KEGG   PATHWAY: npd05132
Entry
npd05132                    Pathway                                
Name
Salmonella infection - Nothoprocta perdicaria (Chilean tinamou)
Description
Salmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, Salmonella enterica, which has numerous serovars.
Following intestinal colonization Salmonella inject effector proteins into the host cells using a type III secretion system (T3SS), T3SS1. Then a small group of effector proteins induce rearrangement of the actin cytoskeleton resulting in membrane ruffles and rapid internalization of the bacteria.The T3SS2 is responsible for translocating effector proteins that direct Salmonella-containing vacuole (SCV) maturation. The majority of the bacteria are known to survive and replicate in SCV.
Class
Human Diseases; Infectious disease: bacterial
Pathway map
npd05132  Salmonella infection
npd05132

Organism
Nothoprocta perdicaria (Chilean tinamou) [GN:npd]
Gene
112958579  PODXL; podocalyxin isoform X1 [KO:K06817]
112951149  PTPRC; receptor-type tyrosine-protein phosphatase C [KO:K06478] [EC:3.1.3.48]
112957210  RAB5A; ras-related protein Rab-5A [KO:K07887]
112951795  RAB5C; ras-related protein Rab-5C [KO:K07889]
112947417  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
112958596  RAB7A; ras-related protein Rab-7a [KO:K07897]
112944643  RAB7B; ras-related protein Rab-7b [KO:K07898]
112954209  PLEKHM1; pleckstrin homology domain-containing family M member 1 [KO:K23282]
112948077  VPS11; vacuolar protein sorting-associated protein 11 homolog [KO:K20179]
112955336  VPS16; vacuolar protein sorting-associated protein 16 homolog [KO:K20180]
112942498  VPS18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
112949380  VPS33A; vacuolar protein sorting-associated protein 33A [KO:K20182]
112942478  VPS39; vam6/Vps39-like protein isoform X1 [KO:K20183]
112943734  VPS41; vacuolar protein sorting-associated protein 41 homolog [KO:K20184]
112954627  RILP; rab-interacting lysosomal protein [KO:K13883]
112956930  DYNC1H1; cytoplasmic dynein 1 heavy chain 1 [KO:K10413]
112951857  DYNC2H1; cytoplasmic dynein 2 heavy chain 1 [KO:K10414]
112944761  DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 [KO:K10415]
112951172  DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415]
112944965  DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 isoform X1 [KO:K10416]
112952602  DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 isoform X1 [KO:K10416]
112953222  DYNC2LI1; cytoplasmic dynein 2 light intermediate chain 1 [KO:K10417]
112954564  DYNLL2; dynein light chain 2, cytoplasmic [KO:K10418]
112945835  dynein light chain 1, cytoplasmic [KO:K10418]
112945836  dynein light chain 1, cytoplasmic-like [KO:K10418]
112946043  dynein light chain 1, cytoplasmic-like [KO:K10418]
112946044  dynein light chain 2, cytoplasmic-like [KO:K10418]
112950039  DYNLRB1; dynein light chain roadblock-type 1 [KO:K10419]
112944987  DYNLRB2; dynein light chain roadblock-type 2 [KO:K10419]
112954156  DYNLT3; dynein light chain Tctex-type 3 [KO:K10420]
112951671  DYNLT1; dynein light chain Tctex-type 1 [KO:K10420]
112955334  DCTN1; dynactin subunit 1 isoform X1 [KO:K04648]
112947083  DCTN3; dynactin subunit 3 [KO:K10425]
112954311  DCTN4; dynactin subunit 4 isoform X1 [KO:K10426]
112960008  DCTN5; dynactin subunit 5 isoform X1 [KO:K10427]
112955426  beta-centractin-like [KO:K16575]
112957071  ACTR1A; alpha-centractin [KO:K16575]
112959677  ACTR10; actin-related protein 10 [KO:K16576]
112947853  tubulin alpha-5 chain-like [KO:K07374]
112954233  tubulin alpha-1B chain [KO:K07374]
112954234  tubulin alpha-1A chain [KO:K07374]
112951603  tubulin alpha-3 chain [KO:K07374]
112951604  tubulin alpha-3 chain-like isoform X1 [KO:K07374]
112952427  tubulin alpha-3 chain [KO:K07374]
112958323  TUBA8; tubulin alpha-8 chain [KO:K07374]
112959211  tubulin alpha-8 chain [KO:K07374]
112947493  TUBB3; tubulin beta-3 chain [KO:K07375]
112947606  tubulin beta-2 chain-like [KO:K07375]
112947609  tubulin beta-1 chain [KO:K07375]
112942833  TUBB6; tubulin beta-6 chain [KO:K07375]
112949753  TUBB1; tubulin beta-1 chain isoform X1 [KO:K07375]
112955799  TUBB4B; tubulin beta-4B chain [KO:K07375]
112943609  FYCO1; FYVE and coiled-coil domain-containing protein 1 isoform X1 [KO:K21954]
112944122  ARL8B; ADP-ribosylation factor-like protein 8B [KO:K07955]
112957925  ADP-ribosylation factor-like protein 8B [KO:K07955]
112959237  ARL8A; ADP-ribosylation factor-like protein 8A [KO:K07955]
112959644  PLEKHM2; pleckstrin homology domain-containing family M member 2 [KO:K15348]
112955435  KIF5B; kinesin-1 heavy chain isoform X1 [KO:K10396]
112957623  kinesin heavy chain-like [KO:K10396]
112958332  KIF5C; kinesin heavy chain [KO:K10396]
112955098  KLC4; kinesin light chain 4 isoform X1 [KO:K10407]
112955353  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
