KEGG   PATHWAY: mpah04714
Entry
mpah04714                   Pathway                                
Name
Thermogenesis - Mus pahari (shrew mouse)
Description
Thermogenesis is essential for warm-blooded animals, ensuring normal cellular and physiological function under conditions of environmental challenge. Thermogenesis in brown and beige adipose tissue is mainly controlled by norepinephrine, which is released from sympathetic nervous system in response to cold or dietary stimuli. The mitochondrial uncoupling protein 1 (UCP1) is responsible for the process whereby chemical energy is converted into heat in these adipocytes. Activation of these adipocytes leads to an increase in calorie consumption and is expected to improve overweight conditions, providing a potential strategy for treating obesity and its related metabolic disorders.
Class
Organismal Systems; Environmental adaptation
Pathway map
mpah04714  Thermogenesis
mpah04714

Other DBs
GO: 1990845
Organism
Mus pahari (shrew mouse) [GN:mpah]
Gene
110337061  Adrb3; beta-3 adrenergic receptor [KO:K04143]
110317699  guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
110317700  neuroendocrine secretory protein 55 [KO:K04632]
110330584  Adcy1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
110328764  Adcy2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
110324646  Adcy3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
110325439  Adcy4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
110329393  Adcy5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
110334500  Adcy6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
110337453  Adcy7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
110334612  Adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
110329624  Adcy9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
110321722  Adcy10; adenylate cyclase type 10 isoform X1 [KO:K11265] [EC:4.6.1.1]
110337220  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
110320995  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
110322391  Creb1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
110320678  Creb3l4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
110316152  Creb3l2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
110326077  Creb3l3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
110338975  Creb3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
110318364  Creb3l1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
110315994  Creb5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
110323056  Prdm16; PR domain zinc finger protein 16 [KO:K22410] [EC:2.1.1.367]
110333340  Znf516; zinc finger protein 516 isoform X1 [KO:K22411]
110322979  Kdm1a; lysine-specific histone demethylase 1A isoform X1 [KO:K11450] [EC:1.14.99.66]
110337649  Ucp1; mitochondrial brown fat uncoupling protein 1 [KO:K08769]
110333384  Kdm3b; lysine-specific demethylase 3B isoform X1 [KO:K15601] [EC:1.14.11.65]
110314829  Kdm3a; lysine-specific demethylase 3A [KO:K15601] [EC:1.14.11.65]
110327497  Smarca4; transcription activator BRG1 isoform X1 [KO:K11647] [EC:5.6.2.-]
110336025  Smarca2; probable global transcription activator SNF2L2 isoform X1 [KO:K11647] [EC:5.6.2.-]
110326275  Smarcb1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 isoform X1 [KO:K11648]
110327067  Smarcc2; SWI/SNF complex subunit SMARCC2 isoform X1 [KO:K11649]
110327166  Smarcc1; SWI/SNF complex subunit SMARCC1 [KO:K11649]
110317300  Smarcd3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 [KO:K11650]
110331326  Smarcd2; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 [KO:K11650]
110334820  Smarcd1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 isoform X1 [KO:K11650]
110331235  Smarce1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 isoform X1 [KO:K11651]
110321359  LOW QUALITY PROTEIN: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-like [KO:K11651]
110331106  Actg1; actin, cytoplasmic 2 [KO:K05692]
110313074  Actb; actin, cytoplasmic 1 [KO:K05692]
110319822  Actl6a; actin-like protein 6A [KO:K11340]
110313172  Actl6b; actin-like protein 6B [KO:K11652]
110337900  Arid1b; AT-rich interactive domain-containing protein 1B isoform X1 [KO:K11653]
110323575  Arid1a; AT-rich interactive domain-containing protein 1A isoform X1 [KO:K11653]
110318397  Dpf1; zinc finger protein neuro-d4 isoform X1 [KO:K22198]
110324350  Dpf3; zinc finger protein DPF3 isoform X1 [KO:K22198]
110317409  Pparg; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
110337870  Map3k5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
110331197  Map2k3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
110334495  Mapk11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
110337896  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
110337946  Mapk14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
110334829  Mapk12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
110330452  Ppargc1a; peroxisome proliferator-activated receptor gamma coactivator 1-alpha [KO:K07202]
110317821  Atf2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
110326146  Sirt6; NAD-dependent protein deacetylase sirtuin-6 isoform X1 [KO:K11416] [EC:2.3.1.286]
110338839  Fgf21; fibroblast growth factor 21 [KO:K22429]
110334778  Plin1; perilipin-1 [KO:K08768]
