KEGG   PATHWAY: pcad04010
Entry
pcad04010                   Pathway                                
Name
MAPK signaling pathway - Physeter macrocephalus (sperm whale)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
pcad04010  MAPK signaling pathway
pcad04010

Other DBs
GO: 0000165
Organism
Physeter macrocephalus (sperm whale) [GN:pcad]
Gene
102973167  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
102973168  IGF2; insulin-like growth factor II [KO:K13769]
102973173  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
102973375  [KO:K03283]
102973542  TGFA; protransforming growth factor alpha isoform X4 [KO:K08774]
102973556  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
102973747  FGF21; fibroblast growth factor 21 isoform X2 [KO:K22429]
102973751  KITLG; kit ligand isoform X1 [KO:K05461]
102973768  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
102973912  MAP3K11; mitogen-activated protein kinase kinase kinase 11 isoform X2 [KO:K04419] [EC:2.7.11.25]
102973938  STK3; serine/threonine-protein kinase 3 isoform X2 [KO:K04412]
102974002  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
102974068  FGF3; fibroblast growth factor 3 [KO:K04358]
102974079  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
102974123  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
102974176  ANGPT4; angiopoietin-4 [KO:K05467]
102974198  RELA; transcription factor p65 isoform X1 [KO:K04735]
102974274  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
102974293  CSF1; macrophage colony-stimulating factor 1 isoform X5 [KO:K05453]
102974321  CACNG1; voltage-dependent calcium channel gamma-1 subunit isoform X2 [KO:K04866]
102974346  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
102974358  [KO:K03283]
102974369  ATF2; LOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
102974372  FGF19; fibroblast growth factor 19 [KO:K22603]
102974383  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
102974392  MRAS; ras-related protein M-Ras [KO:K07831]
102974530  [KO:K04349]
102974606  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
102974802  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
102974882  EFNA2; ephrin-A2 [KO:K05462]
102974888  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
102974987  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
102975241  SRF; serum response factor isoform X1 [KO:K04378]
102975335  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
102975458  JUN; transcription factor Jun [KO:K04448]
102975467  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
102975550  ERBB3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
102975643  TGFB1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
102975726  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X3 [KO:K05085] [EC:2.7.10.1]
102975936  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
102975958  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
102976068  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
102976185  MECOM; histone-lysine N-methyltransferase MECOM isoform X3 [KO:K04462] [EC:2.1.1.367]
102976377  PPM1A; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
102976485  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
102976706  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
102976767  RPS6KA4; ribosomal protein S6 kinase alpha-4 isoform X1 [KO:K16510] [EC:2.7.11.1]
102976778  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
102976909  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
102976971  AKT3; RAC-gamma serine/threonine-protein kinase isoform X3 [KO:K04456] [EC:2.7.11.1]
102976992  FGF10; fibroblast growth factor 10 [KO:K04358]
102977125  KRAS; GTPase KRas isoform X1 [KO:K07827]
102977266  MAPKAPK5; MAP kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
102977345  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
102977369  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
102977417  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
102977431  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
102977440  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X2 [KO:K04865]
102977531  MAPK12; mitogen-activated protein kinase 12 isoform X3 [KO:K04441] [EC:2.7.11.24]
102977668  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X2 [KO:K04467] [EC:2.7.11.10]
102977692  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
102977794  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X2 [KO:K04428] [EC:2.7.11.25]
102977826  IGF1R; insulin-like growth factor 1 receptor isoform X3 [KO:K05087] [EC:2.7.10.1]
102977853  RELB; transcription factor RelB [KO:K09253]
102977865  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
102977934  BDNF; brain-derived neurotrophic factor isoform X6 [KO:K04355]
102977994  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
102978005  [KO:K04409] [EC:2.7.11.1]
102978016  [KO:K12457]
102978047  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X3 [KO:K04432] [EC:2.7.12.2]
102978050  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
102978055  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X2 [KO:K04373] [EC:2.7.11.1]
102978151  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
102978154  EREG; proepiregulin [KO:K09784]
102978436  AREG; amphiregulin isoform X1 [KO:K09782]
102978532  TAOK1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
102978755  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
102978810  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X2 [KO:K04863]
102978925  SOS2; LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
102979009  FGF1; fibroblast growth factor 1 isoform X2 [KO:K18496]
102979076  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
102979195  [KO:K04392]
102979244  PGF; placenta growth factor isoform X1 [KO:K16859]
102979381  PTPN5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
102979404  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
102979428  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102979525  CDC25B; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
102979560  MAP3K21; mitogen-activated protein kinase kinase kinase 21 [KO:K17534] [EC:2.7.11.25]