112942788  ACBD3; Golgi resident protein GCP60 [KO:K23935]
112953407  RHOA; transforming protein RhoA [KO:K04513]
112952037  M6PR; cation-dependent mannose-6-phosphate receptor [KO:K10089]
112943975  RAB9A; ras-related protein Rab-9A [KO:K07899]
112942296  RAB9B; ras-related protein Rab-9B [KO:K07900]
112943320  GCC2; GRIP and coiled-coil domain-containing protein 2 [KO:K20282]
112955120  PFN3; profilin-3 [KO:K05759]
112952119  PFN4; profilin-4 [KO:K05759]
112952355  PFN2; profilin-2 [KO:K05759]
112956756  filamin-A-like [KO:K04437]
112957648  EXOC7; exocyst complex component 7 isoform X1 [KO:K07195]
112957744  EXOC5; exocyst complex component 5 isoform X1 [KO:K19984]
112958578  EXOC4; exocyst complex component 4 [KO:K06111]
112947630  EXOC2; exocyst complex component 2 [KO:K17637]
112943741  RALA; ras-related protein Ral-A [KO:K07834]
112959944  ACTB; actin, cytoplasmic 1 [KO:K05692]
112950999  actin, cytoplasmic type 5 [KO:K05692]
112945270  ACTG1; actin, cytoplasmic 2 [KO:K05692]
112955233  S100A10; protein S100-A10 [KO:K17274]
112959044  ANXA2; annexin A2 [KO:K17092]
112959666  RHOJ; rho-related GTP-binding protein RhoJ [KO:K07864]
112952539  ARHGEF26; rho guanine nucleotide exchange factor 26 [KO:K13744]
112948643  rho-related GTP-binding protein RhoG-like [KO:K07863]
112955770  RHOG; rho-related GTP-binding protein RhoG [KO:K07863]
112948563  ELMO1; engulfment and cell motility protein 1 isoform X1 [KO:K12366]
112955033  ELMO2; engulfment and cell motility protein 2 isoform X1 [KO:K18985]
112945436  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
112949409  MYL2; LOW QUALITY PROTEIN: myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
112945688  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
112945374  myosin regulatory light chain 2B, cardiac muscle isoform [KO:K12756]
112944052  myosin regulatory light chain 2, smooth muscle minor isoform [KO:K12757]
112943286  FHOD1; FH1/FH2 domain-containing protein 1 [KO:K23938]
112957357  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
112959749  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
112950289  NCKAP1L; nck-associated protein 1-like [KO:K05750]
112958241  NCKAP1; nck-associated protein 1 [KO:K05750]
112954275  CYFIP2; cytoplasmic FMR1-interacting protein 2 [KO:K05749]
112943123  CYFIP1; cytoplasmic FMR1-interacting protein 1 isoform X1 [KO:K05749]
112955463  ABI1; abl interactor 1 [KO:K23649]
112956340  WASF3; wiskott-Aldrich syndrome protein family member 3 [KO:K06083]
112946952  wiskott-Aldrich syndrome protein family member 3-like [KO:K06083]
112942908  ACTR2; actin-related protein 2 isoform X1 [KO:K17260]
112948584  ACTR3; actin-related protein 3 isoform X1 [KO:K18584]
112958114  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
112959877  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
112959950  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
112959545  ARPC2; actin-related protein 2/3 complex subunit 2 isoform X1 [KO:K05758]
112945887  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
112956038  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
112951527  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
112943376  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
112951779  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
112957587  MYO6; LOW QUALITY PROTEIN: unconventional myosin-VI [KO:K10358]
112959596  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
112947911  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
112952569  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
112953348  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
112948830  PIK3C2A; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha [KO:K00923] [EC:2.7.1.154]
112944184  PIK3C2G; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma [KO:K00923] [EC:2.7.1.154]
112959125  PIK3C2B; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta [KO:K00923] [EC:2.7.1.154]
112959771  CYTH3; cytohesin-3 isoform X1 [KO:K18441]
112947777  CYTH4; cytohesin-4 [KO:K18441]
112945307  CYTH1; cytohesin-1 [KO:K18441]
112957775  ARF6; ADP-ribosylation factor 6 [KO:K07941]
112952134  ARF1; ADP-ribosylation factor 1 [KO:K07937]
112944188  SNX18; sorting nexin-18 [KO:K17923]
112951651  SNX9; sorting nexin-9 [KO:K17923]
112958746  SNX33; sorting nexin-33 [KO:K17923]
112957901  WASL; neural Wiskott-Aldrich syndrome protein [KO:K23612]
112955329  DNM2; dynamin-2 isoform X1 [KO:K23484] [EC:3.6.5.5]
112945824  toll-like receptor 10 [KO:K10169]
112949303  TLR2; toll-like receptor 2 isoform X1 [KO:K10159]
112958106  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
112955980  TLR4; toll-like receptor 4 [KO:K10160]
112945728  LY96; lymphocyte antigen 96 [KO:K05400]
112954833  TLR5; toll-like receptor 5 [KO:K10168]
112956803  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
