KEGG   PATHWAY: bta04010
Entry
bta04010                    Pathway                                
Name
MAPK signaling pathway - Bos taurus (cow)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
bta04010  MAPK signaling pathway
bta04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Bos taurus (cow) [GN:bta]
Gene
100137872  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100138040  SOS2; son of sevenless homolog 2 [KO:K03099]
100139484  RAPGEF2; rap guanine nucleotide exchange factor 2 [KO:K08018]
100295476  EREG; proepiregulin isoform X1 [KO:K09784]
100295732  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
100298939  HRAS; GTPase HRas isoform 1 [KO:K02833]
100300257  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
100337204  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
100847184  [KO:K02833]
101905399  [KO:K04368] [EC:2.7.12.2]
132342877  [KO:K04873]
280795  FOS; protein c-Fos [KO:K04379]
280829  INS; insulin preproprotein [KO:K04526]
280831  JUN; transcription factor Jun [KO:K04448]
280832  KIT; mast/stem cell growth factor receptor Kit precursor [KO:K05091] [EC:2.7.10.1]
280855  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
280877  NF1; neurofibromin isoform 1 [KO:K08052]
280894  PGF; placenta growth factor precursor [KO:K16859]
280939  TEK; angiopoietin-1 receptor precursor [KO:K05121] [EC:2.7.10.1]
280943  TNF; tumor necrosis factor [KO:K03156]
280991  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
281048  CD14; monocyte differentiation antigen CD14 precursor [KO:K04391]
281073  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
281094  CSF1; macrophage colony-stimulating factor 1 precursor [KO:K05453]
281160  FGF1; fibroblast growth factor 1 [KO:K18496]
281161  FGF2; fibroblast growth factor 2 precursor [KO:K18497]
281165  FLNA; filamin-A [KO:K04437]
281239  IGF1; insulin-like growth factor I preproprotein [KO:K05459]
281240  IGF2; insulin-like growth factor II preproprotein [KO:K13769]
281250  IL1A; interleukin-1 alpha precursor [KO:K04383]
281251  IL1B; interleukin-1 beta precursor [KO:K04519]
281296  MAPT; microtubule-associated protein tau [KO:K04380]
281350  NGF; beta-nerve growth factor precursor [KO:K02582]
281440  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
281542  TP53; cellular tumor antigen p53 [KO:K04451]
281572  VEGFA; vascular endothelial growth factor A isoform 3 precursor [KO:K05448]
281637  ARRB1; beta-arrestin-1 [KO:K04439]
281638  ARRB2; beta-arrestin-2 [KO:K04439]
281768  FGFR1; fibroblast growth factor receptor 1 precursor [KO:K04362] [EC:2.7.10.1]
281769  FGFR3; fibroblast growth factor receptor 3 precursor [KO:K05094] [EC:2.7.10.1]
281831  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
281848  IGF1R; insulin-like growth factor 1 receptor precursor [KO:K05087] [EC:2.7.10.1]
281854  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
281855  IKBKG; NF-kappa-B essential modulator [KO:K07210]
281885  KITLG; kit ligand precursor [KO:K05461]
281994  PPM1A; protein phosphatase 1A isoform 2 [KO:K04457] [EC:3.1.3.16]
281995  PPM1B; protein phosphatase 1B [KO:K04461] [EC:3.1.3.16]
282001  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
282002  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
282031  RAP1A; ras-related protein Rap-1A [KO:K04353]
282032  RASA1; ras GTPase-activating protein 1 [KO:K04352]
282089  TGFB1; transforming growth factor beta-1 proprotein precursor [KO:K13375]
282121  VEGFB; vascular endothelial growth factor B precursor [KO:K16858]
282122  VEGFC; vascular endothelial growth factor C precursor [KO:K05449]
282140  ANGPT1; angiopoietin-1 precursor [KO:K05465]
282141  ANGPT2; angiopoietin-2 precursor [KO:K05466]
282160  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 [KO:K04864]
282161  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 [KO:K04865]
282233  FLT3LG; fms-related tyrosine kinase 3 ligand precursor [KO:K05454]
282254  HSPA1A; heat shock 70 kDa protein 1B [KO:K03283]
282301  PDGFRA; platelet-derived growth factor receptor alpha precursor [KO:K04363] [EC:2.7.10.1]
282321  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
282322  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
282323  PRKACB; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
282325  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
282382  TGFBR1; TGF-beta receptor type-1 precursor [KO:K04674] [EC:2.7.11.30]
282410  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
282411  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
282412  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
282413  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
282488  FAS; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390]
282527  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A precursor [KO:K03158]
282608  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 precursor [KO:K04858]
282648  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
282879  HGF; hepatocyte growth factor precursor [KO:K05460]
286799  VEGFD; vascular endothelial growth factor D precursor [KO:K05449]
286800  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
286850  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
286852  PPP3CA; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
