KEGG   PATHWAY: mun05202
Entry
mun05202                    Pathway                                
Name
Transcriptional misregulation in cancer - Meriones unguiculatus (Mongolian gerbil)
Description
In tumor cells, genes encoding transcription factors (TFs) are often amplified, deleted, rearranged via chromosomal translocation and inversion, or subjected to point mutations that result in a gain- or loss-of- function. In hematopoietic cancers and solid tumors, the translocations and inversions increase or deregulate transcription of the oncogene. Recurrent chromosome translocations generate novel fusion oncoproteins, which are common in myeloid cancers and soft-tissue sarcomas. The fusion proteins have aberrant transcriptional function compared to their wild-type counterparts. These fusion transcription factors alter expression of target genes, and thereby result in a variety of altered cellular properties that contribute to the tumourigenic process.
Class
Human Diseases; Cancer: overview
Pathway map
mun05202  Transcriptional misregulation in cancer
mun05202

Organism
Meriones unguiculatus (Mongolian gerbil) [GN:mun]
Gene
110539463  Il6; interleukin-6 [KO:K05405]
110539611  Mef2c; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
110539612  Fev; protein FEV [KO:K09437]
110539733  Mlf1; myeloid leukemia factor 1 isoform X1 [KO:K15622]
110539751  Rel; proto-oncogene c-Rel isoform X1 [KO:K09254]
110539833  Supt3h; transcription initiation protein SPT3 homolog isoform X1 [KO:K11313]
110540129  Cd86; T-lymphocyte activation antigen CD86 isoform X1 [KO:K05413]
110540396  Hmga2; high mobility group protein HMGI-C [KO:K09283]
110541181  [KO:K11253]
110541339  [KO:K05230]
110542151  Runx1; runt-related transcription factor 1 isoform X1 [KO:K08367]
110542391  Ptk2; focal adhesion kinase 1 isoform X4 [KO:K05725] [EC:2.7.10.2]
110543383  Rxrb; retinoic acid receptor RXR-beta isoform X2 [KO:K08525]
110543658  Kdm6a; lysine-specific demethylase 6A isoform X1 [KO:K11447] [EC:1.14.11.68]
110543676  Bak1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
110543865  [KO:K11253]
110544542  [KO:K05230]
110544853  [KO:K05230]
110544860  Zbtb17; zinc finger and BTB domain-containing protein 17 isoform X1 [KO:K10500]
110545252  Pax7; paired box protein Pax-7 isoform X1 [KO:K09381]
110545269  Hhex; hematopoietically-expressed homeobox protein HHEX [KO:K08024]
110545473  Mycn; N-myc proto-oncogene protein [KO:K09109]
110545767  Bmi1; polycomb complex protein BMI-1 [KO:K11459]
110545833  Lyl1; protein lyl-1 [KO:K15604]
110546102  Ewsr1; RNA-binding protein EWS isoform X1 [KO:K13209]
110546141  Hoxa9; homeobox protein Hox-A9 [KO:K21950]
110546158  Hoxa11; homeobox protein Hox-A11 [KO:K21951]
110546159  Hoxa10; homeobox protein Hox-A10 isoform X1 [KO:K17443]
110546268  Mllt1; protein ENL isoform X1 [KO:K15187]
110546467  Zbtb16; zinc finger and BTB domain-containing protein 16 isoform X1 [KO:K10055]
110546586  Cdkn1a; cyclin-dependent kinase inhibitor 1 isoform X2 [KO:K06625]
110546618  Sin3a; paired amphipathic helix protein Sin3a isoform X1 [KO:K11644]
110546688  Csf1r; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
110547035  Ddx5; probable ATP-dependent RNA helicase DDX5 [KO:K12823] [EC:5.6.2.7]
110547249  Tgfbr2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