110336545  Lipe; hormone-sensitive lipase isoform X1 [KO:K07188] [EC:3.1.1.79]
110322307  Pnpla2; patatin-like phospholipase domain-containing protein 2 isoform X1 [KO:K16816] [EC:3.1.1.3]
110314947  Mgll; monoglyceride lipase isoform X1 [KO:K01054] [EC:3.1.1.23]
110328784  Prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
110323060  Prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
110320445  Prkab2; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
110312867  Prkab1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
110315523  Prkag2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
110322106  Prkag3; 5'-AMP-activated protein kinase subunit gamma-3 isoform X1 [KO:K07200]
110334696  Prkag1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
110319324  Gcg; glucagon [KO:K05259]
110323468  Bmp8a; bone morphogenetic protein 8A isoform X1 [KO:K16622]
110338745  Cnr1; cannabinoid receptor 1 isoform X1 [KO:K04277]
110323909  Nppa; natriuretic peptides A [KO:K12334]
110323786  Nppb; natriuretic peptides B isoform X1 [KO:K12335]
110320830  Npr1; atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
110313055  Prkg1; cGMP-dependent protein kinase 1 isoform X1 [KO:K07376] [EC:2.7.11.12]
110330505  Prkg2; cGMP-dependent protein kinase 2 [KO:K19477] [EC:2.7.11.12]
110330806  Klb; beta-klotho [KO:K22404]
110336809  Fgfr1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
110326472  Frs2; fibroblast growth factor receptor substrate 2 [KO:K12461]
110331195  Grb2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
110335780  Sos1; son of sevenless homolog 1 [KO:K03099]
110324314  Sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
110318967  GTPase HRas-like isoform X1 [KO:K02833]
110319567  Hras; GTPase HRas [KO:K02833]
110338480  GTPase HRas-like [KO:K02833]
110333346  GTPase HRas-like [KO:K02833]
110316221  Kras; GTPase KRas isoform X1 [KO:K07827]
110320340  Nras; GTPase NRas [KO:K07828]
110337879  ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
110313419  Rps6ka6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
110313426  Rps6ka3; ribosomal protein S6 kinase alpha-3 [KO:K04373] [EC:2.7.11.1]
110323590  Rps6ka1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
110318637  Tsc1; hamartin isoform X1 [KO:K07206]
110338315  Tsc2; tuberin isoform X1 [KO:K07207]
110316300  Rheb; GTP-binding protein Rheb [KO:K07208]
110331504  Rptor; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
110323363  Mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
110337886  Mlst8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
110324411  Akt1s1; proline-rich AKT1 substrate 1 isoform X1 [KO:K16184]
110315992  Rps6kb2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
110331448  Rps6kb1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
110322972  Rps6; 40S ribosomal protein S6 [KO:K02991]
110313469  Acsl4; long-chain-fatty-acid--CoA ligase 4 isoform X1 [KO:K01897] [EC:6.2.1.3]
110321273  Acsl3; long-chain-fatty-acid--CoA ligase 3 [KO:K01897] [EC:6.2.1.3]
110332134  Acsl6; long-chain-fatty-acid--CoA ligase 6 isoform X1 [KO:K01897] [EC:6.2.1.3]
110317632  Acsl5; long-chain-fatty-acid--CoA ligase 5 isoform X1 [KO:K01897] [EC:6.2.1.3]
110336203  Acsl1; long-chain-fatty-acid--CoA ligase 1 [KO:K01897] [EC:6.2.1.3]
36165356  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
36165352  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
36165337  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
36165334  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
36165335  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
36165330  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
36165329  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
110321204  Ndufs1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X1 [KO:K03934] [EC:7.1.1.2]
110321406  Ndufs2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial isoform X1 [KO:K03935] [EC:7.1.1.2]
110318572  Ndufs3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
110329019  Ndufs4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial isoform X1 [KO:K03937]
110323693  Ndufs5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
110329167  Ndufs6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
110326881  Ndufs7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
110327359  Ndufs8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
110316888  Ndufv1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial isoform X1 [KO:K03942] [EC:7.1.1.2]
110335628  Ndufv2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
110338235  Ndufv3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
110313685  Ndufa1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
110333203  Ndufa2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
110337062  Ndufa3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
110326234  Ndufa4l2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
110317006  Ndufa4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
110316386  Ndufa5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform X1 [KO:K03949]
110335084  Ndufa6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
110335777  Ndufa7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
110318772  Ndufa8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
