KEGG   PATHWAY: mmf04630
Entry
mmf04630                    Pathway                                
Name
JAK-STAT signaling pathway - Molossus molossus (Pallas's mastiff bat)
Description
The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors.
Class
Environmental Information Processing; Signal transduction
Pathway map
mmf04630  JAK-STAT signaling pathway
mmf04630

Other DBs
GO: 0007259
Organism
Molossus molossus (Pallas's mastiff bat) [GN:mmf]
Gene
118643998  IL2; interleukin-2 [KO:K05429]
118616277  IL4; interleukin-4 [KO:K05430]
118631690  IL7; interleukin-7 isoform X1 [KO:K05431]
118643740  IL9; interleukin-9 [KO:K05432]
118616314  IL15; interleukin-15 isoform X1 [KO:K05433]
118616396  IL21; interleukin-21 [KO:K05434]
118642055  thymic stromal lymphopoietin [KO:K05436]
118632297  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
118624074  IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
118635917  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
118641533  interleukin-4 receptor subunit alpha-like [KO:K05071]
118641654  interleukin-4 receptor subunit alpha-like [KO:K05071]
118641726  IL7R; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072]
118642166  LOW QUALITY PROTEIN: interleukin-9 receptor-like [KO:K05073]
118617636  IL15RA; interleukin-15 receptor subunit alpha isoform X1 [KO:K05074]
118641932  IL21R; interleukin-21 receptor [KO:K05075]
118635573  CRLF2; cytokine receptor-like factor 2 [KO:K05078]
118643573  IL5; interleukin-5 [KO:K05428]
118615980  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
118636573  IL3RA; interleukin-3 receptor subunit alpha [KO:K04737]
118633070  IL5RA; interleukin-5 receptor subunit alpha [KO:K05067]
118636238  granulocyte-macrophage colony-stimulating factor receptor subunit alpha-like [KO:K05066]
118636251  CSF2RA; granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X1 [KO:K05066]
118623610  CSF2RB; cytokine receptor common subunit beta [KO:K04738]
118620458  IL6; interleukin-6 isoform X1 [KO:K05405]
118639458  IL11; interleukin-11 [KO:K05417]
118616327  IL13; interleukin-13 [KO:K05435]
118642332  IL27; interleukin-27 subunit alpha [KO:K22629]
118640106  OSM; oncostatin-M isoform X1 [KO:K05418]
118639768  LIF; leukemia inhibitory factor isoform X1 [KO:K05419]
118627646  CNTF; ciliary neurotrophic factor [KO:K05420]
118642568  CTF1; cardiotrophin-1 isoform X1 [KO:K05422]
118628843  CLCF1; cardiotrophin-like cytokine factor 1 [KO:K05421]
118637082  IL6R; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055]
118642413  IL6ST; interleukin-6 receptor subunit beta [KO:K05060]
118629667  IL11RA; interleukin-11 receptor subunit alpha [KO:K05056]
118635677  IL13RA1; interleukin-13 receptor subunit alpha-1 [KO:K05076]
118636188  IL13RA2; interleukin-13 receptor subunit alpha-2 [KO:K05077]
118616262  IL27RA; interleukin-27 receptor subunit alpha [KO:K19598]
118641523  IL31RA; interleukin-31 receptor subunit alpha [KO:K22630]
118641557  OSMR; oncostatin-M-specific receptor subunit beta [KO:K05057]
118641934  LIFR; leukemia inhibitory factor receptor [KO:K05058]
118629675  CNTFR; ciliary neurotrophic factor receptor subunit alpha isoform X1 [KO:K05059]
118637558  IL10; interleukin-10 [KO:K05443]
118637919  IL19; interleukin-19 [KO:K05444]
118624482  IL22; interleukin-22 [KO:K05445]
118637737  IL20; interleukin-20 [KO:K22667]
118637738  IL24; interleukin-24 [KO:K22668]
118624747  IL26; interleukin-26 [KO:K05446]
118628845  IL10RA; interleukin-10 receptor subunit alpha [KO:K05134]
118617730  IL10RB; interleukin-10 receptor subunit beta [KO:K05135]
118621756  IL20RA; interleukin-20 receptor subunit alpha [KO:K05136]
118633348  IL20RB; LOW QUALITY PROTEIN: interleukin-20 receptor subunit beta [KO:K05137]
118627259  IL22RA1; interleukin-22 receptor subunit alpha-1 [KO:K05138]
118621853  IL22RA2; interleukin-22 receptor subunit alpha-2 [KO:K05139]
118617678  IL12A; interleukin-12 subunit alpha [KO:K05406]
