KEGG   PATHWAY: pgeo04145
Entry
pgeo04145                   Pathway                                
Name
Phagosome - Pseudochaenichthys georgianus (South Georgia icefish)
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
Pathway map
pgeo04145  Phagosome
pgeo04145

Other DBs
GO: 0045335
Organism
Pseudochaenichthys georgianus (South Georgia icefish) [GN:pgeo]
Gene
117446666  vamp3; vesicle-associated membrane protein 3 [KO:K13505]
117460076  syntaxin-12-like isoform X1 [KO:K13813]
117461514  syntaxin-12-like [KO:K13813]
117440022  stx7l; syntaxin-7 [KO:K08488]
117447644  actb1; actin, cytoplasmic 1 [KO:K05692]
117451022  actin, cytoplasmic 1-like [KO:K05692]
117451156  actin, cytoplasmic 1-like [KO:K05692]
117451232  actin, cytoplasmic 1-like [KO:K05692]
117451766  actin, cytoplasmic 1 [KO:K05692]
117451768  actin, cytoplasmic 1-like [KO:K05692]
117450970  coro1a; coronin-1A [KO:K13882]
117447013  stx18; syntaxin-18 [KO:K08492]
117463032  sec22ba; vesicle-trafficking protein SEC22b-A [KO:K08517]
117445665  sec22bb; vesicle-trafficking protein SEC22b-B isoform X1 [KO:K08517]
117454944  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
117443521  LOW QUALITY PROTEIN: H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
117451690  H-2 class II histocompatibility antigen, A-U alpha chain-like [KO:K06752]
117460554  rab5ab; RAB5A, member RAS oncogene family, b [KO:K07887]
117455002  ras-related protein Rab-5A-like [KO:K07887]
117443578  rab5b; ras-related protein Rab-5B [KO:K07888]
117464962  ras-related protein Rab-5C-like [KO:K07889]
117451151  rab5c; ras-related protein Rab-5C [KO:K07889]
117447852  eea1; early endosome antigen 1 isoform X1 [KO:K12478]
117463756  pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
117465616  tfr1b; transferrin receptor 1b [KO:K06503]
117461886  transferrin receptor protein 1-like isoform X1 [KO:K06503]
117451002  hgs; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
117465720  atp6v1ab; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
117458822  V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
117459551  atp6v1ba; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
117461421  V-type proton ATPase subunit C 1-A-like [KO:K02148]
117468049  V-type proton ATPase subunit C 1-B-like [KO:K02148]
117455507  atp6v1c1b; V-type proton ATPase subunit C 1-B [KO:K02148]
117440377  atp6v1d; V-type proton ATPase subunit D [KO:K02149]
117439028  atp6v1e1b; V-type proton ATPase subunit E 1 [KO:K02150]
117448292  atp6v1e1a; V-type proton ATPase subunit E 1a [KO:K02150]
117453862  atp6v0e1; V-type proton ATPase subunit e 1 [KO:K02153]
117451155  atpv0e2; ATPase H+ transporting V0 subunit e2 [KO:K02153]
117464930  V-type proton ATPase 116 kDa subunit a-like isoform X1 [KO:K02154]
117453658  V-type proton ATPase 116 kDa subunit a-like isoform X1 [KO:K02154]
117456370  atp6v0a2a; V-type proton ATPase 116 kDa subunit a [KO:K02154]
117450912  V-type proton ATPase 116 kDa subunit a-like isoform X1 [KO:K02154]
117452711  atp6v0a2b; V-type proton ATPase 116 kDa subunit a [KO:K02154]
117463005  V-type proton ATPase subunit d 1-like isoform X1 [KO:K02146]
117465132  atp6v0d1; V-type proton ATPase subunit d 1 [KO:K02146]
117462304  atp6v1h; V-type proton ATPase subunit H isoform X1 [KO:K02144]
117464441  atp6v0cb; ATPase H+ transporting V0 subunit cb [KO:K02155]
117451446  atp6v0ca; ATPase H+ transporting V0 subunit ca [KO:K02155]
117462275  atp6v0b; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
117449201  atp6ap1b; V-type proton ATPase subunit S1b [KO:K03662]
117449628  atp6ap1a; V-type proton ATPase subunit S1 [KO:K03662]
117446095  si:dkey-13a21.4; ras-related protein Rab-7a [KO:K07897]
117446650  ras-related protein rab7-like [KO:K07897]
117446760  rab7a; ras-related protein Rab-7a [KO:K07897]
117457554  rilp; rab-interacting lysosomal protein isoform X1 [KO:K13883]
117467501  dync1h1; cytoplasmic dynein 1 heavy chain 1 [KO:K10413]
117457535  cytoplasmic dynein 2 heavy chain 1 [KO:K10414]