110316704  Ndufa9; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
110321748  Ndufa10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
110328243  Ndufab1; acyl carrier protein, mitochondrial [KO:K03955]
110335867  Ndufa11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
110326784  Ndufa12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 isoform X1 [KO:K11352]
110336643  Ndufa13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
110324555  Ndufb1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
110317149  Ndufb2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
110322308  Ndufb3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
110326037  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3-like [KO:K03959]
110329959  Ndufb4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
110320492  Ndufb5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform X1 [KO:K03961]
110338914  Ndufb6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform X1 [KO:K03962]
110333533  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6-like [KO:K03962]
110337650  Ndufb7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
110331668  Ndufb8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial isoform X1 [KO:K03964]
110334970  Ndufb9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform X1 [KO:K03965]
110338345  Ndufb10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
110314570  Ndufb11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
110320722  Ndufc1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
110332408  NADH dehydrogenase [ubiquinone] 1 subunit C2 isoform X1 [KO:K03968]
110319018  Ndufaf1; complex I intermediate-associated protein 30, mitochondrial [KO:K18159]
110329129  Ndufaf2; mimitin, mitochondrial [KO:K18160]
110328266  Ndufaf3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 isoform X1 [KO:K09008]
110338942  Ndufaf4; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 [KO:K18161]
110318019  Ndufaf5; arginine-hydroxylase NDUFAF5, mitochondrial [KO:K18162] [EC:2.1.1.-]
110338848  Ndufaf6; NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 isoform X1 [KO:K18163]
110335706  Ndufaf7; protein arginine methyltransferase NDUFAF7, mitochondrial isoform X1 [KO:K18164]
110328746  Sdha; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
110323139  Sdhb; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial isoform X1 [KO:K00235] [EC:1.3.5.1]
110322178  Sdhc; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
110324197  succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial-like isoform X1 [KO:K00237]
110328112  Sdhd; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
110333870  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
36165327  CYTB; cytochrome b [KO:K00412]
110334724  cytochrome c1, heme protein, mitochondrial [KO:K00413]
110327331  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
110318232  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
110323660  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
110334014  cytochrome b-c1 complex subunit 7 [KO:K00417]
110332489  cytochrome b-c1 complex subunit 8 [KO:K00418]
110330872  cytochrome b-c1 complex subunit 9 [KO:K00419]
110326979  cytochrome b-c1 complex subunit 10 [KO:K00420]
36165346  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
36165343  COX2; cytochrome c oxidase subunit II [KO:K02261]
36165339  COX3; cytochrome c oxidase subunit III [KO:K02262]
110319299  cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X1 [KO:K02263]
110337554  cytochrome c oxidase subunit 4 isoform 1, mitochondrial isoform X1 [KO:K02263]
110328046  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
110322258  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
110313018  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
110325548  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
110332943  cytochrome c oxidase subunit 6B1 [KO:K02267]
110336798  cytochrome c oxidase subunit 6B2 isoform X1 [KO:K02267]
110335202  cytochrome c oxidase subunit 6C [KO:K02268]
110328169  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
110338814  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
110335711  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
110313979  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
110330226  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
110329085  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
110332346  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
110324960  cytochrome c oxidase subunit 8C, mitochondrial [KO:K02273]
110339130  cytochrome c oxidase subunit 8B, mitochondrial [KO:K02273]
110331676  protoheme IX farnesyltransferase, mitochondrial [KO:K02257] [EC:2.5.1.141]
110331720  cytochrome c oxidase assembly protein COX11, mitochondrial [KO:K02258]
110335220  cytochrome c oxidase assembly protein COX14 [KO:K18181]
110325962  cytochrome c oxidase assembly protein COX15 homolog [KO:K02259] [EC:1.17.99.9]
110324383  cytochrome c oxidase assembly protein COX16 homolog, mitochondrial isoform X1 [KO:K18182]
110330051  cytochrome c oxidase copper chaperone [KO:K02260]
110330672  mitochondrial inner membrane protein COX18 isoform X1 [KO:K17797]
110339171  cytochrome c oxidase assembly protein COX19 [KO:K18183]
110321759  cytochrome c oxidase protein 20 homolog isoform X1 [KO:K18184]
