Entry Name Axon guidance - Monodelphis domestica (gray short-tailed opossum)
Description Axon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are read by growth cone receptors, and signal transduction pathways downstream of these receptors converge onto the Rho GTPases to elicit changes in cytoskeletal organization that determine which way the growth cone will turn.
Class Organismal Systems; Development and regenerationBRITE hierarchy
Pathway map Ortholog table Other DBs Organism Monodelphis domestica (gray short-tailed opossum) [GN:
mdo ]
Gene 100019524 TRPC1; transient receptor potential cation channel subfamily C member 1 [KO:K04964 ]
100016978 TRPC3; transient receptor potential cation channel subfamily C member 3 [KO:K04966 ]
100021320 TRPC4; transient receptor potential cation channel subfamily C member 4 [KO:K04967 ]
100011660 TRPC6; transient receptor potential cation channel subfamily C member 6 [KO:K04969 ]
100033302 PPP3R1; protein phosphatase 3 regulatory subunit B, alpha [KO:K06268 ]
100026992 RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392 ]
100017517 RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [KO:K07860 ]
100029873 RAC3; ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) [KO:K07861 ]
100033154 LRIG2; leucine rich repeats and immunoglobulin like domains 2 [KO:K24609 ]
554197 NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828 ]
100029727 SEMA7A; semaphorin 7A (John Milton Hagen blood group) [KO:K06529 ]
100617478 BOC; BOC cell adhesion associated, oncogene regulated [KO:K20020 ]
100019317 PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649 ]
100032726 PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649 ]
100616957 PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649 ]
Compound Reference Authors Guan KL, Rao Y.
Title Signalling mechanisms mediating neuronal responses to guidance cues.
Journal Reference Authors Govek EE, Newey SE, Van Aelst L.
Title The role of the Rho GTPases in neuronal development.
Journal Reference Authors Huber AB, Kolodkin AL, Ginty DD, Cloutier JF.
Title Signaling at the growth cone: ligand-receptor complexes and the control of axon growth and guidance.
Journal Reference Authors Negishi M, Oinuma I, Katoh H.
Title Plexins: axon guidance and signal transduction.
Journal Reference Authors Huot J.
Title Ephrin signaling in axon guidance.
Journal Reference Authors Patel BN, Van Vactor DL.
Title Axon guidance: the cytoplasmic tail.
Journal Reference Authors Yu TW, Bargmann CI.
Title Dynamic regulation of axon guidance.
Journal Reference Authors Dickson BJ.
Title Molecular mechanisms of axon guidance.
Journal Reference Authors Barallobre MJ, Pascual M, Del Rio JA, Soriano E.
Title The Netrin family of guidance factors: emphasis on Netrin-1 signalling.
Journal Reference Authors Sabatier C, Plump AS, Le Ma, Brose K, Tamada A, Murakami F, Lee EY, Tessier-Lavigne M.
Title The divergent Robo family protein rig-1/Robo3 is a negative regulator of slit responsiveness required for midline crossing by commissural axons.
Journal Reference Authors Fujita Y, Yamashita T
Title Axon growth inhibition by RhoA/ROCK in the central nervous system.
Journal Reference Authors Yamashita T, Mueller BK, Hata K
Title Neogenin and repulsive guidance molecule signaling in the central nervous system.
Journal Reference Authors van Erp S, van den Heuvel DMA, Fujita Y, Robinson RA, Hellemons AJCGM, Adolfs Y, Van Battum EY, Blokhuis AM, Kuijpers M, Demmers JAA, Hedman H, Hoogenraad CC, Siebold C, Yamashita T, Pasterkamp RJ
Title Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases.
Journal Related mdo04060 Cytokine-cytokine receptor interaction
mdo04810 Regulation of actin cytoskeleton
KO pathway LinkDB All DBs