110547254  [KO:K06571]
110547261  Igf1r; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
110547524  Bcl6; B-cell lymphoma 6 protein [KO:K15618]
110547604  Jmjd1c; probable JmjC domain-containing histone demethylation protein 2C isoform X1 [KO:K11449] [EC:1.14.11.-]
110547766  Fut8; alpha-(1,6)-fucosyltransferase [KO:K00717] [EC:2.4.1.68]
110547767  Max; protein max isoform X1 [KO:K04453]
110547833  Smad1; mothers against decapentaplegic homolog 1 [KO:K04676]
110547945  [KO:K11253]
110547946  Nupr1; nuclear protein 1 [KO:K15626]
110548120  Etv5; ETS translocation variant 5 [KO:K15593]
110548268  Elk4; ETS domain-containing protein Elk-4 [KO:K04376]
110548273  Slc45a3; solute carrier family 45 member 3 [KO:K15379]
110548379  Cdk14; cyclin-dependent kinase 14 isoform X1 [KO:K08821] [EC:2.7.11.22]
110548465  Il2rb; interleukin-2 receptor subunit beta [KO:K05069]
110548554  Hdac1; histone deacetylase 1 isoform X2 [KO:K06067] [EC:3.5.1.98]
110548628  Ccnd2; G1/S-specific cyclin-D2 [KO:K10151]
110548705  Baiap3; BAI1-associated protein 3 [KO:K15621]
110548853  Aspscr1; tether containing UBX domain for GLUT4 isoform X1 [KO:K15627]
110548935  Cebpb; CCAAT/enhancer-binding protein beta [KO:K10048]
110549115  Kmt2a; histone-lysine N-methyltransferase 2A isoform X2 [KO:K09186] [EC:2.1.1.354]
110549176  Rxra; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
110549307  Mmp9; matrix metalloproteinase-9 isoform X1 [KO:K01403] [EC:3.4.24.35]
110549347  Rela; transcription factor p65 isoform X1 [KO:K04735]
110549349  Men1; menin isoform X1 [KO:K14970]
110549416  Pax3; paired box protein Pax-3 isoform X1 [KO:K09381]
110549421  Foxo1; forkhead box protein O1 [KO:K07201]
110549441  Cd40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
110549468  Atm; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
110549489  Bcl2a1; bcl-2-related protein A1 [KO:K02162]
110549556  Tlx3; T-cell leukemia homeobox protein 3 [KO:K15607]
110549803  Ncor1; nuclear receptor corepressor 1 isoform X1 [KO:K04650]
110549889  Hdac2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
110550050  Cebpe; CCAAT/enhancer-binding protein epsilon [KO:K10051]
110550083  Bcl2l1; bcl-2-like protein 1 isoform X1 [KO:K04570]
110550209  Ss18; protein SSXT isoform X1 [KO:K15623]
110550342  Ptcra; pre T-cell antigen receptor alpha [KO:K06056]
110550458  Mllt3; protein AF-9 isoform X1 [KO:K15187]
110550615  Spint1; kunitz-type protease inhibitor 1 [KO:K15619]
110550658  Klf3; Krueppel-like factor 3 [KO:K15605]
110550699  Pdgfa; platelet-derived growth factor subunit A isoform X3 [KO:K04359]
110550731  Spi1; transcription factor PU.1 isoform X1 [KO:K09438]
110550733  Ddb2; DNA damage-binding protein 2 [KO:K10140]
110550822  Pparg; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
110551008  Cdkn1b; cyclin-dependent kinase inhibitor 1B [KO:K06624]
110551012  Etv6; LOW QUALITY PROTEIN: transcription factor ETV6 [KO:K03211]
110551081  Ccnt2; cyclin-T2 isoform X1 [KO:K15188]
110551211  Ngfr; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
110551330  [KO:K11253]
110551338  Tcf3; transcription factor E2-alpha isoform X1 [KO:K09063]
110551365  Cebpa; CCAAT/enhancer-binding protein alpha [KO:K09055]
110551370  Elane; neutrophil elastase [KO:K01327] [EC:3.4.21.37]
