Entry
Name
Cholinergic synapse - Bos taurus (cow)
Description
Acetylcholine (ACh) is a neurotransmitter widely distributed in the central (and also peripheral, autonomic and enteric) nervous system (CNS). In the CNS, ACh facilitates many functions, such as learning, memory, attention and motor control. When released in the synaptic cleft, ACh binds to two distinct types of receptors: Ionotropic nicotinic acetylcholine receptors (nAChR) and metabotropic muscarinic acetylcholine receptors (mAChRs). The activation of nAChR by ACh leads to the rapid influx of Na+ and Ca2+ and subsequent cellular depolarization. Activation of mAChRs is relatively slow (milliseconds to seconds) and, depending on the subtypes present (M1-M5), they directly alter cellular homeostasis of phospholipase C, inositol trisphosphate, cAMP, and free calcium. In the cleft, ACh may also be hydrolyzed by acetylcholinesterase (AChE) into choline and acetate. The choline derived from ACh hydrolysis is recovered by a presynaptic high-affinity choline transporter (CHT).
Class
Organismal Systems; Nervous system
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Bos taurus (cow) [GN:
bta ]
Gene
785833 SLC18A3; vesicular acetylcholine transporter [KO:K14636 ]
281684 CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129 ]
281685 CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131 ]
281686 CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133 ]
536654 GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634 ]
281788 GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635 ]
287026 PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858 ] [EC:3.1.4.11 ]
281985 PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858 ] [EC:3.1.4.11 ]
515669 PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858 ] [EC:3.1.4.11 ]
508888 PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858 ] [EC:3.1.4.11 ]
317697 ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958 ]
281878 ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959 ]
281879 ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960 ]
784876 KCNQ1; potassium voltage-gated channel subfamily KQT member 1 [KO:K04926 ]
505963 KCNQ2; potassium voltage-gated channel subfamily KQT member 2 isoform X1 [KO:K04927 ]
281884 KCNQ3; potassium voltage-gated channel subfamily KQT member 3 [KO:K04928 ]
528741 KCNQ4; potassium voltage-gated channel subfamily KQT member 4 [KO:K04929 ]
613605 KCNQ5; potassium voltage-gated channel subfamily KQT member 5 isoform X1 [KO:K04930 ]
281883 KCNJ2; inward rectifier potassium channel 2 [KO:K04996 ]
538479 KCNJ12; ATP-sensitive inward rectifier potassium channel 12 [KO:K05005 ]
540740 KCNJ14; ATP-sensitive inward rectifier potassium channel 14 [KO:K05007 ]
522170 CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130 ]
512928 CHRM4; muscarinic acetylcholine receptor M4 [KO:K04132 ]
281790 GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630 ]
281791 GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630 ]
539521 GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630 ]
281792 GNAO1; guanine nucleotide-binding protein G(o) subunit alpha [KO:K04534 ]
281201 GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536 ]
281202 GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537 ]
513340 GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825 ]
525962 GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538 ]
535365 GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539 ]
281203 GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826 ]
281204 GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540 ]
100125276 GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541 ]
287018 GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542 ]
104968964 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542 ]
618399 GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543 ]
618470 GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544 ]
613930 GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545 ]
511812 GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546 ]
286850 GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347 ]
529425 GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347 ]
517006 GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547 ]
281796 GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548 ]
281797 GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549 ]
526088 KCNJ3; G protein-activated inward rectifier potassium channel 1 [KO:K04997 ]
520743 KCNJ6; G protein-activated inward rectifier potassium channel 2 [KO:K05000 ]
530001 PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289 ] [EC:2.7.1.153 ]
