KEGG   PATHWAY: npr05168
Entry
npr05168                    Pathway                                
Name
Herpes simplex virus 1 infection - Nanorana parkeri (Xizang Plateau frog)
Description
Herpes simplex virus 1(HSV-1) is a common human pathogen, which initially infects orofacial mucosal surfaces. The virus replicates in epithelial cells at these sites, causing clinically overt disease characterized by vesicular lesions. HSV-1 then penetrates to the nervous system and establishes latency in sensory neurons. Throughout the lifetime of the host, HSV-1 may reactivate from its latent state and reinitiate a lytic infection cycle. HSV-1 has developed various mechanisms to escape its host innate immune responses and increased its capacity to replicate and to persist. ICP34.5, ICP0, ICP27, Us11 and Vhs (UL41) are the proteins involved in viral interference.
Class
Human Diseases; Infectious disease: viral
Pathway map
npr05168  Herpes simplex virus 1 infection
npr05168

Organism
Nanorana parkeri (Xizang Plateau frog) [GN:npr]
Gene
108793733  lymphotoxin-alpha-like [KO:K05468]
108787259  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
108784349  TRAF5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
108791446  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
108797654  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
108791352  IKBKG; NF-kappa-B essential modulator [KO:K07210]
108795750  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
108789059  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
108784114  RELA; transcription factor p65 [KO:K04735]
108786933  putative inhibitor of apoptosis [KO:K16060]
108790979  NECTIN2; nectin-2 isoform X1 [KO:K06081]
108789428  nectin-1-like [KO:K06081]
108788123  nectin-1-like [KO:K06081]
108790634  tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
108798021  PTPN11; tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
108797346  ITGA5; integrin alpha-5 [KO:K06484]
108797421  ITGB3; integrin beta-3 [KO:K06493]
108787987  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
108787186  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
108793109  CARD9; caspase recruitment domain-containing protein 9 [KO:K12794]
108797511  interferon regulatory factor 3-like [KO:K05411]
108797512  interferon regulatory factor 5-like [KO:K05411]
108784730  cellular tumor antigen p53-like [KO:K04451]
108794623  C3; complement C3 [KO:K03990]
108791483  complement C3-like [KO:K03990]
108793646  C5; complement C5 [KO:K03994]
108801843  properdin-like [KO:K15412]
108801844  properdin-like [KO:K15412]
108788197  TLR2; toll-like receptor 2 isoform X1 [KO:K10159]
108791424  toll-like receptor 2 [KO:K10159]
108795015  toll-like receptor 2 [KO:K10159]
108784626  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
108786686  interferon regulatory factor 7-like [KO:K09447]
108790918  TLR3; toll-like receptor 3 [KO:K05401]
108789468  IRAK4; LOW QUALITY PROTEIN: interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
108790442  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
108787821  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
108800110  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
108798164  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
108789386  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
108785587  interleukin-1 beta-like [KO:K04519]
108785600  interleukin-1 beta-like [KO:K04519]
108797293  interleukin-6-like [KO:K05405]
108793742  tumor necrosis factor-like [KO:K03156]
108803420  interleukin-12 subunit beta-like [KO:K05425]
108785404  DDX58; probable ATP-dependent RNA helicase DDX58 [KO:K12646] [EC:5.6.2.6]
108787198  IFIH1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
108790750  TRAF3; TNF receptor-associated factor 3 [KO:K03174]
108804572  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
108795988  cyclic GMP-AMP synthase-like [KO:K17834] [EC:2.7.7.86]
108795990  cyclic GMP-AMP synthase-like [KO:K17834] [EC:2.7.7.86]
108798433  TMEM173; stimulator of interferon genes protein [KO:K12654]
108796512  serine/threonine-protein phosphatase alpha-2 isoform-like [KO:K06269] [EC:3.1.3.16]
108786345  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
108788527  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
