KEGG   PATHWAY: pmua04621
Entry
pmua04621                   Pathway                                
Name
NOD-like receptor signaling pathway - Podarcis muralis (common wall lizard)
Description
Specific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains more than 20 members in mammals and plays a pivotal role in the recognition of intracellular ligands. NOD1 and NOD2, two prototypic NLRs, sense the cytosolic presence of the bacterial peptidoglycan fragments that escaped from endosomal compartments, driving the activation of NF-{kappa}B and MAPK, cytokine production and apoptosis. On the other hand, a different set of NLRs induces caspase-1 activation through the assembly of multiprotein complexes called inflammasomes. The activated of caspase-1 regulates maturation of the pro-inflammatory cytokines IL-1B, IL-18 and drives pyroptosis.
Class
Organismal Systems; Immune system
Pathway map
pmua04621  NOD-like receptor signaling pathway
pmua04621

Organism
Podarcis muralis (common wall lizard) [GN:pmua]
Gene
114607206  NOD1; nucleotide-binding oligomerization domain-containing protein 1 [KO:K08727]
114601914  receptor-interacting serine/threonine-protein kinase 2-like [KO:K08846] [EC:2.7.11.1]
114600449  RIPK2; receptor-interacting serine/threonine-protein kinase 2 [KO:K08846] [EC:2.7.11.1]
114588195  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
114596983  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
114602842  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
114603234  NFKBIB; NF-kappa-B inhibitor beta [KO:K02581]
114592509  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
114603990  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
114587106  RELA; transcription factor p65 [KO:K04735]
114603303  IL1B; interleukin-1 beta [KO:K04519]
114585328  interleukin-18-like [KO:K05482]
114607734  IL6; LOW QUALITY PROTEIN: interleukin-6 [KO:K05405]
114593429  interleukin-6-like [KO:K05405]
114593430  interleukin-6-like [KO:K05405]
114592791  tumor necrosis factor-like [KO:K03156]
114582309  interleukin-8-like [KO:K10030]
114582810  growth-regulated alpha protein-like [KO:K05505]
114607419  cathelicidin-related peptide Oh-Cath-like [KO:K13916]
114607421  cathelicidin-related peptide Oh-Cath-like [KO:K13916]
114593961  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
114605668  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
114594237  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
114596188  TAB3; LOW QUALITY PROTEIN: TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 [KO:K12793]
114586322  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
114582021  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
114596969  MAPK8; LOW QUALITY PROTEIN: mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
114603995  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
114591317  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
114599205  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
114599208  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
114605285  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
114605047  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
114598927  JUN; transcription factor AP-1 [KO:K04448]
114597653  ATG16L1; autophagy-related protein 16-1 isoform X1 [KO:K17890]
114594006  ATG5; autophagy protein 5 [KO:K08339]
114606120  ATG12; ubiquitin-like protein ATG12 [KO:K08336]
114587647  gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
114581486  GABARAP; gamma-aminobutyric acid receptor-associated protein [KO:K08341]
114602042  GABARAPL2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
114586927  microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]
114599514  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
114594437  MAP1LC3C; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
114593314  microtubule-associated proteins 1A/1B light chain 3C-like isoform X1 [KO:K10435]
114592687  microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]
114602109  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
114601226  SUGT1; protein SGT1 homolog isoform X1 [KO:K12795]
114599814  RBCK1; ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform X1 [KO:K10630] [EC:2.3.2.31]
114600121  SHARPIN; sharpin isoform X1 [KO:K10630] [EC:2.3.2.31]
114581718  RNF31; E3 ubiquitin-protein ligase RNF31 [KO:K11974] [EC:2.3.2.31]
114589070  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
114608076  TRIP6; LOW QUALITY PROTEIN: thyroid receptor-interacting protein 6 [KO:K12792]
114606495  ERBIN; erbin isoform X1 [KO:K12796]
114595659  BIRC2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
114583944  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