118615760  IL12B; interleukin-12 subunit beta [KO:K05425]
118623879  IL23A; interleukin-23 subunit alpha [KO:K05426]
118643823  IL12RB1; interleukin-12 receptor subunit beta-1 [KO:K05063]
118626554  IL12RB2; interleukin-12 receptor subunit beta-2 [KO:K05064]
118626700  IL23R; interleukin-23 receptor [KO:K05065]
118642813  EPO; erythropoietin [KO:K05437]
118634340  somatotropin [KO:K05438]
118626233  PRL; prolactin [KO:K05439]
118617476  THPO; thrombopoietin isoform X1 [KO:K06854]
118634776  CSF3; LOW QUALITY PROTEIN: granulocyte colony-stimulating factor [KO:K05423]
118620004  leptin [KO:K05424]
118615339  EPOR; erythropoietin receptor [KO:K05079]
118642611  GHR; growth hormone receptor [KO:K05080]
118642673  PRLR; prolactin receptor [KO:K05081]
118626710  MPL; thrombopoietin receptor [KO:K05082]
118626357  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
118626498  LEPR; leptin receptor [KO:K05062]
118629333  interferon omega-1-like [KO:K05414]
118629850  interferon alpha-14-like [KO:K05414]
118629329  IFNB1; interferon beta [KO:K05415]
118629334  IFNE; LOW QUALITY PROTEIN: interferon epsilon [KO:K05442]
118630282  IFNK; interferon kappa [KO:K05441]
118639483  interferon lambda-1-like [KO:K05447]
118638902  interferon lambda-3-like [KO:K22669]
118638906  interferon lambda-3-like [KO:K22669]
118638907  interferon lambda-3-like [KO:K22669]
118629845  interferon omega-2-like [KO:K05440]
118629890  interferon omega-2-like [KO:K05440]
118629891  interferon omega-2-like [KO:K05440]
118617107  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
118617288  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
118626539  IFNLR1; interferon lambda receptor 1 isoform X1 [KO:K05140]
118624687  IFNG; interferon gamma [KO:K04687]
118621177  IFNGR1; interferon gamma receptor 1 [KO:K05132]
118617140  IFNGR2; interferon gamma receptor 2 isoform X1 [KO:K05133]
118634494  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
118615652  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
118623957  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
118620077  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
118624129  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
118615300  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
118626049  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
118629676  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
118615617  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
118615353  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
118625659  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
118623876  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
118634787  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
118625631  STAT4; signal transducer and activator of transcription 4 isoform X1 [KO:K11222]
118633839  signal transducer and activator of transcription 5A [KO:K11223]
118634401  STAT5B; signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
118623461  STAT6; signal transducer and activator of transcription 6 isoform X1 [KO:K11225]
118631124  IRF9; interferon regulatory factor 9 isoform X1 [KO:K04693]
118633612  CISH; cytokine-inducible SH2-containing protein isoform X1 [KO:K04701]
118642358  SOCS1; suppressor of cytokine signaling 1 [KO:K04694]
118616246  suppressor of cytokine signaling 2-like [KO:K04695]
118624669  SOCS2; suppressor of cytokine signaling 2 [KO:K04695]
118634253  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
118616174  SOCS4; suppressor of cytokine signaling 4 [KO:K04697]
118630957  SOCS5; suppressor of cytokine signaling 5 [KO:K04698]
118618989  SOCS6; suppressor of cytokine signaling 6 [KO:K04699]
118635053  SOCS7; suppressor of cytokine signaling 7 [KO:K04699]
118619009  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
118637247  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539]
