KEGG   PATHWAY: hsa04010
Entry
hsa04010                    Pathway                                
Name
MAPK signaling pathway - Homo sapiens (human)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
hsa04010  MAPK signaling pathway
hsa04010

Network
nt06162  Hepatitis B virus (HBV)
nt06163  Hepatitis C virus (HCV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06166  Human papillomavirus (HPV)
nt06167  Human cytomegalovirus (HCMV)
nt06170  Influenza A virus (IAV)
nt06181  Salmonella
nt06210  ERK signaling (cancer)
nt06211  Other MAPK signaling (cancer)
nt06260  Colorectal cancer
nt06261  Gastric cancer
nt06262  Pancreatic cancer
nt06263  Hepatocellular carcinoma
nt06264  Renal cell carcinoma
nt06265  Bladder cancer
nt06266  Non-small cell lung cancer
nt06268  Melanoma
nt06270  Breast cancer
nt06271  Endometrial cancer
nt06273  Glioma
nt06274  Thyroid cancer
nt06275  Acute myeloid leukemia
nt06276  Chronic myeloid leukemia
nt06324  GHRH-GH-IGF signaling
nt06526  MAPK signaling
  Element
N00001  EGF-EGFR-RAS-ERK signaling pathway
N00015  PDGF-PDGFR-RAS-ERK signaling pathway
N00019  FGF-FGFR-RAS-ERK signaling pathway
N00186  IL1-IL1R-p38 signaling pathway
N00188  IL1-IL1R-JNK signaling pathway
N00215  KITLG-KIT-RAS-ERK signaling pathway
N00216  HGF-MET-RAS-ERK signaling pathway
N00217  FLT3LG-FLT3-RAS-ERK signaling pathway
N00229  TGFA-EGFR-RAS-ERK signaling pathway
N00233  IGF-IGF1R-RAS-ERK signaling pathway
N00277  EREG-EGFR-RAS-ERK signaling pathway
N00279  AREG-EGFR-RAS-ERK signaling pathway
N00542  EGF-EGFR-RAS-JNK signaling pathway
N01119  RAC/CDC42-PAK-ERK signaling pathway
N01592  GF-RTK-RAS-ERK signaling pathway
N01593  Regulation of GF-RTK-RAS-ERK signaling, PTP
N01594  MLK-JNK signaling pathway
N01597  Regulation of GF-RTK-RAS-ERK signaling, SPRED and NF1
N01600  Regulation of GF-RTK-RAS-ERK signaling, RasGAP
N01601  ERK-RSK signaling
N01602  ERK-MYC signaling pathway
Disease
H02157  Short-rib thoracic dysplasia
Drug
D00107  Tacrolimus (USP/INN)
D00184  Cyclosporine (USP)
D00332  Gabapentin (JAN/USP/INN)
D00404  Methsuximide (USP)
D00495  Paramethadione (INN)
D00538  Zonisamide (JP19/USP/INN)
D00539  Ethosuximide (JP19/USP/INN)
D00619  Verapamil hydrochloride (JP19/USP)
D00631  Bepridil hydrochloride (USAN)
D00742  Etanercept (USAN/INN)
D01441  Imatinib mesylate (USAN)
D01977  Gefitinib (JP19/USAN/INN)
D02356  Verapamil (USAN/INN)
D02537  Dronedarone (INN)
D02597  Adalimumab (USAN/INN)
D02598  Infliximab (USAN/INN)
D02630  Penfluridol (USAN/INN)
D02716  Pregabalin (JP19/USAN/INN)
D02970  Aprinocarsen sodium (USAN)
D03065  Becaplermin (USAN/INN)
D03218  Axitinib (JAN/USAN)
D03350  Canertinib dihydrochloride (USAN)
D03441  Certolizumab pegol (USAN/INN)
D03455  Cetuximab (USAN/INN)
D03658  Dasatinib (JAN/INN)
D03736  Doramapimod (USAN/INN)
D03914  Dronedarone hydrochloride (USP)
D04023  Erlotinib hydrochloride (JAN/USAN)
D04024  Lapatinib ditosylate (USAN)
D04358  Golimumab (USAN/INN)
D04696  Lestaurtinib (USAN/INN)
D04862  Masoprocol (USAN/INN)
D05024  Mibefradil dihydrochloride (USAN)
D05029  Midostaurin (JAN/USAN/INN)
D05146  Nerelimomab (USAN/INN)
D05263  Onercept (USAN/INN)
D05350  Panitumumab (USAN/INN)
D05380  Pazopanib hydrochloride (JAN/USAN)
D05393  Pegsunercept (USAN)
D05399  Pelitinib (USAN/INN)
D05480  Pimecrolimus (JAN/USAN/INN)
D06005  Tandutinib (USAN/INN)
D06129  Tiapamil hydrochloride (USAN)
D06272  Sorafenib tosylate (USAN)
D06285  Vatalanib (USAN/INN)
D06402  Sunitinib malate (JAN/USAN)
D06407  Vandetanib (JAN/USAN/INN)
D06413  Nilotinib hydrochloride hydrate (JAN)
D06414  Dasatinib (USAN)
D06635  Rilonacept (USAN/INN)
D06678  Motesanib (USAN)
D07436  Afelimomab (INN)
D07520  Bepridil (INN)
D07907  Erlotinib (INN)
D08066  Imatinib (INN)
D08108  Lapatinib (INN)
D08217  Mibefradil (INN)
D08279  Tozasertib (USAN)
D08344  Tozasertib lactate (USAN)
D08503  Toceranib (USAN)
D08524  Sorafenib (USAN/INN)
D08544  Toceranib phosphate (USAN)
D08552  Sunitinib (INN)
D08556  Tacrolimus (INN)
D08878  Brivanib alaninate (JAN/USAN/INN)
D08881  Cediranib (USAN/INN)
D08883  Cediranib maleate (JAN/USAN)
D08907  Dovitinib lactate (USAN)
D08947  Motesanib diphosphate (USAN)
D08953  Nilotinib (USAN/INN)
D08956  Omacetaxine mepesuccinate (USAN)