108795808  EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 [KO:K16194] [EC:2.7.11.1]
108792731  interferon-induced, double-stranded RNA-activated protein kinase-like [KO:K16195] [EC:2.7.11.1]
108794954  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
108796769  EIF2AK4; eIF-2-alpha kinase GCN2 [KO:K16196] [EC:2.7.11.1]
108799093  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
108787418  EIF2B1; translation initiation factor eIF-2B subunit alpha [KO:K03239]
108802483  EIF2B2; translation initiation factor eIF-2B subunit beta [KO:K03754]
108803706  translation initiation factor eIF-2B subunit gamma-like [KO:K03241]
108803139  EIF2B4; translation initiation factor eIF-2B subunit delta [KO:K03680]
108804667  EIF2B5; translation initiation factor eIF-2B subunit epsilon [KO:K03240]
108790459  HCFC1; host cell factor 1 [KO:K14966]
108789003  HCFC2; host cell factor 2 [KO:K27390]
108800289  POU2F1; POU domain, class 2, transcription factor 1 isoform X1 [KO:K09364]
108789423  POU2F3; POU domain, class 2, transcription factor 3 [KO:K09364]
108785655  POU2F2; POU domain, class 2, transcription factor 2 [KO:K09364]
108794147  interferon alpha/beta receptor 1-like [KO:K05130]
108801343  suppressor of cytokine signaling 3-like [KO:K04696]
108801441  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
108792339  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
108798858  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
108791510  signal transducer and activator of transcription 2-like [KO:K11221]
108797006  zinc finger protein 84-like [KO:K09228]
108788083  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
108788086  zinc finger protein 567-like [KO:K09228]
108788071  zinc finger protein 501-like [KO:K09228]
108788082  gastrula zinc finger protein XlCGF26.1-like [KO:K09228]
108788089  zinc finger protein 585B-like [KO:K09228]
108788098  zinc finger protein 154-like [KO:K09228]
108788102  zinc finger protein OZF-like [KO:K09228]
108799918  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
108799920  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
108799921  zinc finger protein 37 homolog [KO:K09228]
108799923  gastrula zinc finger protein XlCGF26.1-like [KO:K09228]
108801100  gastrula zinc finger protein XlCGF26.1-like [KO:K09228]
108802263  zinc finger protein 500-like [KO:K09228]
108803313  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
108802392  zinc finger protein 2-like [KO:K09228]
108802394  zinc finger protein 135-like [KO:K09228]
108803508  oocyte zinc finger protein XlCOF6-like [KO:K09228]
108798922  zinc finger protein 260-like [KO:K09228]
108800046  gastrula zinc finger protein XlCGF26.1-like [KO:K09228]
108800047  zinc finger protein 260-like [KO:K09228]
108802312  zinc finger protein 239-like [KO:K09228]
108803394  gastrula zinc finger protein XlCGF26.1-like [KO:K09228]
108798177  zinc finger protein 418-like [KO:K09228]
108798191  zinc finger protein 501-like [KO:K09228]
108798193  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
108798199  zinc finger protein 883-like [KO:K09228]
108801415  oocyte zinc finger protein XlCOF6.1-like [KO:K09228]
108801416  endothelial zinc finger protein induced by tumor necrosis factor alpha-like [KO:K09228]
108799111  zinc finger protein OZF-like [KO:K09228]
108799114  zinc finger protein OZF-like [KO:K09228]
108799115  zinc finger protein OZF-like [KO:K09228]
108799116  oocyte zinc finger protein XlCOF7.1-like [KO:K09228]
108801417  zinc finger protein 665-like [KO:K09228]
108801362  zinc finger protein 2-like [KO:K09228]
108801363  zinc finger protein 250-like [KO:K09228]
108801419  oocyte zinc finger protein XlCOF7.1-like [KO:K09228]
108801410  gastrula zinc finger protein XlCGF26.1-like [KO:K09228]
108802613  zinc finger protein OZF-like [KO:K09228]
108799109  zinc finger protein 391-like [KO:K09228]
108797990  oocyte zinc finger protein XlCOF6.1-like [KO:K09228]
108797991  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
108797993  gastrula zinc finger protein XlCGF26.1-like [KO:K09228]
108802449  zinc finger protein OZF-like [KO:K09228]
108803563  zinc finger protein OZF-like [KO:K09228]
108797198  gastrula zinc finger protein XlCGF71.1-like [KO:K09228]