112943501  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
112946540  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
112947715  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
112951648  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
112954154  TAB3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 [KO:K12793]
112948431  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
112953853  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
112958044  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
112957315  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
112952613  NOD1; nucleotide-binding oligomerization domain-containing protein 1 [KO:K08727]
112956927  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
112958398  HSP90B1; endoplasmin [KO:K09487]
112960327  RIPK2; receptor-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K08846] [EC:2.7.11.1]
112950571  receptor-interacting serine/threonine-protein kinase 2-like [KO:K08846] [EC:2.7.11.1]
112949496  CSE1L; exportin-2 [KO:K18423]
112960122  KPNA1; importin subunit alpha-5 isoform X1 [KO:K23940]
112952571  KPNA4; importin subunit alpha-3 [KO:K23583]
112959284  KPNA3; importin subunit alpha-4 [KO:K23583]
112943529  HRAS; GTPase HRas [KO:K02833]
112953017  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
112948263  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
112949088  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
112945932  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
112960040  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
112953655  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
112959724  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
112959727  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
112959234  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
112959267  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
112957684  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
112954523  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
112948967  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
112956827  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
112957980  FOS; proto-oncogene c-Fos [KO:K04379]
112943557  JUN; transcription factor AP-1 [KO:K04448]
112950535  IL1B; interleukin-1 beta [KO:K04519]
112942428  IL6; interleukin-6 [KO:K05405]
112950070  interleukin-8-like [KO:K10030]
112950072  interleukin-8-like [KO:K10030]
112950088  interleukin-8-like [KO:K10030]
112943616  CTNNB1; catenin beta-1 [KO:K02105]
112952974  TCF7; transcription factor 7 [KO:K02620]
112957063  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
112957317  LEF1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
112959422  MYC; myc proto-oncogene protein [KO:K04377]
112946728  FBXO22; F-box only protein 22 [KO:K10302]
112952406  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
112956891  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
112956027  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
112950558  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
112943708  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
112947649  RIPK1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
112960100  GAPDH; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
112952453  TNFSF10; tumor necrosis factor ligand superfamily member 10 isoform X1 [KO:K04721]
112949785  TNFRSF10B; tumor necrosis factor receptor superfamily member 10B [KO:K04722]
112943547  FADD; FAS-associated death domain protein [KO:K02373]
112956289  caspase-8-like isoform X1 [KO:K04398] [EC:3.4.22.61]
112956309  caspase-8-like [KO:K04398] [EC:3.4.22.61]
112959245  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
112942426  cytochrome c [KO:K08738]
112958233  cytochrome c, somatic-like [KO:K08738]
112943408  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
112942609  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
112957190  CASP7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
112952107  RHOB; rho-related GTP-binding protein RhoB [KO:K07856]
112946015  RHOH; rho-related GTP-binding protein RhoH [KO:K07873]
112948774  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112955351  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112955491  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112943201  MLKL; mixed lineage kinase domain-like protein [KO:K08849] [EC:2.7.11.1]
112948527  thioredoxin [KO:K03671]
112958442  TXN2; thioredoxin, mitochondrial [KO:K03671]
112956725  caspase-1-like [KO:K01370] [EC:3.4.22.36]
112948749  IL18; interleukin-18 isoform X1 [KO:K05482]
Compound
C00338  Lipopolysaccharide
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:28875943
  Authors
Bernal-Bayard J, Ramos-Morales F
  Title
Molecular Mechanisms Used by Salmonella to Evade the Immune System.
