KEGG   PATHWAY: zca05012
Entry
zca05012                    Pathway                                
Name
Parkinson disease - Zalophus californianus (California sea lion)
Description
Parkinson disease (PD) is a progressive neurodegenerative movement disorder that results primarily from the death of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc). Both environmental factors and mutations in familial PD-linked genes such as SNCA, Parkin, DJ-1, PINK1 and LRRK2 are associated with PD pathogenesis. These pathogenic mutations and environmental factors are known to cause disease due to oxidative stress, intracellular Ca2+ homeostasis impairment, mitochondrial dysfunctions and altered protein handling compromising key roles of DA neuronal function and survival. The demise of DA neurons located in the SNc leads to a drop in the dopaminergic input to the striatum, which is hypothesized to impede movement by inducing hypo and hyper activity in striatal spiny projection neurons (SPNs) of the direct (dSPNs) and indirect (iSPNs) pathways in the basal ganglia, respectively.
Class
Human Diseases; Neurodegenerative disease
Pathway map
zca05012  Parkinson disease
zca05012

Organism
Zalophus californianus (California sea lion) [GN:zca]
Gene
113912769  ADORA2A; adenosine receptor A2a [KO:K04266]
113912327  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
113936968  neuroendocrine secretory protein 55 [KO:K04632]
113936966  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
113914504  DRD2; D(2) dopamine receptor isoform X1 [KO:K04145]
113930637  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630]
113917448  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
113911420  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
113917313  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
113931821  PRKACB; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
113916866  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
113928441  DRD1; D(1A) dopamine receptor [KO:K04144]
113930195  UBA1; ubiquitin-like modifier-activating enzyme 1 [KO:K03178] [EC:6.2.1.45]
113918533  UBA7; ubiquitin-like modifier-activating enzyme 7 isoform X1 [KO:K10698] [EC:6.2.1.45]
113917744  UBA52; ubiquitin-60S ribosomal protein L40 [KO:K02927]
113929895  ubiquitin [KO:K02927]
113909325  ubiquitin-60S ribosomal protein L40-like [KO:K02927]
113909631  ubiquitin-60S ribosomal protein L40-like [KO:K02927]
113926956  ubiquitin-60S ribosomal protein L40-like [KO:K02927]
118356282  ubiquitin-60S ribosomal protein L40 [KO:K02927]
113923441  ubiquitin-60S ribosomal protein L40-like [KO:K02927]
113931435  ubiquitin-60S ribosomal protein L40 [KO:K02927]
113937178  RPS27A; ubiquitin-40S ribosomal protein S27a [KO:K02977]
113919708  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
113929881  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
113933691  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
113930621  ubiquitin-40S ribosomal protein S27a [KO:K02977]
113928746  polyubiquitin [KO:K04551]
113913252  UBC; polyubiquitin-C [KO:K08770]
113939421  UBB; polyubiquitin-B [KO:K08770]
113913216  ubiquitin-conjugating enzyme E2 L3 [KO:K04552] [EC:2.3.2.23]
113913343  ubiquitin-conjugating enzyme E2 L3-like isoform X1 [KO:K04552] [EC:2.3.2.23]
113925299  ubiquitin-conjugating enzyme E2 L3-like isoform X1 [KO:K04552] [EC:2.3.2.23]
113936476  ubiquitin-conjugating enzyme E2 L3-like [KO:K04552] [EC:2.3.2.23]
113912642  ubiquitin-conjugating enzyme E2 L3-like [KO:K04552] [EC:2.3.2.23]
113912649  UBE2L3; ubiquitin-conjugating enzyme E2 L3 isoform X1 [KO:K04552] [EC:2.3.2.23]
113908682  ubiquitin-conjugating enzyme E2 L3-like [KO:K04552] [EC:2.3.2.23]
113915403  UBE2L6; ubiquitin/ISG15-conjugating enzyme E2 L6 isoform X1 [KO:K04553] [EC:2.3.2.23]
113934283  UBE2J2; ubiquitin-conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
113927073  UBE2J1; ubiquitin-conjugating enzyme E2 J1 isoform X1 [KO:K10578] [EC:2.3.2.23]
113916468  UBE2G2; ubiquitin-conjugating enzyme E2 G2 isoform X1 [KO:K04555] [EC:2.3.2.23]
113939396  UBE2G1; ubiquitin-conjugating enzyme E2 G1 isoform X1 [KO:K10575] [EC:2.3.2.23]
113927504  PRKN; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase parkin [KO:K04556] [EC:2.3.2.31]
113925277  SNCA; LOW QUALITY PROTEIN: alpha-synuclein [KO:K04528]
113911865  GPR37; prosaposin receptor GPR37 [KO:K04243]
113913257  SEPTIN5; septin-5 isoform X1 [KO:K04557]
113929810  synphilin-1 isoform X1 [KO:K04558]
113909577  PSMA6; proteasome subunit alpha type-6 isoform X1 [KO:K02730] [EC:3.4.25.1]
113927275  proteasome subunit alpha type-6-like [KO:K02730] [EC:3.4.25.1]
113911464  PSMA2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
118356768  proteasome subunit alpha type-2-like [KO:K02726] [EC:3.4.25.1]
113909952  PSMA4; proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
113912908  PSMA8; proteasome subunit alpha-type 8 isoform X1 [KO:K02731] [EC:3.4.25.1]
113938523  PSMA7; proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
113909911  PSMA5; proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
113937551  proteasome subunit alpha type-1-like [KO:K02725] [EC:3.4.25.1]
113915225  PSMA1; proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
113908866  PSMA3; proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
113939602  PSMB6; proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
113935070  PSMB7; proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
113939515  PSMB3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
113938649  PSMB2; proteasome subunit beta type-2 [KO:K02734] [EC:3.4.25.1]
113910090  PSMB5; proteasome subunit beta type-5 isoform X1 [KO:K02737] [EC:3.4.25.1]