108803797  oocyte zinc finger protein XlCOF7.1-like [KO:K09228]
108791118  zinc finger protein 436-like [KO:K09228]
108791120  zinc finger protein 567-like [KO:K09228]
108797382  zinc finger protein 436-like [KO:K09228]
108801706  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
108802850  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
108802851  oocyte zinc finger protein XlCOF22-like [KO:K09228]
108803942  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
108803989  zinc finger protein OZF-like [KO:K09228]
108792032  zinc finger protein OZF-like [KO:K09228]
108792040  zinc finger protein 883-like [KO:K09228]
108792044  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
108792046  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
108801667  gastrula zinc finger protein XlCGF52.1-like [KO:K09228]
108801675  zinc finger protein 239-like [KO:K09228]
108803880  zinc finger protein 776-like [KO:K09228]
108803873  gastrula zinc finger protein XlCGF26.1-like [KO:K09228]
108802968  oocyte zinc finger protein XlCOF22-like [KO:K09228]
108802970  gastrula zinc finger protein XlCGF26.1-like [KO:K09228]
108804091  zinc finger protein 585A-like [KO:K09228]
108802967  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
108800703  zinc finger protein 470-like [KO:K09228]
108796622  oocyte zinc finger protein XlCOF22-like [KO:K09228]
108800879  zinc finger protein 567-like [KO:K09228]
108792442  zinc finger protein 2 homolog [KO:K09228]
108792445  zinc finger protein Xfin-like [KO:K09228]
108794613  zinc finger protein 84-like [KO:K09228]
108796629  gastrula zinc finger protein XlCGF26.1-like [KO:K09228]
108796633  gastrula zinc finger protein XlCGF17.1-like [KO:K09228]
108798758  oocyte zinc finger protein XlCOF6-like [KO:K09228]
108800924  zinc finger protein 551-like [KO:K09228]
108803173  oocyte zinc finger protein XlCOF22-like [KO:K09228]
108803176  zinc finger protein 260-like [KO:K09228]
108803200  gastrula zinc finger protein XlCGF26.1-like [KO:K09228]
108803202  zinc finger protein OZF-like [KO:K09228]
108803225  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
108797714  zinc finger protein 883-like [KO:K09228]
108797717  zinc finger protein 345-like [KO:K09228]
108797725  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
108803278  zinc finger protein 135-like [KO:K09228]
108791455  zinc finger protein 585A-like isoform X1 [KO:K09228]
108788077  zinc finger protein 501-like [KO:K09228]
108788080  gastrula zinc finger protein XlCGF26.1-like [KO:K09228]
108802259  gastrula zinc finger protein XlCGF52.1-like [KO:K09228]
108802264  gastrula zinc finger protein XlCGF52.1-like [KO:K09228]
108803304  zinc finger protein 345-like [KO:K09228]
108803314  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
108803328  zinc finger protein 271-like [KO:K09228]
108799916  zinc finger protein 585B-like [KO:K09228]
108799919  zinc finger protein 572-like [KO:K09228]
108801097  zinc finger protein 501-like [KO:K09228]
108788090  oocyte zinc finger protein XlCOF7.1-like [KO:K09228]
108788092  zinc finger protein OZF-like [KO:K09228]
108788094  zinc finger protein 501-like [KO:K09228]
108788096  zinc finger protein 665-like [KO:K09228]
108798258  zinc finger protein 300-like [KO:K09228]
108798259  zinc finger protein 177-like [KO:K09228]
108801569  oocyte zinc finger protein XlCOF6.1-like [KO:K09228]
108801570  zinc finger protein OZF-like [KO:K09228]
108801580  gastrula zinc finger protein XlCGF26.1-like [KO:K09228]
108801583  zinc finger protein 585A-like [KO:K09228]
108801585  zinc finger protein 84-like [KO:K09228]
108801631  LOW QUALITY PROTEIN: oocyte zinc finger protein XlCOF7.1-like [KO:K09228]
108802692  zinc finger protein 605-like [KO:K09228]
108802703  zinc finger protein 665-like [KO:K09228]
108803834  oocyte zinc finger protein XlCOF6.1-like [KO:K09228]
108799117  gastrula zinc finger protein XlCGF71.1-like [KO:K09228]
108799120  zinc finger protein 2-like [KO:K09228]
108799121  zinc finger protein 239-like [KO:K09228]
108801413  gastrula zinc finger protein XlCGF26.1-like [KO:K09228]
108801414  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
108803638  zinc finger protein 260-like [KO:K09228]
108800517  zinc finger protein 835-like [KO:K09228]
