KEGG   PATHWAY: ggo04148
Entry
ggo04148                    Pathway                                
Name
Efferocytosis - Gorilla gorilla gorilla (western lowland gorilla)
Class
Cellular Processes; Transport and catabolism
Pathway map
ggo04148  Efferocytosis
ggo04148

Organism
Gorilla gorilla gorilla (western lowland gorilla) [GN:ggo]
Gene
101126742  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
101147760  CASP7; LOW QUALITY PROTEIN: caspase-7 [KO:K04397] [EC:3.4.22.60]
101136563  caspase-1 isoform X1 [KO:K01370] [EC:3.4.22.36]
101134633  PANX1; pannexin-1 [KO:K03443]
101131285  P2RY2; P2Y purinoceptor 2 [KO:K04269]
129525608  P2RY6; P2Y purinoceptor 6 [KO:K04272]
101151637  P2RY12; P2Y purinoceptor 12 [KO:K04298]
101127850  SPHK1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
129528634  SPHK2; sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
101127904  S1PR1; sphingosine 1-phosphate receptor 1 [KO:K04288]
101154603  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
101151472  ABCA1; phospholipid-transporting ATPase ABCA1 isoform X2 [KO:K05641]
101130222  GPR132; probable G-protein coupled receptor 132 isoform X1 [KO:K08426]
101152705  ADAM17; disintegrin and metalloproteinase domain-containing protein 17 isoform X1 [KO:K06059] [EC:3.4.24.86]
101142970  ADAM10; disintegrin and metalloproteinase domain-containing protein 10 [KO:K06704] [EC:3.4.24.81]
101137562  CX3CL1; fractalkine [KO:K05508]
101125281  CX3CR1; CX3C chemokine receptor 1 isoform X2 [KO:K04192]
101131247  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
101147593  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
101142854  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
101128787  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
101136350  HIF1A; hypoxia-inducible factor 1-alpha isoform X1 [KO:K08268]
101144887  ARNT; aryl hydrocarbon receptor nuclear translocator isoform X1 [KO:K09097]
101141654  EPO; erythropoietin [KO:K05437]
101147948  EPOR; erythropoietin receptor [KO:K05079]
101149427  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
101140164  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101135988  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101125586  CEBPB; CCAAT/enhancer-binding protein beta [KO:K10048]
101134077  PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
101128749  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
101136709  MFGE8; lactadherin [KO:K17253]
101144298  GAS6; growth arrest-specific protein 6 isoform X2 [KO:K05464]
101126479  MERTK; tyrosine-protein kinase Mer isoform X1 [KO:K05117] [EC:2.7.10.1]
101124855  CD36; platelet glycoprotein 4 [KO:K06259]
101135507  THBS1; thrombospondin-1 [KO:K16857]
101132391  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
101126885  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
101146681  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
101150673  PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
101152623  PTGER4; prostaglandin E2 receptor EP4 subtype isoform X1 [KO:K04261]
101149451  DNMT3A; DNA (cytosine-5)-methyltransferase 3A isoform X2 [KO:K17398] [EC:2.1.1.37]
101144410  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X3 [KO:K05870]
101124474  TGFB1; transforming growth factor beta-1 proprotein isoform X2 [KO:K13375]
101140334  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X2 [KO:K05853] [EC:7.2.2.10]
115932652  LOW QUALITY PROTEIN: sarcoplasmic/endoplasmic reticulum calcium ATPase 3-like [KO:K05853] [EC:7.2.2.10]
101141624  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