113927447  PSMB1; proteasome subunit beta type-1 isoform X1 [KO:K02732] [EC:3.4.25.1]
113908589  PSMB4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
113911031  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
113908853  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
113936636  PSMC4; 26S proteasome regulatory subunit 6B [KO:K03063]
113910511  PSMC6; 26S proteasome regulatory subunit 10B isoform X1 [KO:K03064]
113915210  PSMC3; 26S proteasome regulatory subunit 6A [KO:K03065]
113908104  PSMC5; 26S proteasome regulatory subunit 8 isoform X1 [KO:K03066]
113918159  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
113919696  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
113908025  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 isoform X1 [KO:K03033]
113913086  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 [KO:K06693]
113939860  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
113931221  LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 12-like [KO:K03035]
113939837  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 isoform X1 [KO:K03036]
113917893  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
113936647  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
113913999  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 isoform X1 [KO:K03039]
113915839  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
113919926  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 isoform X1 [KO:K03030]
113936650  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
113911872  SEM1; 26S proteasome complex subunit SEM1 [KO:K10881]
113926255  26S proteasome complex subunit SEM1-like [KO:K10881]
113924700  UCHL1; ubiquitin carboxyl-terminal hydrolase isozyme L1 [KO:K05611] [EC:3.4.19.12]
113935072  ubiquitin carboxyl-terminal hydrolase isozyme L1-like [KO:K05611] [EC:3.4.19.12]
113922995  calmodulin-like [KO:K02183]
113923011  CALML3; LOW QUALITY PROTEIN: calmodulin-like protein 3 [KO:K02183]
113936086  CALM3; calmodulin-3 [KO:K02183]
113914077  calmodulin-1-like [KO:K02183]
113929195  calmodulin-1-like [KO:K02183]
113925822  calmodulin-1-like [KO:K02183]
113929739  calmodulin-A-like [KO:K02183]
113914445  CALML6; calmodulin-like protein 6 [KO:K02183]
113908798  CALM1; calmodulin-1 [KO:K02183]
113910547  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
113920384  neo-calmodulin-like [KO:K02183]
113937538  CALM2; calmodulin-2 [KO:K02183]
113922505  calmodulin-A-like [KO:K02183]
118356210  calmodulin-A-like [KO:K02183]
113929050  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
113925843  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
113911484  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
113921368  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
113939784  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
113908736  RYR3; ryanodine receptor 3 [KO:K04963]
113918169  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
113921922  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
113927035  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
113938304  PLCG1; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
113934315  HSPA5; endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
113932654  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha [KO:K09054]
113922091  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
113939180  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
113913021  XBP1; X-box-binding protein 1 [KO:K09027]
113937908  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
113909121  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
113921771  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
113914758  TH; tyrosine 3-monooxygenase isoform X1 [KO:K00501] [EC:1.14.16.2]
113930699  amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
113930952  MAOB; amine oxidase [flavin-containing] B isoform X1 [KO:K00274] [EC:1.4.3.4]
113929486  SLC6A3; sodium-dependent dopamine transporter [KO:K05036]
113925181  SLC18A1; chromaffin granule amine transporter isoform X1 [KO:K08155]
113918955  SLC18A2; synaptic vesicular amine transporter isoform X1 [KO:K08155]
113922954  SLC11A2; natural resistance-associated macrophage protein 2 isoform X1 [KO:K21398]
113933552  SLC39A1; zinc transporter ZIP1 [KO:K14709]
113916377  SLC39A3; zinc transporter ZIP3 isoform X1 [KO:K14709]
113910347  SLC39A2; zinc transporter ZIP2 isoform X1 [KO:K14709]
113925953  SLC39A4; zinc transporter ZIP4 isoform X1 [KO:K14710]
113921815  SLC39A5; zinc transporter ZIP5 [KO:K14711]
113912425  SLC39A6; zinc transporter ZIP6 [KO:K14712]
113926430  SLC39A7; zinc transporter SLC39A7 [KO:K14713]
113924769  SLC39A8; metal cation symporter ZIP8 [KO:K14714]
113909127  SLC39A9; zinc transporter ZIP9 isoform X1 [KO:K14715]
113919432  SLC39A10; zinc transporter ZIP10 isoform X1 [KO:K14716]
113939727  SLC39A11; zinc transporter ZIP11 isoform X1 [KO:K14717]
113922162  SLC39A12; zinc transporter ZIP12 isoform X1 [KO:K14718]
113915400  SLC39A13; zinc transporter ZIP13 isoform X1 [KO:K14719]
113924139  SLC39A14; metal cation symporter ZIP14 isoform X1 [KO:K14720]
4355794  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
4355795  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
4355796  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
4355797  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
4355798  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
4355799  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
4355800  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
113915204  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
113912409  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial isoform X1 [KO:K03943] [EC:7.1.1.2]