118618234  BCL2L1; bcl-2-like protein 1 [KO:K04570]
118621526  PIM1; serine/threonine-protein kinase pim-1 [KO:K04702] [EC:2.7.11.1]
118631560  MYC; myc proto-oncogene protein [KO:K04377]
118628257  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
118624468  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
118621102  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
118621843  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
118624997  aldehyde oxidase 2 [KO:K00157] [EC:1.2.3.1]
118624998  aldehyde oxidase 4-like [KO:K00157] [EC:1.2.3.1]
118625352  aldehyde oxidase [KO:K00157] [EC:1.2.3.1]
118634771  glial fibrillary acidic protein isoform X1 [KO:K05640]
118638465  STAM; signal transducing adapter molecule 1 isoform X1 [KO:K04705]
118625457  STAM2; signal transducing adapter molecule 2 isoform X1 [KO:K04705]
118618282  PTPN2; tyrosine-protein phosphatase non-receptor type 2 isoform X1 [KO:K18026] [EC:3.1.3.48]
118625335  tyrosine-protein phosphatase non-receptor type 2-like [KO:K18026] [EC:3.1.3.48]
118623590  PTPN6; tyrosine-protein phosphatase non-receptor type 6 isoform X1 [KO:K05697] [EC:3.1.3.48]
118641604  CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
118624243  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
118618869  PIAS1; E3 SUMO-protein ligase PIAS1 isoform X1 [KO:K04706] [EC:2.3.2.-]
118618184  PIAS2; E3 SUMO-protein ligase PIAS2 isoform X1 [KO:K16063] [EC:2.3.2.-]
118637634  PIAS3; E3 SUMO-protein ligase PIAS3 isoform X1 [KO:K16064] [EC:2.3.2.-]
118616293  PIAS4; E3 SUMO-protein ligase PIAS4 [KO:K16065] [EC:2.3.2.27]
118635384  four and a half LIM domains protein 1-like [KO:K14365]
118636433  FHL1; four and a half LIM domains protein 1 isoform X1 [KO:K14365]
118639877  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
118633806  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
118630966  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
118616724  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
118643162  HRAS; GTPase HRas isoform X1 [KO:K02833]
118633343  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
118632927  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118626944  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118617106  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118626685  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
118642883  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
118616460  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
118640620  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118619617  LOW QUALITY PROTEIN: RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
118630299  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118638405  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118627075  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
Reference
PMID:22383755
  Authors
Harrison DA
  Title
The Jak/STAT pathway.
  Journal
Cold Spring Harb Perspect Biol 4:a011205 (2012)
DOI:10.1101/cshperspect.a011205
Reference
PMID:22339650
  Authors
Kiu H, Nicholson SE
  Title
Biology and significance of the JAK/STAT signalling pathways.
  Journal
Growth Factors 30:88-106 (2012)
DOI:10.3109/08977194.2012.660936
Reference
PMID:21372217
  Authors
Hervas-Stubbs S, Perez-Gracia JL, Rouzaut A, Sanmamed MF, Le Bon A, Melero I
  Title
Direct effects of type I interferons on cells of the immune system.
  Journal
Clin Cancer Res 17:2619-27 (2011)
DOI:10.1158/1078-0432.CCR-10-1114
Reference
PMID:25217450
  Authors
Fish EN, Platanias LC
  Title
Interferon receptor signaling in malignancy: a network of cellular pathways defining biological outcomes.
  Journal
Mol Cancer Res 12:1691-703 (2014)
DOI:10.1158/1541-7786.MCR-14-0450
Reference
PMID:21034406
  Authors
Ivanenkov YA, Balakin KV, Lavrovsky Y
  Title
Small molecule inhibitors of NF-kB and JAK/STAT signal transduction pathways as promising anti-inflammatory therapeutics.