110551463  Maf; transcription factor Maf isoform X1 [KO:K09035]
110551800  Rxrg; retinoic acid receptor RXR-gamma isoform X1 [KO:K08526]
110551907  Etv4; ETS translocation variant 4 isoform X1 [KO:K15592]
110552013  Plau; urokinase-type plasminogen activator [KO:K01348] [EC:3.4.21.73]
110552128  Dusp6; dual specificity protein phosphatase 6 isoform X1 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
110552180  H3-4; histone H3.1t [KO:K11253]
110552301  Itgb7; integrin beta-7 [KO:K06590]
110552322  Sp1; transcription factor Sp1 isoform X1 [KO:K04684]
110553098  [KO:K11253]
110553099  [KO:K11253]
110553115  [KO:K11253]
110553677  Pbx3; pre-B-cell leukemia transcription factor 3 isoform X1 [KO:K15610]
110553751  Birc3; baculoviral IAP repeat-containing protein 3 isoform X1 [KO:K16060]
110553757  Birc2; baculoviral IAP repeat-containing protein 2 isoform X4 [KO:K16060]
110553821  Pax5; paired box protein Pax-5 isoform X2 [KO:K09383]
110554014  Ss18l1; calcium-responsive transactivator [KO:K15623]
110554034  Wt1; Wilms tumor protein isoform X1 [KO:K09234]
110554310  Per2; period circadian protein homolog 2 isoform X1 [KO:K02633]
110554585  [KO:K15615]
110554586  Six1; homeobox protein SIX1 [KO:K15614]
110554591  Arnt2; aryl hydrocarbon receptor nuclear translocator 2 isoform X1 [KO:K15589]
110554636  Etv1; ETS translocation variant 1 isoform X1 [KO:K09431]
110554829  Pml; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
110554919  Ccna1; cyclin-A1 [KO:K06627]
110555127  Tp53; cellular tumor antigen p53 isoform X1 [KO:K04451]
110555170  Igfbp3; insulin-like growth factor-binding protein 3 [KO:K10138]
110555604  Gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
110555618  Dot1l; histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1 [KO:K11427] [EC:2.1.1.360]
110555641  [KO:K11253]
110555676  Taf15; TATA-binding protein-associated factor 2N [KO:K14651]
110555736  Bcl11b; B-cell lymphoma/leukemia 11B isoform X1 [KO:K22046]
110555956  Runx2; runt-related transcription factor 2 isoform X3 [KO:K09278]
110556006  Tlx1; T-cell leukemia homeobox protein 1 isoform X2 [KO:K09340]
110556332  Bmp2k; BMP-2-inducible protein kinase isoform X1 [KO:K08854] [EC:2.7.11.1]
110556337  Ldb1; LIM domain-binding protein 1 isoform X1 [KO:K15617]
110556621  Plat; tissue-type plasminogen activator isoform X1 [KO:K01343] [EC:3.4.21.68]
110556668  [KO:K11253]
110556669  [KO:K11253]
110556839  Lmo2; rhombotin-2 isoform X2 [KO:K15612]
110557276  Nsd2; histone-lysine N-methyltransferase NSD2 isoform X2 [KO:K11424] [EC:2.1.1.357]
110557311  Fli1; Friend leukemia integration 1 transcription factor isoform X1 [KO:K09436]
110557360  Cd14; monocyte differentiation antigen CD14 [KO:K04391]
110558090  [KO:K01394] [EC:3.4.24.17]
110558100  Nr4a3; nuclear receptor subfamily 4 group A member 3 isoform X1 [KO:K08559]
110558423  Gadd45a; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X2 [KO:K04402]
110558507  Rara; retinoic acid receptor alpha isoform X1 [KO:K08527]
110558602  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X2 [KO:K02580]
110558703  Met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
110558708  Hpgd; 15-hydroxyprostaglandin dehydrogenase [NAD(+)] [KO:K00069] [EC:1.1.1.141]
