KEGG   PATHWAY: mpah04024
Entry
mpah04024                   Pathway                                
Name
cAMP signaling pathway - Mus pahari (shrew mouse)
Description
cAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands including hormones, neurotransmitters, and other signaling molecules. cAMP regulates pivotal physiologic processes including metabolism, secretion, calcium homeostasis, muscle contraction, cell fate, and gene transcription. cAMP acts directly on three main targets: protein kinase A (PKA), the exchange protein activated by cAMP (Epac), and cyclic nucleotide-gated ion channels (CNGCs). PKA modulates, via phosphorylation, a number of cellular substrates, including transcription factors, ion channels, transporters, exchangers, intracellular Ca2+ -handling proteins, and the contractile machinery. Epac proteins function as guanine nucleotide exchange factors (GEFs) for both Rap1 and Rap2. Various effector proteins, including adaptor proteins implicated in modulation of the actin cytoskeleton, regulators of G proteins of the Rho family, and phospholipases, relay signaling downstream from Rap.
Class
Environmental Information Processing; Signal transduction
Pathway map
mpah04024  cAMP signaling pathway
mpah04024

Other DBs
GO: 0019933
Organism
Mus pahari (shrew mouse) [GN:mpah]
Gene
110312794  Ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
110312963  Orai1; calcium release-activated calcium channel protein 1 [KO:K16056]
110313023  Atp2a2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
110313067  Hcar1; hydroxycarboxylic acid receptor 1 isoform X1 [KO:K08401]
110313078  [KO:K08402]
110313330  Atp2b3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
110313596  Cacna1f; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
110313787  Cnga2; cyclic nucleotide-gated olfactory channel [KO:K04949]
110313906  Atp1b4; protein ATP1B4 isoform X1 [KO:K01540]
110314078  Gria3; glutamate receptor 3 isoform X1 [KO:K05199]
110314252  Gpr119; glucose-dependent insulinotropic receptor [KO:K08424]
110314435  [KO:K04630]
110314893  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
110315668  Adcyap1r1; pituitary adenylate cyclase-activating polypeptide type I receptor isoform X1 [KO:K04587]
110315948  Atp2b2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
110315967  Crhr2; corticotropin-releasing factor receptor 2 isoform X1 [KO:K04579]
110315994  Creb5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
110316152  Creb3l2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
110316238  Pde3a; cGMP-inhibited 3',5'-cyclic phosphodiesterase A [KO:K19021] [EC:3.1.4.17]
110316269  Braf; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
110316284  Grin2b; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
110316437  Cftr; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
110316713  Chrm2; muscarinic acetylcholine receptor M2 [KO:K04130]
110316721  Ghrl; appetite-regulating hormone isoform X1 [KO:K05254]
110317041  Rela; transcription factor p65 [KO:K04735]
110317086  Cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
110317161  Npy; pro-neuropeptide Y [KO:K05232]
110317198  Ppp1ca; serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
110317253  Oxtr; oxytocin receptor [KO:K04229]
110317258  Akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
110317622  Vav2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
110317699  [KO:K04632]
110317700  [KO:K04632]
110318089  Bdnf; LOW QUALITY PROTEIN: brain-derived neurotrophic factor [KO:K04355]
110318312  Myl9; myosin regulatory light polypeptide 9 isoform X1 [KO:K12755]
110318364  Creb3l1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
110318780  Rapgef4; rap guanine nucleotide exchange factor 4 isoform X1 [KO:K04351]
110319126  Edn3; endothelin-3 [KO:K05227]
110319211  Grin2d; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
110319241  Oxt; oxytocin-neurophysin 1 [KO:K05243]
110319261  Grin1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
110319324  Gcg; glucagon [KO:K05259]
110319484  Fshb; follitropin subunit beta [KO:K05250]
110319750  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
110319789  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
110319821  Gnai3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
110319846  Vav3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
110319913  Atp1a1; sodium/potassium-transporting ATPase subunit alpha-1 isoform X1 [KO:K01539] [EC:7.2.2.13]
110319929  Pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
110319932  Rap1a; ras-related protein Rap-1A [KO:K04353]
110320020  Mapk3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
110320188  Gria2; glutamate receptor 2 isoform X1 [KO:K05198]
