KEGG   PATHWAY: acun04510
Entry
acun04510                   Pathway                                
Name
Focal adhesion - Athene cunicularia (burrowing owl)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
acun04510  Focal adhesion
acun04510

Other DBs
GO: 0005925
Organism
Athene cunicularia (burrowing owl) [GN:acun]
Gene
113477097  COL1A2; collagen alpha-2(I) chain [KO:K06236]
113478513  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
113479911  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
113479912  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
113480197  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
113483234  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
113483293  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
113482203  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
113482258  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
113482321  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
113477236  collagen alpha-4(VI) chain-like isoform X1 [KO:K06238]
113488314  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
113487441  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
113478716  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
113476109  LAMA1; laminin subunit alpha-1 [KO:K05637]
113478074  LAMA2; laminin subunit alpha-2 [KO:K05637]
113476588  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
113487619  LAMA5; laminin subunit alpha-5 [KO:K06240]
113478128  LAMA4; laminin subunit alpha-4 [KO:K06241]
113491434  LAMB1; laminin subunit beta-1 [KO:K05636]
113488844  LAMB3; laminin subunit beta-3 isoform X1 [KO:K06244]
113491433  LAMB4; laminin subunit beta-4 isoform X1 [KO:K06245]
113482915  LAMC1; laminin subunit gamma-1 [KO:K05635]
113482969  LAMC2; laminin subunit gamma-2 [KO:K06246]
113486426  LAMC3; laminin subunit gamma-3 isoform X1 [KO:K06247]
113486693  CHAD; chondroadherin [KO:K06248]
113491244  RELN; reelin [KO:K06249] [EC:3.4.21.-]
113480732  THBS1; thrombospondin-1 [KO:K16857]
113478616  THBS2; thrombospondin-2 [KO:K04659]
113489279  COMP; cartilage oligomeric matrix protein [KO:K04659]
113489640  THBS4; thrombospondin-4 [KO:K04659]
113490844  THBS3; thrombospondin-3 [KO:K04659]
113482082  FN1; fibronectin [KO:K05717]
113479582  SPP1; osteopontin [KO:K06250]
113487106  VTN; vitronectin [KO:K06251]
113482743  TNR; tenascin-R isoform X1 [KO:K06252]
113483020  TNN; LOW QUALITY PROTEIN: tenascin-N [KO:K06252]
113486473  TNC; tenascin isoform X1 [KO:K06252]
113490952  VWF; von Willebrand factor [KO:K03900]
113479583  IBSP; bone sialoprotein 2 isoform X1 [KO:K06253]
113489589  ITGA1; integrin alpha-1 isoform X1 [KO:K06480]
113489778  ITGA2; integrin alpha-2 [KO:K06481]
113482505  ITGA4; integrin alpha-4 [KO:K06483]
113482064  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
113476922  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
113477582  ITGA9; integrin alpha-9 [KO:K06585]
113483820  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
113482072  ITGAV; integrin alpha-V [KO:K06487]
113476425  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
113489245  ITGB3; integrin beta-3 [KO:K06493]
113486765  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
113482052  ITGB5; integrin beta-5 [KO:K06588]
113482408  ITGB6; integrin beta-6 [KO:K06589]
113476365  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
113485701  EMP2; epithelial membrane protein 2 [KO:K26256]
113485656  PDGFA; LOW QUALITY PROTEIN: platelet-derived growth factor subunit A [KO:K04359]
113488033  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
113479700  PDGFC; platelet-derived growth factor C [KO:K05450]
113484247  PDGFD; platelet-derived growth factor D [KO:K05450]
113479739  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
113491340  IGF1; insulin-like growth factor I [KO:K05459]
113477922  VEGFA; vascular endothelial growth factor A [KO:K05448]
113485862  VEGFD; vascular endothelial growth factor D [KO:K05449]
113479244  VEGFC; vascular endothelial growth factor C [KO:K05449]
113491250  HGF; hepatocyte growth factor [KO:K05460]
113479434  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
113485173  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
113483985  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
113479117  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
113477535  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
113479969  vascular endothelial growth factor receptor kdr-like isoform X1 [KO:K05096] [EC:2.7.10.1]
113485269  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
113485325  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
113491414  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
113475967  EMP1; epithelial membrane protein 1 [KO:K26255]
113487500  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
113490701  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
113480365  ARHGAP5; rho GTPase-activating protein 5 [KO:K13709]
113485019  RHOA; transforming protein RhoA [KO:K04513]
113476436  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
113477643  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
113486078  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
113490665  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
113487097  MYL10; myosin regulatory light chain 10 [KO:K12756]
113476325  myosin regulatory light chain 2, smooth muscle minor isoform-like [KO:K12757]