110558721  Runx1t1; protein CBFA2T1 isoform X1 [KO:K10053]
110558766  Zeb1; zinc finger E-box-binding homeobox 1 isoform X1 [KO:K09299]
110559073  Gadd45g; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
110559153  Prom1; prominin-1 isoform X2 [KO:K06532]
110559443  Ccnt1; cyclin-T1 isoform X1 [KO:K15188]
110559569  [KO:K01353] [EC:3.4.21.79]
110559571  [KO:K01353] [EC:3.4.21.79]
110559633  Ccna2; cyclin-A2 isoform X1 [KO:K06627]
110559723  Wnt16; protein Wnt-16 [KO:K01558]
110559832  Mitf; microphthalmia-associated transcription factor isoform X5 [KO:K09455]
110559911  [KO:K11253]
110560064  Myc; myc proto-oncogene protein [KO:K04377]
110560244  [KO:K11253]
110560579  Erg; transcriptional regulator ERG isoform X4 [KO:K09435]
110560658  Bax; apoptosis regulator BAX isoform X1 [KO:K02159]
110561040  Eya1; eyes absent homolog 1 isoform X4 [KO:K15616] [EC:3.1.3.48]
110561182  Aff1; AF4/FMR2 family member 1 isoform X3 [KO:K15184]
110561450  Ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
110561550  Atf1; cyclic AMP-dependent transcription factor ATF-1 isoform X3 [KO:K09053]
110561622  Igf1; insulin-like growth factor I isoform X5 [KO:K05459]
110561713  Csf2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
110561719  [KO:K04736]
110561822  Il1r2; interleukin-1 receptor type 2 isoform X1 [KO:K04387]
110561989  Tfe3; transcription factor E3 isoform X1 [KO:K09105]
110562241  Mdm2; E3 ubiquitin-protein ligase Mdm2 isoform X2 [KO:K06643] [EC:2.3.2.27]
110562420  [KO:K11253]
110563557  Cdkn2c; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
110563585  Jup; junction plakoglobin [KO:K10056]
110563648  Cdk9; cyclin-dependent kinase 9 [KO:K02211] [EC:2.7.11.22 2.7.11.23]
110563683  Tmprss2; transmembrane protease serine 2 isoform X1 [KO:K09633] [EC:3.4.21.122]
110563759  Traf1; TNF receptor-associated factor 1 isoform X3 [KO:K03172]
110563772  Polk; DNA polymerase kappa isoform X1 [KO:K03511] [EC:2.7.7.7]
110563863  Pbx1; pre-B-cell leukemia transcription factor 1 isoform X1 [KO:K09355]
110564034  Id2; DNA-binding protein inhibitor ID-2 [KO:K17693]
110564388  Tspan7; tetraspanin-7 [KO:K06571]
110564396  Prcc; proline-rich protein PRCC [KO:K13105]
110564540  Fus; RNA-binding protein FUS isoform X3 [KO:K13098]
110564544  Itgam; integrin alpha-M [KO:K06461]
110564977  Ntrk1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
110565116  Meis1; homeobox protein Meis1 isoform X1 [KO:K15613]
110565132  Pax8; paired box protein Pax-8 isoform X1 [KO:K09293]
110565606  [KO:K15624]
110565882  [KO:K01353] [EC:3.4.21.79]
110565889  Gria3; glutamate receptor 3 isoform X1 [KO:K05199]
110566146  Mpo; myeloperoxidase [KO:K10789] [EC:1.11.2.2]
110566672  Nfkbiz; NF-kappa-B inhibitor zeta isoform X1 [KO:K14242]
110566878  [KO:K05230]
132646042  [KO:K11253]
132649316  [KO:K11253]
132653464  [KO:K05230]
132653465  [KO:K05230]
132653466  [KO:K05230]
132653467  [KO:K05230]
132653468  [KO:K05230]
132653469  [KO:K05230]
132653471  [KO:K05230]
132653472  [KO:K05230]
132653473  [KO:K05230]
132653474  [KO:K05230]
Reference
PMID:11607818
  Authors
Alcalay M, Orleth A, Sebastiani C, Meani N, Chiaradonna F, Casciari C, Sciurpi MT, Gelmetti V, Riganelli D, Minucci S, Fagioli M, Pelicci PG
  Title
Common themes in the pathogenesis of acute myeloid leukemia.