286883  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
317696  FGFR4; fibroblast growth factor receptor 4 precursor [KO:K05095] [EC:2.7.10.1]
326284  FGF8; fibroblast growth factor 8 precursor [KO:K04358]
326285  FGF10; fibroblast growth factor 10 precursor [KO:K04358]
327667  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 [KO:K04863]
327671  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
327672  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
327703  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 [KO:K04862]
327708  RAP1B; ras-related protein Rap-1b [KO:K07836]
338031  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
353110  NGFR; tumor necrosis factor receptor superfamily member 16 precursor [KO:K02583]
353111  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
353113  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
386587  GDNF; glial cell line-derived neurotrophic factor precursor [KO:K05452]
404193  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
407111  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
407170  KDR; vascular endothelial growth factor receptor 2 precursor [KO:K05098] [EC:2.7.10.1]
407217  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
408013  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
408015  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
408016  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
408017  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
444881  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
503620  FLT1; vascular endothelial growth factor receptor 1 precursor [KO:K05096] [EC:2.7.10.1]
504336  DAXX; death domain-associated protein 6 [KO:K02308]
504408  RPS6KA5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
504592  MAP3K2; mitogen-activated protein kinase kinase kinase 2 isoform X1 [KO:K04420] [EC:2.7.11.25]
504707  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
504939  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
505369  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
505427  MAP3K12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
505463  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
505485  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
505709  ERBB2; receptor tyrosine-protein kinase erbB-2 precursor [KO:K05083] [EC:2.7.10.1]
505824  NTRK2; BDNF/NT-3 growth factors receptor precursor [KO:K04360] [EC:2.7.10.1]
505847  CDC25B; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
505908  PDGFA; platelet-derived growth factor subunit A precursor [KO:K04359]
506322  NRAS; GTPase NRas [KO:K07828]
506660  NTF4; neurotrophin-4 precursor [KO:K12457]
507061  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
507204  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
507245  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial precursor [KO:K04405]
507319  EFNA1; ephrin-A1 precursor [KO:K05462]
507624  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 [KO:K04406] [EC:2.7.11.1]
508233  RELA; transcription factor p65 [KO:K04735]
508367  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
508943  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X4 [KO:K04421] [EC:2.7.11.25]
509107  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
509109  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
509418  CSF1R; macrophage colony-stimulating factor 1 receptor precursor [KO:K05090] [EC:2.7.10.1]
509779  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
509827  ATF2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
510245  PPP5C; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
510434  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
511077  MYC; myc proto-oncogene protein [KO:K04377]
511190  RPS6KA3; ribosomal protein S6 kinase alpha-3 [KO:K04373] [EC:2.7.11.1]
511224  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
511779  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
512056  RASGRP2; RAS guanyl-releasing protein 2 [KO:K12361]
512254  MEF2C; myocyte-specific enhancer factor 2C [KO:K04454]
512355  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
512700  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
512798  EPHA2; ephrin type-A receptor 2 precursor [KO:K05103] [EC:2.7.10.1]
512841  CRK; adapter molecule crk [KO:K04438]
512943  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
513673  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
514210  MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
514886  STK4; serine/threonine-protein kinase 4 [KO:K04411]
515159  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
515310  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
515640  IL1R1; interleukin-1 receptor type 1 precursor [KO:K04386]
515924  RET; proto-oncogene tyrosine-protein kinase receptor Ret precursor [KO:K05126] [EC:2.7.10.1]
516039  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
516099  HSPB1; heat shock protein beta-1 [KO:K04455]
517192  JUND; transcription factor JunD [KO:K04449]
517953  RPS6KA2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
518180  CRKL; crk-like protein [KO:K04438]
518266  PSPN; persephin [KO:K25416]
519251  MAP3K20; mitogen-activated protein kinase kinase kinase 20 [KO:K04424] [EC:2.7.11.25]
