Entry Name RIG-I-like receptor signaling pathway - Homo sapiens (human)
Description Specific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular viral replication is recognized by a family of cytosolic RNA helicases termed RIG-I-like receptors (RLRs). The RLR proteins include RIG-I, MDA5, and LGP2 and are expressed in both immune and nonimmune cells. Upon recognition of viral nucleic acids, RLRs recruit specific intracellular adaptor proteins to initiate signaling pathways that lead to the synthesis of type I interferon and other inflammatory cytokines, which are important for eliminating viruses.
Class Organismal Systems; Immune systemBRITE hierarchy
Pathway map hsa04622 RIG-I-like receptor signaling pathway
Ortholog table Network Element N00469 RIG-I-IRF7/3 signaling pathway
N00688 RIG-I-NFKB signaling pathway
N01308 MDA5-IRF7/3 signaling pathway
N01564 Post-translational modifications of RIG-I and MDA5
N01565 Adenosine-to-inosine RNA editing by ADAR
Drug D12352 Eclitasertib (USAN/INN)
Organism Homo sapiens (human) [GN:
hsa ]
Gene 57169 ZNFX1; zinc finger NFX1-type containing 1 [KO:K27391 ]
57506 MAVS; mitochondrial antiviral signaling protein [KO:K12648 ]
7187 TRAF3; TNF receptor associated factor 3 [KO:K03174 ]
10010 TANK; TRAF family member associated NFKB activator [KO:K12650 ]
8517 IKBKG; inhibitor of nuclear factor kappa B kinase regulatory subunit gamma [KO:K07210 ]
9641 IKBKE; inhibitor of nuclear factor kappa B kinase subunit epsilon [KO:K07211 ] [EC:2.7.11.10 ]
3661 IRF3; interferon regulatory factor 3 [KO:K05411 ]
3665 IRF7; interferon regulatory factor 7 [KO:K09447 ]
8717 TRADD; TNFRSF1A associated via death domain [KO:K03171 ]
8772 FADD; Fas associated via death domain [KO:K02373 ]
1147 CHUK; component of inhibitor of nuclear factor kappa B kinase complex [KO:K04467 ] [EC:2.7.11.10 ]
4790 NFKB1; nuclear factor kappa B subunit 1 [KO:K02580 ]
5970 RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735 ]
3576 CXCL8; C-X-C motif chemokine ligand 8 [KO:K10030 ]
3627 CXCL10; C-X-C motif chemokine ligand 10 [KO:K12671 ]
9636 ISG15; ISG15 ubiquitin like modifier [KO:K12159 ]
340061 STING1; stimulator of interferon response cGAMP interactor 1 [KO:K12654 ]
5300 PIN1; peptidylprolyl cis/trans isomerase, NIMA-interacting 1 [KO:K09578 ] [EC:5.2.1.8 ]
Compound Reference Authors Yoneyama M, Kikuchi M, Natsukawa T, Shinobu N, Imaizumi T, Miyagishi M, Taira K, Akira S, Fujita T
Title The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses.
Journal Reference Authors Takeuchi O, Akira S
Title MDA5/RIG-I and virus recognition.
Journal Reference Authors Yoneyama M, Fujita T
Title RNA recognition and signal transduction by RIG-I-like receptors.
Journal Reference Authors Nakhaei P, Genin P, Civas A, Hiscott J
Title RIG-I-like receptors: sensing and responding to RNA virus infection.
Journal Reference Authors Moore CB, Ting JP
Title Regulation of mitochondrial antiviral signaling pathways.
Journal Reference Authors Barral PM, Sarkar D, Su ZZ, Barber GN, DeSalle R, Racaniello VR, Fisher PB
Title Functions of the cytoplasmic RNA sensors RIG-I and MDA-5: key regulators of innate immunity.
Journal Reference Authors Schlee M, Hartmann E, Coch C, Wimmenauer V, Janke M, Barchet W, Hartmann G
Title Approaching the RNA ligand for RIG-I?
Journal Reference Authors Saito T, Gale M Jr
Title Differential recognition of double-stranded RNA by RIG-I-like receptors in antiviral immunity.
Journal Reference Authors Kawai T, Akira S
Title Toll-like receptor and RIG-I-like receptor signaling.
Journal Reference Authors Michallet MC, Meylan E, Ermolaeva MA, Vazquez J, Rebsamen M, Curran J, Poeck H, Bscheider M, Hartmann G, Konig M, Kalinke U, Pasparakis M, Tschopp J
Title TRADD protein is an essential component of the RIG-like helicase antiviral pathway.
Journal Reference Authors Yoshida R, Takaesu G, Yoshida H, Okamoto F, Yoshioka T, Choi Y, Akira S, Kawai T, Yoshimura A, Kobayashi T
Title TRAF6 and MEKK1 play a pivotal role in the RIG-I-like helicase antiviral pathway.
Journal Reference Authors Mikkelsen SS, Jensen SB, Chiliveru S, Melchjorsen J, Julkunen I, Gaestel M, Arthur JS, Flavell RA, Ghosh S, Paludan SR
Title RIG-I-mediated activation of p38 MAPK is essential for viral induction of interferon and activation of dendritic cells: dependence on TRAF2 and TAK1.
Journal Reference Authors Liu G, Gack MU
Title Distinct and Orchestrated Functions of RNA Sensors in Innate Immunity.
Journal Related KO pathway LinkDB All DBs
