KEGG   PATHWAY: ko05132
Entry
ko05132                     Pathway                                
Name
Salmonella infection
Description
Salmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, Salmonella enterica, which has numerous serovars.
Following intestinal colonization Salmonella inject effector proteins into the host cells using a type III secretion system (T3SS), T3SS1. Then a small group of effector proteins induce rearrangement of the actin cytoskeleton resulting in membrane ruffles and rapid internalization of the bacteria.The T3SS2 is responsible for translocating effector proteins that direct Salmonella-containing vacuole (SCV) maturation. The majority of the bacteria are known to survive and replicate in SCV.
Class
Human Diseases; Infectious disease: bacterial
Pathway map
ko05132  Salmonella infection
ko05132

Disease
H00111  Typhoid fever
Orthology
K00134  GAPDH, gapA; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12]
K00914  PIK3C3, VPS34; phosphatidylinositol 3-kinase [EC:2.7.1.137]
K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K00923  PIK3C2; phosphatidylinositol-4-phosphate 3-kinase [EC:2.7.1.154]
K01370  CASP1; caspase 1 [EC:3.4.22.36]
K02105  CTNNB1; catenin beta 1
K02159  BAX; apoptosis regulator BAX
K02161  BCL2; apoptosis regulator Bcl-2
K02187  CASP3; caspase 3 [EC:3.4.22.56]
K02373  FADD; FAS-associated death domain protein
K02406  fliC, hag; flagellin
K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
K02620  TCF7, TCF-1; transcription factor 7
K02833  HRAS; GTPase HRas
K02861  RIPK1, RIP1; receptor-interacting serine/threonine-protein kinase 1 [EC:2.7.11.1]
K02985  RP-S3e, RPS3; small subunit ribosomal protein S3e
K03094  SKP1, CBF3D; S-phase kinase-associated protein 1
K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
K03158  TNFRSF1A, TNFR1, CD120a; tumor necrosis factor receptor superfamily member 1A
K03171  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein
K03173  TRAF2; TNF receptor-associated factor 2 [EC:2.3.2.27]
K03175  TRAF6; TNF receptor-associated factor 6 [EC:2.3.2.27]
K03221  yscF, sctF, ssaG, prgI; type III secretion protein F
K03671  TXN, trxA; thioredoxin
K04079  HSP90A, htpG; molecular chaperone HtpG
K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
K04371  ERK, MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K04377  MYC; Myc proto-oncogene protein
K04379  FOS; proto-oncogene protein c-fos
K04391  CD14; monocyte differentiation antigen CD14
K04392  RAC1; Ras-related C3 botulinum toxin substrate 1
K04393  CDC42; cell division control protein 42
K04394  CASP4, CASP11; caspase 4 [EC:3.4.22.57 3.4.22.64]
K04395  CASP5; caspase 5 [EC:3.4.22.58]
K04397  CASP7; caspase 7 [EC:3.4.22.60]
K04398  CASP8; caspase 8 [EC:3.4.22.61]
K04403  MAP3K7IP1, TAB1; TAK1-binding protein 1
K04404  MAP3K7IP2, TAB2; TAK1-binding protein 2
K04409  PAK1; p21-activated kinase 1 [EC:2.7.11.1]
K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7 [EC:2.7.11.25]
K04430  MAP2K4, MKK4; mitogen-activated protein kinase kinase 4 [EC:2.7.12.2]
K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7 [EC:2.7.12.2]
K04432  MAP2K3, MKK3; mitogen-activated protein kinase kinase 3 [EC:2.7.12.2]
K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6 [EC:2.7.12.2]
K04437  FLNA; filamin-A
K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
K04441  P38; p38 MAP kinase [EC:2.7.11.24]
K04448  JUN; transcription factor AP-1
K04456  AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
K04490  TCF7L1; transcription factor 7-like 1
K04491  TCF7L2; transcription factor 7-like 2
K04492  LEF1; lymphoid enhancer-binding factor 1
K04513  RHOA; Ras homolog gene family, member A
K04519  IL1B; interleukin 1 beta
K04648  DCTN1; dynactin 1
K04721  TNFSF10, TRAIL, CD253; tumor necrosis factor ligand superfamily member 10
K04722  TNFRSF10A_B, TRAILR1_2, DR4_5, CD261_2; tumor necrosis factor receptor superfamily member 10A/B
K04729  MYD88; myeloid differentiation primary response protein MyD88
