Entry
Name
Thermogenesis - Mus pahari (shrew mouse)
Description
Thermogenesis is essential for warm-blooded animals, ensuring normal cellular and physiological function under conditions of environmental challenge. Thermogenesis in brown and beige adipose tissue is mainly controlled by norepinephrine, which is released from sympathetic nervous system in response to cold or dietary stimuli. The mitochondrial uncoupling protein 1 (UCP1) is responsible for the process whereby chemical energy is converted into heat in these adipocytes. Activation of these adipocytes leads to an increase in calorie consumption and is expected to improve overweight conditions, providing a potential strategy for treating obesity and its related metabolic disorders.
Class
Organismal Systems; Environmental adaptation
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Mus pahari (shrew mouse) [GN:
mpah ]
Gene
110317699 guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632 ]
110322391 Creb1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870 ]
110320678 Creb3l4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048 ]
110316152 Creb3l2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048 ]
110326077 Creb3l3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048 ]
110338975 Creb3; cyclic AMP-responsive element-binding protein 3 [KO:K09048 ]
110318364 Creb3l1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048 ]
110315994 Creb5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047 ]
110327497 Smarca4; transcription activator BRG1 isoform X1 [KO:K11647 ] [EC:5.6.2.-]
110336025 Smarca2; probable global transcription activator SNF2L2 isoform X1 [KO:K11647 ] [EC:5.6.2.-]
110326275 Smarcb1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 isoform X1 [KO:K11648 ]
110317300 Smarcd3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 [KO:K11650 ]
110331326 Smarcd2; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 [KO:K11650 ]
110334820 Smarcd1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 isoform X1 [KO:K11650 ]
110331235 Smarce1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 isoform X1 [KO:K11651 ]
110321359 LOW QUALITY PROTEIN: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-like [KO:K11651 ]
110337900 Arid1b; AT-rich interactive domain-containing protein 1B isoform X1 [KO:K11653 ]
110323575 Arid1a; AT-rich interactive domain-containing protein 1A isoform X1 [KO:K11653 ]
110317409 Pparg; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530 ]
110330452 Ppargc1a; peroxisome proliferator-activated receptor gamma coactivator 1-alpha [KO:K07202 ]
110317821 Atf2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450 ]
110320445 Prkab2; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199 ]
110312867 Prkab1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199 ]
110315523 Prkag2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200 ]
110322106 Prkag3; 5'-AMP-activated protein kinase subunit gamma-3 isoform X1 [KO:K07200 ]
110334696 Prkag1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200 ]
110331195 Grb2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364 ]
110331504 Rptor; regulatory-associated protein of mTOR isoform X1 [KO:K07204 ]
110337886 Mlst8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266 ]
110321204 Ndufs1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X1 [KO:K03934 ] [EC:7.1.1.2 ]
110321406 Ndufs2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial isoform X1 [KO:K03935 ] [EC:7.1.1.2 ]
110318572 Ndufs3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936 ] [EC:7.1.1.2 ]
110329019 Ndufs4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial isoform X1 [KO:K03937 ]
110323693 Ndufs5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938 ]
110329167 Ndufs6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939 ]
110326881 Ndufs7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940 ] [EC:7.1.1.2 ]
110327359 Ndufs8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941 ] [EC:7.1.1.2 ]
110316888 Ndufv1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial isoform X1 [KO:K03942 ] [EC:7.1.1.2 ]
110338235 Ndufv3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944 ]
110313685 Ndufa1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945 ]
110333203 Ndufa2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946 ]
110337062 Ndufa3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947 ]
110326234 Ndufa4l2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948 ]
110316386 Ndufa5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform X1 [KO:K03949 ]
110335084 Ndufa6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950 ]
110335777 Ndufa7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951 ]
110318772 Ndufa8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952 ]
110316704 Ndufa9; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953 ]
110321748 Ndufa10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954 ]
110335867 Ndufa11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956 ]
110326784 Ndufa12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 isoform X1 [KO:K11352 ]
110336643 Ndufa13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353 ]
110324555 Ndufb1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957 ]
110317149 Ndufb2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958 ]
