KEGG   PATHWAY: anu04613
Entry
anu04613                    Pathway                                
Name
Neutrophil extracellular trap formation - Arvicanthis niloticus (African grass rat)
Description
Neutrophils play a central role in innate immune defense. One of the mechanisms of neutrophil action is the formation of neutrophil extracellular traps (NETs), the extracellular structures composed of chromatin coated with histones, proteases and granular and cytosolic proteins that help catch and kill microorganisms. NETs are formed by a process known as "NETosis" that can be triggered by microorganisms and endogenous stimuli, such as damage-associated molecular patterns and immune complexes, and involves activation in most cases of nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase, which produces reactive oxygen species (ROS). Recent study has reported that there are two different mechanisms of NETosis, including a lytic NETosis and a vital NETosis. Lytic NETosis begins with nuclear delobulation and the disassembly of the nuclear envelope and continues with loss of cellular polarization, chromatin decondensation and plasma membrane rupture. Vital NETosis can occur independently of cell death and involves the secreted expulsion of nuclear chromatin that is accompanied by the release of granule proteins through degranulation.
Class
Organismal Systems; Immune system
Pathway map
anu04613  Neutrophil extracellular trap formation
anu04613

Organism
Arvicanthis niloticus (African grass rat) [GN:anu]
Gene
117712745  low affinity immunoglobulin gamma Fc region receptor IV-like [KO:K06463]
117714378  Syk; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
117698575  Map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
117715476  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
117699009  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
117696143  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
117717711  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
117693439  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
117694361  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
117698038  Ncf1; neutrophil cytosol factor 1 isoform X1 [KO:K08011]
117723186  cytochrome b-245 light chain [KO:K08009]
117716279  Ncf2; neutrophil cytosol factor 2 [KO:K08010]
117719075  Ncf4; neutrophil cytosol factor 4 [KO:K08012]
117697870  Rac1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
117718817  Rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
117694755  Tlr7; toll-like receptor 7 isoform X1 [KO:K05404]
117695526  Tlr8; toll-like receptor 8 [KO:K10170]
117696369  neutrophil elastase [KO:K01327] [EC:3.4.21.37]
117711028  Mpo; myeloperoxidase [KO:K10789] [EC:1.11.2.2]
117697924  Actb; actin, cytoplasmic 1 [KO:K05692]
117710865  Actg1; actin, cytoplasmic 2 [KO:K05692]
117711430  Vdac1; voltage-dependent anion-selective channel protein 1 isoform X1 [KO:K05862]
117717634  LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 1-like [KO:K05862]
117705417  Vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
117721707  Vdac3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
117721894  Slc25a4; ADP/ATP translocase 1 [KO:K05863]
117698523  ADP/ATP translocase 1-like [KO:K05863]
117707501  Slc25a31; ADP/ATP translocase 4 [KO:K05863]
117695364  Slc25a5; ADP/ATP translocase 2 [KO:K05863]
117713753  ADP/ATP translocase 2-like [KO:K05863]
117704931  Ppif; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
117708957  Padi4; protein-arginine deiminase type-4 [KO:K24669] [EC:3.5.3.15]
117707525  Fcgr1a; high affinity immunoglobulin gamma Fc receptor I [KO:K06498]
117712636  Fcgr2a; low affinity immunoglobulin gamma Fc region receptor II-a isoform X1 [KO:K06472]
117712470  Itgam; integrin alpha-M isoform X1 [KO:K06461]
117724530  Itgb2; integrin beta-2 [KO:K06464]
117710925  Itgal; integrin alpha-L isoform X1 [KO:K05718]
117715451  Clec7a; C-type lectin domain family 7 member A isoform X1 [KO:K10074]
117703400  Src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
117712005  Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
117703017  Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
117703351  Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
117703529  Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
117703352  Plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
117723064  Plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
117709948  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
117717067  Prkcb; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
117701003  Prkcg; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