102979652  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
102979832  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
102979864  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
102979902  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102979937  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
102980242  [KO:K04452]
102980301  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102980344  RAP1B; ras-related protein Rap-1b [KO:K07836]
102980379  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
102980413  LAMTOR3; ragulator complex protein LAMTOR3 isoform X1 [KO:K04370]
102980435  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
102980523  VEGFD; vascular endothelial growth factor D [KO:K05449]
102980613  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
102980964  IKBKG; NF-kappa-B essential modulator [KO:K07210]
102981091  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
102981134  FGF6; fibroblast growth factor 6 [KO:K04358]
102981135  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
102981182  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
102981524  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102981568  TAOK3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
102981677  [KO:K03099]
102981739  VEGFA; vascular endothelial growth factor A isoform X7 [KO:K05448]
102981768  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
102982044  FGFR2; fibroblast growth factor receptor 2 isoform X3 [KO:K05093] [EC:2.7.10.1]
102982169  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
102982170  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102982175  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X2 [KO:K04433] [EC:2.7.12.2]
102982227  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
102982240  FGFR3; fibroblast growth factor receptor 3 isoform X4 [KO:K05094] [EC:2.7.10.1]
102982312  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
102982328  NRTN; neurturin [KO:K25414]
102982453  FOS; protein c-Fos [KO:K04379]
102982641  NRAS; LOW QUALITY PROTEIN: GTPase NRas [KO:K07828]
102982651  STMN1; stathmin [KO:K04381]
102982662  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
102982689  HSPA8; LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein [KO:K03283]
102982885  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
102982900  CACNG6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
102982920  RPS6KA1; ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
102982984  FGF5; fibroblast growth factor 5 [KO:K04358]
102983069  TNF; tumor necrosis factor [KO:K03156]
102983100  RASGRP3; ras guanyl-releasing protein 3 isoform X2 [KO:K12362]
102983140  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
102983165  [KO:K04463] [EC:2.7.12.2]
102983188  PLA2G4D; cytosolic phospholipase A2 delta isoform X1 [KO:K16342] [EC:3.1.1.4]
102983466  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
102983555  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X3 [KO:K05454]
102983558  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
102983590  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X3 [KO:K04403]
102983621  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X2 [KO:K04469]
102983681  PLA2G4F; LOW QUALITY PROTEIN: cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
102983803  [KO:K03283]
102983841  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
102983972  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
102984082  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X2 [KO:K04434]
102984157  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
102984161  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
102984239  PLA2G4E; cytosolic phospholipase A2 epsilon isoform X2 [KO:K16342] [EC:3.1.1.4]
102984305  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102984429  NF1; neurofibromin isoform X3 [KO:K08052]
102984443  HSPB1; heat shock protein beta-1 [KO:K04455]
102984518  ARRB1; beta-arrestin-1 [KO:K04439]
102984604  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X2 [KO:K05126] [EC:2.7.10.1]
102984693  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102984741  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
102984762  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
102984905  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
102985093  MAP3K6; mitogen-activated protein kinase kinase kinase 6 isoform X2 [KO:K04425] [EC:2.7.11.25]
102985097  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
102985111  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
102985262  PAK2; serine/threonine-protein kinase PAK 2 isoform X1 [KO:K04410] [EC:2.7.11.1]
102985391  MAP3K2; mitogen-activated protein kinase kinase kinase 2 isoform X1 [KO:K04420] [EC:2.7.11.25]
102985479  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
102985520  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
102985586  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
102985658  TP53; cellular tumor antigen p53 [KO:K04451]
102985661  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
102985781  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X2 [KO:K04373] [EC:2.7.11.1]
102985798  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102985889  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
102985937  FGF16; fibroblast growth factor 16 [KO:K04358]
102986000  RRAS; ras-related protein R-Ras [KO:K07829]
102986061  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
102986227  [KO:K03283]
102986375  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
102986518  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
102986670  GDNF; glial cell line-derived neurotrophic factor isoform X3 [KO:K05452]
102986742  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
102986746  DAXX; death domain-associated protein 6 isoform X1 [KO:K02308]
102986785  KDR; vascular endothelial growth factor receptor 2 isoform X5 [KO:K05098] [EC:2.7.10.1]
102986791  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
102986837  [KO:K04450]
102986915  [KO:K17614] [EC:3.1.3.16 3.1.3.48]