D08963  Pamapimod (INN/USAN)
D09033  Voclosporin (JAN/USAN/INN)
D09315  Canakinumab (USAN/INN)
D09386  Talmapimod (USAN/INN)
D09539  Gabapentin enacarbil (JAN/USAN/INN)
D09589  Brivanib (USAN)
D09602  Dilmapimod (USAN/INN)
D09603  Dilmapimod tosylate (USAN)
D09620  Fresolimumab (USAN/INN)
D09635  Linifanib (USAN/INN)
D09660  Rindopepimut (USAN)
D09666  Selumetinib (USAN/INN)
D09683  Tivozanib (USAN/INN)
D09724  Afatinib (USAN/INN)
D09733  Afatinib dimaleate (USAN)
D09907  Fulranumab (USAN/INN)
D09911  Gevokizumab (USAN/INN)
D09919  Lenvatinib (USAN/INN)
D09920  Lenvatinib mesylate (USAN)
D09939  Olaratumab (USAN/INN)
D09944  Ozoralizumab (USAN)
D09996  Vemurafenib (JAN/USAN/INN)
D10018  Necitumumab (USAN/INN)
D10024  Selumetinib sulfate (JAN/USAN)
D10031  Zalutumumab (USAN/INN)
D10062  Cabozantinib (USAN)
D10064  Dabrafenib (USAN)
D10095  Cabozantinib s-malate (USAN)
D10102  Crenolanib (USAN)
D10103  Crenolanib besylate (USAN)
D10104  Dabrafenib mesylate (USAN)
D10137  Regorafenib hydrate (JAN)
D10138  Regorafenib (USAN/INN)
D10175  Trametinib (USAN)
D10176  Trametinib dimethyl sulfoxide (JAN/USAN)
D10190  Tivozanib hydrochloride (USAN)
D10224  Golvatinib (USAN)
D10229  Masitinib (INN)
D10396  Nintedanib esylate (USAN)
D10405  Cobimetinib (USAN/INN)
D10426  Pimasertib (USAN/INN)
D10465  Golvatinib tartrate (USAN)
D10481  Nintedanib (USAN/INN)
D10486  Pimasertib hydrochloride (USAN)
D10604  Binimetinib (JAN/USAN/INN)
D10615  Cobimetinib fumarate (USAN)
D10766  Osimertinib mesylate (USAN)
D10790  Mirogabalin besylate (USAN)
D10858  Rociletinib (USAN/INN)
D10859  Olmutinib (USAN/INN)
D10913  Burosumab (USAN/INN)
D10943  Istiratumab (USAN/INN)
D10958  Naquotinib (USAN/INN)
D10959  Neflamapimod (USAN/INN)
D10983  Ruclosporin (USAN/INN)
D10988  Selonsertib (JAN/USAN/INN)
D11032  Plitidepsin (INN)
D11038  Ulixertinib (INN)
D11053  Encorafenib (JAN/USAN/INN)
D11115  Olmutinib hydrochloride (USAN)
D11136  Glesatinib (USAN/INN)
D11139  Savolitinib (JAN/USAN/INN)
D11140  Sitravatinib (USAN/INN)
D11141  Tucatinib (USAN/INN)
D11203  Mirogabalin (USAN/INN)
D11210  Flortaucipir F 18 (USAN)
D11244  Vanucizumab (USAN/INN)
D11270  Pexidartinib (USAN/INN)
D11271  Pexidartinib hydrochloride (JAN/USAN)
D11279  Avapritinib (USAN/INN)
D11285  Ravoxertinib (USAN/INN)
D11288  Rivoceranib (USAN/INN)
D11289  Rivoceranib mesylate (USAN)
D11293  Gosuranemab (USAN)
D11378  Edicotinib (USAN)
D11379  Edicotinib hydrochloride (USAN)
D11384  Hydromethylthionine mesylate (USAN)
D11410  Lifirafenib (USAN/INN)
D11411  Lifirafenib maleate (USAN)
D11427  Hydromethylthionine (USAN/INN)
D11430  Nazartinib (USAN/INN)
D11434  Nazartinib mesylate (USAN)
D11452  Tomivosertib (USAN/INN)
D11481  Tomivosertib hydrochloride (USAN)
D11484  Pegcantratinib (USAN/INN)
D11533  Zagotenemab (USAN)
D11540  Razuprotafib (USAN)
D11541  Sitravatinib malate (USAN)
D11589  Infigratinib (USAN/INN)
D11611  Infigratinib phosphate (USAN)
D11675  Mirdametinib (USAN)
D11687  Semorinemab (USAN/INN)
D11703  Opinercept (INN)
D11725  Futibatinib (JAN/USAN/INN)
D11750  Duligotuzumab (USAN)
D11762  Lucitanib (USAN/INN)
D11763  Merestinib (USAN/INN)
D11772  Tesevatinib (USAN/INN)
D11773  Tesevatinib tosylate (USAN)
D11803  Cetuximab sarotalocan (USAN/INN)
D11805  Cetuximab sarotalocan sodium (genetical recombination) (JAN)
D11840  Tilavonemab (USAN/INN)
D11872  Serclutamab (USAN/INN)
D11874  Serclutamab talirine (USAN/INN)
D11885  Surufatinib (USAN/INN)
D11894  Amivantamab (USAN/INN)
D11904  Zansecimab (USAN)
D11969  Mobocertinib succinate (JAN)
D11977  Fruquintinib (JAN/USAN)
D11980  Lazertinib (USAN/INN)
D12001  Mobocertinib (USAN/INN)
D12059  Temuterkib (USAN)
D12060  Temuterkib mesylate (USAN)
D12061  Suvecaltamide (USAN)
D12062  Suvecaltamide hydrocloride (USAN)
D12184  Patritumab deruxtecan (USAN/INN)
D12185  Patritumab (USAN/INN)
D12228  Bepranemab (USAN/INN)
D12229  Poziotinib (USAN/INN)
D12230  Poziotinib hydrochloride (USAN)
D12237  Zunsemetinib (USAN)
D12238  Vimseltinib (USAN/INN)
D12245  Lazertinib mesylate (USAN)
D12258  Aumolertinib (USAN/INN)
D12259  Aumolertinib mesylate (USAN)
D12287  Terevalefim (USAN/INN)
D12291  Tovorafenib (JAN/USAN/INN)
D12343  Fepixnebart (USAN)
D12350  Vilamakitug (USAN)
D12392  Fosgonimeton (USAN/INN)