110322308 Ndufb3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959 ]
110326037 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3-like [KO:K03959 ]
110329959 Ndufb4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960 ]
110320492 Ndufb5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform X1 [KO:K03961 ]
110338914 Ndufb6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform X1 [KO:K03962 ]
110333533 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6-like [KO:K03962 ]
110337650 Ndufb7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963 ]
110331668 Ndufb8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial isoform X1 [KO:K03964 ]
110334970 Ndufb9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform X1 [KO:K03965 ]
110338345 Ndufb10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966 ]
110314570 Ndufb11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351 ]
110320722 Ndufc1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967 ]
110332408 NADH dehydrogenase [ubiquinone] 1 subunit C2 isoform X1 [KO:K03968 ]
110319018 Ndufaf1; complex I intermediate-associated protein 30, mitochondrial [KO:K18159 ]
110328266 Ndufaf3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 isoform X1 [KO:K09008 ]
110338942 Ndufaf4; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 [KO:K18161 ]
110318019 Ndufaf5; arginine-hydroxylase NDUFAF5, mitochondrial [KO:K18162 ] [EC:2.1.1.-]
110338848 Ndufaf6; NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 isoform X1 [KO:K18163 ]
110335706 Ndufaf7; protein arginine methyltransferase NDUFAF7, mitochondrial isoform X1 [KO:K18164 ]
110328746 Sdha; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234 ] [EC:1.3.5.1 ]
110323139 Sdhb; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial isoform X1 [KO:K00235 ] [EC:1.3.5.1 ]
110322178 Sdhc; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236 ]
110324197 succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial-like isoform X1 [KO:K00237 ]
110328112 Sdhd; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237 ]
110323660 cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416 ]
110319299 cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X1 [KO:K02263 ]
110337554 cytochrome c oxidase subunit 4 isoform 1, mitochondrial isoform X1 [KO:K02263 ]
110335711 LOW QUALITY PROTEIN: cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270 ]
110331720 cytochrome c oxidase assembly protein COX11, mitochondrial [KO:K02258 ]
110324383 cytochrome c oxidase assembly protein COX16 homolog, mitochondrial isoform X1 [KO:K18182 ]
110330672 mitochondrial inner membrane protein COX18 isoform X1 [KO:K17797 ]
110331361 cytochrome c oxidase assembly factor 3 homolog, mitochondrial [KO:K18175 ]
110335264 cytochrome c oxidase assembly factor 4 homolog, mitochondrial [KO:K18177 ]
110333376 Atp5a1; ATP synthase subunit alpha, mitochondrial isoform X1 [KO:K02132 ]
110326670 Atp5d; ATP synthase subunit delta, mitochondrial isoform X1 [KO:K02134 ]
110320209 Atp5f1; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127 ]
110318554 Atp5g3; ATP synthase F(0) complex subunit C3, mitochondrial isoform X1 [KO:K02128 ]
110331847 Atp5g1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128 ]
110334965 Atp5g2; ATP synthase F(0) complex subunit C2, mitochondrial isoform X1 [KO:K02128 ]
110320480 ATP synthase subunit d, mitochondrial-like isoform X1 [KO:K02138 ]
110332361 Atp5h; ATP synthase subunit d, mitochondrial isoform X1 [KO:K02138 ]
110324769 Slc25a29; mitochondrial basic amino acids transporter [KO:K15109 ]
110327776 Slc25a20; mitochondrial carnitine/acylcarnitine carrier protein [KO:K15109 ]
Compound
Reference
Authors
Inagaki T, Sakai J, Kajimura S
Title
Transcriptional and epigenetic control of brown and beige adipose cell fate and function.
Journal
Reference
Authors
Harms M, Seale P
Title
Brown and beige fat: development, function and therapeutic potential.
Journal
Reference
Authors
Boon MR, Kooijman S, van Dam AD, Pelgrom LR, Berbee JF, Visseren CA, van Aggele RC, van den Hoek AM, Sips HC, Lombes M, Havekes LM, Tamsma JT, Guigas B, Meijer OC, Jukema JW, Rensen PC
Title
Peripheral cannabinoid 1 receptor blockade activates brown adipose tissue and diminishes dyslipidemia and obesity.
Journal
Reference
Authors
Merlin J, Evans BA, Dehvari N, Sato M, Bengtsson T, Hutchinson DS
Title
Could burning fat start with a brite spark? Pharmacological and nutritional ways to promote thermogenesis.
Journal
Reference
Authors
van Dam AD, Kooijman S, Schilperoort M, Rensen PC, Boon MR
Title
Regulation of brown fat by AMP-activated protein kinase.
Journal
Reference
Authors
Kooijman S, van den Heuvel JK, Rensen PC
Title
Neuronal Control of Brown Fat Activity.
Journal
Reference
Authors
Contreras C, Nogueiras R, Dieguez C, Rahmouni K, Lopez M
Title
Traveling from the hypothalamus to the adipose tissue: The thermogenic pathway.
Journal
Reference
Authors
Fruhbeck G, Mendez-Gimenez L, Fernandez-Formoso JA, Fernandez S, Rodriguez A
Title
Regulation of adipocyte lipolysis.
Journal
Reference
Authors
Tansey JT, Sztalryd C, Hlavin EM, Kimmel AR, Londos C
Title
The central role of perilipin a in lipid metabolism and adipocyte lipolysis.
Journal
Reference
Authors
Collins S, Yehuda-Shnaidman E, Wang H
Title
Positive and negative control of Ucp1 gene transcription and the role of beta-adrenergic signaling networks.
