KEGG   PATHWAY: shon05202
Entry
shon05202                   Pathway                                
Name
Transcriptional misregulation in cancer - Sturnira hondurensis
Description
In tumor cells, genes encoding transcription factors (TFs) are often amplified, deleted, rearranged via chromosomal translocation and inversion, or subjected to point mutations that result in a gain- or loss-of- function. In hematopoietic cancers and solid tumors, the translocations and inversions increase or deregulate transcription of the oncogene. Recurrent chromosome translocations generate novel fusion oncoproteins, which are common in myeloid cancers and soft-tissue sarcomas. The fusion proteins have aberrant transcriptional function compared to their wild-type counterparts. These fusion transcription factors alter expression of target genes, and thereby result in a variety of altered cellular properties that contribute to the tumourigenic process.
Class
Human Diseases; Cancer: overview
Pathway map
shon05202  Transcriptional misregulation in cancer
shon05202

Organism
Sturnira hondurensis [GN:shon]
Gene
118983269  RUNX1; runt-related transcription factor 1 isoform X1 [KO:K08367]
118986159  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
119003703  MPO; myeloperoxidase [KO:K10789] [EC:1.11.2.2]
118990122  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
118995555  RUNX1T1; protein CBFA2T1 isoform X1 [KO:K10053]
118997724  HDAC1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
119000192  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
118987735  SIN3A; paired amphipathic helix protein Sin3a [KO:K11644]
119002794  NCOR1; nuclear receptor corepressor 1 isoform X1 [KO:K04650]
118976331  CEBPA; CCAAT/enhancer-binding protein alpha [KO:K09055]
119003050  PER2; period circadian protein homolog 2 [KO:K02633]
118974517  SPI1; transcription factor PU.1 isoform X1 [KO:K09438]
118998143  CD14; monocyte differentiation antigen CD14 [KO:K04391]
118978279  ITGAM; integrin alpha-M isoform X1 [KO:K06461]
118982019  FCGR1A; high affinity immunoglobulin gamma Fc receptor I isoform X1 [KO:K06498]
118978065  junction plakoglobin [KO:K10056]
118987769  PML; LOW QUALITY PROTEIN: protein PML [KO:K10054] [EC:2.3.2.-]
118978038  RARA; retinoic acid receptor alpha [KO:K08527]
118974983  LOW QUALITY PROTEIN: cyclin-A2-like [KO:K06627]
118994860  CCNA1; cyclin-A1 [KO:K06627]
118995492  CCNA2; cyclin-A2 [KO:K06627]
118980938  CEBPE; CCAAT/enhancer-binding protein epsilon [KO:K10051]
118991885  BCL2A1; bcl-2-related protein A1 [KO:K02162]
119000549  ZBTB16; zinc finger and BTB domain-containing protein 16 [KO:K10055]
118988677  MYC; myc proto-oncogene protein isoform X1 [KO:K04377]
118999915  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
118984424  TCF3; transcription factor E2-alpha isoform X1 [KO:K09063]
118979173  PBX1; pre-B-cell leukemia transcription factor 1 isoform X1 [KO:K09355]
118994004  WNT16; protein Wnt-16 [KO:K01558]
118998968  ETV7; transcription factor ETV7 isoform X1 [KO:K03211]
118978369  ETV6; transcription factor ETV6 isoform X1 [KO:K03211]
118995118  uncharacterized protein LOC118995118 [KO:K10784]
118984390  ELANE; neutrophil elastase [KO:K01327] [EC:3.4.21.37]
118980823  uncharacterized protein LOC118980823 [KO:K01353] [EC:3.4.21.79]
118980881  LOW QUALITY PROTEIN: granzyme H-like [KO:K01353] [EC:3.4.21.79]
118994753  KMT2A; histone-lysine N-methyltransferase 2A isoform X1 [KO:K09186] [EC:2.1.1.354]
118976177  AFF1; AF4/FMR2 family member 1 isoform X1 [KO:K15184]
118980392  CDK9; cyclin-dependent kinase 9 [KO:K02211] [EC:2.7.11.22 2.7.11.23]
118976408  CCNT1; cyclin-T1 [KO:K15188]
119003109  CCNT2; cyclin-T2 isoform X1 [KO:K15188]
118997999  MLLT3; protein AF-9 isoform X1 [KO:K15187]
118984552  MLLT1; protein ENL isoform X1 [KO:K15187]
118984445  DOT1L; histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1 [KO:K11427] [EC:2.1.1.360]
118983159  LMO2; rhombotin-2 isoform X1 [KO:K15612]
118980069  PBX3; pre-B-cell leukemia transcription factor 3 isoform X1 [KO:K15610]
118992272  RUNX2; runt-related transcription factor 2 isoform X1 [KO:K09278]
118995425  SMAD1; mothers against decapentaplegic homolog 1 [KO:K04676]
118999649  KLF3; Krueppel-like factor 3 [KO:K15605]
118977224  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
