KEGG   PATHWAY: uah05225
Entry
uah05225                    Pathway                                
Name
Hepatocellular carcinoma - Ursus arctos horribilis (North American brown bear)
Description
Hepatocellular carcinoma (HCC) is a major type of primary liver cancer and one of the rare human neoplasms etiologically linked to viral factors. It has been shown that, after HBV/HCV infection and alcohol or aflatoxin B1 exposure, genetic and epigenetic changes occur. The recurrent mutated genes were found to be highly enriched in multiple key driver signaling processes, including telomere maintenance, TP53, cell cycle regulation, the Wnt/beta-catenin pathway (CTNNB1 and AXIN1), the phosphatidylinositol-3 kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway. Recent studies using whole-exome sequencing have revealed recurrent mutations in new driver genes involved in the chromatin remodelling (ARID1A and ARID2) and the oxidative stress (NFE2L2) pathways.
Class
Human Diseases; Cancer: specific types
Pathway map
uah05225  Hepatocellular carcinoma
uah05225

Organism
Ursus arctos horribilis (North American brown bear) [GN:uah]
Gene
113268295  TGFA; protransforming growth factor alpha [KO:K08774]
113257444  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
113243959  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
113263646  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
113258609  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
113252535  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
113265250  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
113267584  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
113247385  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
113265986  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
113245295  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
113242690  SHC2; SHC-transforming protein 2 isoform X1 [KO:K17447]
113270120  SHC3; SHC-transforming protein 3 isoform X1 [KO:K17448]
113269597  SHC4; SHC-transforming protein 4 [KO:K17449]
113244637  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
113266205  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
113241630  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
113257418  GTPase HRas-like [KO:K02833]
113257792  KRAS; GTPase KRas isoform X1 [KO:K07827]
113244394  NRAS; GTPase NRas [KO:K07828]
113265980  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
113265167  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
113257190  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
113240885  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
113242822  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
113267646  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
113247020  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
113254799  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
113270537  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
113253989  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
113256705  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
113254730  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
113255266  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
113258976  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
113267192  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
113243572  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
113262966  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
113270510  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
113244028  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
113268897  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
113244178  BAD; bcl2-associated agonist of cell death [KO:K02158]
113258461  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
113252726  MYC; myc proto-oncogene protein [KO:K04377]
113251325  RB1; retinoblastoma-associated protein [KO:K06618]
113258272  E2F1; transcription factor E2F1 [KO:K17454]
113268523  E2F2; transcription factor E2F2 [KO:K09389]
113264513  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
113260787  TERT; telomerase reverse transcriptase [KO:K11126] [EC:2.7.7.49]
113271152  TP53; cellular tumor antigen p53 [KO:K04451]
113243864  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
113254548  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
113270128  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
113242768  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
113243322  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
113243812  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
113264969  DDB2; DNA damage-binding protein 2 [KO:K10140]
113255198  POLK; DNA polymerase kappa [KO:K03511] [EC:2.7.7.7]
113260575  tumor suppressor ARF-like isoform X1 [KO:K06621]