110320262  Pld1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
110320362  Plce1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
110320635  Ptger3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
110320669  Ghsr; growth hormone secretagogue receptor type 1 [KO:K04284]
110320677  Tshb; thyrotropin subunit beta isoform X1 [KO:K05251]
110320678  Creb3l4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
110320830  Npr1; atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
110320932  Camk2d; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
110320957  Sucnr1; succinate receptor 1 [KO:K10042]
110320990  Pde3b; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
110320995  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
110321040  Crh; corticoliberin [KO:K05256]
110321177  Atp1a4; sodium/potassium-transporting ATPase subunit alpha-4 [KO:K01539] [EC:7.2.2.13]
110321229  Kcnk2; potassium channel subfamily K member 2 isoform X1 [KO:K04913]
110321257  Adora1; adenosine receptor A1 isoform X1 [KO:K04265]
110321497  Atp1b1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
110321647  Atp2b4; LOW QUALITY PROTEIN: plasma membrane calcium-transporting ATPase 4 [KO:K05850] [EC:7.2.2.10]
110321722  Adcy10; adenylate cyclase type 10 isoform X1 [KO:K11265] [EC:4.6.1.1]
110321732  Rras2; ras-related protein R-Ras2 [KO:K07830]
110322010  Cacna1s; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
110322093  Gpha2; glycoprotein hormone alpha-2 [KO:K25483]
110322284  Akt3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
110322391  Creb1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
110322397  Cnga3; cyclic nucleotide-gated cation channel alpha-3 isoform X1 [KO:K04950]
110322617  [KO:K01539] [EC:7.2.2.13]
110322756  Pde4b; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
110322856  Slc9a1; sodium/hydrogen exchanger 1 [KO:K05742]
110322865  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
110322986  Grin3a; glutamate receptor ionotropic, NMDA 3A isoform X1 [KO:K05213]
110323012  Gabbr2; gamma-aminobutyric acid type B receptor subunit 2 [KO:K04615]
110323252  Jun; transcription factor AP-1 [KO:K04448]
110323448  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
110323667  Htr1d; 5-hydroxytryptamine receptor 1D [KO:K04153]
110323713  Htr6; 5-hydroxytryptamine receptor 6 [KO:K04162]
110323892  Edn2; endothelin-2 [KO:K16367]
110323909  Nppa; natriuretic peptides A [KO:K12334]
110324181  Rock2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
110324261  Calm1; calmodulin [KO:K02183]
110324329  Ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
110324365  Fos; proto-oncogene c-Fos isoform X1 [KO:K04379]
110324386  Akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
110324476  Tshr; thyrotropin receptor isoform X1 [KO:K04249]
110324484  Nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
110324584  Vipr2; vasoactive intestinal polypeptide receptor 2 [KO:K04590]
110324646  Adcy3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
110324728  Pomc; pro-opiomelanocortin [KO:K05228]
110324843  Gphb5; glycoprotein hormone beta-5 [KO:K25484]
110324877  Sstr1; somatostatin receptor type 1 [KO:K04217]
110325379  Abcc4; multidrug resistance-associated protein 4 isoform X1 [KO:K05673]
110325439  Adcy4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
110325466  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
110325574  Camk2g; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
110325898  Ptger2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
110325961  Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
110326077  Creb3l3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
110326182  Hcn2; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 [KO:K04955]
110326185  Ppp1r12a; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
110326250  Bad; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
110326314  Grin3b; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
110326321  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
110326378  [KO:K04513]
110326390  Gli1; zinc finger protein GLI1 [KO:K16797]
110326448  Pln; cardiac phospholamban [KO:K05852]
110326460  Rap1b; ras-related protein Rap-1b isoform X1 [KO:K07836]
110326786  Adora2a; adenosine receptor A2a [KO:K04266]
110326860  Atp2b1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
110326951  Bves; blood vessel epicardial substance [KO:K21108]
110327048  Amh; muellerian-inhibiting factor [KO:K04665]
110327103  Popdc3; popeye domain-containing protein 3 [KO:K26207]
110327159  Gria4; glutamate receptor 4 isoform X1 [KO:K05200]
110327202  Gnai2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630]