D12393  Fosgonimeton sodium (USAN)
D12409  Barzolvolimab (USAN/INN)
D12411  Emavusertib (USAN/INN)
D12412  Emavusertib hydrochloride (USAN)
D12442  Tucatinib ethanolate (JAN)
D12450  Elenestinib (USAN)
D12455  Lirafugratinib (USAN)
D12456  Lirafugratinib hydrochloride (USAN)
D12457  Tuxobertinib (USAN/INN)
D12473  Zapnometinib (USAN/INN)
D12476  Tuspetinib (USAN/INN)
D12506  Sunvozertinib (USAN/INN)
D12515  Avutometinib (USAN/INN)
D12526  Catequentinib (USAN/INN)
D12532  Emavusertib mesylate (USAN)
D12533  Emavusertib maleate (USAN)
D12534  Avutometinib potassium (USAN)
D12537  Catequentinib hydrochloride (USAN)
D12538  Emavusertib phosphate (USAN)
D12539  emavusertib tosylate (USAN)
D12540  Briquilimab (USAN/INN)
D12545  Tinengotinib (USAN/INN)
D12560  Gamcemetinib (USAN)
D12600  Bezuclastinib (USAN/INN)
D12635  Sozinibercept (USAN/INN)
D12636  Posdinemab (USAN/INN)
D12650  Zanzalintinib (USAN/INN)
D12651  Zanzalintinib fumarate (USAN)
D12730  Tigozertinib (USAN)
D12768  Ficerafusp alfa (USAN)
D12809  Bafisontamab (USAN/INN)
D12819  Ulixacaltamide (USAN/INN)
D12820  Ulixacaltamide hydrochloride (USAN)
D12831  Naporafenib (USAN/INN)
D12848  Etalanetug (USAN)
D12851  Lunlekitug (USAN)
D12854  Nilotinib laurylsulfate (USAN)
D12859  Pebezertinib (USAN)
D12865  Beroterkib (USAN)
D12910  Apinocaltamide (USAN/INN)
D12921  Tizaterkib (USAN/INN)
D12922  Tizaterkib adipate (USAN)
D12932  Bezisterim (USAN/INN)
D12938  Pimicotinib (USAN/INN)
D12939  Pimicotinib hydrochloride (USAN)
D12947  Claturafenib (USAN)
D12956  Firmonertinib (USAN/INN)
D12957  Firmonertinib mesylate (USAN)
D13039  Nedometinib (USAN/INN)
D13058  Migaldendranib (USAN/INN)
D13062  Zipalertinib (JAN/USAN/INN)
D13066  Tilatamig (USAN/INN)
D13067  Tilatamig samrotecan (USAN/INN)
D13097  Polfurmetinib (USAN)
D13098  Sevabertinib (USAN)
D13116  Sevabertinib hydrate (JAN)
D13132  Flezurafenib (USAN/INN)
D13156  Pamvatamig (USAN/INN)
D13166  Vimseltinib dihydrate
D13174  Mosperafenib (USAN/INN)
D13204  Plixorafenib (USAN/INN)
D13226  Turigrobart (USAN)
D13229  Amivantamab (genetical recombination) and vorhyaluronidase alfa (genetical recombination)
D13235  Mifanertinib (INN)
D13236  Tunlametinib (INN)
D13256  Cabozantinib laurylsulfate (USAN)
D13300  Silevertinib (USAN/INN)
D13308  Nilotinib butanedisulfonate (USAN)
D13350  Atebimetinib (USAN/INN)
Other DBs
GO: 0000165
Organism
Homo sapiens (human) [GN:hsa]
Gene
10000  AKT3; RAC-gamma serine/threonine-protein kinase isoform 1 [KO:K04456] [EC:2.7.11.1]
100137049  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
10125  RASGRP1; RAS guanyl-releasing protein 1 isoform a [KO:K04350]
10235  RASGRP2; RAS guanyl-releasing protein 2 isoform a [KO:K12361]
10368  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
10369  CACNG2; voltage-dependent calcium channel gamma-2 subunit isoform 1 [KO:K04867]
10454  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform alpha [KO:K04403]
10746  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
10912  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
11184  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 isoform 2 [KO:K04408] [EC:2.7.11.1]
11221  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
1147  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform 1 [KO:K04467] [EC:2.7.11.10]
115727  RASGRP4; RAS guanyl-releasing protein 4 isoform a [KO:K12363]
123745  PLA2G4E; cytosolic phospholipase A2 epsilon isoform 1 [KO:K16342] [EC:3.1.1.4]
125467750  EFNA4-EFNA3; EFNA4-EFNA3 protein precursor [KO:K05462]
1326  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
1386  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform 1 [KO:K04450]
1398  CRK; adapter molecule crk isoform a [KO:K04438]
1399  CRKL; crk-like protein [KO:K04438]
1432  MAPK14; mitogen-activated protein kinase 14 isoform 2 [KO:K04441] [EC:2.7.11.24]
1435  CSF1; macrophage colony-stimulating factor 1 isoform a precursor [KO:K05453]
1436  CSF1R; macrophage colony-stimulating factor 1 receptor isoform a precursor [KO:K05090] [EC:2.7.10.1]
1616  DAXX; death domain-associated protein 6 isoform a [KO:K02308]
1647  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha isoform 1 [KO:K04402]
1649  DDIT3; DNA damage-inducible transcript 3 protein isoform 2 [KO:K04452]
