Entry Name TNF signaling pathway - Panthera uncia (snow leopard)
Description Tumor necrosis factor (TNF), as a critical cytokine, can induce a wide range of intracellular signal pathways including apoptosis and cell survival as well as inflammation and immunity. Activated TNF is assembled to a homotrimer and binds to its receptors (TNFR1, TNFR2) resulting in the trimerization of TNFR1 or TNFR2. TNFR1 is expressed by nearly all cells and is the major receptor for TNF (also called TNF-alpha). In contrast, TNFR2 is expressed in limited cells such as CD4 and CD8 T lymphocytes, endothelial cells, microglia, oligodendrocytes, neuron subtypes, cardiac myocytes, thymocytes and human mesenchymal stem cells. It is the receptor for both TNF and LTA (also called TNF-beta). Upon binding of the ligand, TNFR mediates the association of some adaptor proteins such as TRADD or TRAF2, which in turn initiate recruitment of signal transducers. TNFR1 signaling induces activation of many genes, primarily controlled by two distinct pathways, NF-kappa B pathway and the MAPK cascade, or apoptosis and necroptosis. TNFR2 signaling activates NF-kappa B pathway including PI3K-dependent NF-kappa B pathway and JNK pathway leading to survival.
Class Environmental Information Processing; Signal transductionBRITE hierarchy
Pathway map Ortholog table Other DBs Organism Panthera uncia (snow leopard) [GN:
puc ]
Gene 125923277 BAG family molecular chaperone regulator 4 isoform X1 [KO:K09558 ]
125916585 tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171 ]
125917180 baculoviral IAP repeat-containing protein 3-like isoform X1 [KO:K16060 ]
125918027 baculoviral IAP repeat-containing protein 3-like isoform X1 [KO:K16060 ]
125919627 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403 ]
125938017 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404 ]
125931582 TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1 [KO:K12793 ]
125911260 cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870 ]
125930188 cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048 ]
125925743 cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048 ]
125934155 cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048 ]
125919439 cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048 ]
125928859 cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048 ]
125911819 cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450 ]
125930855 cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047 ]
125938414 cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049 ]
125933106 LOW QUALITY PROTEIN: serine/threonine-protein phosphatase PGAM5, mitochondrial-like [KO:K15637 ] [EC:3.1.3.16 ]
125933220 tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390 ]
125915409 nucleotide-binding oligomerization domain-containing protein 2 [KO:K10165 ]
125913143 LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
125921289 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
125913493 phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
125935698 phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
125929237 phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649 ]
125927247 LOW QUALITY PROTEIN: disabled homolog 2-interacting protein-like [KO:K19901 ]
Reference Authors Chu WM
Title Tumor necrosis factor.
Journal Reference Authors Shuh M, Bohorquez H, Loss GE Jr, Cohen AJ
Title Tumor Necrosis Factor-alpha: Life and Death of Hepatocytes During Liver Ischemia/Reperfusion Injury.
Journal Ochsner J 13:119-30 (2013)
Reference Authors MacEwan DJ
Title TNF receptor subtype signalling: differences and cellular consequences.
Journal Reference Authors Newton K, Dixit VM
Title Signaling in innate immunity and inflammation.
Journal Reference Authors Pomerantz JL, Baltimore D
Title NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase.
Journal Reference Authors Naude PJ, den Boer JA, Luiten PG, Eisel UL
Title Tumor necrosis factor receptor cross-talk.
Journal Reference Authors Faustman D, Davis M
Title TNF receptor 2 pathway: drug target for autoimmune diseases.
Journal Reference Authors Chan FK, Shisler J, Bixby JG, Felices M, Zheng L, Appel M, Orenstein J, Moss B, Lenardo MJ
Title A role for tumor necrosis factor receptor-2 and receptor-interacting protein in programmed necrosis and antiviral responses.
Journal Reference Authors Lee MY, Nam KH, Choi KC
Title iRhoms; Its Functions and Essential Roles.
Journal Related KO pathway LinkDB All DBs