113476326  myosin regulatory light chain 2, smooth muscle minor isoform [KO:K12757]
113486130  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
113478943  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
113488441  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
113488963  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
113489147  myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
113482370  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
113484301  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
113476670  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
113489462  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
113490107  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
113490878  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like [KO:K00889] [EC:2.7.1.68]
113483859  actin, cytoplasmic type 5 [KO:K05692]
113485595  ACTB; actin, cytoplasmic 1 [KO:K05692]
113483958  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
113477955  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
113480355  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
113484074  TLN2; talin-2 [KO:K06271]
113489601  TLN1; talin-1 isoform X1 [KO:K06271]
113484731  FLNB; filamin-B isoform X1 [KO:K27392]
113486282  PXN; paxillin [KO:K05760]
113482113  ZYX; zyxin isoform X1 [KO:K06273]
113481644  VCL; vinculin [KO:K05700]
113481329  PARVA; alpha-parvin [KO:K06275]
113489124  PARVB; beta-parvin isoform X1 [KO:K06275]
113491136  PARVG; gamma-parvin [KO:K06275]
113485931  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
113477826  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
113490822  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
113480539  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
113479281  GSK3B; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
113476513  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
113486719  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
113485934  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
113487938  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
113483286  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
113483483  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
113483193  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
113489298  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
113489600  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
113481870  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
113486455  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
113483019  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
113485871  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
113490117  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
113486843  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
113482214  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
113483647  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
113479919  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
113478339  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
113481012  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
113487836  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
113484549  BCAR1; breast cancer anti-estrogen resistance protein 1 [KO:K05726]
113486127  CRKL; crk-like protein [KO:K04438]
113487332  CRK; adapter molecule crk [KO:K04438]
113481723  DOCK1; dedicator of cytokinesis protein 1 [KO:K13708]
113486529  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
113488776  RAP1A; ras-related protein Rap-1A [KO:K04353]
113487398  RAP1B; ras-related protein Rap-1b [KO:K07836]
113485089  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
113481395  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
113479790  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
113482645  JUN; transcription factor AP-1 [KO:K04448]
113475894  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
113491225  CAV1; caveolin-1 [KO:K06278]
113491224  CAV2; caveolin-2 [KO:K12958]
113485026  CAV3; caveolin-3 [KO:K12959]
113477834  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
113488759  SHC1; SHC-transforming protein 1 [KO:K06279]
113490173  SHC3; SHC-transforming protein 3 [KO:K17448]
113484090  SHC4; SHC-transforming protein 4 isoform X1 [KO:K17449]
113486738  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
113477828  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
113480382  SOS2; son of sevenless homolog 2 [KO:K03099]
113481169  HRAS; GTPase HRas [KO:K02833]
113484728  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
113484193  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
113486052  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
113481227  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
113488829  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
113491430  inhibitor of apoptosis protein [KO:K16060]
113480037  XIAP; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
113476058  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
acun04010  MAPK signaling pathway
acun04060  Cytokine-cytokine receptor interaction
acun04070  Phosphatidylinositol signaling system
acun04110  Cell cycle
acun04310  Wnt signaling pathway
acun04512  ECM-receptor interaction
acun04810  Regulation of actin cytoskeleton
KO pathway
ko04510   
LinkDB

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