110327244  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
110327251  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
110327684  Atp1b3; sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540]
110327737  Fxyd2; sodium/potassium-transporting ATPase subunit gamma isoform X1 [KO:K01538]
110327760  Drd2; D(2) dopamine receptor [KO:K04145]
110327872  Hcn4; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 [KO:K04957]
110327907  Rhoa; transforming protein RhoA isoform X1 [KO:K04513]
110328160  Htr1b; 5-hydroxytryptamine receptor 1B [KO:K04153]
110328293  Calml4; calmodulin-like protein 4 isoform X1 [KO:K02183]
110328717  Pde4a; cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X1 [KO:K13293] [EC:3.1.4.53]
110328764  Adcy2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
110328811  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
110328970  Pde4d; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1 [KO:K13293] [EC:3.1.4.53]
110328985  F2r; proteinase-activated receptor 1 [KO:K03914]
110329088  Htr1a; 5-hydroxytryptamine receptor 1A [KO:K04153]
110329343  Mapk1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
110329393  Adcy5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
110329400  Rras; ras-related protein R-Ras [KO:K07829]
110329624  Adcy9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
110329701  Grin2a; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
110329910  Htr1f; 5-hydroxytryptamine receptor 1F [KO:K04153]
110329960  Sst; somatostatin [KO:K05237]
110330048  Crebbp; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
110330138  Popdc2; popeye domain-containing protein 2 isoform X1 [KO:K26206]
110330159  Tiam1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
110330449  Mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
110330584  Adcy1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
110330653  Acox3; peroxisomal acyl-coenzyme A oxidase 3 [KO:K00232] [EC:1.3.3.6]
110330750  Cnga1; cGMP-gated cation channel alpha-1 [KO:K04948]
110330906  Drd5; D(1B) dopamine receptor [KO:K05840]
110331006  Camk2b; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
110331056  Gria1; glutamate receptor 1 isoform X1 [KO:K05197]
110331134  Crhr1; corticotropin-releasing factor receptor 1 isoform X1 [KO:K04578]
110331248  Atp2a3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
110331272  Acox1; peroxisomal acyl-coenzyme A oxidase 1 isoform X1 [KO:K00232] [EC:1.3.3.6]
110331528  Rac3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
110331574  Atp1b2; sodium/potassium-transporting ATPase subunit beta-2 [KO:K01540]
110331590  Sox9; transcription factor SOX-9 isoform X1 [KO:K18435]
110331735  Grin2c; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
110331831  Chrm1; muscarinic acetylcholine receptor M1 [KO:K04129]
110331978  Pld2; LOW QUALITY PROTEIN: phospholipase D2 [KO:K01115] [EC:3.1.4.4]
110332388  Ppp1r1b; protein phosphatase 1 regulatory subunit 1B isoform X1 [KO:K15494]
110332471  [KO:K08521]
110332525  Gip; gastric inhibitory polypeptide [KO:K05258]
110332652  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
110332685  Sstr2; somatostatin receptor type 2 isoform X1 [KO:K04218]
110332832  Camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
110333017  Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
110333064  Htr4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
110333208  Arap3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
110333240  Camk4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
110333383  Mc2r; adrenocorticotropic hormone receptor [KO:K04200]
110333506  Adrb2; beta-2 adrenergic receptor [KO:K04142]
110333549  Rock1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
110333582  Gli3; transcriptional activator GLI3 [KO:K06230]
110333595  Ptch1; protein patched homolog 1 [KO:K06225]
110333803  Adrb1; beta-1 adrenergic receptor [KO:K04141]
110333884  Cnga4; cyclic nucleotide-gated cation channel alpha-4 [KO:K04951]
110334152  Drd1; D(1A) dopamine receptor [KO:K04144]
110334170  Calml3; calmodulin-like protein 3 [KO:K02183]
110334180  Edn1; endothelin-1 [KO:K16366]
110334182  [KO:K02183]
110334252  Ryr2; ryanodine receptor 2 [KO:K04962]
110334500  Adcy6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
110334526  Ep300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
110334612  Adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
110334678  Rac2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
110334708  Rapgef3; rap guanine nucleotide exchange factor 3 isoform X1 [KO:K08014]
110334863  Ppara; peroxisome proliferator-activated receptor alpha isoform X1 [KO:K07294]
110335502  Fxyd1; phospholemman isoform X1 [KO:K13360]