118983585  HOXA9; homeobox protein Hox-A9 [KO:K21950]
118983584  HOXA10; homeobox protein Hox-A10 [KO:K17443]
118998488  JMJD1C; probable JmjC domain-containing histone demethylation protein 2C isoform X1 [KO:K11449] [EC:1.14.11.-]
118998571  HMGA2; high mobility group protein HMGI-C [KO:K09283]
118981094  KDM6A; lysine-specific demethylase 6A isoform X1 [KO:K11447] [EC:1.14.11.68]
119000751  lysine-specific demethylase 6A-like isoform X1 [KO:K11447] [EC:1.14.11.68]
118992289  SUPT3H; transcription initiation protein SPT3 homolog isoform X1 [KO:K11313]
118986558  PROM1; prominin-1 isoform X1 [KO:K06532]
118995806  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
118990400  BMP2K; BMP-2-inducible protein kinase isoform X1 [KO:K08854] [EC:2.7.11.1]
118992013  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
118978371  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
119000960  CDK14; cyclin-dependent kinase 14 isoform X1 [KO:K08821] [EC:2.7.11.22]
118988451  MEIS1; homeobox protein Meis1 isoform X1 [KO:K15613]
118983586  HOXA11; homeobox protein Hox-A11 [KO:K21951]
118976669  SIX1; homeobox protein SIX1 [KO:K15614]
118976847  SIX4; homeobox protein SIX4 isoform X1 [KO:K15615]
118995548  EYA1; eyes absent homolog 1 isoform X1 [KO:K15616] [EC:3.1.3.48]
118985009  CDKN2C; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
118984312  HPGD; 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform X1 [KO:K00069] [EC:1.1.1.141]
118974585  GRIA3; glutamate receptor 3 [KO:K05199]
118976615  FUT8; alpha-(1,6)-fucosyltransferase [KO:K00717] [EC:2.4.1.68]
118994918  TLX3; T-cell leukemia homeobox protein 3 [KO:K15607]
118999497  TLX1; T-cell leukemia homeobox protein 1 isoform X1 [KO:K09340]
118976641  BCL11B; B-cell lymphoma/leukemia 11B isoform X1 [KO:K22046]
118999485  LDB1; LIM domain-binding protein 1 isoform X1 [KO:K15617]
118984111  LYL1; protein lyl-1 [KO:K15604]
118987985  HHEX; hematopoietically-expressed homeobox protein HHEX [KO:K08024]
118991604  PTCRA; pre T-cell antigen receptor alpha [KO:K06056]
118988401  REL; proto-oncogene c-Rel isoform X1 [KO:K09254]
118999952  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
118975660  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
118975664  baculoviral IAP repeat-containing protein 3-like [KO:K16060]
118995980  TRAF1; TNF receptor-associated factor 1 [KO:K03172]
118985337  BCL2L1; bcl-2-like protein 1 [KO:K04570]
118990754  CD86; T-lymphocyte activation antigen CD86 isoform X1 [KO:K05413]
118985558  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
118980907  BCL6; B-cell lymphoma 6 protein [KO:K15618]
118981156  MAF; transcription factor Maf isoform X1 [KO:K09035]
118987730  NSD2; histone-lysine N-methyltransferase NSD2 [KO:K11424] [EC:2.1.1.357]
118996181  histone H3.3C-like [KO:K11253]
118981556  histone H3.3A [KO:K11253]
118981932  uncharacterized protein LOC118981932 [KO:K11253]
118982027  histone H3 [KO:K11253]
118990692  histone H3.1 [KO:K11253]
118990693  histone H3.1 [KO:K11253]
118990707  histone H3.1-like [KO:K11253]
118990721  uncharacterized protein LOC118990721 [KO:K11253]
118982826  histone H3 [KO:K11253]
119000437  histone H3.3A [KO:K11253]
118977896  histone H3.1 [KO:K11253]
118977899  histone H3.1 [KO:K11253]
118977900  histone H3.1 [KO:K11253]
119003148  histone H3.3A [KO:K11253]
119003217  LOW QUALITY PROTEIN: histone H3.3C [KO:K11253]
118979669  PAX5; paired box protein Pax-5 isoform X1 [KO:K09383]
118981929  PAX8; paired box protein Pax-8 isoform X1 [KO:K09293]
118990275  PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
118980369  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
118991475  RXRB; retinoic acid receptor RXR-beta isoform X1 [KO:K08525]
118979266  RXRG; retinoic acid receptor RXR-gamma isoform X1 [KO:K08526]
118998335  TFE3; transcription factor E3 isoform X1 [KO:K09105]
118998962  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
118984844  TMPRSS2; transmembrane protease serine 2 [KO:K09633] [EC:3.4.21.122]
118984824  ERG; transcriptional regulator ERG isoform X1 [KO:K09435]
118993498  PLAU; urokinase-type plasminogen activator [KO:K01348] [EC:3.4.21.73]
118993206  PLAT; tissue-type plasminogen activator isoform X1 [KO:K01343] [EC:3.4.21.68]
118975721  stromelysin-1-like [KO:K01394] [EC:3.4.24.17]