117714642  Atg7; ubiquitin-like modifier-activating enzyme ATG7 [KO:K08337]
117701157  fMet-Leu-Phe receptor isoform X1 [KO:K04172]
117700849  formyl peptide receptor-related sequence 7 [KO:K04173]
117701152  Fpr2; N-formyl peptide receptor 2 [KO:K04173]
117701169  formyl peptide receptor-related sequence 3-like [KO:K04173]
117701175  formyl peptide receptor-related sequence 3 [KO:K04173]
117706649  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
117693421  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
117708986  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
117721973  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
117723761  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
117708961  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
117697536  Akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
117706636  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117721481  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
117709409  Mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
117707042  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
117722582  Rela; transcription factor p65 [KO:K04735]
117705843  C3; complement C3 [KO:K03990]
117703602  C5; complement C5 [KO:K03994]
117700540  C5ar1; C5a anaphylatoxin chemotactic receptor 1 [KO:K04010]
117722492  high mobility group protein B1-like [KO:K10802]
117715227  high mobility group protein B1-like [KO:K10802]
117697902  Hmgb1; high mobility group protein B1 [KO:K10802]
117705943  high mobility group protein B1-like [KO:K10802]
117716243  high mobility group protein B1-like [KO:K10802]
117716335  high mobility group protein B1-like [KO:K10802]
117707282  high mobility group protein B1-like [KO:K10802]
117707544  high mobility group protein B1-like [KO:K10802]
117699910  high mobility group protein B1-like [KO:K10802]
117717870  high mobility group protein B1-like [KO:K10802]
117719062  high mobility group protein B1-like [KO:K10802]
117693575  high mobility group protein B1-like [KO:K10802]
117694617  high mobility group protein B1-like [KO:K10802]
117694712  high mobility group protein B1-like [KO:K10802]
117695498  high mobility group protein B1-like [KO:K10802]
117707783  Tlr2; toll-like receptor 2 [KO:K10159]
117709586  Tlr4; toll-like receptor 4 isoform X1 [KO:K10160]
117724304  Mapk14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
117724423  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
117718601  Mapk12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
117718602  Mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
117709947  Itga2b; integrin alpha-IIb [KO:K06476]
117710850  Itgb3; integrin beta-3 [KO:K06493]
117707632  Fga; fibrinogen alpha chain [KO:K03903]
117707813  Fgb; fibrinogen beta chain isoform X1 [KO:K03904]
117707110  Fgg; fibrinogen gamma chain isoform X1 [KO:K03905]
117711502  Gp1ba; platelet glycoprotein Ib alpha chain [KO:K06261]
117702267  platelet glycoprotein Ib alpha chain-like [KO:K06261]
117715558  Vwf; von Willebrand factor [KO:K03900]
117716337  Selp; P-selectin [KO:K06496]
117698140  Selplg; P-selectin glycoprotein ligand 1 [KO:K06544]
117724835  Ager; advanced glycosylation end product-specific receptor isoform X1 [KO:K19722]
117699797  Casp4; caspase-4 isoform X1 [KO:K04394] [EC:3.4.22.57 3.4.22.64]
117699845  caspase-1-like [KO:K01370] [EC:3.4.22.36]
117718475  gasdermin-D-like [KO:K20917]
117718638  gasdermin-D-like [KO:K20917]
117719262  LOW QUALITY PROTEIN: gasdermin-D-like [KO:K20917]
117719265  gasdermin-D-like [KO:K20917]
117719373  LOW QUALITY PROTEIN: gasdermin-D-like [KO:K20917]
117703480  Hat1; histone acetyltransferase type B catalytic subunit [KO:K11303] [EC:2.3.1.48]
117714844  histone H2A.J [KO:K11251]
117712330  histone H2A.V isoform X1 [KO:K11251]
117698909  histone H2AX [KO:K11251]
117724402  core histone macro-H2A.2 [KO:K11251]
117707546  histone H2A type 2-B [KO:K11251]
117707558  histone H2A type 2-A [KO:K11251]
117707559  histone H2A type 2-A [KO:K11251]
117707561  histone H2A type 2-C [KO:K11251]
117707849  histone H2A.Z [KO:K11251]
117709042  histone H2A.V-like [KO:K11251]
117701963  histone H2A type 1-H-like [KO:K11251]
117701964  histone H2A type 1-B isoform X1 [KO:K11251]
117701969  histone H2A type 1-B-like [KO:K11251]
117701972  histone H2A type 1-B-like [KO:K11251]
117694218  histone H2A-Bbd type 2/3-like [KO:K11251]
117694222  histone H2A-Bbd type 2/3-like [KO:K11251]
117695007  histone H2A-Bbd type 2/3-like [KO:K11251]
117695008  histone H2A-Bbd type 2/3-like [KO:K11251]
117695014  histone H2A-Bbd type 2/3-like [KO:K11251]
117695041  histone H2A-Bbd type 2/3-like [KO:K11251]
117695446  histone H2A-Bbd type 1-like [KO:K11251]