1843  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
1844  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
1845  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
1846  DUSP4; dual specificity protein phosphatase 4 isoform 1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
1847  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
1848  DUSP6; dual specificity protein phosphatase 6 isoform a [KO:K21946] [EC:3.1.3.16 3.1.3.48]
1849  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
1850  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
1852  DUSP9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
1942  EFNA1; ephrin-A1 isoform a precursor [KO:K05462]
1943  EFNA2; ephrin-A2 precursor [KO:K05462]
1944  EFNA3; ephrin-A3 precursor [KO:K05462]
1945  EFNA4; ephrin-A4 isoform a precursor [KO:K05462]
1946  EFNA5; ephrin-A5 isoform 1 precursor [KO:K05462]
1950  EGF; pro-epidermal growth factor isoform 1 preproprotein [KO:K04357]
1956  EGFR; epidermal growth factor receptor isoform a precursor [KO:K04361] [EC:2.7.10.1]
1969  EPHA2; ephrin type-A receptor 2 isoform 1 precursor [KO:K05103] [EC:2.7.10.1]
2002  ELK1; ETS domain-containing protein Elk-1 isoform a [KO:K04375]
2005  ELK4; ETS domain-containing protein Elk-4 isoform a [KO:K04376]
2064  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform a precursor [KO:K05083] [EC:2.7.10.1]
2065  ERBB3; receptor tyrosine-protein kinase erbB-3 isoform 1 precursor [KO:K05084] [EC:2.7.10.1]
2066  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform JM-a/CYT-1 precursor [KO:K05085] [EC:2.7.10.1]
2069  EREG; proepiregulin preproprotein [KO:K09784]
207  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
208  AKT2; RAC-beta serine/threonine-protein kinase isoform 1 [KO:K04456] [EC:2.7.11.1]
2122  MECOM; histone-lysine N-methyltransferase MECOM isoform f [KO:K04462] [EC:2.1.1.367]
2246  FGF1; fibroblast growth factor 1 isoform 1 precursor [KO:K18496]
2247  FGF2; fibroblast growth factor 2 isoform 34 kDa [KO:K18497]
2248  FGF3; fibroblast growth factor 3 precursor [KO:K04358]
2249  FGF4; fibroblast growth factor 4 precursor [KO:K04358]
2250  FGF5; fibroblast growth factor 5 isoform 1 precursor [KO:K04358]
2251  FGF6; fibroblast growth factor 6 precursor [KO:K04358]
2252  FGF7; fibroblast growth factor 7 precursor [KO:K04358]
2253  FGF8; fibroblast growth factor 8 isoform E precursor [KO:K04358]
2254  FGF9; fibroblast growth factor 9 precursor [KO:K04358]
2255  FGF10; fibroblast growth factor 10 precursor [KO:K04358]
2260  FGFR1; fibroblast growth factor receptor 1 isoform 1 precursor [KO:K04362] [EC:2.7.10.1]
2261  FGFR3; fibroblast growth factor receptor 3 isoform 1 precursor [KO:K05094] [EC:2.7.10.1]
2263  FGFR2; fibroblast growth factor receptor 2 isoform 1 precursor [KO:K05093] [EC:2.7.10.1]
2264  FGFR4; fibroblast growth factor receptor 4 isoform 1 precursor [KO:K05095] [EC:2.7.10.1]
2277  VEGFD; vascular endothelial growth factor D preproprotein [KO:K05449]
22800  RRAS2; ras-related protein R-Ras2 isoform a [KO:K07830]
22808  MRAS; ras-related protein M-Ras isoform 1 precursor [KO:K07831]
23118  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform a [KO:K04404]
2316  FLNA; filamin-A isoform 2 [KO:K04437]
23162  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform 1 [KO:K04436]
2321  FLT1; vascular endothelial growth factor receptor 1 isoform 1 precursor [KO:K05096] [EC:2.7.10.1]
2322  FLT3; receptor-type tyrosine-protein kinase FLT3 precursor [KO:K05092] [EC:2.7.10.1]
2323  FLT3LG; fms-related tyrosine kinase 3 ligand isoform 1 precursor [KO:K05454]
2324  FLT4; vascular endothelial growth factor receptor 3 isoform 1 precursor [KO:K05097] [EC:2.7.10.1]
2353  FOS; protein c-Fos [KO:K04379]
23542  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
255189  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
25780  RASGRP3; ras guanyl-releasing protein 3 isoform 1 [KO:K12362]
26281  FGF20; fibroblast growth factor 20 [KO:K04358]
26291  FGF21; fibroblast growth factor 21 precursor [KO:K22429]
2668  GDNF; glial cell line-derived neurotrophic factor isoform 1 preproprotein [KO:K05452]
27006  FGF22; fibroblast growth factor 22 isoform 1 precursor [KO:K04358]