118985553  MMP9; matrix metalloproteinase-9 isoform X1 [KO:K01403] [EC:3.4.24.35]
118980542  ZEB1; zinc finger E-box-binding homeobox 1 [KO:K09299]
118994652  IL1R2; interleukin-1 receptor type 2 isoform X1 [KO:K04387]
118993571  SPINT1; kunitz-type protease inhibitor 1 isoform X1 [KO:K15619]
118993756  ETV1; ETS translocation variant 1 isoform X1 [KO:K09431]
119002325  ETV4; ETS translocation variant 4 isoform X1 [KO:K15592]
118974179  ETV5; ETS translocation variant 5 [KO:K15593]
119001653  SLC45A3; solute carrier family 45 member 3 [KO:K15379]
119001725  ELK4; ETS domain-containing protein Elk-4 isoform X1 [KO:K04376]
119003702  DDX5; probable ATP-dependent RNA helicase DDX5 [KO:K12823] [EC:5.6.2.7]
118979423  MYCN; N-myc proto-oncogene protein [KO:K09109]
118976606  MAX; protein max isoform X1 [KO:K04453]
118989366  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
118988708  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
118974748  TP53; cellular tumor antigen p53 [KO:K04451]
118995171  BMI1; polycomb complex protein BMI-1 [KO:K11459]
118986310  ZBTB17; zinc finger and BTB domain-containing protein 17 isoform X1 [KO:K10500]
118978151  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
118991691  MEN1; menin isoform X1 [KO:K14970]
118991261  EWSR1; RNA-binding protein EWS isoform X1 [KO:K13209]
118987810  LOW QUALITY PROTEIN: RNA-binding protein EWS-like [KO:K13209]
118981514  FLI1; Friend leukemia integration 1 transcription factor isoform X1 [KO:K09436]
119002367  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
118988742  ID2; DNA-binding protein inhibitor ID-2 [KO:K17693]
118994719  DNA-binding protein inhibitor ID-2-like [KO:K17693]
119004086  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
118983487  IGFBP3; insulin-like growth factor-binding protein 3 [KO:K10138]
118975402  FEV; protein FEV [KO:K09437]
118976396  ATF1; cyclic AMP-dependent transcription factor ATF-1 isoform X1 [KO:K09053]
118991887  aryl hydrocarbon receptor nuclear translocator 2 isoform X1 [KO:K15589]
118988241  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
118983436  MITF; microphthalmia-associated transcription factor isoform X1 [KO:K09455]
118983141  WT1; Wilms tumor protein isoform X1 [KO:K09234]
118995064  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
119002352  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
118978905  BAIAP3; BAI1-associated protein 3 [KO:K15621]
118983774  TSPAN7; tetraspanin-7 [KO:K06571]
118987462  MLF1; myeloid leukemia factor 1 isoform X1 [KO:K15622]
118979676  NR4A3; nuclear receptor subfamily 4 group A member 3 [KO:K08559]
119001426  TAF15; TATA-binding protein-associated factor 2N isoform X1 [KO:K14651]
118975904  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
118996488  CEBPB; CCAAT/enhancer-binding protein beta [KO:K10048]
118995815  NFKBIZ; NF-kappa-B inhibitor zeta isoform X1 [KO:K14242]
118979949  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
118991736  RELA; transcription factor p65 [KO:K04735]
118999083  C-X-C motif chemokine 15-like isoform X1 [KO:K10030]
118999088  CXCL8; interleukin-8 [KO:K10030]
118975401  PAX3; paired box protein Pax-3 isoform X1 [KO:K09381]
118986286  PAX7; paired box protein Pax-7 isoform X1 [KO:K09381]
118994827  FOXO1; forkhead box protein O1 [KO:K07201]
118986919  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
118995808  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
118996560  SS18L1; calcium-responsive transactivator [KO:K15623]
118977302  SS18; protein SSXT isoform X1 [KO:K15623]
119002547  ASPSCR1; tether containing UBX domain for GLUT4 isoform X1 [KO:K15627]
118984458  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
118984673  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
118978970  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
118991499  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
118974481  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
118977345  POLK; DNA polymerase kappa isoform X1 [KO:K03511] [EC:2.7.7.7]
Reference
PMID:11607818
  Authors
Alcalay M, Orleth A, Sebastiani C, Meani N, Chiaradonna F, Casciari C, Sciurpi MT, Gelmetti V, Riganelli D, Minucci S, Fagioli M, Pelicci PG
  Title
Common themes in the pathogenesis of acute myeloid leukemia.