  Journal
Oncogene 20:5680-94 (2001)
DOI:10.1038/sj.onc.1204642
Reference
PMID:12032780
  Authors
Scandura JM, Boccuni P, Cammenga J, Nimer SD
  Title
Transcription factor fusions in acute leukemia: variations on a theme.
  Journal
Oncogene 21:3422-44 (2002)
DOI:10.1038/sj.onc.1205315
Reference
PMID:12529654
  Authors
Roumier C, Fenaux P, Lafage M, Imbert M, Eclache V, Preudhomme C
  Title
New mechanisms of AML1 gene alteration in hematological malignancies.
  Journal
Leukemia 17:9-16 (2003)
DOI:10.1038/sj.leu.2402766
Reference
PMID:10717473
  Authors
Lutterbach B, Hiebert SW
  Title
Role of the transcription factor AML-1 in acute leukemia and hematopoietic differentiation.
  Journal
Gene 245:223-35 (2000)
DOI:10.1016/S0378-1119(00)00014-7
Reference
PMID:19075268
  Authors
Koschmieder S, Halmos B, Levantini E, Tenen DG
  Title
Dysregulation of the C/EBPalpha differentiation pathway in human cancer.
  Journal
J Clin Oncol 27:619-28 (2009)
DOI:10.1200/JCO.2008.17.9812
Reference
PMID:11340171
  Authors
Johansen LM, Iwama A, Lodie TA, Sasaki K, Felsher DW, Golub TR, Tenen DG
  Title
c-Myc is a critical target for c/EBPalpha in granulopoiesis.
  Journal
Mol Cell Biol 21:3789-806 (2001)
DOI:10.1128/MCB.21.11.3789-3806.2001
Reference
PMID:15985538
  Authors
Gery S, Gombart AF, Yi WS, Koeffler C, Hofmann WK, Koeffler HP
  Title
Transcription profiling of C/EBP targets identifies Per2 as a gene implicated in myeloid leukemia.
  Journal
Blood 106:2827-36 (2005)
DOI:10.1182/blood-2005-01-0358
Reference
PMID:12393465
  Authors
Vangala RK, Heiss-Neumann MS, Rangatia JS, Singh SM, Schoch C, Tenen DG, Hiddemann W, Behre G
  Title
The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia.
  Journal
Blood 101:270-7 (2003)
DOI:10.1182/blood-2002-04-1288
Reference
PMID:12130514
  Authors
Mueller BU, Pabst T, Osato M, Asou N, Johansen LM, Minden MD, Behre G, Hiddemann W, Ito Y, Tenen DG
  Title
Heterozygous PU.1 mutations are associated with acute myeloid leukemia.
  Journal
Blood 100:998-1007 (2002)
DOI:10.1182/blood.V100.3.998
Reference
PMID:15160934
  Authors
Jing Y
  Title
The PML-RARalpha fusion protein and targeted therapy for acute promyelocytic leukemia.
  Journal
Leuk Lymphoma 45:639-48 (2004)
DOI:10.1080/10428190310001609933
Reference
PMID:15024077
  Authors
Muller-Tidow C, Steffen B, Cauvet T, Tickenbrock L, Ji P, Diederichs S, Sargin B, Kohler G, Stelljes M, Puccetti E, Ruthardt M, deVos S, Hiebert SW, Koeffler HP, Berdel WE, Serve H
  Title
Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells.
  Journal
Mol Cell Biol 24:2890-904 (2004)
DOI:10.1128/MCB.24.7.2890-2904.2004
Reference
PMID:19855079
  Authors
Rice KL, Hormaeche I, Doulatov S, Flatow JM, Grimwade D, Mills KI, Leiva M, Ablain J, Ambardekar C, McConnell MJ, Dick JE, Licht JD
  Title
Comprehensive genomic screens identify a role for PLZF-RARalpha as a positive regulator of cell proliferation via direct regulation of c-MYC.
