KEGG   PATHWAY: hsyr03420
Entry
hsyr03420                   Pathway                                
Name
Nucleotide excision repair - Hibiscus syriacus (Rose-of-Sharon)
Description
Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar.
Class
Genetic Information Processing; Replication and repair
Pathway map
hsyr03420  Nucleotide excision repair
hsyr03420

Other DBs
GO: 0006289
Organism
Hibiscus syriacus (Rose-of-Sharon) [GN:hsyr]
Gene
120198424  DNA polymerase I A, chloroplastic/mitochondrial-like [KO:K02335] [EC:2.7.7.7]
120160446  DNA polymerase I A, chloroplastic/mitochondrial-like [KO:K02335] [EC:2.7.7.7]
120179762  RING-box protein 1a-like [KO:K03868] [EC:2.3.2.32]
120114829  RING-box protein 1a [KO:K03868] [EC:2.3.2.32]
120149883  RING-box protein 1a-like [KO:K03868] [EC:2.3.2.32]
120167838  RING-box protein 1a-like isoform X1 [KO:K03868] [EC:2.3.2.32]
120218694  RING-box protein 1a-like [KO:K03868] [EC:2.3.2.32]
120156633  RING-box protein 1a-like [KO:K03868] [EC:2.3.2.32]
120193390  RING-box protein 1a-like [KO:K03868] [EC:2.3.2.32]
120211863  RING-box protein 1a-like [KO:K03868] [EC:2.3.2.32]
120119401  cullin-4-like [KO:K10609]
120169965  cullin-4-like [KO:K10609]
120170869  cullin-4-like [KO:K10609]
120172955  cullin-4-like [KO:K10609]
120210354  cullin-4-like [KO:K10609]
120149435  LOW QUALITY PROTEIN: DNA damage-binding protein 1a-like [KO:K10610]
120143373  LOW QUALITY PROTEIN: protein DAMAGED DNA-BINDING 2 [KO:K10140]
120161027  DNA repair protein RAD4 isoform X1 [KO:K10838]
120162974  ubiquitin receptor RAD23c-like [KO:K10839]
120179714  ubiquitin receptor RAD23b-like isoform X1 [KO:K10839]
120181184  ubiquitin receptor RAD23c-like isoform X1 [KO:K10839]
120217760  ubiquitin receptor RAD23b-like [KO:K10839]
120217819  ubiquitin receptor RAD23b-like [KO:K10839]
120203789  ubiquitin receptor RAD23c-like isoform X1 [KO:K10839]
120187549  ubiquitin receptor RAD23c-like isoform X1 [KO:K10839]
120193352  ubiquitin receptor RAD23c-like isoform X1 [KO:K10839]
120210307  ubiquitin receptor RAD23b-like isoform X1 [KO:K10839]
120190963  WD repeat-containing protein ATCSA-1-like [KO:K10570]
120191384  WD repeat-containing protein ATCSA-1-like [KO:K10570]
120153587  LOW QUALITY PROTEIN: protein CHROMATIN REMODELING 8-like [KO:K10841]
120121004  LOW QUALITY PROTEIN: protein CHROMATIN REMODELING 8-like [KO:K10841]
120200540  UV-stimulated scaffold protein A homolog [KO:K23720]
120153501  UV-stimulated scaffold protein A homolog [KO:K23720]
120121154  UV-stimulated scaffold protein A homolog [KO:K23720]
120216257  LOW QUALITY PROTEIN: DNA-directed RNA polymerase II subunit RPB1-like [KO:K03006] [EC:2.7.7.6]
120141629  DNA-directed RNA polymerase II subunit RPB1-like [KO:K03006] [EC:2.7.7.6]
120217215  DNA-directed RNA polymerase II subunit RPB2 [KO:K03010] [EC:2.7.7.6]
120119357  DNA-directed RNA polymerase II subunit RPB2-like [KO:K03010] [EC:2.7.7.6]
120117027  DNA-directed RNA polymerases II, IV and V subunit 3-like [KO:K03011]
120142709  DNA-directed RNA polymerases II, IV and V subunit 3 [KO:K03011]
120146967  DNA-directed RNA polymerases IV and V subunit 4-like isoform X1 [KO:K03012]
120212598  DNA-directed RNA polymerase II subunit 4-like [KO:K03012]
120119155  DNA-directed RNA polymerases IV and V subunit 4-like isoform X1 [KO:K03012]
120185624  DNA-directed RNA polymerase II subunit 4-like [KO:K03012]
120159744  DNA-directed RNA polymerase II subunit 4 [KO:K03012]
120146602  DNA-directed RNA polymerase V subunit 5A-like isoform X1 [KO:K03013]