117710598  histone H2A type 3 [KO:K11251]
117713523  histone H2A type 1-B [KO:K11251]
117713526  histone H2A type 1-H-like [KO:K11251]
117713667  histone H2A type 1-B [KO:K11251]
117713671  histone H2A type 1-B-like [KO:K11251]
117713675  histone H2A type 1-B-like [KO:K11251]
117713676  histone H2A type 1-B-like [KO:K11251]
117713724  histone H2A type 1-H-like [KO:K11251]
117713878  histone H2A type 4 [KO:K11251]
117714021  core histone macro-H2A.1 isoform X1 [KO:K11251]
117714301  histone H2A type 1-B-like [KO:K11251]
117714302  histone H2A type 1-B-like [KO:K11251]
117714303  histone H2A type 1-B [KO:K11251]
117714304  histone H2A type 1-B [KO:K11251]
117714305  histone H2A type 1-B-like [KO:K11251]
117714411  histone H2A type 1-B-like [KO:K11251]
117707747  histone H2B type 2-F [KO:K11252]
117700350  histone H2B subacrosomal variant-like [KO:K11252]
117701965  histone H2B type 1-C/E/F/G/I [KO:K11252]
117701966  histone H2B type 1-C/E/F/G/I [KO:K11252]
117701968  histone H2B type 1-C/E/F/G/I [KO:K11252]
117701973  histone H2B type 1-C/E/F/G/I [KO:K11252]
117693947  histone H2B type 1-A-like [KO:K11252]
117710596  histone H2B type 3-B [KO:K11252]
117713524  histone H2B type 1-H [KO:K11252]
117713525  histone H2B type 1-M [KO:K11252]
117710800  histone H2B type 3-A [KO:K11252]
117713668  histone H2B type 1-C/E/F/G/I [KO:K11252]
117713669  histone H2B type 1-C/E/F/G/I [KO:K11252]
117713670  histone H2B type 1-C/E/F/G/I [KO:K11252]
117713826  histone H2B type 1-K [KO:K11252]
117713827  histone H2B type 1-C/E/F/G/I [KO:K11252]
117713836  histone H2B type 1-C/E/F/G/I [KO:K11252]
117713993  histone H2B type 1-A [KO:K11252]
117714306  histone H2B type 1-C/E/F/G/I [KO:K11252]
117714307  histone H2B type 1-C/E/F/G/I [KO:K11252]
117714308  histone H2B type 1-C/E/F/G/I [KO:K11252]
117714309  histone H2B type 1-B [KO:K11252]
117714310  histone H2B type 1-C/E/F/G/I [KO:K11252]
117705412  histone H3.3A-like [KO:K11253]
117698521  histone H3.3A-like [KO:K11253]
117717595  histone H3.3A-like [KO:K11253]
117724885  histone H3.3A-like [KO:K11253]
117701974  histone H3-like centromeric protein CSE4 [KO:K11253]
117709564  histone H3.3A-like [KO:K11253]
117709992  histone H3.3A [KO:K11253]
117710597  histone H3.1 [KO:K11253]
117713386  histone H3-like centromeric protein CSE4 [KO:K11253]
117713522  histone H3.1 [KO:K11253]
117721411  histone H3.3A [KO:K11253]
117704315  histone H3.3A-like [KO:K11253]
117714314  uncharacterized protein LOC117714314 [KO:K11253]
117707392  uncharacterized protein LOC117707392 [KO:K11253]
117714299  histone H3 [KO:K11253]
117714300  histone H3 [KO:K11253]
117714312  histone H3 [KO:K11253]
117724593  Hdac2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
117709000  Hdac1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
117719791  Hdac3; histone deacetylase 3 [KO:K11404] [EC:3.5.1.98]
117722211  Hdac4; histone deacetylase 4 isoform X1 [KO:K11406] [EC:3.5.1.98]
117710073  Hdac5; histone deacetylase 5 isoform X1 [KO:K11406] [EC:3.5.1.98]
117694531  Hdac6; histone deacetylase 6 [KO:K11407] [EC:3.5.1.98]
117694578  LOW QUALITY PROTEIN: histone deacetylase 6-like [KO:K11407] [EC:3.5.1.98]
117718522  Hdac7; histone deacetylase 7 isoform X1 [KO:K11408] [EC:3.5.1.98]
117695496  Hdac8; histone deacetylase 8 isoform X1 [KO:K11405] [EC:3.5.1.98]
117717004  Hdac9; histone deacetylase 9 isoform X1 [KO:K11409] [EC:3.5.1.98]
117719184  Hdac10; polyamine deacetylase HDAC10 isoform X1 [KO:K18671] [EC:3.5.1.98]
117715261  Hdac11; histone deacetylase 11 [KO:K11418] [EC:3.5.1.98]
117705954  cathepsin G [KO:K01319] [EC:3.4.21.20]
117693561  cathelicidin antimicrobial peptide-like [KO:K13916]
117693683  cathelicidin antimicrobial peptide-like [KO:K13916]
117693689  cathelicidin antimicrobial peptide-like [KO:K13916]
117693690  cathelicidin antimicrobial peptide-like [KO:K13916]
117693696  cathelicidin antimicrobial peptide-like [KO:K13916]
117694332  Clcn4; H(+)/Cl(-) exchange transporter 4 [KO:K05012]
117694447  Clcn5; H(+)/Cl(-) exchange transporter 5 isoform X1 [KO:K05012]
117721492  Clcn3; H(+)/Cl(-) exchange transporter 3 isoform X1 [KO:K05012]
117699922  Aqp9; aquaporin-9 [KO:K09877]
Compound
C00027  Hydrogen peroxide
C00039  DNA
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00464  Mannan
C00518  Hyaluronate
C00551  beta-D-Glucan
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05151  12-O-Tetradecanoylphorbol 13-acetate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11221  Formylmethionyl-leucyl-phenylalanine methyl ester
Reference
PMID:29543328
  Authors
Van Avondt K, Hartl D
  Title
Mechanisms and disease relevance of neutrophil extracellular trap formation.