108801636  zinc finger protein 883-like [KO:K09228]
108801637  oocyte zinc finger protein XlCOF7.1-like [KO:K09228]
108801663  LOW QUALITY PROTEIN: zinc finger protein 25-like [KO:K09228]
108801664  zinc finger protein OZF-like [KO:K09228]
108801666  LOW QUALITY PROTEIN: zinc finger protein 260-like [KO:K09228]
108802406  zinc finger protein OZF-like [KO:K09228]
108803448  zinc finger protein 2 homolog [KO:K09228]
108803450  zinc finger protein 268-like isoform X1 [KO:K09228]
108803453  oocyte zinc finger protein XlCOF6.1-like [KO:K09228]
108803652  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
108803663  zinc finger protein 260-like [KO:K09228]
108803677  zinc finger protein OZF-like [KO:K09228]
108803680  gastrula zinc finger protein XlCGF17.1-like [KO:K09228]
108801451  LOW QUALITY PROTEIN: zinc finger protein 271-like [KO:K09228]
108801454  gastrula zinc finger protein XlCGF17.1-like [KO:K09228]
108801455  zinc finger protein 260-like [KO:K09228]
108792033  zinc finger protein OZF-like [KO:K09228]
108792038  zinc finger protein OZF-like [KO:K09228]
108796274  zinc finger protein 3-like [KO:K09228]
108799110  oocyte zinc finger protein XlCOF6.1-like [KO:K09228]
108801272  zinc finger protein 260-like [KO:K09228]
108801273  LOW QUALITY PROTEIN: oocyte zinc finger protein XlCOF7.1-like [KO:K09228]
108801278  LOW QUALITY PROTEIN: oocyte zinc finger protein XlCOF7.1-like [KO:K09228]
108803526  zinc finger protein 665-like [KO:K09228]
108803550  oocyte zinc finger protein XlCOF6.1-like [KO:K09228]
108798172  LOW QUALITY PROTEIN: zinc finger protein 260-like [KO:K09228]
108798174  zinc finger protein 501-like [KO:K09228]
108798202  gastrula zinc finger protein XlCGF26.1-like [KO:K09228]
108801568  oocyte zinc finger protein XlCOF6.1-like [KO:K09228]
108803730  LOW QUALITY PROTEIN: zinc finger protein 135-like [KO:K09228]
108798919  gastrula zinc finger protein XlCGF26.1-like [KO:K09228]
108798920  gastrula zinc finger protein XlCGF26.1-like [KO:K09228]
108800045  oocyte zinc finger protein XlCOF6-like [KO:K09228]
108803380  zinc finger protein 271-like [KO:K09228]
108796630  gastrula zinc finger protein XlCGF26.1-like [KO:K09228]
108796632  gastrula zinc finger protein XlCGF17.1-like [KO:K09228]
108798755  zinc finger protein OZF-like [KO:K09228]
108798757  oocyte zinc finger protein XlCOF6.1-like [KO:K09228]
108800919  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
108803191  zinc finger protein 271-like [KO:K09228]
108803226  zinc finger protein OZF-like [KO:K09228]
108791117  zinc finger protein 37 homolog [KO:K09228]
108801705  gastrula zinc finger protein XlCGF52.1-like [KO:K09228]
108803926  zinc finger protein 436-like [KO:K09228]
108803996  gastrula zinc finger protein XlCGF26.1-like [KO:K09228]
108799619  LOW QUALITY PROTEIN: zinc finger protein 845-like [KO:K09228]
108799621  zinc finger protein 260-like [KO:K09228]
108800702  zinc finger protein 883-like [KO:K09228]
108801851  gastrula zinc finger protein XlCGF17.1-like [KO:K09228]
108801853  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
108802966  gastrula zinc finger protein XlCGF26.1-like [KO:K09228]
108802969  zinc finger protein 850-like [KO:K09228]
108804110  zinc finger protein 271-like [KO:K09228]
108796623  zinc finger protein OZF-like [KO:K09228]
108798687  zinc finger protein 850-like [KO:K09228]
108800872  zinc finger protein 234-like [KO:K09228]
108800874  oocyte zinc finger protein XlCOF6.1-like [KO:K09228]
108802013  zinc finger protein 84-like [KO:K09228]
108797718  gastrula zinc finger protein XlCGF26.1-like [KO:K09228]
108800981  oocyte zinc finger protein XlCOF6-like [KO:K09228]
108793207  oocyte zinc finger protein XlCOF6-like [KO:K09228]
108802921  zinc finger protein 605-like [KO:K09228]
108802922  zinc finger protein 850-like [KO:K09228]
108802953  zinc finger protein Xfin-like [KO:K09228]
108794614  zinc finger protein 84-like [KO:K09228]
108798500  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
108788354  DAXX; death domain-associated protein 6 [KO:K02308]
108788360  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
108788391  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
108788355  TAPBP; tapasin [KO:K08058]
108795629  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
