KEGG   PATHWAY: ko05132
Entry
ko05132                     Pathway                                
Name
Salmonella infection
Description
Salmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, Salmonella enterica, which has numerous serovars.
Following intestinal colonization Salmonella inject effector proteins into the host cells using a type III secretion system (T3SS), T3SS1. Then a small group of effector proteins induce rearrangement of the actin cytoskeleton resulting in membrane ruffles and rapid internalization of the bacteria.The T3SS2 is responsible for translocating effector proteins that direct Salmonella-containing vacuole (SCV) maturation. The majority of the bacteria are known to survive and replicate in SCV.
Class
Human Diseases; Infectious disease: bacterial
Pathway map
ko05132  Salmonella infection
ko05132

Disease
H00111  Typhoid fever
Orthology
K11014  cytolethal distending toxin subunit B
K11023  pertussis toxin subunit 1 [EC:2.4.2.-]
K19298  subtilase cytotoxin, subunit B
K06817  podocalyxin-like
K06478  receptor-type tyrosine-protein phosphatase C [EC:3.1.3.48]
K13085  phosphatidylinositol-4,5-bisphosphate 4-phosphatase [EC:3.1.3.78]
K07887  Ras-related protein Rab-5A
K07888  Ras-related protein Rab-5B
K07889  Ras-related protein Rab-5C
K00914  phosphatidylinositol 3-kinase [EC:2.7.1.137]
K15347  secreted effector protein SifA
K07897  Ras-related protein Rab-7A
K07898  Ras-related protein Rab-7B
K23282  pleckstrin homology domain-containing family M member 1
K20179  vacuolar protein sorting-associated protein 11
K20180  vacuolar protein sorting-associated protein 16
K20181  vacuolar protein sorting-associated protein 18
K20182  vacuolar protein sorting-associated protein 33A
K20183  Vam6/Vps39-like protein vacuolar protein sorting-associated protein 39
K20184  vacuolar protein sorting-associated protein 41
K23936  secreted effector protein SopD2
K13883  Rab-interacting lysosomal protein
K10413  dynein cytoplasmic 1 heavy chain
K10414  dynein cytoplasmic 2 heavy chain
K10415  dynein cytoplasmic 1 intermediate chain
K10416  dynein cytoplasmic 1 light intermediate chain
K10417  dynein cytoplasmic 2 light intermediate chain
K10418  dynein light chain LC8-type
K10419  dynein light chain roadblock-type
K10420  dynein light chain Tctex-type 1/3
K04648  dynactin 1
K10424  dynactin 2
K10425  dynactin 3
K10426  dynactin 4
K10427  dynactin 5
K10428  dynactin 6
K16575  centractin
K16576  actin-related protein 10
K07374  tubulin alpha
K07375  tubulin beta
K21954  FYVE and coiled-coil domain-containing protein 1
K07955  ADP-ribosylation factor-like protein 8
K15348  pleckstrin homology domain-containing family M member 2
K10396  kinesin family member 5
K10407  kinesin light chain
K15352  secreted effector protein PipB2
K15350  secreted effector protein SseF
K15351  secreted effector protein SseG
K23935  golgi resident protein GCP60
K04513  Ras homolog gene family, member A
K15349  secreted effector protein SseJ
K10089  cation-dependent mannose-6-phosphate receptor
K07899  Ras-related protein Rab-9A
K07900  Ras-related protein Rab-9B
K20282  GRIP and coiled-coil domain-containing protein 2
K23937  syntaxin 10
K15353  E3 ubiquitin-protein ligase SspH2
K15354  secreted effector protein SseI
K05759  profilin
K04437  filamin-A
K15366  salmonella plasmid virulence protein B
K07195  exocyst complex component 7
K19984  exocyst complex component 5
K06111  exocyst complex component 4