K04730  IRAK1; interleukin-1 receptor-associated kinase 1 [EC:2.7.11.1]
K04733  IRAK4; interleukin-1 receptor-associated kinase 4 [EC:2.7.11.1]
K04734  NFKBIA; NF-kappa-B inhibitor alpha
K04735  RELA; transcription factor p65
K05400  LY96, MD-2; lymphocyte antigen 96
K05403  TIRAP; toll-interleukin 1 receptor (TIR) domain-containing adaptor protein
K05405  IL6; interleukin 6
K05482  IL18, IL1F4; interleukin 18
K05692  ACTB_G1; actin beta/gamma 1
K05733  PAK3, MRX30; p21-activated kinase 3 [EC:2.7.11.1]
K05749  CYFIP; cytoplasmic FMR1 interacting protein
K05750  NCKAP1, NAP125; NCK-associated protein 1
K05752  C3ORF10, HSPC300; chromosome 3 open reading frame 10
K05754  ARPC5; actin related protein 2/3 complex, subunit 5
K05755  ARPC4; actin related protein 2/3 complex, subunit 4
K05756  ARPC3; actin related protein 2/3 complex, subunit 3
K05757  ARPC1A_B; actin related protein 2/3 complex, subunit 1A/1B
K05758  ARPC2; actin related protein 2/3 complex, subunit 2
K05759  PFN; profilin
K06071  PKN1; serine/threonine-protein kinase N1 [EC:2.7.11.13]
K06083  WASF3; WAS protein family, member 3
K06111  EXOC4, SEC8; exocyst complex component 4
K06478  PTPRC, CD45; receptor-type tyrosine-protein phosphatase C [EC:3.1.3.48]
K06817  PODXL; podocalyxin-like
K07195  EXOC7, EXO70; exocyst complex component 7
K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
K07374  TUBA; tubulin alpha
K07375  TUBB; tubulin beta
K07829  RRAS; Ras-related protein R-Ras
K07834  RALA; Ras-related protein Ral-A
K07856  RHOB; Ras homolog gene family, member B
K07863  RHOG; Ras homolog gene family, member G
K07864  RHOJ, TCL; Ras homolog gene family, member J
K07873  RHOH, TTF; Ras homolog gene family, member H
K07887  RAB5A; Ras-related protein Rab-5A
K07888  RAB5B; Ras-related protein Rab-5B
K07889  RAB5C; Ras-related protein Rab-5C
K07897  RAB7A; Ras-related protein Rab-7A
K07898  RAB7B; Ras-related protein Rab-7B
K07899  RAB9A, RAB9; Ras-related protein Rab-9A
K07900  RAB9B; Ras-related protein Rab-9B
K07937  ARF1_2; ADP-ribosylation factor 1/2
K07941  ARF6; ADP-ribosylation factor 6
K07955  ARL8; ADP-ribosylation factor-like protein 8
K08598  yopJ; YopJ protease family
K08727  NOD1, CARD4; nucleotide-binding oligomerization domain-containing protein 1
K08738  CYC; cytochrome c
K08846  RIPK2; receptor-interacting serine/threonine-protein kinase 2 [EC:2.7.11.1]
K08847  RIPK3; receptor-interacting serine/threonine-protein kinase 3 [EC:2.7.11.1]
K08849  MLKL; mixed lineage kinase domain-like [EC:2.7.11.1]
K09487  HSP90B, TRA1; heat shock protein 90kDa beta
K10030  IL8, CXCL8; interleukin 8
K10089  M6PR; cation-dependent mannose-6-phosphate receptor
K10159  TLR2, CD282; toll-like receptor 2
K10160  TLR4, CD284; toll-like receptor 4
K10161  TLR9, CD289; toll-like receptor 9
K10168  TLR5; toll-like receptor 5
K10169  TLR6, CD286; toll-like receptor 6
K10302  FBXO22; F-box protein 22
K10351  MYL2; myosin regulatory light chain 2
K10358  MYO6; myosin VI
K10396  KIF5; kinesin family member 5 (plus-end-directed kinesin ATPase) [EC:5.6.1.3]
K10407  KLC; kinesin light chain
K10413  DYNC1H; dynein cytoplasmic 1 heavy chain
K10414  DYNC2H, DNCH2; dynein cytoplasmic 2 heavy chain
K10415  DYNC1I, DNCI; dynein cytoplasmic 1 intermediate chain
K10416  DYNC1LI, DNCLI; dynein cytoplasmic 1 light intermediate chain
K10417  DYNC2LI; dynein cytoplasmic 2 light intermediate chain
K10418  DYNLL; dynein light chain LC8-type
K10419  DYNLRB, DNCL2; dynein light chain roadblock-type
K10420  DYNLT1_3; dynein light chain Tctex-type 1/3
K10424  DCTN2; dynactin 2
K10425  DCTN3; dynactin 3
K10426  DCTN4; dynactin 4
K10427  DCTN5; dynactin 5
K10428  DCTN6; dynactin 6
K11014  cdtB; cytolethal distending toxin subunit B
K11023  ptxA, artA, pltA; pertussis toxin subunit 1 [EC:2.4.2.-]
K12366  ELMO1, CED12; engulfment and cell motility protein 1
K12753  MYL5; myosin regulatory light chain 5
K12754  MYL7; myosin regulatory light chain 7
K12755  MYL9; myosin regulatory light chain 9
K12756  MYL10; myosin regulatory light chain 10
K12757  MYL12; myosin regulatory light chain 12