  Journal
Mini Rev Med Chem 11:55-78 (2011)
DOI:10.2174/138955711793564079
Reference
PMID:25587654
  Authors
O'Shea JJ, Schwartz DM, Villarino AV, Gadina M, McInnes IB, Laurence A
  Title
The JAK-STAT pathway: impact on human disease and therapeutic intervention.
  Journal
Annu Rev Med 66:311-28 (2015)
DOI:10.1146/annurev-med-051113-024537
Reference
PMID:24069565
  Authors
Zoranovic T, Grmai L, Bach EA
  Title
Regulation of proliferation, cell competition, and cellular growth by the Drosophila JAK-STAT pathway.
  Journal
JAKSTAT 2:e25408 (2013)
DOI:10.4161/jkst.25408
Reference
PMID:16204702
  Authors
Ungureanu D, Silvennoinen O
  Title
SLIM trims STATs: ubiquitin E3 ligases provide insights for specificity in the regulation of cytokine signaling.
  Journal
Sci STKE 2005:pe49 (2005)
DOI:10.1126/stke.3042005pe49
Reference
PMID:23735217
  Authors
Richard AJ, Stephens JM
  Title
The role of JAK-STAT signaling in adipose tissue function.
  Journal
Biochim Biophys Acta 1842:431-9 (2014)
DOI:10.1016/j.bbadis.2013.05.030
Reference
PMID:24606160
  Authors
Sun Y, Lehmbecker A, Kalkuhl A, Deschl U, Sun W, Rohn K, Tzvetanova ID, Nave KA, Baumgartner W, Ulrich R
  Title
STAT3 represents a molecular switch possibly inducing astroglial instead of oligodendroglial differentiation of oligodendroglial progenitor cells in Theiler's murine encephalomyelitis.
  Journal
Neuropathol Appl Neurobiol 41:347-70 (2015)
DOI:10.1111/nan.12133
Reference
PMID:10851053
  Authors
Hirano T, Ishihara K, Hibi M
  Title
Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors.
  Journal
Oncogene 19:2548-56 (2000)
DOI:10.1038/sj.onc.1203551
Reference
PMID:11114747
  Authors
Rane SG, Reddy EP
  Title
Janus kinases: components of multiple signaling pathways.
  Journal
Oncogene 19:5662-79 (2000)
DOI:10.1038/sj.onc.1203925
Reference
PMID:8682149
  Authors
Heim MH
  Title
The Jak-STAT pathway: specific signal transduction from the cell membrane to the nucleus.
  Journal
Eur J Clin Invest 26:1-12 (1996)
DOI:10.1046/j.1365-2362.1996.103248.x
Reference
PMID:30267440
  Authors
Morris R, Kershaw NJ, Babon JJ
  Title
The molecular details of cytokine signaling via the JAK/STAT pathway.
  Journal
Protein Sci 27:1984-2009 (2018)
DOI:10.1002/pro.3519
Reference
PMID:34492272
  Authors
Tzeng HT, Chyuan IT, Lai JH
  Title
Targeting the JAK-STAT pathway in autoimmune diseases and cancers: A focus on molecular mechanisms and therapeutic potential.
  Journal
Biochem Pharmacol 193:114760 (2021)
DOI:10.1016/j.bcp.2021.114760
Reference
PMID:32203403
  Authors
Salas A, Hernandez-Rocha C, Duijvestein M, Faubion W, McGovern D, Vermeire S, Vetrano S, Vande Casteele N
  Title
JAK-STAT pathway targeting for the treatment of inflammatory bowel disease.
  Journal
Nat Rev Gastroenterol Hepatol 17:323-337 (2020)
DOI:10.1038/s41575-020-0273-0
Related
pathway
mmf04010  MAPK signaling pathway
mmf04060  Cytokine-cytokine receptor interaction
mmf04110  Cell cycle
mmf04120  Ubiquitin mediated proteolysis
mmf04151  PI3K-Akt signaling pathway
mmf04210  Apoptosis
KO pathway
ko04630   
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