614838 PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X3 [KO:K21290 ]
515621 PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290 ]
101905399 LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 1-like [KO:K04368 ] [EC:2.7.12.2 ]
282178 CHRNA7; neuronal acetylcholine receptor subunit alpha-7 precursor [KO:K04809 ]
537251 CHRNA4; neuronal acetylcholine receptor subunit alpha-4 precursor [KO:K04806 ]
517519 CHRNB2; neuronal acetylcholine receptor subunit beta-2 precursor [KO:K04813 ]
282702 CHRNA3; neuronal acetylcholine receptor subunit alpha-3 precursor [KO:K04805 ]
282181 CHRNB4; neuronal acetylcholine receptor subunit beta-4 precursor [KO:K04815 ]
539113 CHRNA6; neuronal acetylcholine receptor subunit alpha-6 isoform X1 [KO:K04808 ]
281713 CREB1; cyclic AMP-responsive element-binding protein 1 [KO:K05870 ]
509107 ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374 ]
281715 CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048 ]
513105 CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048 ]
513010 CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048 ]
529566 CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X5 [KO:K09048 ]
785086 CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048 ]
534129 CREB5; cyclic AMP-responsive element-binding protein 5 [KO:K09047 ]
282162 CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515 ] [EC:2.7.11.17 ]
525416 CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515 ] [EC:2.7.11.17 ]
530719 CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515 ] [EC:2.7.11.17 ]
532713 CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta [KO:K04515 ] [EC:2.7.11.17 ]
282306 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
517948 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
504531 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
282308 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
286865 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
282307 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649 ]
282648 CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344 ]
282410 CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849 ]
408015 CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850 ]
408013 CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851 ]
509779 CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853 ]
100337204 CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857 ]
512311 SLC5A7; high affinity choline transporter 1 [KO:K14387 ]
Compound
C01245 D-myo-Inositol 1,4,5-trisphosphate
C04637 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
Reference
Authors
Nestler EJ, Hyman SE, Malenka RC.
Title
Molecular neuropharmacology: A foundation for clinical neuroscience
Journal
The McGraw-Hill Companies, Inc. (2001)
Reference
Authors
Nicholls JG, Martin AR, Wallace BG, Fuchs PA.
Title
From neuron to brain, 4th ed.
Journal
Sunderland, MA: Sinauer associates (2001)
Reference
Authors
Dajas-Bailador F, Wonnacott S
Title
Nicotinic acetylcholine receptors and the regulation of neuronal signalling.
Journal
Reference
Authors
Resende RR, Adhikari A
Title
Cholinergic receptor pathways involved in apoptosis, cell proliferation and neuronal differentiation.
Journal
Reference
Authors
Origlia N, Kuczewski N, Pesavento E, Aztiria E, Domenici L
Title
The role of cholinergic system in neuronal plasticity: focus on visual cortex and muscarinic receptors.
Journal
Arch Ital Biol 146:165-88 (2008)
Reference
Authors
Oldenburg IA, Ding JB
Title
Cholinergic modulation of synaptic integration and dendritic excitability in the striatum.
Journal
Reference
Authors
Lanzafame AA, Christopoulos A, Mitchelson F
Title
Cellular signaling mechanisms for muscarinic acetylcholine receptors.
Journal
Reference
Authors
Brown DA
Title
Muscarinic acetylcholine receptors (mAChRs) in the nervous system: some functions and mechanisms.
Journal
Reference
Authors
Chang KT, Berg DK
Title
Voltage-gated channels block nicotinic regulation of CREB phosphorylation and gene expression in neurons.
Journal
Reference
Authors
Soreq H, Seidman S
Title
Acetylcholinesterase--new roles for an old actor.
Journal
Reference
Authors
Sharma G, Vijayaraghavan S
Title
Nicotinic receptor signaling in nonexcitable cells.
Journal
Reference
Authors
Araque A, Martin ED, Perea G, Arellano JI, Buno W
Title
Synaptically released acetylcholine evokes Ca2+ elevations in astrocytes in hippocampal slices.
Journal
Reference
Authors
Lucas-Meunier E, Fossier P, Baux G, Amar M
Title
Cholinergic modulation of the cortical neuronal network.
Journal
Reference
Authors
Abreu-Villaca Y, Filgueiras CC, Manhaes AC
Title
Developmental aspects of the cholinergic system.
Journal
Related pathway
KO pathway
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