101124707  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X3 [KO:K05853] [EC:7.2.2.10]
101134676  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X28 [KO:K04515] [EC:2.7.11.17]
101153594  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
101148194  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X8 [KO:K04515] [EC:2.7.11.17]
101136547  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
101134492  MAPK12; mitogen-activated protein kinase 12 isoform X2 [KO:K04441] [EC:2.7.11.24]
101134843  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
101148438  MAPK13; mitogen-activated protein kinase 13 isoform X3 [KO:K04441] [EC:2.7.11.24]
101152640  MAPK14; mitogen-activated protein kinase 14 isoform X2 [KO:K04441] [EC:2.7.11.24]
101151250  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
101135686  ALOX5; polyunsaturated fatty acid 5-lipoxygenase [KO:K00461] [EC:1.13.11.34]
101130490  ALOX15; polyunsaturated fatty acid lipoxygenase ALOX15 isoform X1 [KO:K00460] [EC:1.13.11.33]
101150765  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101147735  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101133211  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101146122  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101124273  DUSP8; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101137316  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
134758532  dual specificity protein phosphatase 7-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
115933338  dual specificity protein phosphatase 7-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101148130  ANO6; anoctamin-6 isoform X1 [KO:K19500]
101130924  ANO3; anoctamin-3 isoform X4 [KO:K19498]
101144912  ANO4; anoctamin-4 isoform X1 [KO:K19499]
101124774  ANO5; anoctamin-5 isoform X1 [KO:K19480]
101126127  ANO7; anoctamin-7 isoform X1 [KO:K19501]
101135692  ANO9; anoctamin-9 isoform X1 [KO:K19503]
129528795  BSG; basigin isoform X1 [KO:K06535]
101146778  XKR8; XK-related protein 8 [KO:K26813]
101149060  XKR9; XK-related protein 9 isoform X3 [KO:K26814]
101148193  XKR7; XK-related protein 7 [KO:K26811]
101154607  XKR4; XK-related protein 4 [KO:K26811]
115930097  XKR6; XK-related protein 6 [KO:K26811]
101126969  ATP8A1; phospholipid-transporting ATPase IA isoform X1 [KO:K14802] [EC:7.6.2.1]
101127464  ATP8A2; phospholipid-transporting ATPase IB isoform X1 [KO:K14802] [EC:7.6.2.1]
101130545  ATP11C; phospholipid-transporting ATPase IG isoform X5 [KO:K26934] [EC:7.6.2.1]
101135145  ATP11A; phospholipid-transporting ATPase IH isoform X1 [KO:K26934] [EC:7.6.2.1]
101139526  ATP11B; phospholipid-transporting ATPase IF isoform X1 [KO:K26934] [EC:7.6.2.1]
101150105  TMEM30A; cell cycle control protein 50A [KO:K26935]
101133009  TMEM30B; cell cycle control protein 50B [KO:K26935]
101137681  LOW QUALITY PROTEIN: cell cycle control protein 50C [KO:K26935]
109024645  LOW QUALITY PROTEIN: cell cycle control protein 50B [KO:K26935]
101149936  PROS1; vitamin K-dependent protein S [KO:K03908]
101147670  LOW QUALITY PROTEIN: vitamin K-dependent protein S-like [KO:K03908]
101148851  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
101149719  ITGB3; integrin beta-3 isoform X4 [KO:K06493]
101127698  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
101128109  AXL; tyrosine-protein kinase receptor UFO isoform X1 [KO:K05115] [EC:2.7.10.1]
129527103  TYRO3; tyrosine-protein kinase receptor TYRO3 [KO:K05116] [EC:2.7.10.1]
101140934  ADGRB1; adhesion G protein-coupled receptor B1 isoform X1 [KO:K04596]