27091  CACNG5; voltage-dependent calcium channel gamma-5 subunit isoform 1 [KO:K04870]
27092  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
27330  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform 2 [KO:K04373] [EC:2.7.11.1]
2768  GNA12; guanine nucleotide-binding protein subunit alpha-12 isoform 1 [KO:K04346]
283748  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
284  ANGPT1; angiopoietin-1 isoform 1 precursor [KO:K05465]
285  ANGPT2; angiopoietin-2 isoform a precursor [KO:K05466]
2872  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 isoform 2 [KO:K04372] [EC:2.7.11.1]
2885  GRB2; growth factor receptor-bound protein 2 isoform 1 [KO:K04364]
3082  HGF; hepatocyte growth factor isoform 1 preproprotein [KO:K05460]
3164  NR4A1; nuclear receptor subfamily 4immunitygroup A member 1 isoform 1 [KO:K04465]
3265  HRAS; GTPase HRas isoform 1 [KO:K02833]
3303  HSPA1A; heat shock 70 kDa protein 1A [KO:K03283]
3304  HSPA1B; heat shock 70 kDa protein 1B [KO:K03283]
3305  HSPA1L; heat shock 70 kDa protein 1-like [KO:K03283]
3310  HSPA6; heat shock 70 kDa protein 6 [KO:K03283]
3312  HSPA8; heat shock cognate 71 kDa protein isoform 1 [KO:K03283]
3315  HSPB1; heat shock protein beta-1 [KO:K04455]
3479  IGF1; insulin-like growth factor 1 isoform 3 preproprotein [KO:K05459]
3480  IGF1R; insulin-like growth factor 1 receptor isoform 1 precursor [KO:K05087] [EC:2.7.10.1]
3481  IGF2; insulin-like growth factor 2 isoform 1 preproprotein [KO:K13769]
355  FAS; tumor necrosis factor receptor superfamily member 6 isoform 1 precursor [KO:K04390]
3551  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform 1 [KO:K07209] [EC:2.7.11.10]
3552  IL1A; interleukin-1 alpha precursor [KO:K04383]
3553  IL1B; interleukin-1 beta proprotein [KO:K04519]
3554  IL1R1; interleukin-1 receptor type 1 isoform 1 precursor [KO:K04386]
3556  IL1RAP; interleukin-1 receptor accessory protein isoform 1 precursor [KO:K04723]
356  FASLG; tumor necrosis factor ligand superfamily member 6 isoform 1 [KO:K04389]
3630  INS; insulin preproprotein [KO:K04526]
3643  INSR; insulin receptor isoform Long preproprotein [KO:K04527] [EC:2.7.10.1]
3654  IRAK1; interleukin-1 receptor-associated kinase 1 isoform 1 [KO:K04730] [EC:2.7.11.1]
369  ARAF; serine/threonine-protein kinase A-Raf isoform 1 [KO:K08845] [EC:2.7.11.1]
3725  JUN; transcription factor Jun [KO:K04448]
3727  JUND; transcription factor JunD isoform JunD-FL [KO:K04449]
374  AREG; amphiregulin preproprotein [KO:K09782]
3791  KDR; vascular endothelial growth factor receptor 2 precursor [KO:K05098] [EC:2.7.10.1]
3815  KIT; mast/stem cell growth factor receptor Kit isoform 1 precursor [KO:K05091] [EC:2.7.10.1]
3845  KRAS; GTPase KRas isoform a [KO:K07827]
3925  STMN1; stathmin isoform a [KO:K04381]
408  ARRB1; beta-arrestin-1 isoform A [KO:K04439]
409  ARRB2; beta-arrestin-2 isoform 1 [KO:K04439]
4137  MAPT; microtubule-associated protein tau isoform 1 [KO:K04380]
4149  MAX; protein max isoform a [KO:K04453]
4208  MEF2C; myocyte-specific enhancer factor 2C isoform 1 [KO:K04454]
4214  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
4215  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform 2 [KO:K04421] [EC:2.7.11.25]
4216  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform a [KO:K04428] [EC:2.7.11.25]
4217  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform 2 [KO:K04426] [EC:2.7.11.25]
4233  MET; hepatocyte growth factor receptor isoform b preproprotein [KO:K05099] [EC:2.7.10.1]
4254  KITLG; kit ligand isoform b precursor [KO:K05461]
4293  MAP3K9; mitogen-activated protein kinase kinase kinase 9 isoform 2 [KO:K04417] [EC:2.7.11.25]
4294  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
4296  MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
4609  MYC; myc proto-oncogene protein isoform 1 [KO:K04377]
4615  MYD88; myeloid differentiation primary response protein MyD88 isoform 2 [KO:K04729]
4616  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
468  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
4763  NF1; neurofibromin isoform 1 [KO:K08052]
4772  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform F [KO:K04446]
4775  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform 1 [KO:K17333]