519269  RRAS2; ras-related protein R-Ras2 [KO:K07830]
519331  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
519644  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 precursor [KO:K04860]
519657  FGF22; fibroblast growth factor 22 precursor [KO:K04358]
519958  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
520039  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
520058  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 [KO:K04414] [EC:2.7.11.1]
521196  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
521475  FGF19; fibroblast growth factor 19 [KO:K22603]
521616  CACNG6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
522002  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 [KO:K04408] [EC:2.7.11.1]
522419  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X2 [KO:K05085] [EC:2.7.10.1]
522670  RELB; transcription factor RelB [KO:K09253]
522866  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
523745  RASGRP3; ras guanyl-releasing protein 3 [KO:K12362]
523746  RPS6KA4; ribosomal protein S6 kinase alpha-4 [KO:K16510] [EC:2.7.11.1]
523962  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
524806  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
524957  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
525072  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
525562  NRTN; neurturin [KO:K25414]
525647  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 [KO:K04372] [EC:2.7.11.1]
525931  PDGFD; platelet-derived growth factor D [KO:K05450]
526227  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
526364  PLA2G4E; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
526392  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
526469  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
527165  PDGFRB; platelet-derived growth factor receptor beta precursor [KO:K05089] [EC:2.7.10.1]
528390  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
529146  MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
529375  RASGRP4; RAS guanyl-releasing protein 4 [KO:K12363]
529382  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
529425  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
530239  FGF23; fibroblast growth factor 23 [KO:K22428]
530315  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
530812  ARTN; artemin [KO:K25415]
531209  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
531391  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
532209  MECOM; histone-lysine N-methyltransferase MECOM isoform X8 [KO:K04462] [EC:2.1.1.367]
532393  NTF3; neurotrophin-3 precursor [KO:K04356]
532712  CDC42; cell division control protein 42 homolog [KO:K04393]
533039  SRF; serum response factor [KO:K04378]
533125  RASGRP1; RAS guanyl-releasing protein 1 [KO:K04350]
533155  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
533199  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
533491  RASA2; ras GTPase-activating protein 2 [KO:K08053]
533527  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
533692  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
533729  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
533815  STK3; serine/threonine-protein kinase 3 [KO:K04412]
533897  TAOK2; serine/threonine-protein kinase TAO2 [KO:K04429] [EC:2.7.11.1]
533908  RPS6KA1; ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
533929  FGF18; fibroblast growth factor 18 precursor [KO:K04358]
533953  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
534069  TGFB2; transforming growth factor beta-2 proprotein precursor [KO:K13376]
534125  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
534492  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
534620  TAOK3; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
534923  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
535298  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
535327  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
535376  TGFBR2; TGF-beta receptor type-2 precursor [KO:K04388] [EC:2.7.11.30]
535622  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
535625  MAPKAPK5; MAP kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
536051  BRAF; serine/threonine-protein kinase B-raf isoform X9 [KO:K04365] [EC:2.7.11.1]
536337  PTPRR; receptor-type tyrosine-protein phosphatase R isoform 1 [KO:K04458] [EC:3.1.3.48]
536532  TAOK1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
536771  FGF5; fibroblast growth factor 5 precursor [KO:K04358]
537380  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
537598  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 [KO:K04436]
537631  MAPK10; mitogen-activated protein kinase 10 isoform 2 [KO:K04440] [EC:2.7.11.24]
537682  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
537703  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
538340  MAP3K9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
538496  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
538519  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
538751  AREG; amphiregulin precursor [KO:K09782]
538957  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
539083  FGF20; fibroblast growth factor 20 [KO:K04358]
539124  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
