Entry Name Insulin resistance - Panthera uncia (snow leopard)
Description Insulin resistance is a condition where cells become resistant to the effects of insulin. It is often found in people with health disorders, including obesity, type 2 diabetes mellitus, non-alcoholic fatty liver disease, and cardiovascular diseases. In this diagram multiple mechanisms underlying insulin resistance are shown: (a) increased phosphorylation of IRS (insulin receptor substrate) protein through serine/threonine kinases, such as JNK1 and IKKB, and protein kinase C, (b) increased IRS-1 proteasome degradation via mTOR signaling pathway, (c) decreased activation of signaling molecules including PI3K and AKT, (d) increase in activity of phosphatases including PTPs, PTEN, and PP2A. Regulatory actions such as oxidative stress, mitochondrial dysfunction, accumulation of intracellular lipid derivatives (diacylglycrol and ceramides), and inflammation (via IL-6 and TNFA) contribute to these mechanisms. Consequently, insulin resistance causes reduced GLUT4 translocation, resulting in glucose takeup and glycogen synthesis in skeletal muscle as well as increased hepatic gluconeogenesis and decreased glycogen synthesis in liver. At the bottom of the diagram, interplay between O-GlcNAcylation and serine/threonine phosphorylation is shown. Studies suggested that elevated O-GlcNAc level was correlated to high glucose-induced insulin resistance. Donor UDP-GlcNAc is induced through hexosamine biosynthesis pathway and added to proteins by O-GlcNAc transferase. Elevation of O-GlcNAc modification alters phosphorylation and function of key insulin signaling proteins including IRS-1, PI3K, PDK1, Akt and other transcription factor and cofactors, resulting in the attenuation of insulin signaling cascade.
Class Human Diseases; Endocrine and metabolic diseaseBRITE hierarchy
Pathway map Ortholog table Organism Panthera uncia (snow leopard) [GN:
puc ]
Gene 125930634 LOW QUALITY PROTEIN: serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269 ] [EC:3.1.3.16 ]
125923395 protein phosphatase 1 regulatory subunit 3B isoform X1 [KO:K07189 ]
125913143 LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
125921289 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
125913493 phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
125935698 phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
125929237 phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649 ]
125926571 signal transducer and activator of transcription 3 isoform X1 [KO:K04692 ]
125926175 solute carrier family 2, facilitated glucose transporter member 4 [KO:K07191 ]
125913268 5'-AMP-activated protein kinase subunit beta-2 isoform X1 [KO:K07199 ]
125919017 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200 ]
125911173 5'-AMP-activated protein kinase subunit gamma-3 isoform X1 [KO:K07200 ]
125921896 long-chain fatty acid transport protein 4 [KO:K08745 ] [EC:6.2.1.-]
125929216 long-chain fatty acid transport protein 1 isoform X1 [KO:K08745 ] [EC:6.2.1.-]
125925761 long-chain fatty acid transport protein 3 [KO:K08772 ] [EC:6.2.1.-]
125922303 serine/threonine-protein phosphatase 2A activator isoform X1 [KO:K17605 ]
125927545 sterol regulatory element-binding protein 1 isoform X1 [KO:K07197 ]
125921604 solute carrier family 2, facilitated glucose transporter member 2 [KO:K07593 ]
125934565 peroxisome proliferator-activated receptor gamma coactivator 1-beta [KO:K17962 ]
125928190 LOW QUALITY PROTEIN: carbohydrate-responsive element-binding protein [KO:K09113 ]
125922677 peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1 [KO:K07202 ]
125931744 UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform X1 [KO:K09667 ] [EC:2.4.1.255 ]
125912696 solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299 ]
125911260 cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870 ]
125930188 cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048 ]
125925743 cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048 ]
125934155 cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048 ]
125919439 cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048 ]
125928859 cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048 ]
125930855 cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047 ]
Compound C00043 UDP-N-acetyl-alpha-D-glucosamine
C00352 D-Glucosamine 6-phosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
C06156 alpha-D-Glucosamine 1-phosphate
Reference Authors Martins AR, Nachbar RT, Gorjao R, Vinolo MA, Festuccia WT, Lambertucci RH, Cury-Boaventura MF, Silveira LR, Curi R, Hirabara SM
Title Mechanisms underlying skeletal muscle insulin resistance induced by fatty acids: importance of the mitochondrial function.
