, Fan Y, Ahmadpoor X, Wang Y, Li ZA, Zhu W, Lin H
  Title
Targeting lysosomal quality control as a therapeutic strategy against aging and diseases.
  Journal
Med Res Rev 44:2472-2509 (2024)
DOI:10.1002/med.22047
Reference
PMID:40759742
  Authors
Radulovic M, Yang C, Stenmark H
  Title
Lysosomal membrane homeostasis and its importance in physiology and disease.
  Journal
Nat Rev Mol Cell Biol 27:71-87 (2026)
DOI:10.1038/s41580-025-00873-w
Reference
PMID:41214333
  Authors
Watson ET, Wegeng WR, Aravani S, Ernst AM, von Blume J
  Title
Mechanistic insights into cargo sorting and export from the Golgi apparatus.
  Journal
Nat Rev Mol Cell Biol 26:940-956 (2025)
DOI:10.1038/s41580-025-00907-3
Related
pathway
mcoc00511  Other glycan degradation
mcoc00531  Glycosaminoglycan degradation
mcoc04130  SNARE interactions in vesicular transport
mcoc04140  Autophagy - animal
mcoc04144  Endocytosis
mcoc04145  Phagocytosis
mcoc04150  mTOR signaling pathway
mcoc04620  Toll-like receptor signaling pathway
KO pathway
ko04142   

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