Journal
Reference
Authors
Robidoux J, Cao W, Quan H, Daniel KW, Moukdar F, Bai X, Floering LM, Collins S
Title
Selective activation of mitogen-activated protein (MAP) kinase kinase 3 and p38alpha MAP kinase is essential for cyclic AMP-dependent UCP1 expression in adipocytes.
Journal
Reference
Authors
Hattori K, Naguro I, Okabe K, Funatsu T, Furutani S, Takeda K, Ichijo H
Title
ASK1 signalling regulates brown and beige adipocyte function.
Journal
Reference
Authors
Abe Y, Rozqie R, Matsumura Y, Kawamura T, Nakaki R, Tsurutani Y, Tanimura-Inagaki K, Shiono A, Magoori K, Nakamura K, Ogi S, Kajimura S, Kimura H, Tanaka T, Fukami K, Osborne TF, Kodama T, Aburatani H, Inagaki T, Sakai J
Title
JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis.
Journal
Reference
Authors
Dempersmier J, Sambeat A, Gulyaeva O, Paul SM, Hudak CS, Raposo HF, Kwan HY, Kang C, Wong RH, Sul HS
Title
Cold-inducible Zfp516 activates UCP1 transcription to promote browning of white fat and development of brown fat.
Journal
Reference
Authors
Sambeat A, Gulyaeva O, Dempersmier J, Tharp KM, Stahl A, Paul SM, Sul HS
Title
LSD1 Interacts with Zfp516 to Promote UCP1 Transcription and Brown Fat Program.
Journal
Reference
Authors
Villarroya F, Peyrou M, Giralt M
Title
Transcriptional regulation of the uncoupling protein-1 gene.
Journal
Reference
Authors
Cao W, Daniel KW, Robidoux J, Puigserver P, Medvedev AV, Bai X, Floering LM, Spiegelman BM, Collins S
Title
p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene.
Journal
Reference
Authors
Hondares E, Iglesias R, Giralt A, Gonzalez FJ, Giralt M, Mampel T, Villarroya F
Title
Thermogenic activation induces FGF21 expression and release in brown adipose tissue.
Journal
Reference
Authors
Yao L, Cui X, Chen Q, Yang X, Fang F, Zhang J, Liu G, Jin W, Chang Y
Title
Cold-Inducible SIRT6 Regulates Thermogenesis of Brown and Beige Fat.
Journal
Reference
Authors
Klingenberg M
Title
UCP1 - A sophisticated energy valve.
Journal
Reference
Authors
Bertholet AM, Kirichok Y
Title
UCP1: A transporter for H(+) and fatty acid anions.
Journal
Reference
Authors
Betz MJ, Enerback S
Title
Targeting thermogenesis in brown fat and muscle to treat obesity and metabolic disease.
Journal
Reference
Authors
Tseng YH, Cypess AM, Kahn CR
Title
Cellular bioenergetics as a target for obesity therapy.
Journal
Reference
Authors
Fenzl A, Kiefer FW
Title
Brown adipose tissue and thermogenesis.
Journal
Reference
Authors
Minard AY, Tan SX, Yang P, Fazakerley DJ, Domanova W, Parker BL, Humphrey SJ, Jothi R, Stockli J, James DE
Title
mTORC1 Is a Major Regulatory Node in the FGF21 Signaling Network in Adipocytes.
Journal
Reference
Authors
Fisher FM, Kleiner S, Douris N, Fox EC, Mepani RJ, Verdeguer F, Wu J, Kharitonenkov A, Flier JS, Maratos-Flier E, Spiegelman BM
Title
FGF21 regulates PGC-1alpha and browning of white adipose tissues in adaptive thermogenesis.
Journal
Reference
Authors
Zois NE, Bartels ED, Hunter I, Kousholt BS, Olsen LH, Goetze JP
Title
Natriuretic peptides in cardiometabolic regulation and disease.
Journal
Reference
Authors
Indiveri C, Iacobazzi V, Tonazzi A, Giangregorio N, Infantino V, Convertini P, Console L, Palmieri F
Title
The mitochondrial carnitine/acylcarnitine carrier: function, structure and physiopathology.
Journal
Reference
Authors
McCoin CS, Knotts TA, Adams SH
Title
Acylcarnitines--old actors auditioning for new roles in metabolic physiology.
Journal
Reference
Authors
Ohtomo T, Ino K, Miyashita R, Chigira M, Nakamura M, Someya K, Inaba N, Fujita M, Takagi M, Yamada J
Title
Chronic high-fat feeding impairs adaptive induction of mitochondrial fatty acid combustion-associated proteins in brown adipose tissue of mice.
Journal
Related pathway
mpah04923 Regulation of lipolysis in adipocytes
KO pathway
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