4790  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform 2 proprotein [KO:K02580]
4791  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform a [KO:K04469]
4803  NGF; beta-nerve growth factor precursor [KO:K02582]
4804  NGFR; tumor necrosis factor receptor superfamily member 16 precursor [KO:K02583]
4893  NRAS; GTPase NRas [KO:K07828]
4902  NRTN; neurturin preproprotein [KO:K25414]
4908  NTF3; neurotrophin-3 isoform 2 preproprotein [KO:K04356]
4909  NTF4; neurotrophin-4 preproprotein [KO:K12457]
4914  NTRK1; high affinity nerve growth factor receptor isoform 2 precursor [KO:K03176] [EC:2.7.10.1]
4915  NTRK2; BDNF/NT-3 growth factors receptor isoform c precursor [KO:K04360] [EC:2.7.10.1]
5058  PAK1; serine/threonine-protein kinase PAK 1 isoform 2 [KO:K04409] [EC:2.7.11.1]
5062  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
51135  IRAK4; interleukin-1 receptor-associated kinase 4 isoform a [KO:K04733] [EC:2.7.11.1]
51295  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform 1 precursor [KO:K04405]
51347  TAOK3; serine/threonine-protein kinase TAO3 isoform b [KO:K04429] [EC:2.7.11.1]
51378  ANGPT4; angiopoietin-4 isoform 1 precursor [KO:K05467]
5154  PDGFA; platelet-derived growth factor subunit A isoform 1 preproprotein [KO:K04359]
5155  PDGFB; platelet-derived growth factor subunit B isoform 1 preproprotein [KO:K17386]
5156  PDGFRA; platelet-derived growth factor receptor alpha isoform 1 precursor [KO:K04363] [EC:2.7.10.1]
5159  PDGFRB; platelet-derived growth factor receptor beta isoform 1 precursor [KO:K05089] [EC:2.7.10.1]
51701  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
51776  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform 1 [KO:K04424] [EC:2.7.11.25]
5228  PGF; placenta growth factor isoform 2 precursor [KO:K16859]
5321  PLA2G4A; cytosolic phospholipase A2 isoform 1 [KO:K16342] [EC:3.1.1.4]
5494  PPM1A; protein phosphatase 1A isoform 1 [KO:K04457] [EC:3.1.3.16]
5495  PPM1B; protein phosphatase 1B isoform 1 [KO:K04461] [EC:3.1.3.16]
5530  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform 1 [KO:K04348] [EC:3.1.3.16]
5532  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform b [KO:K04348] [EC:3.1.3.16]
5533  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform 2 [KO:K04348] [EC:3.1.3.16]
5534  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
5535  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
5536  PPP5C; serine/threonine-protein phosphatase 5 isoform 1 [KO:K04460] [EC:3.1.3.16]
5566  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform Calpha1 [KO:K04345] [EC:2.7.11.11]
5567  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform 2 [KO:K04345] [EC:2.7.11.11]
5568  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
5578  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
5579  PRKCB; protein kinase C beta type isoform 1 [KO:K19662] [EC:2.7.11.13]
55799  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 precursor [KO:K04860]
5582  PRKCG; protein kinase C gamma type isoform 2 [KO:K19663] [EC:2.7.11.13]
5594  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
5595  MAPK3; mitogen-activated protein kinase 3 isoform 1 [KO:K04371] [EC:2.7.11.24]
55970  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
5598  MAPK7; mitogen-activated protein kinase 7 isoform 1 [KO:K04464] [EC:2.7.11.24]
5599  MAPK8; mitogen-activated protein kinase 8 isoform alpha2 [KO:K04440] [EC:2.7.11.24]
5600  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
5601  MAPK9; mitogen-activated protein kinase 9 isoform alpha2 [KO:K04440] [EC:2.7.11.24]
5602  MAPK10; mitogen-activated protein kinase 10 isoform 1 [KO:K04440] [EC:2.7.11.24]
5603  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
56034  PDGFC; platelet-derived growth factor C precursor [KO:K05450]
5604  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform 1 [KO:K04368] [EC:2.7.12.2]
5605  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform 1 [KO:K04369] [EC:2.7.12.2]
5606  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform B [KO:K04432] [EC:2.7.12.2]
5607  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform A [KO:K04463] [EC:2.7.12.2]
5608  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform 1 [KO:K04433] [EC:2.7.12.2]