  Journal
Oncogene 20:5680-94 (2001)
DOI:10.1038/sj.onc.1204642
Reference
PMID:12032780
  Authors
Scandura JM, Boccuni P, Cammenga J, Nimer SD
  Title
Transcription factor fusions in acute leukemia: variations on a theme.
  Journal
Oncogene 21:3422-44 (2002)
DOI:10.1038/sj.onc.1205315
Reference
PMID:12529654
  Authors
Roumier C, Fenaux P, Lafage M, Imbert M, Eclache V, Preudhomme C
  Title
New mechanisms of AML1 gene alteration in hematological malignancies.
  Journal
Leukemia 17:9-16 (2003)
DOI:10.1038/sj.leu.2402766
Reference
PMID:10717473
  Authors
Lutterbach B, Hiebert SW
  Title
Role of the transcription factor AML-1 in acute leukemia and hematopoietic differentiation.
  Journal
Gene 245:223-35 (2000)
DOI:10.1016/S0378-1119(00)00014-7
Reference
PMID:19075268
  Authors
Koschmieder S, Halmos B, Levantini E, Tenen DG
  Title
Dysregulation of the C/EBPalpha differentiation pathway in human cancer.
  Journal
J Clin Oncol 27:619-28 (2009)
DOI:10.1200/JCO.2008.17.9812
Reference
PMID:11340171
  Authors
Johansen LM, Iwama A, Lodie TA, Sasaki K, Felsher DW, Golub TR, Tenen DG
  Title
c-Myc is a critical target for c/EBPalpha in granulopoiesis.
  Journal
Mol Cell Biol 21:3789-806 (2001)
DOI:10.1128/MCB.21.11.3789-3806.2001
Reference
PMID:15985538
  Authors
Gery S, Gombart AF, Yi WS, Koeffler C, Hofmann WK, Koeffler HP
  Title
Transcription profiling of C/EBP targets identifies Per2 as a gene implicated in myeloid leukemia.
  Journal
Blood 106:2827-36 (2005)
DOI:10.1182/blood-2005-01-0358
Reference
PMID:12393465
  Authors
Vangala RK, Heiss-Neumann MS, Rangatia JS, Singh SM, Schoch C, Tenen DG, Hiddemann W, Behre G
  Title
The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia.
  Journal
Blood 101:270-7 (2003)
DOI:10.1182/blood-2002-04-1288
Reference
PMID:12130514
  Authors
Mueller BU, Pabst T, Osato M, Asou N, Johansen LM, Minden MD, Behre G, Hiddemann W, Ito Y, Tenen DG
  Title
Heterozygous PU.1 mutations are associated with acute myeloid leukemia.
  Journal
Blood 100:998-1007 (2002)
DOI:10.1182/blood.V100.3.998
Reference
PMID:15160934
  Authors
Jing Y
  Title
The PML-RARalpha fusion protein and targeted therapy for acute promyelocytic leukemia.