Journal Reference Authors Bouzakri K, Roques M, Gual P, Espinosa S, Guebre-Egziabher F, Riou JP, Laville M, Le Marchand-Brustel Y, Tanti JF, Vidal H
Title Reduced activation of phosphatidylinositol-3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle cells from patients with type 2 diabetes.
Journal Reference Authors Choi K, Kim YB
Title Molecular mechanism of insulin resistance in obesity and type 2 diabetes.
Journal Reference Authors Ahmad F, Goldstein BJ
Title Increased abundance of specific skeletal muscle protein-tyrosine phosphatases in a genetic model of insulin-resistant obesity and diabetes mellitus.
Journal Reference Authors George S, Rochford JJ, Wolfrum C, Gray SL, Schinner S, Wilson JC, Soos MA, Murgatroyd PR, Williams RM, Acerini CL, Dunger DB, Barford D, Umpleby AM, Wareham NJ, Davies HA, Schafer AJ, Stoffel M, O'Rahilly S, Barroso I
Title A family with severe insulin resistance and diabetes due to a mutation in AKT2.
Journal Reference Authors Snel M, Jonker JT, Schoones J, Lamb H, de Roos A, Pijl H, Smit JW, Meinders AE, Jazet IM
Title Ectopic fat and insulin resistance: pathophysiology and effect of diet and lifestyle interventions.
Journal Reference Authors Morino K, Petersen KF, Shulman GI
Title Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction.
Journal Reference Authors Plomgaard P, Bouzakri K, Krogh-Madsen R, Mittendorfer B, Zierath JR, Pedersen BK
Title Tumor necrosis factor-alpha induces skeletal muscle insulin resistance in healthy human subjects via inhibition of Akt substrate 160 phosphorylation.
Journal Reference Authors Kim JA, Wei Y, Sowers JR
Title Role of mitochondrial dysfunction in insulin resistance.
Journal Reference Authors Steinberg GR, Michell BJ, van Denderen BJ, Watt MJ, Carey AL, Fam BC, Andrikopoulos S, Proietto J, Gorgun CZ, Carling D, Hotamisligil GS, Febbraio MA, Kay TW, Kemp BE
Title Tumor necrosis factor alpha-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling.
Journal Reference Authors Ruderman NB, Saha AK, Vavvas D, Witters LA
Title Malonyl-CoA, fuel sensing, and insulin resistance.
Journal Reference Authors Saha AK, Kurowski TG, Colca JR, Ruderman NB
Title Lipid abnormalities in tissues of the KKAy mouse: effects of pioglitazone on malonyl-CoA and diacylglycerol.
Journal Reference Authors Blachnio-Zabielska AU, Koutsari C, Tchkonia T, Jensen MD
Title Sphingolipid content of human adipose tissue: relationship to adiponectin and insulin resistance.
Journal Reference Authors Larter CZ, Farrell GC
Title Insulin resistance, adiponectin, cytokines in NASH: Which is the best target to treat?
Journal Reference Authors Koo SH, Satoh H, Herzig S, Lee CH, Hedrick S, Kulkarni R, Evans RM, Olefsky J, Montminy M
Title PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3.
Journal Reference Authors Slawson C, Copeland RJ, Hart GW
Title O-GlcNAc signaling: a metabolic link between diabetes and cancer?
Journal Reference Authors Ruan HB, Singh JP, Li MD, Wu J, Yang X
Title Cracking the O-GlcNAc code in metabolism.
Journal Reference Authors Muoio DM, Newgard CB
Title Obesity-related derangements in metabolic regulation.
Journal Reference Authors Itani SI, Zhou Q, Pories WJ, MacDonald KG, Dohm GL
Title Involvement of protein kinase C in human skeletal muscle insulin resistance and obesity.
Journal Related puc00514 Other types of O-glycan biosynthesis
puc00520 Amino sugar and nucleotide sugar metabolism
KO pathway LinkDB All DBs