113256363  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
113259981  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
113243982  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
113243540  TGFB1; transforming growth factor beta-1 isoform X1 [KO:K13375]
113268733  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
113270312  TGFB3; transforming growth factor beta-3 [KO:K13377]
113260405  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
113253847  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
113253394  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
113240893  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
113253422  SMAD4; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
113257365  WNT1; proto-oncogene Wnt-1 [KO:K03209]
113263284  WNT2; protein Wnt-2 [KO:K00182]
113244420  WNT2B; protein Wnt-2b [KO:K00182]
113265670  WNT3; proto-oncogene Wnt-3 [KO:K00312]
113247468  WNT3A; protein Wnt-3a [KO:K00312]
113268542  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
113258043  WNT5B; protein Wnt-5b [KO:K00444]
113256990  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
113250444  WNT6; protein Wnt-6 isoform X1 [KO:K00445]
113241648  WNT7B; protein Wnt-7b [KO:K00572]
113257229  WNT7A; protein Wnt-7a [KO:K00572]
113261780  WNT8A; protein Wnt-8a [KO:K00714]
113251621  WNT8B; protein Wnt-8b [KO:K00714]
113247507  WNT9A; protein Wnt-9a isoform X1 [KO:K01064]
113257662  WNT10B; protein Wnt-10b [KO:K01357]
113248677  WNT10A; protein Wnt-10a [KO:K01357]
113269338  WNT11; protein Wnt-11 [KO:K01384]
113266506  WNT16; protein Wnt-16 [KO:K01558]
113259790  FZD1; frizzled-1 [KO:K02432]
113250581  FZD7; frizzled-7 [KO:K02432]
113265349  FZD2; frizzled-2 [KO:K02235]
113269945  FZD3; frizzled-3 isoform X1 [KO:K02329]
113269406  FZD4; frizzled-4 isoform X1 [KO:K02354]
113250522  FZD5; frizzled-5 [KO:K02375]
113244264  FZD8; frizzled-8 [KO:K02375]
113252851  FZD6; frizzled-6 [KO:K02376]
113267800  FZD9; frizzled-9 [KO:K02842]
113267107  FZD10; frizzled-10 [KO:K02842]
113257877  LRP6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
113244001  LRP5; low-density lipoprotein receptor-related protein 5 isoform X1 [KO:K03068]
113254396  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
113270636  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
113271107  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
113251777  FRAT1; proto-oncogene FRAT1 [KO:K03069]
113251778  FRAT2; GSK-3-binding protein FRAT2 [KO:K03096]
113251972  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
113245367  AXIN1; axin-1 isoform X1 [KO:K02157]
113265246  AXIN2; axin-2 [KO:K04385]
113254991  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
113242735  APC2; adenomatous polyposis coli protein 2 [KO:K02085]
113253816  CTNNB1; catenin beta-1 [KO:K02105]
113263933  CSNK1A1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
113261735  TCF7; transcription factor 7 isoform X1 [KO:K02620]
113243231  TCF7L1; transcription factor 7-like 1 isoform X1 [KO:K04490]
113251942  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
113255544  LEF1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
113242989  KEAP1; kelch-like ECH-associated protein 1 [KO:K10456]
113250729  NFE2L2; nuclear factor erythroid 2-related factor 2 isoform X1 [KO:K05638]
113256008  HMOX1; heme oxygenase 1 isoform X1 [KO:K00510] [EC:1.14.14.18]
113252434  NQO1; NAD(P)H dehydrogenase [quinone] 1 [KO:K00355] [EC:1.6.5.2]
113247073  glutathione S-transferase theta-2B-like [KO:K00799] [EC:2.5.1.18]
113247088  glutathione S-transferase theta-4-like isoform X1 [KO:K00799] [EC:2.5.1.18]
113247089  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
113244886  glutathione S-transferase Mu 4-like [KO:K00799] [EC:2.5.1.18]
113257838  MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
113244917  glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
113255690  MGST2; microsomal glutathione S-transferase 2 isoform X1 [KO:K00799] [EC:2.5.1.18]
113268693  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
113251904  GSTO1; glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
113251905  glutathione S-transferase omega-2 [KO:K00799] [EC:2.5.1.18]
113247021  glutathione S-transferase theta-3-like [KO:K00799] [EC:2.5.1.18]
113247025  glutathione S-transferase theta-1 [KO:K00799] [EC:2.5.1.18]
113261183  GSTA4; glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
113261185  glutathione S-transferase A4-like [KO:K00799] [EC:2.5.1.18]
113261186  glutathione S-transferase A1-like [KO:K00799] [EC:2.5.1.18]
113261187  glutathione S-transferase A3-like [KO:K00799] [EC:2.5.1.18]
113261188  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