113920393  NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial-like [KO:K03943] [EC:7.1.1.2]
113914779  NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial-like [KO:K03943] [EC:7.1.1.2]
113918208  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
113928501  LOW QUALITY PROTEIN: uncharacterized protein LOC113928501 [KO:K03944]
113931401  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
113908037  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
113917199  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
113920583  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
118356633  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
113920690  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
118356882  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
113929533  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
113909655  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
113937435  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
113922818  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
113917862  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
113914078  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
113934784  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
113918892  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
113929103  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
113919327  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2-like [KO:K03946]
113935895  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
113922790  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
113914357  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
113914893  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
113911583  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
113931319  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
113921503  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
113911895  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
113915657  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
113909155  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
113937504  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
113938051  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
113938352  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
113933567  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
113911381  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
113918704  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
113931398  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
113928925  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like isoform X1 [KO:K03949]
113927239  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like isoform X1 [KO:K03949]
113911734  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform X1 [KO:K03949]
113919925  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
113923802  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
113921591  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
113917598  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
113934048  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
113922724  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
113920580  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
113932454  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
113916759  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
113922087  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
113918932  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
113908954  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
113925679  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1-like [KO:K03957]
113911795  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1-like [KO:K03957]
113916205  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1-like [KO:K03957]
113912479  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1-like [KO:K03957]
113911619  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
113920563  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
113918479  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
118356917  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
113917957  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
113933996  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform X1 [KO:K03962]
113916286  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
113923573  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
113936929  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
118356796  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
113933001  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
113930220  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
113919936  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
113932201  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial isoform X1 [KO:K03935] [EC:7.1.1.2]
113913911  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
113929521  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
113911645  NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial-like [KO:K03937]
113931189  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial-like [KO:K03937]
113927801  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
113937005  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
113927778  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
113929658  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial isoform X1 [KO:K03939]
113916151  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940] [EC:7.1.1.2]
113914353  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
113925439  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial isoform X1 [KO:K03967]