108801525  CALR; calreticulin [KO:K08057]
108783796  calreticulin-like [KO:K08057]
108786523  major histocompatibility complex class I-related gene protein-like [KO:K06751]
108786524  major histocompatibility complex class I-related gene protein-like [KO:K06751]
108788346  major histocompatibility complex class I-related gene protein-like [KO:K06751]
108802227  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
108786520  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
108786556  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
108788345  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
108788373  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
108800515  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
108800521  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
108800550  B2M; beta-2-microglobulin [KO:K08055]
108788347  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
108788348  HLA class II histocompatibility antigen, DM beta chain-like [KO:K06752]
108788351  class II histocompatibility antigen, M alpha chain [KO:K06752]
108788352  rano class II histocompatibility antigen, B alpha chain-like [KO:K06752]
108788365  H-2 class II histocompatibility antigen, A-Q alpha chain-like [KO:K06752]
108788366  HLA class II histocompatibility antigen, DRB1-15 beta chain-like [KO:K06752]
108785799  CD74; HLA class II histocompatibility antigen gamma chain isoform X1 [KO:K06505]
108785765  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
108796670  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
108798423  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
108797628  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
108802963  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
108789013  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
108794095  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
108787157  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
108794671  TSC1; hamartin [KO:K07206]
108791228  TSC2; tuberin isoform X1 [KO:K07207]
108784341  RHEB; GTP-binding protein Rheb [KO:K07208]
108796319  serine/threonine-protein kinase mTOR-like [KO:K07203] [EC:2.7.11.1]
108788505  SRSF protein kinase 1-like isoform X1 [KO:K15409] [EC:2.7.11.1]
108787375  SRSF1; serine/arginine-rich splicing factor 1 isoform X1 [KO:K12890]
108786410  SRSF2; serine/arginine-rich splicing factor 2 isoform X1 [KO:K12891]
108796149  SRSF3; serine/arginine-rich splicing factor 3 isoform X1 [KO:K12892]
108798644  SRSF5; serine/arginine-rich splicing factor 5 [KO:K12893]
108792965  SRSF4; serine/arginine-rich splicing factor 4 [KO:K12893]
108795758  serine/arginine-rich splicing factor 5-like isoform X1 [KO:K12893]
108787982  SRSF6; serine/arginine-rich splicing factor 6 isoform X1 [KO:K12893]
108792738  SRSF7; serine/arginine-rich splicing factor 7 isoform X1 [KO:K12896]
108787782  SRSF9; serine/arginine-rich splicing factor 9 isoform X1 [KO:K21123]
108794524  NXF1; nuclear RNA export factor 1 [KO:K14284]
108784729  ALYREF; THO complex subunit 4 [KO:K12881]
108795559  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
108795999  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
108793910  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
108785454  FADD; FAS-associated death domain protein [KO:K02373]
108795080  caspase-8-like [KO:K04398] [EC:3.4.22.61]
108791565  BH3-interacting domain death agonist-like [KO:K04726]
108796054  BAX; apoptosis regulator BAX [KO:K02159]
108787278  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
108794161  BAD; bcl2-associated agonist of cell death [KO:K02158]
108793666  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
108786979  BCL2L1; bcl-2-like protein 1 [KO:K04570]
108802029  cytochrome c [KO:K08738]
108791216  cytochrome c, somatic [KO:K08738]
108798110  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
108797190  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
108794589  caspase-3-like [KO:K02187] [EC:3.4.22.56]
108794597  caspase-3-like [KO:K02187] [EC:3.4.22.56]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
C20935  2-5A
Reference
PMID:12787566
  Authors
Granger SW, Rickert S
  Title
LIGHT-HVEM signaling and the regulation of T cell-mediated immunity.