113244018  glutathione S-transferase P isoform X1 [KO:K23790] [EC:2.5.1.18]
113244019  glutathione S-transferase P-like [KO:K23790] [EC:2.5.1.18]
113245979  TXNRD2; thioredoxin reductase 2, mitochondrial [KO:K22182] [EC:1.8.1.9]
113257278  TXNRD3; thioredoxin reductase 3 isoform X1 [KO:K22182] [EC:1.8.1.9]
113256059  TXNRD1; thioredoxin reductase 1, cytoplasmic isoform X1 [KO:K22182] [EC:1.8.1.9]
113259246  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
113263211  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
113255714  GAB1; GRB2-associated-binding protein 1 isoform X1 [KO:K09593]
113244519  ACTG1; actin, cytoplasmic 2 [KO:K05692]
113267965  ACTB; actin, cytoplasmic 1 [KO:K05692]
113254722  ACTL6A; actin-like protein 6A isoform X1 [KO:K11340]
113267524  ACTL6B; actin-like protein 6B [KO:K11652]
113257631  SMARCD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 [KO:K11650]
113265284  SMARCD2; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 [KO:K11650]
113241487  SMARCD3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 [KO:K11650]
113247113  PHF10; PHD finger protein 10 isoform X1 [KO:K22197]
113243627  DPF1; zinc finger protein neuro-d4 [KO:K22198]
113270371  DPF3; zinc finger protein DPF3 isoform X1 [KO:K22198]
113268454  ARID1A; AT-rich interactive domain-containing protein 1A isoform X1 [KO:K11653]
113259591  ARID1B; AT-rich interactive domain-containing protein 1B isoform X1 [KO:K11653]
113265474  SMARCE1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 [KO:K11651]
113247081  SMARCB1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 isoform X1 [KO:K11648]
113256434  SMARCC2; SWI/SNF complex subunit SMARCC2 isoform X1 [KO:K11649]
113256819  SMARCC1; SWI/SNF complex subunit SMARCC1 [KO:K11649]
113243008  SMARCA4; transcription activator BRG1 isoform X1 [KO:K11647] [EC:5.6.2.-]
113270180  SMARCA2; probable global transcription activator SNF2L2 isoform X1 [KO:K11647] [EC:5.6.2.-]
113257707  ARID2; AT-rich interactive domain-containing protein 2 isoform X1 [KO:K11765]
113256958  PBRM1; protein polybromo-1 isoform X1 [KO:K11757]
113252224  BRD7; bromodomain-containing protein 7 isoform X1 [KO:K11723]
Compound
C00027  Hydrogen peroxide
C00039  DNA
C00076  Calcium cation
C00165  Diacylglycerol
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01471  Acrolein
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06793  Vinyl chloride
C06800  Aflatoxin B1
C16844  Hydroxyl radical
C21641  Hydroperoxyl radical
C21642  4-Hydroxynonenal
Reference
PMID:20639898
  Authors
Whittaker S, Marais R, Zhu AX
  Title
The role of signaling pathways in the development and treatment of hepatocellular carcinoma.
  Journal
Oncogene 29:4989-5005 (2010)
DOI:10.1038/onc.2010.236
Reference
PMID:26099527
  Authors
Zucman-Rossi J, Villanueva A, Nault JC, Llovet JM
  Title
Genetic Landscape and Biomarkers of Hepatocellular Carcinoma.
  Journal
Gastroenterology 149:1226-1239.e4 (2015)
DOI:10.1053/j.gastro.2015.05.061
Reference
PMID:17295177
  Authors
Villanueva A, Newell P, Chiang DY, Friedman SL, Llovet JM.
  Title
Genomics and signaling pathways in hepatocellular carcinoma.
  Journal
Semin Liver Dis 27:55-76 (2007)
DOI:10.1055/s-2006-960171
Reference
PMID:16799620
  Authors
Breuhahn K, Longerich T, Schirmacher P
  Title
Dysregulation of growth factor signaling in human hepatocellular carcinoma.
  Journal
Oncogene 25:3787-800 (2006)
DOI:10.1038/sj.onc.1209556
Reference
PMID:19387255
  Authors
Minguez B, Tovar V, Chiang D, Villanueva A, Llovet JM
  Title
Pathogenesis of hepatocellular carcinoma and molecular therapies.
  Journal
Curr Opin Gastroenterol 25:186-94 (2009)
DOI:10.1097/MOG.0b013e32832962a1
Reference
PMID:21829020
  Authors
Kudo M
  Title
Signaling pathway and molecular-targeted therapy for hepatocellular carcinoma.
  Journal
Dig Dis 29:289-302 (2011)
DOI:10.1159/000327562
Reference
PMID:23994386
  Authors
Nault JC, Zucman-Rossi J
  Title
Genetics of hepatocellular carcinoma: the next generation.
  Journal
J Hepatol 60:224-6 (2014)
DOI:10.1016/j.jhep.2013.08.019
Reference
PMID:11935086
  Authors
Rocken C, Carl-McGrath S.
  Title
Pathology and pathogenesis of hepatocellular carcinoma.
  Journal
Dig Dis 19:269-78 (2001)
DOI:10.1159/000050693
Reference
PMID:21303380
  Authors
Cornella H, Alsinet C, Villanueva A
  Title
Molecular pathogenesis of hepatocellular carcinoma.
  Journal
Alcohol Clin Exp Res 35:821-5 (2011)
DOI:10.1111/j.1530-0277.2010.01406.x
Reference
PMID:27895396
  Authors
Niu ZS, Niu XJ, Wang WH
  Title
Genetic alterations in hepatocellular carcinoma: An update.
  Journal
World J Gastroenterol 22:9069-9095 (2016)
DOI:10.3748/wjg.v22.i41.9069
Reference
PMID:11956813
  Authors
Tannapfel A, Wittekind C
  Title
Genes involved in hepatocellular carcinoma: deregulation in cell cycling and apoptosis.