113924059  NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial-like [KO:K03967]
113914678  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
113928413  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
113908731  succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
113925738  LOW QUALITY PROTEIN: succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial-like [KO:K00235] [EC:1.3.5.1]
113939295  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
113932312  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
113915905  succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like [KO:K00236]
113913831  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
113927231  succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
113936090  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
113914728  LOW QUALITY PROTEIN: cytochrome b-c1 complex subunit Rieske, mitochondrial-like [KO:K00411] [EC:7.1.1.8]
4355793  CYTB; cytochrome b [KO:K00412]
113926313  cytochrome c1, heme protein, mitochondrial [KO:K00413]
113917309  cytochrome b-c1 complex subunit 1, mitochondrial isoform X1 [KO:K00414]
113932530  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
113924949  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
113929477  cytochrome b-c1 complex subunit 7 [KO:K00417]
113916725  cytochrome b-c1 complex subunit 7 [KO:K00417]
113920996  cytochrome b-c1 complex subunit 7-like [KO:K00417]
113929909  cytochrome b-c1 complex subunit 7-like [KO:K00417]
113922904  cytochrome b-c1 complex subunit 7-like [KO:K00417]
113915330  cytochrome b-c1 complex subunit 7-like [KO:K00417]
113928989  cytochrome b-c1 complex subunit 8 [KO:K00418]
113912962  cytochrome b-c1 complex subunit 9 [KO:K00419]
113916653  cytochrome b-c1 complex subunit 10 [KO:K00420]
113920123  cytochrome b-c1 complex subunit 10 [KO:K00420]
4355792  COX3; cytochrome c oxidase subunit III [KO:K02262]
4355790  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
4355791  COX2; cytochrome c oxidase subunit II [KO:K02261]
113935939  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
113923759  cytochrome c oxidase subunit 4 isoform 1, mitochondrial-like isoform X1 [KO:K02263]
113936988  cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X1 [KO:K02263]
113930718  cytochrome c oxidase subunit 4 isoform 1, mitochondrial-like [KO:K02263]
113910035  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
113924373  cytochrome c oxidase subunit 5B, mitochondrial-like [KO:K02265]
113937506  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
113922885  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
113932138  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
113912785  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
113912698  cytochrome c oxidase subunit 6A1, mitochondrial-like [KO:K02266]
113937313  cytochrome c oxidase subunit 6A1, mitochondrial-like [KO:K02266]
113933286  cytochrome c oxidase subunit 6A1, mitochondrial-like [KO:K02266]
113911411  cytochrome c oxidase subunit 6A1, mitochondrial-like [KO:K02266]
113935658  cytochrome c oxidase subunit 6B1 [KO:K02267]
113935893  cytochrome c oxidase subunit 6B2 [KO:K02267]
113928873  cytochrome c oxidase subunit 6B1-like [KO:K02267]
113933690  cytochrome c oxidase subunit 6B1 [KO:K02267]
113936123  cytochrome c oxidase subunit 6B1-like [KO:K02267]
113919493  cytochrome c oxidase subunit 6B1-like [KO:K02267]
113920877  cytochrome c oxidase subunit 6B1-like [KO:K02267]
113922861  cytochrome c oxidase subunit 6B1-like [KO:K02267]
113932787  cytochrome c oxidase subunit 6B1 [KO:K02267]
113922735  cytochrome c oxidase subunit 6C [KO:K02268]
113910988  cytochrome c oxidase subunit 6C-like [KO:K02268]
118356769  cytochrome c oxidase subunit 6C-like [KO:K02268]
113935661  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
113927616  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
113914679  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
113925227  cytochrome c oxidase subunit 7A-related protein, mitochondrial-like [KO:K02270]
113922403  cytochrome c oxidase subunit 7A-related protein, mitochondrial-like [KO:K02270]
113938347  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
118356054  cytochrome c oxidase subunit 7A2, mitochondrial-like [KO:K02270]
118356194  cytochrome c oxidase subunit 7A1, mitochondrial-like [KO:K02270]
113936745  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
113925088  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
113931503  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
113914243  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
113919563  cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
118356894  cytochrome c oxidase subunit 7B2, mitochondrial-like [KO:K02271]
113915131  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
113929849  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
113917812  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
113931482  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
113924844  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
113913901  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
113938009  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
113908893  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
113923771  cytochrome c oxidase subunit 8A, mitochondrial-like [KO:K02273]
113927572  cytochrome c oxidase subunit 8A, mitochondrial-like [KO:K02273]
113914501  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
113924066  cytochrome c oxidase subunit 8A, mitochondrial-like [KO:K02273]
113938694  cytochrome c oxidase subunit 8A, mitochondrial-like [KO:K02273]
113932958  cytochrome c oxidase subunit 8A, mitochondrial-like [KO:K02273]