5609  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform 3 [KO:K04431] [EC:2.7.12.2]
5623  PSPN; persephin preproprotein [KO:K25416]
57551  TAOK1; serine/threonine-protein kinase TAO1 isoform 1 [KO:K04429] [EC:2.7.11.1]
5778  PTPN7; tyrosine-protein phosphatase non-receptor type 7 isoform 1 [KO:K18019] [EC:3.1.3.48]
5801  PTPRR; receptor-type tyrosine-protein phosphatase R isoform 1 precursor [KO:K04458] [EC:3.1.3.48]
5871  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 isoform 1 [KO:K04414] [EC:2.7.11.1]
5879  RAC1; ras-related C3 botulinum toxin substrate 1 isoform Rac1 [KO:K04392]
5880  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
5881  RAC3; ras-related C3 botulinum toxin substrate 3 isoform 1 [KO:K07861]
5894  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform b [KO:K04366] [EC:2.7.11.1]
5906  RAP1A; ras-related protein Rap-1A precursor [KO:K04353]
5908  RAP1B; ras-related protein Rap-1b isoform 1 precursor [KO:K07836]
5921  RASA1; ras GTPase-activating protein 1 isoform 1 [KO:K04352]
5922  RASA2; ras GTPase-activating protein 2 isoform 2 [KO:K08053]
5923  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform 1 [KO:K04349]
5924  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
59283  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
59284  CACNG7; voltage-dependent calcium channel gamma-7 subunit isoform 1 [KO:K04872]
59285  CACNG6; voltage-dependent calcium channel gamma-6 subunit isoform a [KO:K04871]
5970  RELA; transcription factor p65 isoform 1 [KO:K04735]
5971  RELB; transcription factor RelB isoform 1 [KO:K09253]
5979  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform a precursor [KO:K05126] [EC:2.7.10.1]
6195  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform a [KO:K04373] [EC:2.7.11.1]
6196  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform a [KO:K04373] [EC:2.7.11.1]
6197  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform 1 [KO:K04373] [EC:2.7.11.1]
6237  RRAS; ras-related protein R-Ras [KO:K07829]
627  BDNF; neurotrophic factor BDNF precursor form isoform a preproprotein [KO:K04355]
6300  MAPK12; mitogen-activated protein kinase 12 isoform 1 [KO:K04441] [EC:2.7.11.24]
6416  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform 1 [KO:K04430] [EC:2.7.12.2]
6654  SOS1; son of sevenless homolog 1 isoform 1 [KO:K03099]
6655  SOS2; son of sevenless homolog 2 isoform 1 [KO:K03099]
6722  SRF; serum response factor isoform 1 [KO:K04378]
673  BRAF; serine/threonine-protein kinase B-raf isoform 1 [KO:K04365] [EC:2.7.11.1]
6788  STK3; serine/threonine-protein kinase 3 isoform 1 [KO:K04412]
6789  STK4; serine/threonine-protein kinase 4 isoform 1 [KO:K04411]
6885  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform B [KO:K04427] [EC:2.7.11.25]
7010  TEK; angiopoietin-1 receptor isoform 1 precursor [KO:K05121] [EC:2.7.10.1]
7039  TGFA; protransforming growth factor alpha isoform 1 preproprotein [KO:K08774]
7040  TGFB1; transforming growth factor beta-1 proprotein preproprotein [KO:K13375]
7042  TGFB2; transforming growth factor beta-2 proprotein isoform 2 preproprotein [KO:K13376]
7043  TGFB3; transforming growth factor beta-3 proprotein isoform 1 preproprotein [KO:K13377]
7046  TGFBR1; TGF-beta receptor type-1 isoform 1 precursor [KO:K04674] [EC:2.7.11.30]
7048  TGFBR2; TGF-beta receptor type-2 isoform B precursor [KO:K04388] [EC:2.7.11.30]
7124  TNF; tumor necrosis factor [KO:K03156]
7132  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform 1 precursor [KO:K03158]
7157  TP53; cellular tumor antigen p53 isoform a [KO:K04451]
7186  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
7189  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
7422  VEGFA; vascular endothelial growth factor A, long form isoform b [KO:K05448]
7423  VEGFB; vascular endothelial growth factor B isoform VEGFB-186 precursor [KO:K16858]
7424  VEGFC; vascular endothelial growth factor C preproprotein [KO:K05449]
773  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform 4 [KO:K04344]
774  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform 1 [KO:K04849]
775  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform 18 [KO:K04850]
776  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform b [KO:K04851]