K12758  MYLPF; fast skeletal myosin light chain 2
K12793  MAP3K7IP3, TAB3; TAK1-binding protein 3
K12799  PYCARD, ASC; apoptosis-associated speck-like protein containing a CARD
K12800  NLRP3, PYPAF1; NACHT, LRR and PYD domains-containing protein 3
K12805  NLRC4, CARD12; NLR family CARD domain-containing protein 4
K12807  NAIP, BIRC1; baculoviral IAP repeat-containing protein 1
K13085  ipgD, sopB; phosphatidylinositol-4,5-bisphosphate 4-phosphatase [EC:3.1.3.78]
K13284  sipA, ipaA; invasin A
K13285  sipB, ipaB, bipB; invasin B
K13286  sipC, ipaC, bipC; invasin C
K13450  ospF, mkaD, spvC; phosphothreonine lyase [EC:4.2.3.-]
K13740  sptP; secreted effector protein SptP
K13741  sopE; guanine nucleotide exchange factor SopE
K13744  ARHGEF26, SGEF; Rho guanine nucleotide exchange factor 26
K13883  RILP; Rab-interacting lysosomal protein
K14021  BAK, BAK1; Bcl-2 homologous antagonist/killer
K15343  sspH1; E3 ubiquitin-protein ligase SspH1
K15347  sifA; secreted effector protein SifA
K15348  PLEKHM2, SKIP; pleckstrin homology domain-containing family M member 2
K15349  sseJ; secreted effector protein SseJ
K15350  sseF; secreted effector protein SseF
K15351  sseG; secreted effector protein SseG
K15352  pipB2; secreted effector protein PipB2
K15353  sspH2; E3 ubiquitin-protein ligase SspH2
K15354  sseI, srfH; secreted effector protein SseI
K15366  spvB; salmonella plasmid virulence protein B
K16060  BIRC2_3; baculoviral IAP repeat-containing protein 2/3
K16575  ACTR1, ARP1; centractin
K16576  ACTR10, ARP11; actin-related protein 10
K17092  ANXA2; annexin A2
K17260  ACTR2, ARP2; actin-related protein 2
K17274  S100A10; protein S100-A10
K17388  ROCK2; Rho-associated protein kinase 2 [EC:2.7.11.39]
K17637  EXOC2, SEC5; exocyst complex component 2
K17923  SNX9_18_33; sorting nexin-9/18/33
K18015  elaD, sseL; deubiquitinase [EC:3.4.22.-]
K18423  CSE1, CAS, XPO2; exportin-2 (importin alpha re-exporter)
K18441  CYTH; cytohesin
K18584  ACTR3, ARP3; actin-related protein 3
K18985  ELMO2, CED12A; engulfment and cell motility protein 2
K19298  subB, artB, pltB; subtilase cytotoxin, subunit B
K19557  spvD; salmonella plasmid virulence protein D
K19984  EXOC5, SEC10; exocyst complex component 5
K20179  VPS11, PEP5; vacuolar protein sorting-associated protein 11
K20180  VPS16; vacuolar protein sorting-associated protein 16
K20181  VPS18, PEP3; vacuolar protein sorting-associated protein 18
K20182  VPS33A; vacuolar protein sorting-associated protein 33A
K20183  VPS39, VAM6; Vam6/Vps39-like protein vacuolar protein sorting-associated protein 39
K20184  VPS41; vacuolar protein sorting-associated protein 41
K20282  GCC2; GRIP and coiled-coil domain-containing protein 2
K20917  GSDMD; gasdermin-D
K21289  PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma [EC:2.7.1.153]
K21954  FYCO1; FYVE and coiled-coil domain-containing protein 1
K22487  prgJ; type III secretion system protein
K23282  PLEKHM1; pleckstrin homology domain-containing family M member 1
K23484  DNM2; dynamin 2
K23583  KPNA3_4; importin subunit alpha-4/3
K23612  WASL; neural Wiskott-Aldrich syndrome protein
K23649  ABI1; abl interactor 1
K23934  AHNAK; neuroblast differentiation-associated protein AHNAK
K23935  ACBD3; golgi resident protein GCP60
K23936  sopD2; secreted effector protein SopD2
K23937  STX10; syntaxin 10
K23938  FHOD1; FH1/FH2 domain-containing protein 1
K23940  KPNA1; importin subunit alpha-5
K23941  pipA, gogA, gtgA; PipA/GogA/GtgA family effector protease
K23942  gogB; Gifsy-1 prophage leucine-rich repeat protein
K23943  sseK3; type III secretion system effector arginine glycosyltransferase
K23944  sseK1; type III secretion system effector arginine glycosyltransferase
K23945  sseK2; type III secretion system effector
K23946  slrP; E3 ubiquitin-protein ligase SlrP
Compound
C00338  Lipopolysaccharide
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:28875943
  Authors
Bernal-Bayard J, Ramos-Morales F
  Title
Molecular Mechanisms Used by Salmonella to Evade the Immune System.