120134000  DNA-directed RNA polymerases II and IV subunit 5A-like [KO:K03013]
120189876  DNA-directed RNA polymerases II and IV subunit 5A-like [KO:K03013]
120208919  DNA-directed RNA polymerase V subunit 5A-like [KO:K03013]
120144513  DNA-directed RNA polymerases II and IV subunit 5A [KO:K03013]
120210607  DNA-directed RNA polymerases II and IV subunit 5A-like [KO:K03013]
120118684  DNA-directed RNA polymerases II, IV and V subunit 6A-like [KO:K03014]
120167004  DNA-directed RNA polymerases II, IV and V subunit 6A-like [KO:K03014]
120172177  DNA-directed RNA polymerases II, IV and V subunit 6A-like [KO:K03014]
120139916  DNA-directed RNA polymerases II, IV and V subunit 6A-like [KO:K03014]
120140403  DNA-directed RNA polymerases II, IV and V subunit 6A-like [KO:K03014]
120165777  DNA-directed RNA polymerase II subunit RPB7-like [KO:K03015]
120136628  DNA-directed RNA polymerase II subunit RPB7-like [KO:K03015]
120170266  DNA-directed RNA polymerase II subunit RPB7-like [KO:K03015]
120189261  DNA-directed RNA polymerase II subunit RPB7 [KO:K03015]
120219412  DNA-directed RNA polymerases II, IV and V subunit 8B-like [KO:K03016]
120143465  DNA-directed RNA polymerases II, IV and V subunit 8B-like [KO:K03016]
120176070  DNA-directed RNA polymerases II, IV and V subunit 8B-like [KO:K03016]
120127893  DNA-directed RNA polymerases II, IV and V subunit 8B-like [KO:K03016]
120119968  DNA-directed RNA polymerases II, IV and V subunit 9A-like [KO:K03017]
120123833  DNA-directed RNA polymerases II, IV and V subunit 9A [KO:K03017]
120176066  DNA-directed RNA polymerases II, IV and V subunit 9A [KO:K03017]
120127792  DNA-directed RNA polymerases II, IV and V subunit 9A-like [KO:K03017]
120216094  DNA-directed RNA polymerases I, II, and III subunit RPABC5 [KO:K03007]
120167111  DNA-directed RNA polymerase subunit 10-like protein [KO:K03007]
120202000  DNA-directed RNA polymerases I, II, and III subunit RPABC5 [KO:K03007]
120146915  DNA-directed RNA polymerases II, IV and V subunit 12-like [KO:K03009]
120217173  DNA-directed RNA polymerases II, IV and V subunit 12 [KO:K03009]
120204096  DNA-directed RNA polymerases II, IV and V subunit 12-like [KO:K03009]
120165318  DNA-directed RNA polymerases II, IV and V subunit 11 [KO:K03008]
120136704  DNA-directed RNA polymerases II, IV and V subunit 11 [KO:K03008]
120188609  DNA-directed RNA polymerases II, IV and V subunit 11 [KO:K03008]
120199799  cyclin-dependent kinase D-1-like [KO:K02202] [EC:2.7.11.22 2.7.11.23]
120135063  cyclin-dependent kinase D-3-like [KO:K02202] [EC:2.7.11.22 2.7.11.23]
120204594  cyclin-dependent kinase D-3-like isoform X1 [KO:K02202] [EC:2.7.11.22 2.7.11.23]
120210668  cyclin-dependent kinase D-3-like isoform X1 [KO:K02202] [EC:2.7.11.22 2.7.11.23]
120178790  cyclin-dependent kinase D-1-like isoform X1 [KO:K02202] [EC:2.7.11.22 2.7.11.23]
120130748  uncharacterized protein LOC120130748 [KO:K10842]
120120861  uncharacterized protein LOC120120861 [KO:K10842]
120160078  uncharacterized protein LOC120160078 [KO:K10842]
120163315  cyclin-H1-1-like [KO:K06634]
120167193  LOW QUALITY PROTEIN: cyclin-H1-1-like [KO:K06634]
120163573  general transcription and DNA repair factor IIH helicase subunit XPB1 [KO:K10843] [EC:5.6.2.4]
120185942  general transcription and DNA repair factor IIH helicase subunit XPB1-like [KO:K10843] [EC:5.6.2.4]
120155132  general transcription and DNA repair factor IIH subunit TFB5 [KO:K10845]
120129694  general transcription and DNA repair factor IIH subunit TFB1-1-like isoform X1 [KO:K03141]