102986916  BRAF; serine/threonine-protein kinase B-raf isoform X3 [KO:K04365] [EC:2.7.11.1]
102986924  PTPRR; receptor-type tyrosine-protein phosphatase R isoform X3 [KO:K04458] [EC:3.1.3.48]
102986927  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
102987032  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
102987099  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X10 [KO:K04857]
102987293  RASA2; ras GTPase-activating protein 2 isoform X4 [KO:K08053]
102987522  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
102987740  PPP5C; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
102987866  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
102988128  MYC; myc proto-oncogene protein [KO:K04377]
102988187  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X6 [KO:K04858]
102988344  [KO:K04446]
102988471  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
102988605  TAOK2; serine/threonine-protein kinase TAO2 isoform X2 [KO:K04429] [EC:2.7.11.1]
102988669  NGF; beta-nerve growth factor isoform X2 [KO:K02582]
102988864  FLNA; filamin-A [KO:K04437]
102988868  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
102988971  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K04372] [EC:2.7.11.1]
102989016  DUSP9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
102989017  FGF2; fibroblast growth factor 2 [KO:K18497]
102989030  [KO:K03283]
102989050  DUSP6; dual specificity protein phosphatase 6 isoform X1 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
102989074  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102989089  EFNA1; ephrin-A1 isoform X2 [KO:K05462]
102989111  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
102989137  NLK; serine/threonine-protein kinase NLK isoform X2 [KO:K04468] [EC:2.7.11.24]
102989152  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
102989228  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
102989372  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
102989373  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
102989448  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
102989494  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
102989551  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
102989745  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
102989784  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
102989848  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
102989853  [KO:K07836]
102989857  MAX; protein max isoform X1 [KO:K04453]
102989984  VEGFC; vascular endothelial growth factor C isoform X2 [KO:K05449]
102990012  FGF9; fibroblast growth factor 9 [KO:K04358]
102990087  [KO:K04456] [EC:2.7.11.1]
102990100  CRKL; crk-like protein [KO:K04438]
102990192  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
102990275  NTRK1; high affinity nerve growth factor receptor isoform X2 [KO:K03176] [EC:2.7.10.1]
102990276  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X2 [KO:K04392]
102990302  MAPK13; mitogen-activated protein kinase 13 isoform X3 [KO:K04441] [EC:2.7.11.24]
102990377  MAPKAPK3; MAP kinase-activated protein kinase 3 isoform X5 [KO:K04444] [EC:2.7.11.1]
102990448  PTPN7; LOW QUALITY PROTEIN: tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
102990526  CD14; monocyte differentiation antigen CD14 [KO:K04391]
102990537  [KO:K12361]
102990550  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
102990552  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
102990600  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
102990601  HSPA6; LOW QUALITY PROTEIN: heat shock 70 kDa protein 6 [KO:K03283]
102990815  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X8 [KO:K04348] [EC:3.1.3.16]
102991161  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
102991211  MAP3K9; mitogen-activated protein kinase kinase kinase 9 isoform X2 [KO:K04417] [EC:2.7.11.25]
102991269  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
102991639  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
102991774  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X3 [KO:K04431] [EC:2.7.12.2]
102991867  RASA1; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
102991966  FGF23; fibroblast growth factor 23 [KO:K22428]
102992191  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
102992196  HGF; hepatocyte growth factor isoform X2 [KO:K05460]
102992313  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
102992439  [KO:K07828]
102992553  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
102992556  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
102992595  JUND; transcription factor JunD [KO:K04449]
102992726  FGF20; fibroblast growth factor 20 [KO:K04358]
102992898  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X2 [KO:K04436]
102992923  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
102993033  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
102993151  [KO:K04859]
102993207  TRAF6; TNF receptor-associated factor 6 isoform X2 [KO:K03175] [EC:2.3.2.27]
102993259  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
102993403  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
102993410  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
102993417  FGF18; fibroblast growth factor 18 [KO:K04358]
102993818  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
102993910  IL1A; interleukin-1 alpha [KO:K04383]
102994142  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
102994150  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102994151  PSPN; LOW QUALITY PROTEIN: persephin [KO:K25416]
102994154  FGF7; fibroblast growth factor 7 [KO:K04358]
102994188  IL1B; interleukin-1 beta [KO:K04519]
102994214  CRK; adapter molecule crk isoform X1 [KO:K04438]
102994287  IL1RAP; interleukin-1 receptor accessory protein isoform X2 [KO:K04723]
102994311  MAP3K12; mitogen-activated protein kinase kinase kinase 12 isoform X1 [KO:K04423] [EC:2.7.11.25]
102994335  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
102994349  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
102994715  HRAS; GTPase HRas isoform X2 [KO:K02833]
102994784  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