  Journal
Virchows Arch 440:345-52 (2002)
DOI:10.1007/s00428-002-0617-x
Reference
PMID:23426905
  Authors
Shiraha H, Yamamoto K, Namba M
  Title
Human hepatocyte carcinogenesis (review).
  Journal
Int J Oncol 42:1133-8 (2013)
DOI:10.3892/ijo.2013.1829
Reference
PMID:23887712
  Authors
Nault JC, Mallet M, Pilati C, Calderaro J, Bioulac-Sage P, Laurent C, Laurent A, Cherqui D, Balabaud C, Zucman-Rossi J
  Title
High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions.
  Journal
Nat Commun 4:2218 (2013)
DOI:10.1038/ncomms3218
Reference
PMID:22561517
  Authors
Guichard C, Amaddeo G, Imbeaud S, Ladeiro Y, Pelletier L, Maad IB, Calderaro J, Bioulac-Sage P, Letexier M, Degos F, Clement B, Balabaud C, Chevet E, Laurent A, Couchy G, Letouze E, Calvo F, Zucman-Rossi J
  Title
Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma.
  Journal
Nat Genet 44:694-8 (2012)
DOI:10.1038/ng.2256
Reference
  Authors
Praslicka BJ, Kerins MJ, Ooi A
  Title
The complex role of NRF2 in cancer: a genomic view
  Journal
Curr Opin Toxicol 1:37-45 (2016)
DOI:10.1016/j.cotox.2016.09.003
Reference
PMID:24024136
  Authors
Kansanen E, Kuosmanen SM, Leinonen H, Levonen AL
  Title
The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer.
  Journal
Redox Biol 1:45-9 (2013)
DOI:10.1016/j.redox.2012.10.001
Reference
PMID:21251164
  Authors
Taguchi K, Motohashi H, Yamamoto M
  Title
Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution.
  Journal
Genes Cells 16:123-40 (2011)
DOI:10.1111/j.1365-2443.2010.01473.x
Reference
PMID:20019356
  Authors
Klaunig JE, Kamendulis LM, Hocevar BA
  Title
Oxidative stress and oxidative damage in carcinogenesis.
  Journal
Toxicol Pathol 38:96-109 (2010)
DOI:10.1177/0192623309356453
Reference
PMID:11193292
  Authors
Krupp G, Bonatz G, Parwaresch R
  Title
Telomerase, immortality and cancer.
  Journal
Biotechnol Annu Rev 6:103-40 (2000)
DOI:10.1016/S1387-2656(00)06020-8
Reference
PMID:27323951
  Authors
Jafri MA, Ansari SA, Alqahtani MH, Shay JW
  Title
Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies.
  Journal
Genome Med 8:69 (2016)
DOI:10.1186/s13073-016-0324-x
Reference
PMID:27029895
  Authors
Shay JW
  Title
Role of Telomeres and Telomerase in Aging and Cancer.
  Journal
Cancer Discov 6:584-93 (2016)
DOI:10.1158/2159-8290.CD-16-0062
Reference
PMID:27508192
  Authors
Granito A, Guidetti E, Gramantieri L
  Title
c-MET receptor tyrosine kinase as a molecular target in advanced hepatocellular carcinoma.
  Journal
J Hepatocell Carcinoma 2:29-38 (2015)
DOI:10.2147/JHC.S77038
Reference
PMID:16934487
  Authors
Vita M, Henriksson M
  Title
The Myc oncoprotein as a therapeutic target for human cancer.
  Journal
Semin Cancer Biol 16:318-30 (2006)
DOI:10.1016/j.semcancer.2006.07.015
Reference
PMID:24096051
  Authors
Qu A, Jiang C, Cai Y, Kim JH, Tanaka N, Ward JM, Shah YM, Gonzalez FJ
  Title
Role of Myc in hepatocellular proliferation and hepatocarcinogenesis.
  Journal
J Hepatol 60:331-8 (2014)
DOI:10.1016/j.jhep.2013.09.024
Related
pathway
uah04010  MAPK signaling pathway
uah04020  Calcium signaling pathway
uah04110  Cell cycle
uah04115  p53 signaling pathway
uah04151  PI3K-Akt signaling pathway
uah04310  Wnt signaling pathway
uah04350  TGF-beta signaling pathway
uah04932  Non-alcoholic fatty liver disease
uah04936  Alcoholic liver disease
uah05160  Hepatitis C
uah05161  Hepatitis B
KO pathway
ko05225   
LinkDB

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