120116393  general transcription and DNA repair factor IIH subunit TFB1-1-like isoform X1 [KO:K03141]
120168015  general transcription factor IIH subunit 2-like [KO:K03142]
120155535  general transcription factor IIH subunit 2-like [KO:K03142]
120130042  general transcription and DNA repair factor IIH subunit TFB4-like isoform X1 [KO:K03143]
120216939  LOW QUALITY PROTEIN: general transcription and DNA repair factor IIH subunit TFB4-like [KO:K03143]
120214669  general transcription and DNA repair factor IIH subunit TFB2-like [KO:K03144]
120206052  general transcription and DNA repair factor IIH subunit TFB2-like [KO:K03144]
120147502  DNA repair protein UVH3-like [KO:K10846]
120121740  LOW QUALITY PROTEIN: DNA repair protein UVH3-like [KO:K10846]
120162325  replication protein A 70 kDa DNA-binding subunit A-like [KO:K07466]
120115803  replication protein A 70 kDa DNA-binding subunit B-like [KO:K07466]
120164764  replication protein A 70 kDa DNA-binding subunit A-like [KO:K07466]
120166293  replication protein A 70 kDa DNA-binding subunit A-like [KO:K07466]
120174322  replication protein A 70 kDa DNA-binding subunit A-like [KO:K07466]
120158646  replication protein A 70 kDa DNA-binding subunit B-like [KO:K07466]
120192582  replication protein A 70 kDa DNA-binding subunit A-like isoform X1 [KO:K07466]
120179086  replication protein A 32 kDa subunit B-like [KO:K10739]
120132079  replication protein A 32 kDa subunit A-like [KO:K10739]
120132289  replication protein A 32 kDa subunit B-like isoform X1 [KO:K10739]
120132308  replication protein A 32 kDa subunit B-like isoform X1 [KO:K10739]
120182152  replication protein A 32 kDa subunit B-like [KO:K10739]
120157040  replication protein A 32 kDa subunit B-like [KO:K10739]
120183892  replication protein A 14 kDa subunit B-like [KO:K10740]
120202702  replication protein A 14 kDa subunit B-like [KO:K10740]
120173191  replication protein A 14 kDa subunit B-like [KO:K10740]
120158111  replication protein A 14 kDa subunit B-like [KO:K10740]
120164381  DNA repair endonuclease UVH1-like [KO:K10848] [EC:3.1.-.-]
120128832  DNA repair endonuclease UVH1-like [KO:K10848] [EC:3.1.-.-]
120124689  DNA excision repair protein ERCC-1 isoform X1 [KO:K10849]
120123266  LOW QUALITY PROTEIN: DNA polymerase delta catalytic subunit-like [KO:K02327] [EC:2.7.7.7]
120169661  DNA polymerase delta small subunit-like [KO:K02328]
120177759  DNA polymerase delta small subunit-like [KO:K02328]
120219437  uncharacterized protein LOC120219437 [KO:K03504]
120143972  uncharacterized protein LOC120143972 [KO:K03504]
120113702  DNA polymerase delta subunit 4-like [KO:K03505]
120153976  uncharacterized protein LOC120153976 [KO:K03505]
120170122  DNA polymerase delta subunit 4-like [KO:K03505]
120170130  DNA polymerase delta subunit 4-like [KO:K03505]
120121461  uncharacterized protein LOC120121461 [KO:K03505]
120123442  DNA polymerase delta subunit 4-like isoform X1 [KO:K03505]
120129146  uncharacterized protein LOC120129146 isoform X1 [KO:K03505]
120148367  LOW QUALITY PROTEIN: DNA polymerase epsilon catalytic subunit A-like [KO:K02324] [EC:2.7.7.7]
120156933  LOW QUALITY PROTEIN: DNA polymerase epsilon catalytic subunit A-like [KO:K02324] [EC:2.7.7.7]
120219071  DNA polymerase epsilon subunit B-like [KO:K02325] [EC:2.7.7.7]
120131929  DNA polymerase epsilon subunit 3-like [KO:K02326] [EC:2.7.7.7]
120199312  proliferating cell nuclear antigen-like [KO:K04802]
120167898  proliferating cell nuclear antigen [KO:K04802]
120169677  proliferating cell nuclear antigen-like [KO:K04802]
120170420  proliferating cell nuclear antigen-like [KO:K04802]