  Journal
Cytokine Growth Factor Rev 14:289-96 (2003)
DOI:10.1016/S1359-6101(03)00031-5
Reference
PMID:19495760
  Authors
Steinberg MW, Shui JW, Ware CF, Kronenberg M
  Title
Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners.
  Journal
Semin Immunopathol 31:207-21 (2009)
DOI:10.1007/s00281-009-0157-4
Reference
PMID:20221426
  Authors
MacLeod IJ, Minson T
  Title
Binding of herpes simplex virus type-1 virions leads to the induction of intracellular signalling in the absence of virus entry.
  Journal
PLoS One 5:e9560 (2010)
DOI:10.1371/journal.pone.0009560
Reference
PMID:23150579
  Authors
Gianni T, Leoni V, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G
  Title
alphavbeta3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1.
  Journal
Proc Natl Acad Sci U S A 109:19792-7 (2012)
DOI:10.1073/pnas.1212597109
Reference
PMID:25375272
  Authors
Gianni T, Campadelli-Fiume G
  Title
The epithelial alphavbeta3-integrin boosts the MYD88-dependent TLR2 signaling in response to viral and bacterial components.
  Journal
PLoS Pathog 10:e1004477 (2014)
DOI:10.1371/journal.ppat.1004477
Reference
PMID:15056211
  Authors
Spear PG
  Title
Herpes simplex virus: receptors and ligands for cell entry.
  Journal
Cell Microbiol 6:401-10 (2004)
DOI:10.1111/j.1462-5822.2004.00389.x
Reference
PMID:12855695
  Authors
Boutell C, Everett RD
  Title
The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and Ubiquitinates p53.
  Journal
J Biol Chem 278:36596-602 (2003)
DOI:10.1074/jbc.M300776200
Reference
PMID:24262390
  Authors
Ma Y, He B
  Title
Recognition of herpes simplex viruses: toll-like receptors and beyond.
  Journal
J Mol Biol 426:1133-47 (2014)
DOI:10.1016/j.jmb.2013.11.012
Reference
PMID:26952111
  Authors
Su C, Zhan G, Zheng C
  Title
Evasion of host antiviral innate immunity by HSV-1, an update.
  Journal
Virol J 13:38 (2016)
DOI:10.1186/s12985-016-0495-5
Reference
PMID:21994567
  Authors
Melchjorsen J, Matikainen S, Paludan SR
  Title
Activation and evasion of innate antiviral immunity by herpes simplex virus.
  Journal
Viruses 1:737-59 (2009)
DOI:10.3390/v1030737
Reference
PMID:15276609
  Authors
Morrison LA
  Title
The Toll of herpes simplex virus infection.
  Journal
Trends Microbiol 12:353-6 (2004)
DOI:10.1016/j.tim.2004.06.001
Reference
PMID:29298887
  Authors
Zheng C
  Title
Evasion of Cytosolic DNA-Stimulated Innate Immune Responses by Herpes Simplex Virus 1.