539140  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
539175  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
539334  IL1RAP; interleukin-1 receptor accessory protein precursor [KO:K04723]
539835  HSPA6; heat shock 70 kDa protein 6 [KO:K03283]
539941  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
539969  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
540106  PDGFB; platelet-derived growth factor subunit B precursor [KO:K17386]
540190  HSPA1L; heat shock 70 kDa protein 1-like [KO:K03283]
540203  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
540309  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
540317  FGF6; fibroblast growth factor 6 [KO:K04358]
540380  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
540388  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
540421  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
540616  MAX; protein max [KO:K04453]
540758  FGF16; fibroblast growth factor 16 [KO:K04358]
540776  EFNA3; ephrin-A3 precursor [KO:K05462]
540803  MRAS; ras-related protein M-Ras [KO:K07831]
541127  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
541140  KRAS; GTPase KRas [KO:K07827]
541175  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
613731  FGF9; fibroblast growth factor 9 [KO:K04358]
613787  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
614077  PTPN7; tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
614306  DUSP9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
614453  EFNA2; ephrin-A2 precursor [KO:K05462]
614598  MAP3K6; mitogen-activated protein kinase kinase kinase 6 [KO:K04425] [EC:2.7.11.25]
615215  MAPKAPK3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
615432  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
615727  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
615850  PTPN5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
615879  EFNA4; ephrin-A4 precursor [KO:K05462]
616014  MAP3K21; mitogen-activated protein kinase kinase kinase 21 [KO:K17534] [EC:2.7.11.25]
616115  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
616317  STMN1; stathmin [KO:K04381]
616503  RRAS; ras-related protein R-Ras [KO:K07829]
616742  EFNA5; ephrin-A5 precursor [KO:K05462]
616885  FGF7; fibroblast growth factor 7 precursor [KO:K04358]
617585  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
617701  BDNF; brain-derived neurotrophic factor precursor [KO:K04355]
617915  ANGPT4; angiopoietin-4 precursor [KO:K05467]
618405  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
618474  FGF4; fibroblast growth factor 4 precursor [KO:K04358]
618481  FGF3; fibroblast growth factor 3 [KO:K04358]
618644  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
618893  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
618906  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
619066  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
777788  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
781037  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
781184  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
782032  [KO:K03175] [EC:2.3.2.27]
784075  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
785016  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
785576  FGF21; fibroblast growth factor 21 [KO:K22429]
785655  ERBB3; receptor tyrosine-protein kinase erbB-3 precursor [KO:K05084] [EC:2.7.10.1]
785909  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
786886  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
787278  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
788091  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
789148  [KO:K07836]
790867  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform [KO:K04348] [EC:3.1.3.16]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
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MAP kinases.
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Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
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Tanoue T, Nishida E.
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Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
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MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
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Huang EJ, Reichardt LF.
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Trk receptors: roles in neuronal signal transduction.
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Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
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Yang SH, Sharrocks AD, Whitmarsh AJ.
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Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
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Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
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The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
bta04070  Phosphatidylinositol signaling system
bta04110  Cell cycle
bta04115  p53 signaling pathway
bta04210  Apoptosis
bta04310  Wnt signaling pathway
bta04668  TNF signaling pathway
KO pathway
ko04010   

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