  Journal
Leuk Lymphoma 45:639-48 (2004)
DOI:10.1080/10428190310001609933
Reference
PMID:15024077
  Authors
Muller-Tidow C, Steffen B, Cauvet T, Tickenbrock L, Ji P, Diederichs S, Sargin B, Kohler G, Stelljes M, Puccetti E, Ruthardt M, deVos S, Hiebert SW, Koeffler HP, Berdel WE, Serve H
  Title
Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells.
  Journal
Mol Cell Biol 24:2890-904 (2004)
DOI:10.1128/MCB.24.7.2890-2904.2004
Reference
PMID:19855079
  Authors
Rice KL, Hormaeche I, Doulatov S, Flatow JM, Grimwade D, Mills KI, Leiva M, Ablain J, Ambardekar C, McConnell MJ, Dick JE, Licht JD
  Title
Comprehensive genomic screens identify a role for PLZF-RARalpha as a positive regulator of cell proliferation via direct regulation of c-MYC.
  Journal
Blood 114:5499-511 (2009)
DOI:10.1182/blood-2009-03-206524
Reference
PMID:10500199
  Authors
McWhirter JR, Neuteboom ST, Wancewicz EV, Monia BP, Downing JR, Murre C
  Title
Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia.
  Journal
Proc Natl Acad Sci U S A 96:11464-9 (1999)
DOI:10.1073/pnas.96.20.11464
Reference
PMID:15156184
  Authors
Zelent A, Greaves M, Enver T
  Title
Role of the TEL-AML1 fusion gene in the molecular pathogenesis of childhood acute lymphoblastic leukaemia.
  Journal
Oncogene 23:4275-83 (2004)
DOI:10.1038/sj.onc.1207672
Reference
PMID:14630078
  Authors
Sawinska M, Ladon D
  Title
Mechanism, detection and clinical significance of the reciprocal translocation t(12;21)(p12;q22) in the children suffering from acute lymphoblastic leukaemia.
  Journal
Leuk Res 28:35-42 (2004)
DOI:10.1016/S0145-2126(03)00160-7
Reference
PMID:19141473
  Authors
Guenther MG, Lawton LN, Rozovskaia T, Frampton GM, Levine SS, Volkert TL, Croce CM, Nakamura T, Canaani E, Young RA
  Title
Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia.
  Journal
Genes Dev 22:3403-8 (2008)
DOI:10.1101/gad.1741408
Reference
PMID:16169901
  Authors
Xia ZB, Popovic R, Chen J, Theisler C, Stuart T, Santillan DA, Erfurth F, Diaz MO, Zeleznik-Le NJ
  Title
The MLL fusion gene, MLL-AF4, regulates cyclin-dependent kinase inhibitor CDKN1B (p27kip1) expression.
  Journal
Proc Natl Acad Sci U S A 102:14028-33 (2005)
DOI:10.1073/pnas.0506464102
Reference
PMID:21518926
  Authors
Wang QF, Wu G, Mi S, He F, Wu J, Dong J, Luo RT, Mattison R, Kaberlein JJ, Prabhakar S, Ji H, Thirman MJ
  Title
MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome.
  Journal
Blood 117:6895-905 (2011)
DOI:10.1182/blood-2010-12-324699
Reference
PMID:14701735
  Authors
Zeisig BB, Milne T, Garcia-Cuellar MP, Schreiner S, Martin ME, Fuchs U, Borkhardt A, Chanda SK, Walker J, Soden R, Hess JL, Slany RK
  Title
Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization.
  Journal
Mol Cell Biol 24:617-28 (2004)
DOI:10.1128/MCB.24.2.617-628.2004
Reference
PMID:19133982
  Authors
Riz I, Hawley TS, Johnston H, Hawley RG
  Title
Role of TLX1 in T-cell acute lymphoblastic leukaemia pathogenesis.
  Journal
Br J Haematol 145:140-3 (2009)
DOI:10.1111/j.1365-2141.2008.07556.x
Reference
PMID:12511414
  Authors
Barth TF, Martin-Subero JI, Joos S, Menz CK, Hasel C, Mechtersheimer G, Parwaresch RM, Lichter P, Siebert R, Mooller P
  Title
Gains of 2p involving the REL locus correlate with nuclear c-Rel protein accumulation in neoplastic cells of classical Hodgkin lymphoma.
  Journal
Blood 101:3681-6 (2003)
DOI:10.1182/blood-2002-08-2577
Reference
PMID:11313274
  Authors
Hinz M, Loser P, Mathas S, Krappmann D, Dorken B, Scheidereit C
  Title
Constitutive NF-kappaB maintains high expression of a characteristic gene network, including CD40, CD86, and a set of antiapoptotic genes in Hodgkin/Reed-Sternberg cells.