101128100  TIMD4; T-cell immunoglobulin and mucin domain-containing protein 4 [KO:K26936]
101127501  HAVCR1; hepatitis A virus cellular receptor 1 isoform X1 [KO:K20413]
101128469  HAVCR2; hepatitis A virus cellular receptor 2 [KO:K20414]
101150956  AGER; advanced glycosylation end product-specific receptor isoform X2 [KO:K19722]
101127095  STAB1; stabilin-1 isoform X2 [KO:K19020]
101130203  STAB2; stabilin-2 [KO:K19013]
101128620  PTK2; focal adhesion kinase 1 isoform X14 [KO:K05725] [EC:2.7.10.2]
101132653  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X3 [KO:K05726]
101127403  CRKL; crk-like protein [KO:K04438]
101154185  CRK; adapter molecule crk isoform X1 [KO:K04438]
101136141  ELMO1; engulfment and cell motility protein 1 isoform X2 [KO:K12366]
101127665  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
101135430  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X3 [KO:K04392]
101153981  ADAM9; disintegrin and metalloproteinase domain-containing protein 9 [KO:K06834] [EC:3.4.24.-]
101149397  CALR; calreticulin [KO:K08057]
129533651  C1QA; complement C1q subcomponent subunit A [KO:K03986]
101124764  C1QB; complement C1q subcomponent subunit B [KO:K03987]
101141927  C1QC; complement C1q subcomponent subunit C isoform X1 [KO:K03988]
129526061  LRP1; prolow-density lipoprotein receptor-related protein 1 [KO:K04550]
101153350  MEGF10; multiple epidermal growth factor-like domains protein 10 isoform X1 [KO:K24068]
101130103  MEGF11; multiple epidermal growth factor-like domains protein 11 isoform X1 [KO:K24068]
101132405  SCARF1; scavenger receptor class F member 1 isoform X1 [KO:K24318]
101152471  GULP1; PTB domain-containing engulfment adapter protein 1 isoform X4 [KO:K23285]
101130579  RAB17; ras-related protein Rab-17 isoform X1 [KO:K07909]
101144180  RAB5A; ras-related protein Rab-5A [KO:K07887]
101136077  RAB5B; ras-related protein Rab-5B isoform X1 [KO:K07888]
101126272  RAB5C; ras-related protein Rab-5C isoform X2 [KO:K07889]
101147290  TGFBRAP1; transforming growth factor-beta receptor-associated protein 1 isoform X2 [KO:K20177]
101126500  VPS8; vacuolar protein sorting-associated protein 8 homolog [KO:K20178]
101134413  VPS11; vacuolar protein sorting-associated protein 11 homolog isoform X1 [KO:K20179]
101145691  VPS16; vacuolar protein sorting-associated protein 16 homolog [KO:K20180]
101154056  VPS18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
101129749  VPS33A; vacuolar protein sorting-associated protein 33A isoform X1 [KO:K20182]
101127537  RAB14; ras-related protein Rab-14 [KO:K07881]
101138184  VPS39; vam6/Vps39-like protein isoform X2 [KO:K20183]
101144476  VPS41; vacuolar protein sorting-associated protein 41 homolog isoform X1 [KO:K20184]
101124687  RAB7A; ras-related protein Rab-7a [KO:K07897]
101139328  RAB7B; ras-related protein Rab-7b [KO:K07898]
101141555  SLC66A1; lysosomal amino acid transporter 1 homolog isoform X1 [KO:K23678]
101133624  ARG2; arginase-2, mitochondrial [KO:K01476] [EC:3.5.3.1]
101146743  ARG1; arginase-1 [KO:K01476] [EC:3.5.3.1]
101128406  ODC1; ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
101125247  CH25H; cholesterol 25-hydroxylase [KO:K10223] [EC:1.14.99.38]
101126697  NR1H3; oxysterols receptor LXR-alpha isoform X1 [KO:K08536]
101132204  NR1H2; oxysterols receptor LXR-beta isoform X1 [KO:K08535]
101128037  CPT1A; carnitine O-palmitoyltransferase 1, liver isoform [KO:K08765] [EC:2.3.1.21]
101141306  CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform isoform X1 [KO:K19523] [EC:2.3.1.21]