  Journal
Blood 114:5499-511 (2009)
DOI:10.1182/blood-2009-03-206524
Reference
PMID:10500199
  Authors
McWhirter JR, Neuteboom ST, Wancewicz EV, Monia BP, Downing JR, Murre C
  Title
Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia.
  Journal
Proc Natl Acad Sci U S A 96:11464-9 (1999)
DOI:10.1073/pnas.96.20.11464
Reference
PMID:15156184
  Authors
Zelent A, Greaves M, Enver T
  Title
Role of the TEL-AML1 fusion gene in the molecular pathogenesis of childhood acute lymphoblastic leukaemia.
  Journal
Oncogene 23:4275-83 (2004)
DOI:10.1038/sj.onc.1207672
Reference
PMID:14630078
  Authors
Sawinska M, Ladon D
  Title
Mechanism, detection and clinical significance of the reciprocal translocation t(12;21)(p12;q22) in the children suffering from acute lymphoblastic leukaemia.
  Journal
Leuk Res 28:35-42 (2004)
DOI:10.1016/S0145-2126(03)00160-7
Reference
PMID:19141473
  Authors
Guenther MG, Lawton LN, Rozovskaia T, Frampton GM, Levine SS, Volkert TL, Croce CM, Nakamura T, Canaani E, Young RA
  Title
Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia.
  Journal
Genes Dev 22:3403-8 (2008)
DOI:10.1101/gad.1741408
Reference
PMID:16169901
  Authors
Xia ZB, Popovic R, Chen J, Theisler C, Stuart T, Santillan DA, Erfurth F, Diaz MO, Zeleznik-Le NJ
  Title
The MLL fusion gene, MLL-AF4, regulates cyclin-dependent kinase inhibitor CDKN1B (p27kip1) expression.
  Journal
Proc Natl Acad Sci U S A 102:14028-33 (2005)
DOI:10.1073/pnas.0506464102
Reference
PMID:21518926
  Authors
Wang QF, Wu G, Mi S, He F, Wu J, Dong J, Luo RT, Mattison R, Kaberlein JJ, Prabhakar S, Ji H, Thirman MJ
  Title
MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome.
  Journal
Blood 117:6895-905 (2011)
DOI:10.1182/blood-2010-12-324699
Reference
PMID:14701735
  Authors
Zeisig BB, Milne T, Garcia-Cuellar MP, Schreiner S, Martin ME, Fuchs U, Borkhardt A, Chanda SK, Walker J, Soden R, Hess JL, Slany RK
  Title
Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization.
  Journal
Mol Cell Biol 24:617-28 (2004)
DOI:10.1128/MCB.24.2.617-628.2004
Reference
PMID:19133982
  Authors
Riz I, Hawley TS, Johnston H, Hawley RG
  Title
Role of TLX1 in T-cell acute lymphoblastic leukaemia pathogenesis.
  Journal
Br J Haematol 145:140-3 (2009)
DOI:10.1111/j.1365-2141.2008.07556.x
Reference
PMID:12511414
  Authors
Barth TF, Martin-Subero JI, Joos S, Menz CK, Hasel C, Mechtersheimer G, Parwaresch RM, Lichter P, Siebert R, Mooller P
  Title
Gains of 2p involving the REL locus correlate with nuclear c-Rel protein accumulation in neoplastic cells of classical Hodgkin lymphoma.
  Journal
Blood 101:3681-6 (2003)
DOI:10.1182/blood-2002-08-2577
Reference
PMID:11313274
  Authors
Hinz M, Loser P, Mathas S, Krappmann D, Dorken B, Scheidereit C
  Title
Constitutive NF-kappaB maintains high expression of a characteristic gene network, including CD40, CD86, and a set of antiapoptotic genes in Hodgkin/Reed-Sternberg cells.
  Journal
Blood 97:2798-807 (2001)
DOI:10.1182/blood.V97.9.2798
Reference
PMID:12670461
  Authors
Zuzel M, Cawley JC.