777  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform 1 [KO:K04852]
778  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform 1 [KO:K04853]
7786  MAP3K12; mitogen-activated protein kinase kinase kinase 12 isoform 2 [KO:K04423] [EC:2.7.11.25]
779  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
781  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform 3 preproprotein [KO:K04858]
782  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform 1 [KO:K04862]
783  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform 2 [KO:K04863]
784  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform 1 [KO:K04864]
785  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform b [KO:K04865]
786  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
7867  MAPKAPK3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
80310  PDGFD; platelet-derived growth factor D isoform 1 precursor [KO:K05450]
8074  FGF23; fibroblast growth factor 23 precursor [KO:K22428]
80824  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
836  CASP3; caspase-3 isoform a preproprotein [KO:K02187] [EC:3.4.22.56]
84451  MAP3K21; mitogen-activated protein kinase kinase kinase 21 [KO:K17534] [EC:2.7.11.25]
84867  PTPN5; tyrosine-protein phosphatase non-receptor type 5 isoform a [KO:K18018] [EC:3.1.3.48]
8491  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform 1 [KO:K04406] [EC:2.7.11.1]
8517  IKBKG; NF-kappa-B essential modulator isoform a [KO:K07210]
8550  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform 2 [KO:K04442] [EC:2.7.11.1]
8569  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform 1 [KO:K04372] [EC:2.7.11.1]
8605  PLA2G4C; cytosolic phospholipase A2 gamma isoform 1 precursor [KO:K16342] [EC:3.1.1.4]
8649  LAMTOR3; ragulator complex protein LAMTOR3 isoform 1 [KO:K04370]
8681  JMJD7-PLA2G4B; JMJD7-PLA2G4B protein isoform b [KO:K16342] [EC:3.1.1.4]
8682  PEA15; astrocytic phosphoprotein PEA-15 isoform b [KO:K29115]
8717  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
8817  FGF18; fibroblast growth factor 18 precursor [KO:K04358]
8822  FGF17; fibroblast growth factor 17 isoform 1 precursor [KO:K04358]
8823  FGF16; fibroblast growth factor 16 [KO:K04358]
8911  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I isoform a [KO:K04856]
8912  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform a [KO:K04855]
8913  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform 1 [KO:K04854]
8986  RPS6KA4; ribosomal protein S6 kinase alpha-4 isoform a [KO:K16510] [EC:2.7.11.1]
9020  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
9048  ARTN; artemin isoform 1 preproprotein [KO:K25415]
9064  MAP3K6; mitogen-activated protein kinase kinase kinase 6 isoform 1 [KO:K04425] [EC:2.7.11.25]
9175  MAP3K13; mitogen-activated protein kinase kinase kinase 13 isoform 1 [KO:K04422] [EC:2.7.11.25]
9252  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform a [KO:K04445] [EC:2.7.11.1]
9254  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform c precursor [KO:K04859]
9261  MAPKAPK2; MAP kinase-activated protein kinase 2 isoform 2 [KO:K04443] [EC:2.7.11.1]
929  CD14; monocyte differentiation antigen CD14 precursor [KO:K04391]
9344  TAOK2; serine/threonine-protein kinase TAO2 isoform 1 [KO:K04429] [EC:2.7.11.1]
93589  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
9448  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform 4 [KO:K04407] [EC:2.7.11.1]
9479  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
9693  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform 5 [KO:K08018]
994  CDC25B; M-phase inducer phosphatase 2 isoform 1 [KO:K05866] [EC:3.1.3.48]
9965  FGF19; fibroblast growth factor 19 precursor [KO:K22603]
998  CDC42; cell division control protein 42 homolog isoform 1 precursor [KO:K04393]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
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Related
pathway
hsa04020  Calcium signaling pathway
hsa04070  Phosphatidylinositol signaling system
hsa04110  Cell cycle
hsa04115  p53 signaling pathway
hsa04210  Apoptosis
hsa04310  Wnt signaling pathway
hsa04668  TNF signaling pathway
KO pathway
ko04010   

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