  Journal
Eur J Clin Invest 48 Suppl 2:e12919 (2018)
DOI:10.1111/eci.12919
Reference
PMID:31518165
  Authors
Sorvillo N, Cherpokova D, Martinod K, Wagner DD
  Title
Extracellular DNA NET-Works With Dire Consequences for Health.
  Journal
Circ Res 125:470-488 (2019)
DOI:10.1161/CIRCRESAHA.119.314581
Reference
PMID:28990587
  Authors
Papayannopoulos V
  Title
Neutrophil extracellular traps in immunity and disease.
  Journal
Nat Rev Immunol 18:134-147 (2018)
DOI:10.1038/nri.2017.105
Reference
PMID:24837201
  Authors
Liu FC, Chuang YH, Tsai YF, Yu HP
  Title
Role of neutrophil extracellular traps following injury.
  Journal
Shock 41:491-8 (2014)
DOI:10.1097/SHK.0000000000000146
Reference
PMID:27570525
  Authors
Yang H, Biermann MH, Brauner JM, Liu Y, Zhao Y, Herrmann M
  Title
New Insights into Neutrophil Extracellular Traps: Mechanisms of Formation and Role in Inflammation.
  Journal
Front Immunol 7:302 (2016)
DOI:10.3389/fimmu.2016.00302
Reference
PMID:28983472
  Authors
Zawrotniak M, Bochenska O, Karkowska-Kuleta J, Seweryn-Ozog K, Aoki W, Ueda M, Kozik A, Rapala-Kozik M
  Title
Aspartic Proteases and Major Cell Wall Components in Candida albicans Trigger the Release of Neutrophil Extracellular Traps.
  Journal
Front Cell Infect Microbiol 7:414 (2017)
DOI:10.3389/fcimb.2017.00414
Reference
PMID:29382950
  Authors
Honda M, Kubes P
  Title
Neutrophils and neutrophil extracellular traps in the liver and gastrointestinal system.
  Journal
Nat Rev Gastroenterol Hepatol 15:206-221 (2018)
DOI:10.1038/nrgastro.2017.183
Reference
PMID:31416265
  Authors
Hamam HJ, Palaniyar N
  Title
Post-Translational Modifications in NETosis and NETs-Mediated Diseases.
  Journal
Biomolecules 9:E369 (2019)
DOI:10.3390/biom9080369
Reference
PMID:31767647
  Authors
Burgener SS, Schroder K
  Title
Neutrophil Extracellular Traps in Host Defense.
  Journal
Cold Spring Harb Perspect Biol 12:a037028 (2020)
DOI:10.1101/cshperspect.a037028
Reference
PMID:33202203
  Authors
Vorobjeva NV, Chernyak BV
  Title
NETosis: Molecular Mechanisms, Role in Physiology and Pathology.
  Journal
Biochemistry (Mosc) 85:1178-1190 (2020)
DOI:10.1134/S0006297920100065
Reference
PMID:31416173
  Authors
Ravindran M, Khan MA, Palaniyar N
  Title
Neutrophil Extracellular Trap Formation: Physiology, Pathology, and Pharmacology.
  Journal
Biomolecules 9:E365 (2019)
DOI:10.3390/biom9080365
Reference
PMID:28267716
  Authors
Jorch SK, Kubes P
  Title
An emerging role for neutrophil extracellular traps in noninfectious disease.