114590009  soluble scavenger receptor cysteine-rich domain-containing protein SSC5D-like isoform X1 [KO:K03173] [EC:2.3.2.27]
114592029  TNF receptor-associated factor 1-like [KO:K03173] [EC:2.3.2.27]
114594702  TRAF5; TNF receptor-associated factor 5 [KO:K09849]
114600173  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
114589210  CARD9; caspase recruitment domain-containing protein 9 isoform X1 [KO:K12794]
114594180  TNFAIP3; tumor necrosis factor alpha-induced protein 3 [KO:K11859] [EC:3.4.19.12]
114604226  MAVS; LOW QUALITY PROTEIN: mitochondrial antiviral-signaling protein [KO:K12648]
114583728  TRAF3; TNF receptor-associated factor 3 [KO:K03174]
114605270  TBK1; LOW QUALITY PROTEIN: serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
114599921  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
114605543  TANK; TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
114582063  IRF3; LOW QUALITY PROTEIN: interferon regulatory factor 3 [KO:K05411]
114599743  IRF7; interferon regulatory factor 7 isoform X1 [KO:K09447]
114588052  IFNK; interferon kappa [KO:K05414]
114585581  NLRX1; NLR family member X1 [KO:K12653]
114602666  ANTXR1; LOW QUALITY PROTEIN: anthrax toxin receptor 1 [KO:K20909]
114604066  ANTXR2; anthrax toxin receptor 2 [KO:K20909]
114596966  ANTXRL; anthrax toxin receptor-like [KO:K20909]
114583250  uncharacterized protein LOC114583250 [KO:K12798]
114582857  apoptosis-associated speck-like protein containing a CARD isoform X1 [KO:K12799]
114582861  apoptosis-associated speck-like protein containing a CARD [KO:K12799]
114582865  apoptosis-associated speck-like protein containing a CARD [KO:K12799]
114582859  pyrin-like [KO:K12799]
114585476  caspase-1-like isoform X1 [KO:K01370] [EC:3.4.22.36]
114600980  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
114599826  BCL2L1; bcl-2-like protein 1 [KO:K04570]
114594906  CTSB; cathepsin B [KO:K01363] [EC:3.4.22.1]
114600470  NLRP6; LOW QUALITY PROTEIN: NACHT, LRR and PYD domains-containing protein 6 [KO:K12800]
114595632  PANX1; pannexin-1 isoform X1 [KO:K03443]
114586134  P2RX7; P2X purinoceptor 7 isoform X1 [KO:K05220]
114597702  TRPM2; transient receptor potential cation channel subfamily M member 2 isoform X1 [KO:K04977] [EC:3.6.1.13]
114584753  TRPM7; LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily M member 7 [KO:K04982] [EC:2.7.11.1]
114585507  transient receptor potential cation channel subfamily V member 2-like [KO:K04971]
114585508  transient receptor potential cation channel subfamily V member 2-like [KO:K04971]
114587867  CASR; extracellular calcium-sensing receptor [KO:K04612]
114593343  GPRC6A; G-protein coupled receptor family C group 6 member A [KO:K04622]
114593658  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
114593659  PLCB4; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
114593800  PLCB2; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
114586167  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
114591812  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
114604922  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
114599227  ITPR3; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
114591267  VDAC1; voltage-dependent anion-selective channel protein 1 isoform X1 [KO:K05862]
114597053  VDAC2; voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15040]
114602847  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
114597256  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
114586818  2'-5'-oligoadenylate synthase 1A-like [KO:K14216] [EC:2.7.7.84]
114598514  RNASEL; 2-5A-dependent ribonuclease [KO:K01165]
114585449  DHX33; ATP-dependent RNA helicase DHX33 isoform X1 [KO:K17820] [EC:5.6.2.6]
114598010  MFN1; mitofusin-1 [KO:K21356] [EC:3.6.5.-]
114602877  MFN2; LOW QUALITY PROTEIN: mitofusin-2 [KO:K06030] [EC:3.6.5.-]
114600956  RIPK1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
114582853  uncharacterized protein LOC114582853 [KO:K08847] [EC:2.7.11.1]
114582501  RIPK3; receptor-interacting serine/threonine-protein kinase 3 [KO:K08847] [EC:2.7.11.1]
114605220  DNM1L; dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
114587347  dynamin-1-like protein [KO:K17065] [EC:3.6.5.5]
114605826  NAMPT; nicotinamide phosphoribosyltransferase [KO:K03462] [EC:2.4.2.12]
114596171  cytochrome b-245 heavy chain isoform X1 [KO:K21421] [EC:1.-.-.-]
114602128  cytochrome b-245 light chain [KO:K08009]
114586265  TXNIP; thioredoxin-interacting protein [KO:K20910]
114587593  thioredoxin [KO:K03671]
114588051  thioredoxin-like [KO:K03671]
114605524  TXN2; thioredoxin, mitochondrial isoform X1 [KO:K03671]
114598654  NEK7; serine/threonine-protein kinase Nek7 isoform X1 [KO:K20876] [EC:2.7.11.34]