120171552  proliferating cell nuclear antigen-like [KO:K04802]
120171821  proliferating cell nuclear antigen-like [KO:K04802]
120141994  proliferating cell nuclear antigen-like [KO:K04802]
120142191  proliferating cell nuclear antigen-like [KO:K04802]
120158512  proliferating cell nuclear antigen-like [KO:K04802]
120143105  proliferating cell nuclear antigen-like [KO:K04802]
120160021  proliferating cell nuclear antigen-like [KO:K04802]
120194275  proliferating cell nuclear antigen 2-like [KO:K04802]
120161675  proliferating cell nuclear antigen-like [KO:K04802]
120195781  LOW QUALITY PROTEIN: replication factor C subunit 1-like [KO:K10754]
120204352  LOW QUALITY PROTEIN: replication factor C subunit 1-like [KO:K10754]
120181561  replication factor C subunit 4-like [KO:K10755]
120199325  replication factor C subunit 2-like [KO:K10755]
120117412  replication factor C subunit 2 [KO:K10755]
120169112  replication factor C subunit 4-like [KO:K10755]
120143126  replication factor C subunit 2-like isoform X1 [KO:K10755]
120130054  replication factor C subunit 3-like [KO:K10756]
120163246  replication factor C subunit 3-like [KO:K10756]
120180390  replication factor C subunit 5-like [KO:K10756]
120183776  uncharacterized protein LOC120183776 [KO:K10756]
120200748  replication factor C subunit 3-like [KO:K10756]
120153033  uncharacterized protein LOC120153033 [KO:K10756]
120121399  replication factor C subunit 3-like [KO:K10756]
120154352  replication factor C subunit 5-like [KO:K10756]
120123631  replication factor C subunit 3-like [KO:K10756]
120141786  uncharacterized protein LOC120141786 [KO:K10756]
120129117  replication factor C subunit 3 isoform X1 [KO:K10756]
120195002  replication factor C subunit 3-like [KO:K10756]
120113512  DNA ligase 1-like [KO:K10747] [EC:6.5.1.1 6.5.1.6 6.5.1.7]
120206322  DNA ligase 1-like [KO:K10747] [EC:6.5.1.1 6.5.1.6 6.5.1.7]
Reference
PMID:11436314
  Authors
Sugasawa K.
  Title
[Molecular mechanism of mammalian nucleotide excision repair]
  Journal
Tanpakushitsu Kakusan Koso 46:893-901 (2001)
Reference
PMID:11436316
  Authors
Nakatsu Y.
  Title
[Transcription-coupled repair and Cockayne syndrome]
  Journal
Tanpakushitsu Kakusan Koso 46:908-15 (2001)
Reference
PMID:11436323
  Authors
Nakagawa N, Masui R, Kuramitsu S.
  Title
[Structure and function of DNA repair enzyme UvrB from Thermus thermophilus HB8]
  Journal
Tanpakushitsu Kakusan Koso 46:968-75 (2001)
Reference
PMID:17276014
  Authors
Kraemer KH, Patronas NJ, Schiffmann R, Brooks BP, Tamura D, DiGiovanna JJ.
  Title
Xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome: a complex genotype-phenotype relationship.
  Journal
Neuroscience 145:1388-96 (2007)
DOI:10.1016/j.neuroscience.2006.12.020
Reference
PMID:17884153
  Authors
Saldivar JS, Wu X, Follen M, Gershenson D.
  Title
Nucleotide excision repair pathway review I: implications in ovarian cancer and platinum sensitivity.
  Journal
Gynecol Oncol 107:S56-71 (2007)
DOI:10.1016/j.ygyno.2007.07.043
Reference
PMID:16922398
  Authors
Sugasawa K.
  Title
[DNA repair pathways involving Cul4A ubiquitin ligases]
  Journal
Tanpakushitsu Kakusan Koso 51:1339-44 (2006)
Reference
PMID:18018633
  Authors
Ito S, Ando D, Tanaka K.
  Title
[Cross-talk between DNA repair and transcription: molecular mechanism and disorders]
  Journal
Tanpakushitsu Kakusan Koso 52:1823-31 (2007)
Related
pathway
hsyr03020  RNA polymerase
hsyr04120  Ubiquitin mediated proteolysis
KO pathway
ko03420   
LinkDB

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