K17637  exocyst complex component 2
K07834  Ras-related protein Ral-A
K13286  invasin C
K13284  invasin A
K05692  actin beta/gamma 1
K17274  protein S100-A10
K17092  annexin A2
K23934  neuroblast differentiation-associated protein AHNAK
K13741  guanine nucleotide exchange factor SopE
K13740  secreted effector protein SptP
K07864  Ras homolog gene family, member J
K13744  Rho guanine nucleotide exchange factor 26
K07863  Ras homolog gene family, member G
K12366  engulfment and cell motility protein 1
K18985  engulfment and cell motility protein 2
K17388  Rho-associated protein kinase 2 [EC:2.7.11.39]
K10351  myosin regulatory light chain 2
K12753  myosin regulatory light chain 5
K12754  myosin regulatory light chain 7
K12755  myosin regulatory light chain 9
K12756  myosin regulatory light chain 10
K12757  myosin regulatory light chain 12
K12758  fast skeletal myosin light chain 2
K23938  FH1/FH2 domain-containing protein 1
K04393  cell division control protein 42
K04392  Ras-related C3 botulinum toxin substrate 1
K05750  NCK-associated protein 1
K05749  cytoplasmic FMR1 interacting protein
K23649  abl interactor 1
K05752  chromosome 3 open reading frame 10
K06083  WAS protein family, member 3
K17260  actin-related protein 2
K18584  actin-related protein 3
K05757  actin related protein 2/3 complex, subunit 1A/1B
K05758  actin related protein 2/3 complex, subunit 2
K05756  actin related protein 2/3 complex, subunit 3
K05755  actin related protein 2/3 complex, subunit 4
K05754  actin related protein 2/3 complex, subunit 5
K04409  p21-activated kinase 1 [EC:2.7.11.1]
K05733  p21-activated kinase 3 [EC:2.7.11.1]
K10358  myosin VI
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K21289  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma [EC:2.7.1.153]
K00923  phosphatidylinositol-4-phosphate 3-kinase [EC:2.7.1.154]
K18441  cytohesin
K07941  ADP-ribosylation factor 6
K07937  ADP-ribosylation factor 1/2
K17923  sorting nexin-9/18/33
K23612  neural Wiskott-Aldrich syndrome protein
K23484  dynamin 2 [EC:3.6.5.5]
K10169  toll-like receptor 6
K10159  toll-like receptor 2
K05403  toll-interleukin 1 receptor (TIR) domain-containing adaptor protein
K04729  myeloid differentiation primary response protein MyD88
K04391  monocyte differentiation antigen CD14
K10160  toll-like receptor 4
K05400  lymphocyte antigen 96
K02406  flagellin
K10168  toll-like receptor 5
K10161  toll-like receptor 9
K04730  interleukin-1 receptor-associated kinase 1 [EC:2.7.11.1]
K04733  interleukin-1 receptor-associated kinase 4 [EC:2.7.11.1]
K03175  TNF receptor-associated factor 6 [EC:2.3.2.27]
K04427  mitogen-activated protein kinase kinase kinase 7 [EC:2.7.11.25]
K04403  TAK1-binding protein 1
K04404  TAK1-binding protein 2
K12793  TAK1-binding protein 3
K07210  inhibitor of nuclear factor kappa-B kinase subunit gamma
K04467  inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
K07209  inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
K04734  NF-kappa-B inhibitor alpha
K02580  nuclear factor NF-kappa-B p105 subunit
K04735  transcription factor p65
K08727  nucleotide-binding oligomerization domain-containing protein 1
K04079  molecular chaperone HtpG
K09487  heat shock protein 90kDa beta
K08846  receptor-interacting serine/threonine-protein kinase 2 [EC:2.7.11.1]
K18423  exportin-2 (importin alpha re-exporter)
K23940  importin subunit alpha-5
K23583  importin subunit alpha-4/3
K02985  small subunit ribosomal protein S3e