110335717  Fshr; follicle-stimulating hormone receptor isoform X1 [KO:K04247]
110335720  Adcyap1; pituitary adenylate cyclase-activating polypeptide isoform X1 [KO:K05262]
110335829  Gabbr1; gamma-aminobutyric acid type B receptor subunit 1 [KO:K04615]
110335904  Lhcgr; lutropin-choriogonadotropic hormone receptor [KO:K04248]
110336102  Calm2; calmodulin isoform X1 [KO:K02183]
110336107  Vav1; proto-oncogene vav isoform X1 [KO:K05730]
110336418  Pde4c; cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform X1 [KO:K13293] [EC:3.1.4.53]
110336420  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
110336466  Calm3; calmodulin [KO:K02183]
110336545  Lipe; hormone-sensitive lipase isoform X1 [KO:K07188] [EC:3.1.1.79]
110336690  Tnni3; troponin I, cardiac muscle [KO:K12044]
110336755  Gipr; gastric inhibitory polypeptide receptor [KO:K04580]
110337017  Npy1r; neuropeptide Y receptor type 1 [KO:K04204]
110337068  Atp1a3; sodium/potassium-transporting ATPase subunit alpha-3 isoform X1 [KO:K01539] [EC:7.2.2.13]
110337220  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
110337377  Ednra; endothelin-1 receptor isoform X1 [KO:K04197]
110337453  Adcy7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
110337499  Hhip; hedgehog-interacting protein [KO:K06231]
110337606  Cngb1; cyclic nucleotide-gated cation channel beta-1 isoform X1 [KO:K04952]
110337875  Pde10a; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X1 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
110338214  Glp1r; glucagon-like peptide 1 receptor [KO:K04581]
110338336  Sstr5; somatostatin receptor type 5 [KO:K04221]
110338394  Atp2a1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
110338407  Afdn; afadin isoform X1 [KO:K05702]
110338514  Vip; VIP peptides isoform X1 [KO:K05264]
110338625  Ffar2; free fatty acid receptor 2 [KO:K04328]
110338824  Cngb3; cyclic nucleotide-gated cation channel beta-3 [KO:K04953]
110338938  Cga; glycoprotein hormones alpha chain [KO:K08522]
110338975  Creb3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
110339030  Rac1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
Compound
C00020  AMP
C00042  Succinate
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00186  (S)-Lactate
C00212  Adenosine
C00238  Potassium cation
C00288  HCO3-
C00334  4-Aminobutanoate
C00416  Phosphatidate
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00698  Cl-
C00780  Serotonin
C00788  L-Adrenaline
C01089  (R)-3-Hydroxybutanoate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01312  Prostaglandin I2
C01330  Sodium cation
C01996  Acetylcholine
C03758  Dopamine
C20792  Oleoylethanolamide
C20793  3-Hydroxyoctanoate
Reference
PMID:11493633
  Authors
Fimia GM, Sassone-Corsi P
  Title
Cyclic AMP signalling.
  Journal
J Cell Sci 114:1971-2 (2001)
Reference
PMID:18323530
  Authors
Serezani CH, Ballinger MN, Aronoff DM, Peters-Golden M
  Title
Cyclic AMP: master regulator of innate immune cell function.
  Journal
Am J Respir Cell Mol Biol 39:127-32 (2008)
DOI:10.1165/rcmb.2008-0091TR
Reference
PMID:24281338
  Authors
Oldenburger A, Maarsingh H, Schmidt M
  Title
Multiple facets of cAMP signalling and physiological impact: cAMP compartmentalization in the lung.
  Journal
Pharmaceuticals (Basel) 5:1291-331 (2012)
DOI:10.3390/ph5121291
Reference
PMID:24613710
  Authors
Ahuja M, Jha A, Maleth J, Park S, Muallem S
  Title
cAMP and Ca signaling in secretory epithelia: Crosstalk and synergism.
  Journal
Cell Calcium 55:385-393 (2014)
DOI:10.1016/j.ceca.2014.01.006
Reference
PMID:22082266
  Authors
Shirshev SV
  Title
Role of Epac proteins in mechanisms of cAMP-dependent immunoregulation.
  Journal
Biochemistry (Mosc) 76:981-98 (2011)
DOI:10.1134/S000629791109001X
Reference
PMID:18176800
  Authors
Roscioni SS, Elzinga CR, Schmidt M
  Title
Epac: effectors and biological functions.
  Journal
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Front Physiol 2:67 (2011)
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Epac/Rap and PKA are novel mechanisms of ANP-induced Rac-mediated pulmonary endothelial barrier protection.
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J Cell Physiol 215:715-24 (2008)
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Related
pathway
mpah00071  Fatty acid degradation
mpah04015  Rap1 signaling pathway
mpah04020  Calcium signaling pathway
mpah04151  PI3K-Akt signaling pathway
mpah04210  Apoptosis
mpah04260  Cardiac muscle contraction
mpah04340  Hedgehog signaling pathway
mpah04720  Long-term potentiation
mpah04740  Olfactory transduction
mpah04972  Pancreatic secretion
mpah04976  Bile secretion
KO pathway
ko04024   

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