114588839  BRCC3; lys-63-specific deubiquitinase BRCC36 [KO:K11864] [EC:3.4.19.-]
114585294  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
114594537  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
114583248  uncharacterized protein LOC114583248 [KO:K12801]
114582834  caspase recruitment domain-containing protein 8-like [KO:K12801]
114582838  caspase recruitment domain-containing protein 8-like [KO:K12801]
114582843  caspase recruitment domain-containing protein 8-like [KO:K12801]
114582849  NACHT, LRR and PYD domains-containing protein 1b allele 5-like [KO:K12801]
114592389  GPSM3; G-protein-signaling modulator 3 [KO:K15838]
114604258  PSTPIP1; proline-serine-threonine phosphatase-interacting protein 1 [KO:K12804]
114596831  FADD; FAS-associated death domain protein isoform X1 [KO:K02373]
114584088  uncharacterized protein LOC114584088 [KO:K20865]
114589765  protein kinase C delta type-like [KO:K06068] [EC:2.7.11.13]
114591604  PRKCD; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
114584873  TP53BP1; TP53-binding protein 1 isoform X1 [KO:K20915]
114587551  transforming protein RhoA-like isoform X1 [KO:K04513]
114591506  RHOA; transforming protein RhoA [KO:K04513]
114590796  PKN1; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
114598784  PKN2; serine/threonine-protein kinase N2 isoform X1 [KO:K23691] [EC:2.7.11.13]
114585427  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
114603385  guanylate-binding protein 1-like [KO:K20899]
114603382  guanylate-binding protein 1-like [KO:K20899]
114603383  guanylate-binding protein 1-like isoform X1 [KO:K20899]
114603384  guanylate-binding protein 1-like [KO:K20899]
114603386  guanylate-binding protein 1-like [KO:K20899]
114603389  guanylate-binding protein 1-like [KO:K20899]
114603387  guanylate-binding protein 1-like isoform X1 [KO:K20899]
114602175  guanylate-binding protein 1-like [KO:K20899]
114596050  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
114596047  interferon alpha/beta receptor 2-like [KO:K05131]
114596048  interferon alpha/beta receptor 2-like [KO:K05131]
114598891  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
114587501  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
114607449  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
114586539  STAT2; LOW QUALITY PROTEIN: signal transducer and activator of transcription 2 [KO:K11221]
114582464  IRF9; interferon regulatory factor 9 [KO:K04693]
114589367  TLR4; LOW QUALITY PROTEIN: toll-like receptor 4 [KO:K10160]
114588582  TICAM1; LOW QUALITY PROTEIN: TIR domain-containing adapter molecule 1 [KO:K05842]
114607585  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
114605640  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
114601175  TMEM173; stimulator of interferon genes protein isoform X1 [KO:K12654]
Compound
C00002  ATP
C00076  Calcium cation
C00155  L-Homocysteine
C00238  Potassium cation
C00533  Nitric oxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:23124073
  Authors
Vandenabeele P, Bertrand MJ
  Title
The role of the IAP E3 ubiquitin ligases in regulating pattern-recognition receptor signalling.
  Journal
Nat Rev Immunol 12:833-44 (2012)
DOI:10.1038/nri3325
Reference
PMID:16493424
  Authors
Strober W, Murray PJ, Kitani A, Watanabe T
  Title
Signalling pathways and molecular interactions of NOD1 and NOD2.
  Journal
Nat Rev Immunol 6:9-20 (2006)
DOI:10.1038/nri1747
Reference
PMID:24718315
  Authors
Estornes Y, Bertrand MJ
  Title
IAPs, regulators of innate immunity and inflammation.
  Journal
Semin Cell Dev Biol 39:106-14 (2015)
DOI:10.1016/j.semcdb.2014.03.035
Reference
PMID:24707857
  Authors
Jakopin Z
  Title
Nucleotide-binding oligomerization domain (NOD) inhibitors: a rational approach toward inhibition of NOD signaling pathway.
  Journal
J Med Chem 57:6897-918 (2014)
DOI:10.1021/jm401841p
Reference
PMID:25526305
  Authors
Caruso R, Warner N, Inohara N, Nunez G
  Title
NOD1 and NOD2: signaling, host defense, and inflammatory disease.
  Journal
Immunity 41:898-908 (2014)
DOI:10.1016/j.immuni.2014.12.010
Reference
PMID:19767725
  Authors
Murray PJ
  Title
Beyond peptidoglycan for Nod2.
  Journal
Nat Immunol 10:1053-4 (2009)
DOI:10.1038/ni1009-1053
Reference
PMID:20643110
  Authors
Lecat A, Piette J, Legrand-Poels S
  Title
The protein Nod2: an innate receptor more complex than previously assumed.
  Journal
Biochem Pharmacol 80:2021-31 (2010)
DOI:10.1016/j.bcp.2010.07.016
Reference
PMID:26655628
  Authors
Man SM, Kanneganti TD
  Title
Converging roles of caspases in inflammasome activation, cell death and innate immunity.
  Journal
Nat Rev Immunol 16:7-21 (2016)
DOI:10.1038/nri.2015.7
Reference
PMID:27291964
  Authors
Broz P, Dixit VM
  Title
Inflammasomes: mechanism of assembly, regulation and signalling.