101147238  CPT1C; palmitoyl thioesterase CPT1C isoform X2 [KO:K19524] [EC:2.3.1.21]
101131106  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
101147879  SIRT1; NAD-dependent protein deacetylase sirtuin-1 isoform X3 [KO:K11411] [EC:2.3.1.286]
101150155  PBX1; pre-B-cell leukemia transcription factor 1 isoform X2 [KO:K09355]
101130439  IL10; interleukin-10 [KO:K05443]
101125617  LIPA; lysosomal acid lipase/cholesteryl ester hydrolase [KO:K01052] [EC:3.1.1.13]
101141752  PPARD; peroxisome proliferator-activated receptor delta isoform X1 [KO:K04504]
101145851  SLC2A1; solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299]
101135111  SLC16A1; monocarboxylate transporter 1 [KO:K08179]
101132422  SGK1; serine/threonine-protein kinase Sgk1 isoform X3 [KO:K13302] [EC:2.7.11.1]
101131909  CD47; leukocyte surface antigen CD47 isoform X2 [KO:K06266]
109025466  CD24; signal transducer CD24 isoform X1 [KO:K06469]
101141492  PECAM1; platelet endothelial cell adhesion molecule isoform X1 [KO:K06471]
134757701  SIGLEC10; sialic acid-binding Ig-like lectin 10 isoform X1 [KO:K06749]
101135429  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X3 [KO:K06551]
101129558  signal-regulatory protein gamma [KO:K06551]
101130144  signal-regulatory protein beta-1 [KO:K06551]
129523460  SIRPB1; signal-regulatory protein beta-1 [KO:K06551]
101144977  LOW QUALITY PROTEIN: tyrosine-protein phosphatase non-receptor type substrate 1-like [KO:K06551]
101137792  PTPN6; tyrosine-protein phosphatase non-receptor type 6 isoform X2 [KO:K05697] [EC:3.1.3.48]
101133729  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
Compound
C00002  ATP
C00003  NAD+
C00019  S-Adenosyl-L-methionine
C00031  D-Glucose
C00062  L-Arginine
C00073  L-Methionine
C00075  UTP
C00077  L-Ornithine
C00134  Putrescine
C00162  Fatty acid
C00186  (S)-Lactate
C00187  Cholesterol
C00584  Prostaglandin E2
C02530  Cholesterol ester
C02737  Phosphatidylserine
C04230  1-Acyl-sn-glycero-3-phosphocholine
C06124  Sphingosine 1-phosphate
C06314  Lipoxin A4
C15519  25-Hydroxycholesterol
C15610  Cholest-5-ene-3beta,26-diol
C18178  Resolvin D1
Reference
PMID:31822793
  Authors
Doran AC, Yurdagul A Jr, Tabas I
  Title
Efferocytosis in health and disease.
  Journal
Nat Rev Immunol 20:254-267 (2020)
DOI:10.1038/s41577-019-0240-6
Reference
PMID:36028471
  Authors
Zhang J, Ding W, Zhao M, Liu J, Xu Y, Wan J, Wang M
  Title
Mechanisms of efferocytosis in determining inflammation resolution: Therapeutic potential and the association with cardiovascular disease.
  Journal
Br J Pharmacol 179:5151-5171 (2022)
DOI:10.1111/bph.15939
Reference
PMID:30165442
  Authors
Kawano M, Nagata S
  Title
Efferocytosis and autoimmune disease.
  Journal
Int Immunol 30:551-558 (2018)
DOI:10.1093/intimm/dxy055
Reference
PMID:35650427
  Authors
Mehrotra P, Ravichandran KS
  Title
Drugging the efferocytosis process: concepts and opportunities.
  Journal
Nat Rev Drug Discov 21:601-620 (2022)
DOI:10.1038/s41573-022-00470-y
Reference
PMID:28496201
  Authors
Park SY, Kim IS
  Title
Engulfment signals and the phagocytic machinery for apoptotic cell clearance.
  Journal
Exp Mol Med 49:e331 (2017)
DOI:10.1038/emm.2017.52
Reference
PMID:28137963
  Authors
Kojima Y, Weissman IL, Leeper NJ
  Title
The Role of Efferocytosis in Atherosclerosis.
  Journal
Circulation 135:476-489 (2017)
DOI:10.1161/CIRCULATIONAHA.116.025684
Related
pathway
ggo00010  Glycolysis / Gluconeogenesis
ggo04140  Autophagy - animal
ggo04145  Phagosome
KO pathway
ko04148   
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