  Journal
Curr Issues Mol Biol 25:133-168 (2018)
DOI:10.21775/cimb.025.133
Reference
PMID:28848711
  Authors
Hume PJ, Singh V, Davidson AC, Koronakis V
  Title
Swiss Army Pathogen: The Salmonella Entry Toolkit.
  Journal
Front Cell Infect Microbiol 7:348 (2017)
DOI:10.3389/fcimb.2017.00348
Reference
PMID:31402916
  Authors
Wemyss MA, Pearson JS
  Title
Host Cell Death Responses to Non-typhoidal Salmonella Infection.
  Journal
Front Immunol 10:1758 (2019)
DOI:10.3389/fimmu.2019.01758
Reference
PMID:27974148
  Authors
Bierschenk D, Boucher D, Schroder K
  Title
Salmonella-induced inflammasome activation in humans.
  Journal
Mol Immunol 86:38-43 (2017)
DOI:10.1016/j.molimm.2016.11.009
Reference
PMID:29477730
  Authors
Pinaud L, Sansonetti PJ, Phalipon A
  Title
Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors.
  Journal
Trends Microbiol 26:266-283 (2018)
DOI:10.1016/j.tim.2018.01.010
Reference
PMID:25749450
  Authors
LaRock DL, Chaudhary A, Miller SI
  Title
Salmonellae interactions with host processes.
  Journal
Nat Rev Microbiol 13:191-205 (2015)
DOI:10.1038/nrmicro3420
Reference
PMID:17983751
  Authors
Ramsden AE, Holden DW, Mota LJ
  Title
Membrane dynamics and spatial distribution of Salmonella-containing vacuoles.
  Journal
Trends Microbiol 15:516-24 (2007)
DOI:10.1016/j.tim.2007.10.002
Reference
PMID:22702524
  Authors
van der Heijden J, Finlay BB
  Title
Type III effector-mediated processes in Salmonella infection.
  Journal
Future Microbiol 7:685-703 (2012)
DOI:10.2217/fmb.12.49
Reference
PMID:27222578
  Authors
Galan JE
  Title
Typhoid toxin provides a window into typhoid fever and the biology of Salmonella Typhi.
  Journal
Proc Natl Acad Sci U S A 113:6338-44 (2016)
DOI:10.1073/pnas.1606335113
Reference
PMID:19157959
  Authors
McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V
  Title
Salmonella takes control: effector-driven manipulation of the host.
  Journal
Curr Opin Microbiol 12:117-24 (2009)
DOI:10.1016/j.mib.2008.12.001
Reference
PMID:12675800
  Authors
Miao EA, Brittnacher M, Haraga A, Jeng RL, Welch MD, Miller SI
  Title
Salmonella effectors translocated across the vacuolar membrane interact with the actin cytoskeleton.
  Journal
Mol Microbiol 48:401-15 (2003)
DOI:10.1046/j.1365-2958.2003.t01-1-03456.x
Reference
PMID:17074883
  Authors
Patel JC, Galan JE
  Title
Differential activation and function of Rho GTPases during Salmonella-host cell interactions.
  Journal
J Cell Biol 175:453-63 (2006)
DOI:10.1083/jcb.200605144
Reference
PMID:18411289
  Authors
Wasylnka JA, Bakowski MA, Szeto J, Ohlson MB, Trimble WS, Miller SI, Brumell JH
  Title
Role for myosin II in regulating positioning of Salmonella-containing vacuoles and intracellular replication.
  Journal
Infect Immun 76:2722-35 (2008)
DOI:10.1128/IAI.00152-08
Reference
PMID:10499590
  Authors
Fu Y, Galan JE
  Title
A salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion.
  Journal
Nature 401:293-7 (1999)
DOI:10.1038/45829
Related
pathway
npd04010  MAPK signaling pathway
npd04210  Apoptosis
npd04217  Necroptosis
npd04621  NOD-like receptor signaling pathway
KO pathway
ko05132   
LinkDB

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