  Journal
Nat Med 23:279-287 (2017)
DOI:10.1038/nm.4294
Reference
PMID:31342866
  Authors
Goggs R, Jeffery U, LeVine DN, Li RHL
  Title
Neutrophil-Extracellular Traps, Cell-Free DNA, and Immunothrombosis in Companion Animals: A Review.
  Journal
Vet Pathol 57:6-23 (2020)
DOI:10.1177/0300985819861721
Reference
PMID:27876233
  Authors
Kim SJ, Jenne CN
  Title
Role of platelets in neutrophil extracellular trap (NET) production and tissue injury.
  Journal
Semin Immunol 28:546-554 (2016)
DOI:10.1016/j.smim.2016.10.013
Reference
PMID:29572545
  Authors
de Bont CM, Boelens WC, Pruijn GJM
  Title
NETosis, complement, and coagulation: a triangular relationship.
  Journal
Cell Mol Immunol 16:19-27 (2019)
DOI:10.1038/s41423-018-0024-0
Reference
PMID:31129510
  Authors
Zawrotniak M, Bartnicka D, Rapala-Kozik M
  Title
UVA and UVB radiation induce the formation of neutrophil extracellular traps by human polymorphonuclear cells.
  Journal
J Photochem Photobiol B 196:111511 (2019)
DOI:10.1016/j.jphotobiol.2019.111511
Reference
PMID:21293492
  Authors
Remijsen Q, Kuijpers TW, Wirawan E, Lippens S, Vandenabeele P, Vanden Berghe T
  Title
Dying for a cause: NETosis, mechanisms behind an antimicrobial cell death modality.
  Journal
Cell Death Differ 18:581-8 (2011)
DOI:10.1038/cdd.2011.1
Reference
PMID:23819131
  Authors
Zawrotniak M, Rapala-Kozik M
  Title
Neutrophil extracellular traps (NETs) - formation and implications.
  Journal
Acta Biochim Pol 60:277-84 (2013)
Reference
PMID:28373871
  Authors
Rosales C
  Title
Fcgamma Receptor Heterogeneity in Leukocyte Functional Responses.
  Journal
Front Immunol 8:280 (2017)
DOI:10.3389/fimmu.2017.00280
Reference
PMID:25716722
  Authors
Vorobjeva NV, Pinegin BV
  Title
Neutrophil extracellular traps: mechanisms of formation and role in health and disease.
  Journal
Biochemistry (Mosc) 79:1286-96 (2014)
DOI:10.1134/S0006297914120025
Reference
PMID:28220120
  Authors
Delgado-Rizo V, Martinez-Guzman MA, Iniguez-Gutierrez L, Garcia-Orozco A, Alvarado-Navarro A, Fafutis-Morris M
  Title
Neutrophil Extracellular Traps and Its Implications in Inflammation: An Overview.
  Journal
Front Immunol 8:81 (2017)
DOI:10.3389/fimmu.2017.00081
Reference
PMID:30023352
  Authors
Fonseca Z, Diaz-Godinez C, Mora N, Aleman OR, Uribe-Querol E, Carrero JC, Rosales C
  Title
Entamoeba histolytica Induce Signaling via Raf/MEK/ERK for Neutrophil Extracellular Trap (NET) Formation.
  Journal
Front Cell Infect Microbiol 8:226 (2018)
DOI:10.3389/fcimb.2018.00226
Reference
PMID:27923601
  Authors
Agraz-Cibrian JM, Giraldo DM, Mary FM, Urcuqui-Inchima S
  Title
Understanding the molecular mechanisms of NETs and their role in antiviral innate immunity.
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Virus Res 228:124-133 (2017)
DOI:10.1016/j.virusres.2016.11.033
Reference
PMID:27698656
  Authors
Schonrich G, Raftery MJ
  Title
Neutrophil Extracellular Traps Go Viral.
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Front Immunol 7:366 (2016)
DOI:10.3389/fimmu.2016.00366
Reference
PMID:22817992
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Saitoh T, Komano J, Saitoh Y, Misawa T, Takahama M, Kozaki T, Uehata T, Iwasaki H, Omori H, Yamaoka S, Yamamoto N, Akira S
  Title
Neutrophil extracellular traps mediate a host defense response to human immunodeficiency virus-1.
  Journal
Cell Host Microbe 12:109-16 (2012)
DOI:10.1016/j.chom.2012.05.015
Reference
PMID:29908538
  Authors
Kumar S, Gupta E, Kaushik S, Jyoti A
  Title
Neutrophil Extracellular Traps: Formation and Involvement in Disease Progression.
  Journal
Iran J Allergy Asthma Immunol 17:208-220 (2018)
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