  Journal
J Virol 92:e00099-17 (2018)
DOI:10.1128/JVI.00099-17
Reference
PMID:19344302
  Authors
Grandi P, Peruzzi P, Reinhart B, Cohen JB, Chiocca EA, Glorioso JC
  Title
Design and application of oncolytic HSV vectors for glioblastoma therapy.
  Journal
Expert Rev Neurother 9:505-17 (2009)
DOI:10.1586/ern.09.9
Reference
PMID:23115300
  Authors
Lussignol M, Queval C, Bernet-Camard MF, Cotte-Laffitte J, Beau I, Codogno P, Esclatine A
  Title
The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR.
  Journal
J Virol 87:859-71 (2013)
DOI:10.1128/JVI.01158-12
Reference
PMID:17229694
  Authors
Sanchez R, Mohr I
  Title
Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein.
  Journal
J Virol 81:3455-64 (2007)
DOI:10.1128/JVI.02520-06
Reference
PMID:12826401
  Authors
Wysocka J, Herr W
  Title
The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.
  Journal
Trends Biochem Sci 28:294-304 (2003)
DOI:10.1016/S0968-0004(03)00088-4
Reference
PMID:27367734
  Authors
Fleming SB
  Title
Viral Inhibition of the IFN-Induced JAK/STAT Signalling Pathway: Development of Live Attenuated Vaccines by Mutation of Viral-Encoded IFN-Antagonists.
  Journal
Vaccines (Basel) 4:E23 (2016)
DOI:10.3390/vaccines4030023
Reference
PMID:15163721
  Authors
Yokota S, Yokosawa N, Okabayashi T, Suzutani T, Miura S, Jimbow K, Fujii N
  Title
Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway.
  Journal
J Virol 78:6282-6 (2004)
DOI:10.1128/JVI.78.12.6282-6286.2004
Reference
PMID:23864622
  Authors
Gu H, Zheng Y, Roizman B
  Title
Interaction of herpes simplex virus ICP0 with ND10 bodies: a sequential process of adhesion, fusion, and retention.
  Journal
J Virol 87:10244-54 (2013)
DOI:10.1128/JVI.01487-13
Reference
PMID:21994592
  Authors
Tavalai N, Stamminger T
  Title
Interplay between Herpesvirus Infection and Host Defense by PML Nuclear Bodies.
  Journal
Viruses 1:1240-64 (2009)
DOI:10.3390/v1031240
Reference
PMID:21146386
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
  Journal
Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:12960333
  Authors
Neumann J, Eis-Hubinger AM, Koch N
  Title
Herpes simplex virus type 1 targets the MHC class II processing pathway for immune evasion.
  Journal
J Immunol 171:3075-83 (2003)
DOI:10.4049/jimmunol.171.6.3075
Reference
PMID:25798530
  Authors
Liu X, Cohen JI
  Title
The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside.
  Journal
Virology 479-480:568-77 (2015)
DOI:10.1016/j.virol.2015.02.040
Reference
PMID:28468873
  Authors
Vink EI, Smiley JR, Mohr I
  Title
Subversion of Host Responses to Energy Insufficiency by Us3 Supports Herpes Simplex Virus 1 Replication during Stress.
  Journal
J Virol 91:e00295-17 (2017)
DOI:10.1128/JVI.00295-17
Reference
PMID:18508584
  Authors
Sandri-Goldin RM
  Title
The many roles of the regulatory protein ICP27 during herpes simplex virus infection.
  Journal
Front Biosci 13:5241-56 (2008)
DOI:10.2741/3078
Reference
PMID:15078920
  Authors
Sandri-Goldin RM
  Title
Viral regulation of mRNA export.
  Journal
J Virol 78:4389-96 (2004)
DOI:10.1128/JVI.78.9.4389-4396.2004
Reference
PMID:27154074
  Authors
Yu X, He S
  Title
The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways.
  Journal
Virol J 13:77 (2016)
DOI:10.1186/s12985-016-0528-0
Related
pathway
npr03040  Spliceosome
npr03050  Proteasome
npr04115  p53 signaling pathway
npr04210  Apoptosis
npr04620  Toll-like receptor signaling pathway
npr04622  RIG-I-like receptor signaling pathway
KO pathway
ko05168   
LinkDB

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