K02833  GTPase HRas
K04366  RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
K04369  mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
K04371  mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K04432  mitogen-activated protein kinase kinase 3 [EC:2.7.12.2]
K04433  mitogen-activated protein kinase kinase 6 [EC:2.7.12.2]
K04441  p38 MAP kinase [EC:2.7.11.24]
K04430  mitogen-activated protein kinase kinase 4 [EC:2.7.12.2]
K04431  mitogen-activated protein kinase kinase 7 [EC:2.7.12.2]
K04440  mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
K04379  proto-oncogene protein c-fos
K04448  transcription factor AP-1
K03156  tumor necrosis factor superfamily, member 2
K04519  interleukin 1 beta
K05405  interleukin 6
K10030  interleukin 8
K02105  catenin beta 1
K02620  transcription factor 7
K04490  transcription factor 7-like 1
K04491  transcription factor 7-like 2
K04492  lymphoid enhancer-binding factor 1
K04377  Myc proto-oncogene protein
K19557  salmonella plasmid virulence protein D
K23941  PipA/GogA/GtgA family effector protease
K15343  E3 ubiquitin-protein ligase SspH1
K06071  serine/threonine-protein kinase N1 [EC:2.7.11.13]
K23942  Gifsy-1 prophage leucine-rich repeat protein
K10302  F-box protein 22
K03094  S-phase kinase-associated protein 1
K08598  YopJ protease family
K18015  deubiquitinase [EC:3.4.22.-]
K13450  phosphothreonine lyase [EC:4.2.3.-]
K03158  tumor necrosis factor receptor superfamily member 1A
K03173  TNF receptor-associated factor 2 [EC:2.3.2.27]
K03171  tumor necrosis factor receptor type 1-associated DEATH domain protein
K16060  baculoviral IAP repeat-containing protein 2/3
K02861  receptor-interacting serine/threonine-protein kinase 1 [EC:2.7.11.1]
K00134  glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12]
K04721  tumor necrosis factor ligand superfamily member 10
K04722  tumor necrosis factor receptor superfamily member 10A/B
K02373  FAS-associated death domain protein
K04398  caspase 8 [EC:3.4.22.61]
K08847  receptor-interacting serine/threonine-protein kinase 3 [EC:2.7.11.1]
K02159  apoptosis regulator BAX
K14021  Bcl-2 homologous antagonist/killer
K08738  cytochrome c
K02161  apoptosis regulator Bcl-2
K02187  caspase 3 [EC:3.4.22.56]
K04397  caspase 7 [EC:3.4.22.60]
K07856  Ras homolog gene family, member B
K07873  Ras homolog gene family, member H
K07829  Ras-related protein R-Ras
K04456  RAC serine/threonine-protein kinase [EC:2.7.11.1]
K08849  mixed lineage kinase domain-like [EC:2.7.11.1]
K23943  type III secretion system effector arginine glycosyltransferase
K23944  type III secretion system effector arginine glycosyltransferase
K23945  type III secretion system effector
K23946  E3 ubiquitin-protein ligase SlrP [EC:2.3.2.27]
K03671  thioredoxin
K12800  NACHT, LRR and PYD domains-containing protein 3
K22487  type III secretion system protein
K03221  type III secretion protein F
K12807  baculoviral IAP repeat-containing protein 1
K12805  NLR family CARD domain-containing protein 4
K12799  apoptosis-associated speck-like protein containing a CARD
K01370  caspase 1 [EC:3.4.22.36]
K05482  interleukin 18
K04394  caspase 4 [EC:3.4.22.57 3.4.22.64]
K04395  caspase 5 [EC:3.4.22.58]
K20917  gasdermin-D
K13285  invasin B
Compound
C00338  Lipopolysaccharide
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:28875943
  Authors
Bernal-Bayard J, Ramos-Morales F
  Title
Molecular Mechanisms Used by Salmonella to Evade the Immune System.