117466500  cytoplasmic dynein 1 intermediate chain 2-like isoform X1 [KO:K10415]
117461773  cytoplasmic dynein 1 intermediate chain 2-like isoform X1 [KO:K10415]
117455379  cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415]
117466668  dync1li2; cytoplasmic dynein 1 light intermediate chain 2 isoform X1 [KO:K10416]
117455259  dync1li1; cytoplasmic dynein 1 light intermediate chain 1 isoform X1 [KO:K10416]
117466596  tubulin alpha chain-like [KO:K07374]
117460233  tubulin alpha-1C chain-like isoform X1 [KO:K07374]
117457867  tubulin alpha-4A chain-like [KO:K07374]
117449176  tubulin alpha-1C chain-like [KO:K07374]
117449410  tubulin alpha-1C chain-like [KO:K07374]
117449495  tubulin alpha-1B chain isoform X1 [KO:K07374]
117449496  tubulin alpha-1B chain-like isoform X1 [KO:K07374]
117449498  tubulin alpha-1B chain-like [KO:K07374]
117449499  tubulin alpha chain-like [KO:K07374]
117442932  tubulin alpha-1C chain-like isoform X1 [KO:K07374]
117450024  tubulin alpha chain-like [KO:K07374]
117444413  tubulin alpha-1D chain [KO:K07374]
117450801  tubulin alpha chain [KO:K07374]
117450817  LOW QUALITY PROTEIN: tubulin alpha chain-like [KO:K07374]
117450885  tubulin alpha chain-like [KO:K07374]
117450886  tubulin alpha chain-like [KO:K07374]
117451887  tubulin alpha-1C chain-like [KO:K07374]
117452353  tubulin alpha-1C chain-like [KO:K07374]
117465967  tubulin beta-1 chain-like [KO:K07375]
117465968  tubulin beta-4B chain [KO:K07375]
117467327  tubulin beta-1 chain-like [KO:K07375]
117467328  tubulin beta-4B chain-like [KO:K07375]
117461463  tubb5; tubulin beta-5 chain [KO:K07375]
117467502  tubulin beta-1 chain-like [KO:K07375]
117467898  tubulin beta-1 chain [KO:K07375]
117468111  tubulin beta-1 chain-like [KO:K07375]
117462999  tubulin beta-2A chain isoform X1 [KO:K07375]
117463041  tubulin beta chain-like [KO:K07375]
117464695  tubulin beta-4B chain-like [KO:K07375]
117447292  tubb1; tubulin beta-1 chain [KO:K07375]
117441829  tubulin beta-1 chain-like [KO:K07375]
117450688  tubb4bl; tubulin beta chain [KO:K07375]
117445026  tubulin beta-4B chain-like [KO:K07375]
117445235  tubulin beta-1 chain [KO:K07375]
117445265  tubulin beta-1 chain-like [KO:K07375]
117445310  tubulin beta-4B chain [KO:K07375]
117445678  tubulin beta chain-like [KO:K07375]
117452267  tubulin beta-4 chain [KO:K07375]
117466426  lamp1a; lysosome-associated membrane glycoprotein 1a [KO:K06528]
117466669  lamp1b; lysosome-associated membrane glycoprotein 1b [KO:K06528]
117454034  lamp2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
117466265  pikfyve; LOW QUALITY PROTEIN: 1-phosphatidylinositol 3-phosphate 5-kinase [KO:K00921] [EC:2.7.1.150]
117460849  m6pr; cation-dependent mannose-6-phosphate receptor [KO:K10089]
117452369  nos1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
117467534  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
117467535  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
117452281  ctsla; LOW QUALITY PROTEIN: cathepsin La [KO:K01365] [EC:3.4.22.15]
117460976  cathepsin S-like [KO:K01368] [EC:3.4.22.27]
117446700  sec61a1; protein transport protein Sec61 subunit alpha-like 1 [KO:K10956]
117446824  protein transport protein Sec61 subunit alpha [KO:K10956]
117460263  sec61b; protein transport protein Sec61 subunit beta [KO:K09481]
117465753  sec61g; protein transport protein Sec61 subunit gamma [KO:K07342]
117460585  tap1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
117464709  tap2t; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
117455098  tap2a; antigen peptide transporter 2a [KO:K05654] [EC:7.4.2.14]
117462325  calreticulin-like [KO:K08057]
117445475  calreticulin-like [KO:K08057]
117445664  calreticulin-like [KO:K08057]
117457539  Fc receptor-like A [KO:K06498]
117443069  low affinity immunoglobulin gamma Fc region receptor II-like [KO:K06472]
117443075  low affinity immunoglobulin gamma Fc region receptor II-like isoform X1 [KO:K06472]
117461504  complement C1r-A subcomponent-like [KO:K01330] [EC:3.4.21.41]
