Entry Name Prolactin signaling pathway - Physeter catodon (sperm whale)
Description Prolactin (PRL) is a polypeptide hormone known to be involved in a wide range of biological functions including osmoregulation, lactation, reproduction, growth and development, endocrinology and metabolism, brain and behavior, and immunomodulation. PRL mediates its action through PRLR, a transmembrane protein of the hematopoietin cytokine receptor superfamily. At the protein level, the long PRLR isoform (long-R) and several short PRLR isoforms (short-R) have been detected. Acting through the long-R, PRL activates many signaling cascades including Jak2/Stat, the major cascade, Src kinase, phosphatidylinositol-3-kinase (PI3K)/AKT, and mitogen-activated protein kinase (MAPK) pathways. PRL cannot activate Jak2/Stat5 through the short-R, but can activate pathways including MAPK and PI3K pathways.
Class Organismal Systems; Endocrine systemBRITE hierarchy
Pathway map Ortholog table Other DBs Organism Physeter catodon (sperm whale) [GN:
pcad ]
Gene 102986098 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
102978952 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
102977108 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
102975555 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
102991779 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
102991192 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649 ]
102978925 SOS2; LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099 ]
102977655 STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220 ]
102976764 STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692 ]
102994339 STAT5B; signal transducer and activator of transcription 5B [KO:K11224 ]
102978976 TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473 ]
102988430 TNFRSF11A; tumor necrosis factor receptor superfamily member 11A [KO:K05147 ]
102981135 NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580 ]
102994489 ELF5; ETS-related transcription factor Elf-5 isoform X2 [KO:K17101 ]
102984344 SLC2A2; solute carrier family 2, facilitated glucose transporter member 2 isoform X1 [KO:K07593 ]
Compound C00355 3,4-Dihydroxy-L-phenylalanine
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Binart N, Bachelot A, Bouilly J
Title Impact of prolactin receptor isoforms on reproduction.
Journal Reference Authors Bachelot A, Binart N
Title Reproductive role of prolactin.
Journal Reference Authors Hennighausen L, Robinson GW
Title Information networks in the mammary gland.
Journal Reference Authors Bouilly J, Sonigo C, Auffret J, Gibori G, Binart N
Title Prolactin signaling mechanisms in ovary.
Journal Reference Authors Oakes SR, Rogers RL, Naylor MJ, Ormandy CJ
Title Prolactin regulation of mammary gland development.
Journal Reference Authors Frasor J, Gibori G
Title Prolactin regulation of estrogen receptor expression.
Journal Reference Authors Bole-Feysot C, Goffin V, Edery M, Binart N, Kelly PA
Title Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice.
Journal Reference Authors Weinhaus AJ, Stout LE, Bhagroo NV, Brelje TC, Sorenson RL
Title Regulation of glucokinase in pancreatic islets by prolactin: a mechanism for increasing glucose-stimulated insulin secretion during pregnancy.
Journal Reference Authors Grattan DR, Kokay IC
Title Prolactin: a pleiotropic neuroendocrine hormone.
Journal Reference Authors Yu-Lee LY, Luo G, Book ML, Morris SM
Title Lactogenic hormone signal transduction.
Journal Reference Authors Tam SP, Lau P, Djiane J, Hilton DJ, Waters MJ
Title Tissue-specific induction of SOCS gene expression by PRL.
Journal Reference Authors Halperin J, Devi SY, Elizur S, Stocco C, Shehu A, Rebourcet D, Unterman TG, Leslie ND, Le J, Binart N, Gibori G
Title Prolactin signaling through the short form of its receptor represses forkhead transcription factor FOXO3 and its target gene galt causing a severe ovarian defect.
Journal Reference Authors Sakamoto K, Creamer BA, Triplett AA, Wagner KU
Title The Janus kinase 2 is required for expression and nuclear accumulation of cyclin D1 in proliferating mammary epithelial cells.
Journal Reference Authors Oakes SR, Hilton HN, Ormandy CJ
Title The alveolar switch: coordinating the proliferative cues and cell fate decisions that drive the formation of lobuloalveoli from ductal epithelium.
Journal Related KO pathway LinkDB All DBs