  Journal
Curr Issues Mol Biol 25:133-168 (2018)
DOI:10.21775/cimb.025.133
Reference
PMID:28848711
  Authors
Hume PJ, Singh V, Davidson AC, Koronakis V
  Title
Swiss Army Pathogen: The Salmonella Entry Toolkit.
  Journal
Front Cell Infect Microbiol 7:348 (2017)
DOI:10.3389/fcimb.2017.00348
Reference
PMID:31402916
  Authors
Wemyss MA, Pearson JS
  Title
Host Cell Death Responses to Non-typhoidal Salmonella Infection.
  Journal
Front Immunol 10:1758 (2019)
DOI:10.3389/fimmu.2019.01758
Reference
PMID:27974148
  Authors
Bierschenk D, Boucher D, Schroder K
  Title
Salmonella-induced inflammasome activation in humans.
  Journal
Mol Immunol 86:38-43 (2017)
DOI:10.1016/j.molimm.2016.11.009
Reference
PMID:29477730
  Authors
Pinaud L, Sansonetti PJ, Phalipon A
  Title
Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors.
  Journal
Trends Microbiol 26:266-283 (2018)
DOI:10.1016/j.tim.2018.01.010
Reference
PMID:25749450
  Authors
LaRock DL, Chaudhary A, Miller SI
  Title
Salmonellae interactions with host processes.
  Journal
Nat Rev Microbiol 13:191-205 (2015)
DOI:10.1038/nrmicro3420
Reference
PMID:17983751
  Authors
Ramsden AE, Holden DW, Mota LJ
  Title
Membrane dynamics and spatial distribution of Salmonella-containing vacuoles.
  Journal
Trends Microbiol 15:516-24 (2007)
DOI:10.1016/j.tim.2007.10.002
Reference
PMID:22702524
  Authors
van der Heijden J, Finlay BB
  Title
Type III effector-mediated processes in Salmonella infection.
  Journal
Future Microbiol 7:685-703 (2012)
DOI:10.2217/fmb.12.49
Reference
PMID:27222578
  Authors
Galan JE
  Title
Typhoid toxin provides a window into typhoid fever and the biology of Salmonella Typhi.
  Journal
Proc Natl Acad Sci U S A 113:6338-44 (2016)
DOI:10.1073/pnas.1606335113
Reference
PMID:19157959
  Authors
McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V
  Title
Salmonella takes control: effector-driven manipulation of the host.
  Journal
Curr Opin Microbiol 12:117-24 (2009)
DOI:10.1016/j.mib.2008.12.001
Reference
PMID:12675800
  Authors
Miao EA, Brittnacher M, Haraga A, Jeng RL, Welch MD, Miller SI
  Title
Salmonella effectors translocated across the vacuolar membrane interact with the actin cytoskeleton.
  Journal
Mol Microbiol 48:401-15 (2003)
DOI:10.1046/j.1365-2958.2003.t01-1-03456.x
Reference
PMID:17074883
  Authors
Patel JC, Galan JE
  Title
Differential activation and function of Rho GTPases during Salmonella-host cell interactions.
  Journal
J Cell Biol 175:453-63 (2006)
DOI:10.1083/jcb.200605144
Reference
PMID:18411289
  Authors
Wasylnka JA, Bakowski MA, Szeto J, Ohlson MB, Trimble WS, Miller SI, Brumell JH
  Title
Role for myosin II in regulating positioning of Salmonella-containing vacuoles and intracellular replication.
  Journal
Infect Immun 76:2722-35 (2008)
DOI:10.1128/IAI.00152-08
Reference
PMID:10499590
  Authors
Fu Y, Galan JE
  Title
A salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion.
  Journal
Nature 401:293-7 (1999)
DOI:10.1038/45829
Related
pathway
ko03070  Bacterial secretion system
ko04010  MAPK signaling pathway
ko04064  NF-kappa B signaling pathway
ko04210  Apoptosis
ko04217  Necroptosis
ko04621  NOD-like receptor signaling pathway

DBGET integrated database retrieval system