  Journal
Curr Issues Mol Biol 25:133-168 (2018)
DOI:10.21775/cimb.025.133
Reference
PMID:28848711
  Authors
Hume PJ, Singh V, Davidson AC, Koronakis V
  Title
Swiss Army Pathogen: The Salmonella Entry Toolkit.
  Journal
Front Cell Infect Microbiol 7:348 (2017)
DOI:10.3389/fcimb.2017.00348
Reference
PMID:31402916
  Authors
Wemyss MA, Pearson JS
  Title
Host Cell Death Responses to Non-typhoidal Salmonella Infection.
  Journal
Front Immunol 10:1758 (2019)
DOI:10.3389/fimmu.2019.01758
Reference
PMID:27974148
  Authors
Bierschenk D, Boucher D, Schroder K
  Title
Salmonella-induced inflammasome activation in humans.
  Journal
Mol Immunol 86:38-43 (2017)
DOI:10.1016/j.molimm.2016.11.009
Reference
PMID:29477730
  Authors
Pinaud L, Sansonetti PJ, Phalipon A
  Title
Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors.
  Journal
Trends Microbiol 26:266-283 (2018)
DOI:10.1016/j.tim.2018.01.010
Reference
PMID:25749450
  Authors
LaRock DL, Chaudhary A, Miller SI
  Title
Salmonellae interactions with host processes.
  Journal
Nat Rev Microbiol 13:191-205 (2015)
DOI:10.1038/nrmicro3420
Reference
PMID:17983751
  Authors
Ramsden AE, Holden DW, Mota LJ
  Title
Membrane dynamics and spatial distribution of Salmonella-containing vacuoles.
  Journal
Trends Microbiol 15:516-24 (2007)
DOI:10.1016/j.tim.2007.10.002
Reference
PMID:22702524
  Authors
van der Heijden J, Finlay BB
  Title
Type III effector-mediated processes in Salmonella infection.
  Journal
Future Microbiol 7:685-703 (2012)
DOI:10.2217/fmb.12.49
Reference
PMID:27222578
  Authors
Galan JE
  Title
Typhoid toxin provides a window into typhoid fever and the biology of Salmonella Typhi.
  Journal
Proc Natl Acad Sci U S A 113:6338-44 (2016)
DOI:10.1073/pnas.1606335113
Reference
PMID:19157959
  Authors
McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V
  Title
Salmonella takes control: effector-driven manipulation of the host.
  Journal
Curr Opin Microbiol 12:117-24 (2009)
DOI:10.1016/j.mib.2008.12.001
Reference
PMID:12675800
  Authors
Miao EA, Brittnacher M, Haraga A, Jeng RL, Welch MD, Miller SI
  Title
Salmonella effectors translocated across the vacuolar membrane interact with the actin cytoskeleton.
  Journal
Mol Microbiol 48:401-15 (2003)
DOI:10.1046/j.1365-2958.2003.t01-1-03456.x
Reference
PMID:17074883
  Authors
Patel JC, Galan JE
  Title
Differential activation and function of Rho GTPases during Salmonella-host cell interactions.
  Journal
J Cell Biol 175:453-63 (2006)
DOI:10.1083/jcb.200605144
Reference
PMID:18411289
  Authors
Wasylnka JA, Bakowski MA, Szeto J, Ohlson MB, Trimble WS, Miller SI, Brumell JH
  Title
Role for myosin II in regulating positioning of Salmonella-containing vacuoles and intracellular replication.
  Journal
Infect Immun 76:2722-35 (2008)
DOI:10.1128/IAI.00152-08
Reference
PMID:10499590
  Authors
Fu Y, Galan JE
  Title
A salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion.
  Journal
Nature 401:293-7 (1999)
DOI:10.1038/45829
Related
pathway
ko03070  Bacterial secretion system
ko04010  MAPK signaling pathway
ko04064  NF-kappa B signaling pathway
ko04210  Apoptosis
ko04217  Necroptosis
ko04621  NOD-like receptor signaling pathway
LinkDB

DBGET integrated database retrieval system