102994898  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
102994908  [KO:K03283]
102995190  [KO:K03283]
102995288  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
102995361  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
102995367  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X13 [KO:K04463] [EC:2.7.12.2]
102995371  ANGPT1; angiopoietin-1 [KO:K05465]
102995465  [KO:K03283]
102995661  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
102995727  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
102995821  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 isoform X2 [KO:K04408] [EC:2.7.11.1]
102995915  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
102995949  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
102996185  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
102996270  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
102996298  RASGRP4; RAS guanyl-releasing protein 4 [KO:K12363]
102996353  MAPK8; mitogen-activated protein kinase 8 isoform X3 [KO:K04440] [EC:2.7.11.24]
102996376  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
102996495  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
102996744  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
102996804  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
102996862  [KO:K05090] [EC:2.7.10.1]
102996980  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
112062410  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
112062628  INS; insulin [KO:K04526]
112063854  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
112065332  ARTN; artemin [KO:K25415]
112065477  PPP3R2; LOW QUALITY PROTEIN: calcineurin subunit B type 2 [KO:K06268]
112067418  FGF4; fibroblast growth factor 4 [KO:K04358]
112067521  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
114483863  FGFR4; LOW QUALITY PROTEIN: fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
114483947  [KO:K04364]
114484431  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
114485485  [KO:K07210]
114487158  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
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PMID:12676795
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Annu Rev Biochem 72:609-42 (2003)
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PMID:11369511
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Harper SJ, LoGrasso P.
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Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
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Cell Signal 13:299-310 (2001)
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Reference
PMID:12390245
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Takeda K, Ichijo H
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Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
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Genes Cells 7:1099-111 (2002)
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PMID:14597384
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Gene 320:3-21 (2003)
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PMID:12566928
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Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
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The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
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Neurosignals 11:270-81 (2002)
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PMID:12849693
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Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
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Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
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PMID:20602996
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Lemmon MA, Schlessinger J
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Cell signaling by receptor tyrosine kinases.
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Cell 141:1117-34 (2010)
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PMID:22367796
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Skaper SD
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The neurotrophin family of neurotrophic factors: an overview.
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Methods Mol Biol 846:1-12 (2012)
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PMID:23085193
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Chu WM
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Tumor necrosis factor.
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Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
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Newton K, Dixit VM
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Signaling in innate immunity and inflammation.
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Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
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Gaestel M, Kotlyarov A, Kracht M
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Targeting innate immunity protein kinase signalling in inflammation.
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Nat Rev Drug Discov 8:480-99 (2009)
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PMID:23664135
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Ajibade AA, Wang HY, Wang RF
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Cell type-specific function of TAK1 in innate immune signaling.
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Trends Immunol 34:307-16 (2013)
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PMID:24892271
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Turner MD, Nedjai B, Hurst T, Pennington DJ
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Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
pcad04070  Phosphatidylinositol signaling system
pcad04110  Cell cycle
pcad04115  p53 signaling pathway
pcad04210  Apoptosis
pcad04310  Wnt signaling pathway
pcad04668  TNF signaling pathway
KO pathway
ko04010   

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