  Journal
Blood 97:2798-807 (2001)
DOI:10.1182/blood.V97.9.2798
Reference
PMID:12670461
  Authors
Zuzel M, Cawley JC.
  Title
The biology of hairy cells.
  Journal
Best Pract Res Clin Haematol 16:1-13 (2003)
DOI:10.1016/S1521-6926(02)00082-8
Reference
PMID:14998494
  Authors
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Overexpression of c-maf is a frequent oncogenic event in multiple myeloma that promotes proliferation and pathological interactions with bone marrow stroma.
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Cancer Cell 5:191-9 (2004)
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The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells.
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Blood 117:211-20 (2011)
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Haematologica 94:78-86 (2009)
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Chromosomal rearrangement of the PAX-5 locus in lymphoplasmacytic lymphoma with t(9;14)(p13;q32).
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Leuk Lymphoma 34:25-33 (1999)
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PMID:10784387
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The t(9;14)(p13;q32) translocation in B-cell non-Hodgkin's lymphoma.
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Leuk Lymphoma 36:435-45 (2000)
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Curr Opin Genet Dev 19:82-91 (2009)
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Translocations in epithelial cancers.
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Biochim Biophys Acta 1796:201-15 (2009)
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The paired box-8/peroxisome proliferator-activated receptor-gamma oncogene in thyroid tumorigenesis.
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Endocrinology 148:932-5 (2007)
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The renal cell carcinoma-associated oncogenic fusion protein PRCCTFE3 provokes p21 WAF1/CIP1-mediated cell cycle delay.
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Exp Cell Res 315:2399-409 (2009)
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Nat Rev Cancer 8:497-511 (2008)
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An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression.
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Cancer Cell 17:443-54 (2010)
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TMPRSS2/ERG promotes epithelial to mesenchymal transition through the ZEB1/ZEB2 axis in a prostate cancer model.
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ETV1 is a novel androgen receptor-regulated gene that mediates prostate cancer cell invasion.
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Mol Endocrinol 21:1835-46 (2007)
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Characterization of TMPRSS2:ETV5 and SLC45A3:ETV5 gene fusions in prostate cancer.
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Cancer Res 68:73-80 (2008)
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The MYCN oncogene and differentiation in neuroblastoma.
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Semin Cancer Biol 21:256-66 (2011)
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PMID:20153925
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MYCN oncoprotein targets and their therapeutic potential.
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The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma.
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Proc Natl Acad Sci U S A 102:731-6 (2005)
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Bmi1 is a MYCN target gene that regulates tumorigenesis through repression of KIF1Bbeta and TSLC1 in neuroblastoma.
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p53 is a direct transcriptional target of MYCN in neuroblastoma.
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Nat Clin Pract Endocrinol Metab 2:562-70 (2006)
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Oncogene 22:1-9 (2003)
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Ewing Sarcoma, an enigmatic malignancy of likely progenitor cell origin, driven by transcription factor oncogenic fusions.
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Cancer Res 69:7140-50 (2009)
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Oncogene 22:41-9 (2003)
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Fusion of the EWS-related gene TAF2N to TEC in extraskeletal myxoid chondrosarcoma.
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Int J Cancer 115:556-60 (2005)
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Oncogene 28:270-8 (2009)
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PAX3-FOXO1 fusion gene in rhabdomyosarcoma.
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Cancer Lett 270:10-8 (2008)
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Identification of target genes regulated by PAX3 and PAX3-FKHR in embryogenesis and alveolar rhabdomyosarcoma.
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Genomics 79:278-84 (2002)
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The SYT-SSX fusion protein down-regulates the cell proliferation regulator COM1 in t(x;18) synovial sarcoma.
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Mol Cell Biol 27:1348-55 (2007)
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PMID:19472090
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Expression of MET in alveolar soft part sarcoma.
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Mutations in the p53 Tumor Suppressor Gene: Important Milestones at the Various Steps of Tumorigenesis.
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Recent advances in p53 research and cancer treatment.
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J Biomed Biotechnol 2011:978312 (2011)
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Related
pathway
shon04115  p53 signaling pathway
shon05211  Renal cell carcinoma
shon05215  Prostate cancer
shon05216  Thyroid cancer
shon05221  Acute myeloid leukemia
KO pathway
ko05202   
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