117464363  integrin alpha-X-like isoform X1 [KO:K06461]
117462825  itgb2; integrin beta-2 [KO:K06464]
117463419  complement C3-like isoform X1 [KO:K03990]
117463503  complement C3-like isoform X1 [KO:K03990]
117463489  complement C3-like [KO:K03990]
117463707  complement C3-like isoform X1 [KO:K03990]
117463708  complement C3-like [KO:K03990]
117468038  colec11; collectin-11 isoform X1 [KO:K10066]
117462598  LOW QUALITY PROTEIN: collectin-12-like [KO:K10062]
117465553  collectin-12-like [KO:K10062]
117453186  itga2.2; integrin alpha-2 [KO:K06481]
117449041  itga5; LOW QUALITY PROTEIN: integrin alpha-5 [KO:K06484]
117465739  itgb1a; integrin beta-1a isoform X1 [KO:K05719]
117460819  integrin beta-1-like [KO:K05719]
117464826  itgb3b; integrin beta-3b [KO:K06493]
117450945  itgb3a; integrin beta-3a [KO:K06493]
117466188  itgb5; LOW QUALITY PROTEIN: integrin beta-5 [KO:K06588]
117467640  thrombospondin-1-like isoform X1 [KO:K16857]
117439911  thbs1b; thrombospondin-1 [KO:K16857]
117459762  thbs2a; thrombospondin-2 isoform X1 [KO:K04659]
117465050  thrombospondin-2-like [KO:K04659]
117445427  comp; cartilage oligomeric matrix protein [KO:K04659]
117453065  thbs4a; LOW QUALITY PROTEIN: thrombospondin-4a [KO:K04659]
117460761  toll-like receptor 2 type-1 isoform X1 [KO:K10159]
117463567  toll-like receptor 2 [KO:K10159]
117447943  toll-like receptor 2 [KO:K10159]
117468414  toll-like receptor 1 [KO:K10169]
117465572  pla2r1; secretory phospholipase A2 receptor isoform X1 [KO:K06560]
117465958  mrc1a; macrophage mannose receptor 1 [KO:K06560]
117461867  macrophage mannose receptor 1-like isoform X1 [KO:K06560]
117462379  LOW QUALITY PROTEIN: macrophage mannose receptor 1-like [KO:K06560]
117462757  macrophage mannose receptor 1-like isoform X1 [KO:K06560]
117462860  macrophage mannose receptor 1-like isoform X1 [KO:K06560]
117455946  macrophage mannose receptor 1 [KO:K06560]
117451251  mrc2; C-type mannose receptor 2 isoform X1 [KO:K06560]
117448208  CD209 antigen-like isoform X1 [KO:K06563]
117453062  marco; macrophage receptor MARCO [KO:K13884]
117468316  cd36; platelet glycoprotein 4 isoform X1 [KO:K06259]
117442916  cytochrome b-245 light chain [KO:K08009]
117441459  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
117464310  rac1a; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
117451605  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
117458315  ncf1; neutrophil cytosol factor 1 [KO:K08011]
117465731  ncf2; neutrophil cytosol factor 2 isoform X1 [KO:K08010]
117440729  ncf4; neutrophil cytosol factor 4 [KO:K08012]
Compound
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
PMID:15894272
  Authors
Stuart LM, Ezekowitz RA
  Title
Phagocytosis: elegant complexity.
  Journal
Immunity 22:539-50 (2005)
DOI:10.1016/j.immuni.2005.05.002
Reference
PMID:10684585
  Authors
Tjelle TE, Lovdal T, Berg T
  Title
Phagosome dynamics and function.
  Journal
Bioessays 22:255-63 (2000)
DOI:10.1002/(SICI)1521-1878(200003)22:3<255::AID-BIES7>3.0.CO;2-R
Reference
PMID:18492791
  Authors
Dupuy AG, Caron E
  Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
  Journal
J Cell Sci 121:1773-83 (2008)
DOI:10.1242/jcs.018036
Reference
PMID:15036145
  Authors
Brumell JH, Grinstein S
  Title
Salmonella redirects phagosomal maturation.
  Journal
Curr Opin Microbiol 7:78-84 (2004)
DOI:10.1016/j.mib.2003.12.005
Reference
PMID:17245426
  Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
  Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
  Journal
EMBO J 26:313-24 (2007)
DOI:10.1038/sj.emboj.7601511
Reference
PMID:17637737
  Authors
Luzio JP, Pryor PR, Bright NA
  Title
Lysosomes: fusion and function.
  Journal
Nat Rev Mol Cell Biol 8:622-32 (2007)
DOI:10.1038/nrm2217
Reference
PMID:18513324
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x
Related
pathway
pgeo04142  Lysosome
pgeo04144  Endocytosis
pgeo04620  Toll-like receptor signaling pathway
KO pathway
ko04145   
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