  Title
The biology of hairy cells.
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Best Pract Res Clin Haematol 16:1-13 (2003)
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PMID:14998494
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Overexpression of c-maf is a frequent oncogenic event in multiple myeloma that promotes proliferation and pathological interactions with bone marrow stroma.
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Cancer Cell 5:191-9 (2004)
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The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells.
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Blood 117:211-20 (2011)
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MMSET deregulation affects cell cycle progression and adhesion regulons in t(4;14) myeloma plasma cells.
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Haematologica 94:78-86 (2009)
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Leuk Lymphoma 34:25-33 (1999)
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The t(9;14)(p13;q32) translocation in B-cell non-Hodgkin's lymphoma.
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Leuk Lymphoma 36:435-45 (2000)
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Oncogenic gene fusions in epithelial carcinomas.
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Curr Opin Genet Dev 19:82-91 (2009)
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Translocations in epithelial cancers.
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Biochim Biophys Acta 1796:201-15 (2009)
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Reddi HV, McIver B, Grebe SK, Eberhardt NL
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The paired box-8/peroxisome proliferator-activated receptor-gamma oncogene in thyroid tumorigenesis.
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Endocrinology 148:932-5 (2007)
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The renal cell carcinoma-associated oncogenic fusion protein PRCCTFE3 provokes p21 WAF1/CIP1-mediated cell cycle delay.
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Exp Cell Res 315:2399-409 (2009)
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Recurrent gene fusions in prostate cancer.
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Nat Rev Cancer 8:497-511 (2008)
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An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression.
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Cancer Cell 17:443-54 (2010)
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TMPRSS2/ERG promotes epithelial to mesenchymal transition through the ZEB1/ZEB2 axis in a prostate cancer model.
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PLoS One 6:e21650 (2011)
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ETV1 is a novel androgen receptor-regulated gene that mediates prostate cancer cell invasion.
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Mol Endocrinol 21:1835-46 (2007)
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Characterization of TMPRSS2:ETV5 and SLC45A3:ETV5 gene fusions in prostate cancer.
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Cancer Res 68:73-80 (2008)
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PMID:21849159
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The MYCN oncogene and differentiation in neuroblastoma.
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Semin Cancer Biol 21:256-66 (2011)
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Reference
PMID:20153925
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MYCN oncoprotein targets and their therapeutic potential.
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Cancer Lett 293:144-57 (2010)
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PMID:15644444
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The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma.
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Proc Natl Acad Sci U S A 102:731-6 (2005)
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Bmi1 is a MYCN target gene that regulates tumorigenesis through repression of KIF1Bbeta and TSLC1 in neuroblastoma.
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Oncogene 29:2681-90 (2010)
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PMID:20145147
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p53 is a direct transcriptional target of MYCN in neuroblastoma.
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Cancer Res 70:1377-88 (2010)
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N-MYC regulates focal adhesion kinase expression in human neuroblastoma.
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J Biol Chem 282:12503-16 (2007)
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A SP1/MIZ1/MYCN repression complex recruits HDAC1 at the TRKA and p75NTR promoters and affects neuroblastoma malignancy by inhibiting the cell response to NGF.
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Cancer Res 71:404-12 (2011)
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Mechanisms of disease: multiple endocrine neoplasia type 1-relation to chromatin modifications and transcription regulation.
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Nat Clin Pract Endocrinol Metab 2:562-70 (2006)
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Menin, histone h3 methyltransferases, and regulation of cell proliferation: current knowledge and perspective.
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Curr Mol Med 8:805-15 (2008)
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Unusual clinical and pathological presentation of a neuroendocrine tumor in a patient with multiple endocrine neoplasia type 1.
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Endocr J 56:887-95 (2009)
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In search of tumor suppressing functions of menin.
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Mol Cell Endocrinol 265-266:34-41 (2007)
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PMID:15826838
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Fusion oncogenes in tumor development.