110331361  cytochrome c oxidase assembly factor 3 homolog, mitochondrial [KO:K18175]
110335264  cytochrome c oxidase assembly factor 4 homolog, mitochondrial [KO:K18177]
110322535  cytochrome c oxidase assembly factor 5 [KO:K18178]
110337690  cytochrome c oxidase assembly factor 6 homolog [KO:K18179]
110323636  cytochrome c oxidase assembly factor 7 [KO:K18180]
110333376  Atp5a1; ATP synthase subunit alpha, mitochondrial isoform X1 [KO:K02132]
110324657  ATP synthase subunit beta, mitochondrial-like [KO:K02133] [EC:7.1.2.2]
110326266  Atp5b; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
110333647  Atp5c1; ATP synthase subunit gamma, mitochondrial [KO:K02136]
110326670  Atp5d; ATP synthase subunit delta, mitochondrial isoform X1 [KO:K02134]
110319359  Atp5e; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
110329905  Atp5o; ATP synthase subunit O, mitochondrial [KO:K02137]
36165340  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
110320209  Atp5f1; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
110318554  Atp5g3; ATP synthase F(0) complex subunit C3, mitochondrial isoform X1 [KO:K02128]
110331847  Atp5g1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
110334965  Atp5g2; ATP synthase F(0) complex subunit C2, mitochondrial isoform X1 [KO:K02128]
110320480  ATP synthase subunit d, mitochondrial-like isoform X1 [KO:K02138]
110332361  Atp5h; ATP synthase subunit d, mitochondrial isoform X1 [KO:K02138]
110330930  Atp5i; ATP synthase subunit e, mitochondrial [KO:K02129]
110313222  Atp5j2; ATP synthase subunit f, mitochondrial [KO:K02130]
110318096  ATP synthase subunit f, mitochondrial-like [KO:K02130]
110329067  ATP synthase subunit f, mitochondrial-like [KO:K02130]
110329594  Atp5j; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
36165341  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
110327846  Atp5l; ATP synthase subunit g, mitochondrial [KO:K02140]
110323321  Cpt2; carnitine O-palmitoyltransferase 2, mitochondrial isoform X1 [KO:K08766] [EC:2.3.1.21]
110324769  Slc25a29; mitochondrial basic amino acids transporter [KO:K15109]
110327776  Slc25a20; mitochondrial carnitine/acylcarnitine carrier protein [KO:K15109]
110338994  Cpt1a; carnitine O-palmitoyltransferase 1, liver isoform [KO:K08765] [EC:2.3.1.21]
110334540  Cpt1b; carnitine O-palmitoyltransferase 1, muscle isoform [KO:K19523] [EC:2.3.1.21]
110319999  Cpt1c; carnitine O-palmitoyltransferase 1, brain isoform isoform X1 [KO:K19524] [EC:2.3.1.21]
Compound
C00002  ATP
C00004  NADH
C00008  ADP
C00010  CoA
C00024  Acetyl-CoA
C00040  Acyl-CoA
C00080  H+
C00116  Glycerol
C00162  Fatty acid
C00165  Diacylglycerol
C00318  L-Carnitine
C00422  Triacylglycerol
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00745  Nicotine
C00942  3',5'-Cyclic GMP
C00951  Estradiol-17beta
C01352  FADH2
C01885  1-Acylglycerol
C02301  O-Acylcarnitine
C02465  Triiodothyronine
C11695  Anandamide
C13856  2-Arachidonoylglycerol
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Nat Rev Mol Cell Biol 17:480-95 (2016)
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Nat Med 19:1252-63 (2013)
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Peripheral cannabinoid 1 receptor blockade activates brown adipose tissue and diminishes dyslipidemia and obesity.
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FASEB J 28:5361-75 (2014)
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Mol Nutr Food Res 60:18-42 (2016)
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  Title
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Trends Mol Med 21:571-9 (2015)
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Trends Endocrinol Metab 26:657-68 (2015)
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Nutr Res Rev 27:63-93 (2014)
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IUBMB Life 56:379-85 (2004)
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Positive and negative control of Ucp1 gene transcription and the role of beta-adrenergic signaling networks.
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Int J Obes (Lond) 34 Suppl 1:S28-33 (2010)
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Selective activation of mitogen-activated protein (MAP) kinase kinase 3 and p38alpha MAP kinase is essential for cyclic AMP-dependent UCP1 expression in adipocytes.
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Mol Cell Biol 25:5466-79 (2005)
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Nat Commun 7:11158 (2016)
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  Title
JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis.
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Nat Commun 6:7052 (2015)
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Mol Cell 57:235-46 (2015)
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Biochem Biophys Rep 10:32-38 (2017)
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Related
pathway
mpah00020  Citrate cycle (TCA cycle)
mpah00190  Oxidative phosphorylation
mpah04010  MAPK signaling pathway
mpah04022  cGMP-PKG signaling pathway
mpah04024  cAMP signaling pathway
mpah04150  mTOR signaling pathway
mpah04923  Regulation of lipolysis in adipocytes
KO pathway
ko04714   
LinkDB

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