Entry
Name
C-type lectin receptor signaling pathway - Sarcophilus harrisii (Tasmanian devil)
Description
C-type lectin receptors (CLRs) are a large superfamily of proteins characterized by the presence of one or more C-type lectin-like domains (CTLDs). CLRs function as pattern-recognition receptors (PRRs) for pathogen-derived ligands in dendric cells, macrophages, neutrophils, etc., such as Dectin-1 and Dectin-2 for recognition of fungi-derived B-glucan and high mannose-type carbohydrates. Upon ligand binding, CLRs stimulate intracellular signaling cascades that induce the production of inflammatory cytokines and chemokines, consequently triggering innate and adaptive immunity to pathogens.
Class
Organismal Systems; Immune system
BRITE hierarchy
Pathway map
shr04625 C-type lectin receptor signaling pathway
Ortholog table
Organism
Sarcophilus harrisii (Tasmanian devil) [GN:
shr ]
Gene
100919206 PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X2 [KO:K05859 ] [EC:3.1.4.11 ]
100918532 ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X7 [KO:K04958 ]
100916996 ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X2 [KO:K04960 ]
100917281 PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
100915297 PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X2 [KO:K04348 ] [EC:3.1.3.16 ]
100918408 PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
100926364 NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446 ]
100920251 NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X2 [KO:K17332 ]
100917473 NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333 ]
100920502 NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334 ]
100925851 PYCARD; apoptosis-associated speck-like protein containing a CARD [KO:K12799 ]
100931004 CARD9; caspase recruitment domain-containing protein 9 [KO:K12794 ]
100924978 MALT1; mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform X1 [KO:K07369 ] [EC:3.4.22.-]
100919027 NFKBIA; LOW QUALITY PROTEIN: NF-kappa-B inhibitor alpha [KO:K04734 ]
100917619 NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580 ]
100923264 FCER1G; high affinity immunoglobulin epsilon receptor subunit gamma [KO:K07983 ]
100913854 ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532 ]
105749862 STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220 ]
100933167 STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221 ]
100929811 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
100932099 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
105749979 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
100926892 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
100924976 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649 ]
100935230 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
Compound
C01245 D-myo-Inositol 1,4,5-trisphosphate
C21790 Mycobacterial trehalose dimycolate
G13115 Mannose-capped lipoarabinomannan
Reference
Authors
Geijtenbeek TB, Gringhuis SI
Title
C-type lectin receptors in the control of T helper cell differentiation.
Journal
Reference
Authors
Hajishengallis G, Lambris JD
Title
Microbial manipulation of receptor crosstalk in innate immunity.
Journal
Reference
Authors
Iliev ID, Leonardi I
Title
Fungal dysbiosis: immunity and interactions at mucosal barriers.
Journal
Reference
Authors
Richardson MB, Williams SJ
Title
MCL and Mincle: C-Type Lectin Receptors That Sense Damaged Self and Pathogen-Associated Molecular Patterns.
Journal
Reference
Authors
Vautier S, MacCallum DM, Brown GD
Title
C-type lectin receptors and cytokines in fungal immunity.
Journal
Reference
Authors
Gauglitz GG, Callenberg H, Weindl G, Korting HC
Title
Host defence against Candida albicans and the role of pattern-recognition receptors.
Journal
Reference
Authors
Cunha C, Carvalho A, Esposito A, Bistoni F, Romani L
Title
DAMP signaling in fungal infections and diseases.
Journal
Reference
Authors
Tang J, Lin G, Langdon WY, Tao L, Zhang J
Title
Regulation of C-Type Lectin Receptor-Mediated Antifungal Immunity.
Journal
Reference
Authors
Mayer S, Raulf MK, Lepenies B
Title
C-type lectins: their network and roles in pathogen recognition and immunity.
Journal
Reference
Authors
Plato A, Willment JA, Brown GD
Title
C-type lectin-like receptors of the dectin-1 cluster: ligands and signaling pathways.
Journal
Reference
Authors
Dupaul-Chicoine J, Saleh M
Title
A new path to IL-1beta production controlled by caspase-8.
Journal
Reference
Authors
Batbayar S, Lee DH, Kim HW
Title
Immunomodulation of Fungal beta-Glucan in Host Defense Signaling by Dectin-1.
Journal
Reference
Authors
Bendickova K, Tidu F, Fric J
Title
Calcineurin-NFAT signalling in myeloid leucocytes: new prospects and pitfalls in immunosuppressive therapy.
Journal
Reference
Authors
den Dunnen J, Gringhuis SI, Geijtenbeek TB
Title
Innate signaling by the C-type lectin DC-SIGN dictates immune responses.
Journal
Reference
Authors
Marakalala MJ, Ndlovu H
Title
Signaling C-type lectin receptors in antimycobacterial immunity.
Journal
Reference
Authors
Gringhuis SI, Kaptein TM, Wevers BA, Mesman AW, Geijtenbeek TB
Title
Fucose-specific DC-SIGN signalling directs T helper cell type-2 responses via IKKepsilon- and CYLD-dependent Bcl3 activation.
Journal
Reference
Authors
Geijtenbeek TB, Gringhuis SI
Title
Signalling through C-type lectin receptors: shaping immune responses.
Journal
Reference
Authors
Gringhuis SI, den Dunnen J, Litjens M, van der Vlist M, Wevers B, Bruijns SC, Geijtenbeek TB
Title
Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-kappaB activation through Raf-1 and Syk.
Journal
Related pathway
shr04658 Th1 and Th2 cell differentiation
KO pathway
LinkDB
All DBs