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Semin Cancer Biol 15:236-43 (2005)
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PMID:12527902
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Upregulation of Id2, an oncogenic helix-loop-helix protein, is mediated by the chimeric EWS/ets protein in Ewing sarcoma.
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Oncogene 22:1-9 (2003)
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PMID:18648544
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IGF1 is a common target gene of Ewing's sarcoma fusion proteins in mesenchymal progenitor cells.
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PLoS One 3:e2634 (2008)
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PMID:17250957
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The Biology of Ewing sarcoma.
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Cancer Lett 254:1-10 (2007)
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Ewing Sarcoma, an enigmatic malignancy of likely progenitor cell origin, driven by transcription factor oncogenic fusions.
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Int J Clin Exp Pathol 3:338-47 (2010)
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Advances in Ewing's sarcoma research: where are we now and what lies ahead?
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Cancer Res 69:7140-50 (2009)
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PMID:12527906
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Oncogene 22:41-9 (2003)
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PMID:15826834
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The EWS-WT1 gene fusion in desmoplastic small round cell tumor.
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Semin Cancer Biol 15:197-205 (2005)
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J Pathol 217:83-93 (2009)
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PMID:18330902
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The hTAF II 68-TEC fusion protein functions as a strong transcriptional activator.
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Int J Cancer 122:2446-53 (2008)
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Fusion of the EWS-related gene TAF2N to TEC in extraskeletal myxoid chondrosarcoma.
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Myxoid liposarcoma FUS-DDIT3 fusion oncogene induces C/EBP beta-mediated interleukin 6 expression.
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Int J Cancer 115:556-60 (2005)
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PMID:18850010
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The myxoid liposarcoma FUS-DDIT3 fusion oncoprotein deregulates NF-kappaB target genes by interaction with NFKBIZ.
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Oncogene 28:270-8 (2009)
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Reference
PMID:20863376
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Willems SM, Schrage YM, Bruijn IH, Szuhai K, Hogendoorn PC, Bovee JV
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Kinome profiling of myxoid liposarcoma reveals NF-kappaB-pathway kinase activity and casein kinase II inhibition as a potential treatment option.
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Mol Cancer 9:257 (2010)
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Reference
PMID:18457914
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Linardic CM
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PAX3-FOXO1 fusion gene in rhabdomyosarcoma.
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Cancer Lett 270:10-8 (2008)
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Reference
PMID:11863357
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Identification of target genes regulated by PAX3 and PAX3-FKHR in embryogenesis and alveolar rhabdomyosarcoma.
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Genomics 79:278-84 (2002)
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Reference
PMID:17101797
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Ishida M, Miyamoto M, Naitoh S, Tatsuda D, Hasegawa T, Nemoto T, Yokozeki H, Nishioka K, Matsukage A, Ohki M, Ohta T
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The SYT-SSX fusion protein down-regulates the cell proliferation regulator COM1 in t(x;18) synovial sarcoma.
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Mol Cell Biol 27:1348-55 (2007)
DOI:10.1128/MCB.00658-06
Reference
PMID:19472090
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Jun HJ, Lee J, Lim do H, Park JO, Ahn G, Seo SW, Sung KS, Lim do H, Yoo KH, Choi YL
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Expression of MET in alveolar soft part sarcoma.
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Med Oncol 27:459-65 (2010)
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Reference
PMID:21779514
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Rivlin N, Brosh R, Oren M, Rotter V
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Mutations in the p53 Tumor Suppressor Gene: Important Milestones at the Various Steps of Tumorigenesis.
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Genes Cancer 2:466-74 (2011)
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Reference
PMID:21765642
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Suzuki K, Matsubara H
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Recent advances in p53 research and cancer treatment.
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J Biomed Biotechnol 2011:978312 (2011)
DOI:10.1155/2011/978312
Related
pathway
mun04115  p53 signaling pathway
mun05211  Renal cell carcinoma
mun05215  Prostate cancer
mun05216  Thyroid cancer
mun05221  Acute myeloid leukemia
KO pathway
ko05202   

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