  Journal
Nat Rev Immunol 16:407-20 (2016)
DOI:10.1038/nri.2016.58
Reference
PMID:25879280
  Authors
Man SM, Kanneganti TD
  Title
Regulation of inflammasome activation.
  Journal
Immunol Rev 265:6-21 (2015)
DOI:10.1111/imr.12296
Reference
PMID:26549800
  Authors
Jo EK, Kim JK, Shin DM, Sasakawa C
  Title
Molecular mechanisms regulating NLRP3 inflammasome activation.
  Journal
Cell Mol Immunol 13:148-59 (2016)
DOI:10.1038/cmi.2015.95
Reference
PMID:23846113
  Authors
Broz P, Monack DM
  Title
Newly described pattern recognition receptors team up against intracellular pathogens.
  Journal
Nat Rev Immunol 13:551-65 (2013)
DOI:10.1038/nri3479
Reference
PMID:22430786
  Authors
Rathinam VA, Vanaja SK, Fitzgerald KA
  Title
Regulation of inflammasome signaling.
  Journal
Nat Immunol 13:333-42 (2012)
DOI:10.1038/ni.2237
Reference
PMID:24840700
  Authors
Sutterwala FS, Haasken S, Cassel SL
  Title
Mechanism of NLRP3 inflammasome activation.
  Journal
Ann N Y Acad Sci 1319:82-95 (2014)
DOI:10.1111/nyas.12458
Reference
PMID:23702978
  Authors
Latz E, Xiao TS, Stutz A
  Title
Activation and regulation of the inflammasomes.
  Journal
Nat Rev Immunol 13:397-411 (2013)
DOI:10.1038/nri3452
Reference
PMID:25145756
  Authors
Blander JM
  Title
A long-awaited merger of the pathways mediating host defence and programmed cell death.
  Journal
Nat Rev Immunol 14:601-18 (2014)
DOI:10.1038/nri3720
Reference
PMID:23215645
  Authors
von Moltke J, Ayres JS, Kofoed EM, Chavarria-Smith J, Vance RE
  Title
Recognition of bacteria by inflammasomes.
  Journal
Annu Rev Immunol 31:73-106 (2013)
DOI:10.1146/annurev-immunol-032712-095944
Reference
PMID:25330206
  Authors
Abais JM, Xia M, Zhang Y, Boini KM, Li PL
  Title
Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector?
  Journal
Antioxid Redox Signal 22:1111-29 (2015)
DOI:10.1089/ars.2014.5994
Reference
PMID:25879288
  Authors
Storek KM, Monack DM
  Title
Bacterial recognition pathways that lead to inflammasome activation.
  Journal
Immunol Rev 265:112-29 (2015)
DOI:10.1111/imr.12289
Reference
PMID:27012466
  Authors
Hu H, Sun SC
  Title
Ubiquitin signaling in immune responses.
  Journal
Cell Res 26:457-83 (2016)
DOI:10.1038/cr.2016.40
Reference
PMID:26121197
  Authors
Guo H, Callaway JB, Ting JP
  Title
Inflammasomes: mechanism of action, role in disease, and therapeutics.
  Journal
Nat Med 21:677-87 (2015)
DOI:10.1038/nm.3893
Reference
PMID:26482951
  Authors
Man SM, Kanneganti TD
  Title
Gasdermin D: the long-awaited executioner of pyroptosis.
  Journal
Cell Res 25:1183-4 (2015)
DOI:10.1038/cr.2015.124
Reference
PMID:22819539
  Authors
Rathinam VA, Vanaja SK, Waggoner L, Sokolovska A, Becker C, Stuart LM, Leong JM, Fitzgerald KA
  Title
TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria.
  Journal
Cell 150:606-19 (2012)
DOI:10.1016/j.cell.2012.07.007
Reference
PMID:21575908
  Authors
Kerur N, Veettil MV, Sharma-Walia N, Bottero V, Sadagopan S, Otageri P, Chandran B
  Title
IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection.
  Journal
Cell Host Microbe 9:363-75 (2011)
DOI:10.1016/j.chom.2011.04.008
Reference
PMID:29148036
  Authors
Heilig R, Broz P
  Title
Function and mechanism of the pyrin inflammasome.
  Journal
Eur J Immunol 48:230-238 (2018)
DOI:10.1002/eji.201746947
Reference
PMID:25816776
  Authors
Chakrabarti A, Banerjee S, Franchi L, Loo YM, Gale M Jr, Nunez G, Silverman RH
  Title
RNase L activates the NLRP3 inflammasome during viral infections.
  Journal
Cell Host Microbe 17:466-77 (2015)
DOI:10.1016/j.chom.2015.02.010
Related
pathway
pmua04010  MAPK signaling pathway
pmua04140  Autophagy - animal
pmua04620  Toll-like receptor signaling pathway
KO pathway
ko04621   
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