113912583  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
113922573  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
113922064  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
113931520  ATP synthase subunit gamma, mitochondrial-like isoform X1 [KO:K02136]
113916664  ATP synthase subunit gamma, mitochondrial-like [KO:K02136]
113917088  ATP5F1D; LOW QUALITY PROTEIN: ATP synthase subunit delta, mitochondrial [KO:K02134]
113938644  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
4355788  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
113924993  ATP synthase F(0) complex subunit B1, mitochondrial-like [KO:K02127]
118356834  ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
113924798  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
113912591  ATP synthase F(0) complex subunit B1, mitochondrial-like [KO:K02127]
113929839  ATP synthase F(0) complex subunit B1, mitochondrial-like [KO:K02127]
113921855  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial isoform X1 [KO:K02128]
113936755  ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
113919175  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
113912413  ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
113924510  ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
113916546  ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
113929199  ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
113937717  ATP synthase F(0) complex subunit C3, mitochondrial-like [KO:K02128]
113939560  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial isoform X1 [KO:K02128]
113911785  ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
113931478  ATP synthase subunit d, mitochondrial-like [KO:K02138]
113924279  ATP synthase subunit d, mitochondrial-like [KO:K02138]
113930829  ATP synthase subunit d, mitochondrial-like [KO:K02138]
113929105  ATP synthase subunit d, mitochondrial-like [KO:K02138]
118357011  ATP synthase subunit d, mitochondrial-like [KO:K02138]
118357105  ATP synthase subunit d, mitochondrial-like [KO:K02138]
113937102  ATP synthase subunit d, mitochondrial-like [KO:K02138]
118357243  ATP synthase subunit d, mitochondrial-like [KO:K02138]
113921886  ATP synthase subunit d, mitochondrial-like [KO:K02138]
113939471  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
113922775  ATP synthase subunit d, mitochondrial-like [KO:K02138]
118356289  ATP synthase subunit d, mitochondrial [KO:K02138]
113919721  ATP synthase subunit d, mitochondrial-like [KO:K02138]
113920673  ATP synthase subunit d, mitochondrial-like [KO:K02138]
118356418  ATP synthase subunit d, mitochondrial-like [KO:K02138]
113918544  ATP5PO; ATP synthase subunit O, mitochondrial isoform X1 [KO:K02137]
113910274  ATP synthase subunit O, mitochondrial-like [KO:K02137]
113911305  ATP synthase subunit O, mitochondrial-like [KO:K02137]
113936225  ATP synthase-coupling factor 6, mitochondrial-like [KO:K02131]
113925168  ATP synthase-coupling factor 6, mitochondrial-like [KO:K02131]
113932917  ATP synthase-coupling factor 6, mitochondrial-like [KO:K02131]
113933086  ATP synthase-coupling factor 6, mitochondrial-like [KO:K02131]
113924334  ATP synthase-coupling factor 6, mitochondrial-like [KO:K02131]
113916473  ATP5PF; ATP synthase-coupling factor 6, mitochondrial isoform X1 [KO:K02131]
113910552  ATP synthase-coupling factor 6, mitochondrial-like [KO:K02131]
113934839  ATP synthase-coupling factor 6, mitochondrial-like [KO:K02131]
4355789  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
113911064  PINK1; serine/threonine-protein kinase PINK1, mitochondrial [KO:K05688] [EC:2.7.11.1]
113923487  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
113921477  LRRK2; leucine-rich repeat serine/threonine-protein kinase 2 isoform X1 [KO:K08844] [EC:2.7.11.1]
113936941  HTRA2; LOW QUALITY PROTEIN: serine protease HTRA2, mitochondrial [KO:K08669] [EC:3.4.21.108]
113933713  TRAP1; heat shock protein 75 kDa, mitochondrial [KO:K09488]
113928933  VDAC1; voltage-dependent anion-selective channel protein 1 isoform X1 [KO:K05862]
113933268  voltage-dependent anion-selective channel protein 1 [KO:K05862]
113927034  voltage-dependent anion-selective channel protein 1-like [KO:K05862]
113923387  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
113922046  voltage-dependent anion-selective channel protein 3 [KO:K15041]
113925640  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
113924817  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
113931264  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
113931446  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
113925955  SLC25A31; ADP/ATP translocase 4 isoform X1 [KO:K05863]
113933553  ADP/ATP translocase 3-like [KO:K05863]
113924501  LOW QUALITY PROTEIN: ADP/ATP translocase 2-like [KO:K05863]
113923899  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial isoform X1 [KO:K09565] [EC:5.2.1.8]
113911261  cytochrome c [KO:K08738]
113926974  cytochrome c-like [KO:K08738]
113921409  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
113909591  CASP9; LOW QUALITY PROTEIN: caspase-9 [KO:K04399] [EC:3.4.22.62]
113924509  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
113909781  PARK7; Parkinson disease protein 7 [KO:K05687] [EC:3.5.1.124]
113919238  Parkinson disease protein 7 homolog [KO:K05687] [EC:3.5.1.124]
113928786  Parkinson disease protein 7 homolog [KO:K05687] [EC:3.5.1.124]
113922510  Parkinson disease protein 7 homolog [KO:K05687] [EC:3.5.1.124]
113936987  BCL2L1; bcl-2-like protein 1 [KO:K04570]
113935677  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
113917859  MFN1; mitofusin-1 isoform X1 [KO:K21356] [EC:3.6.5.-]
113934218  MFN2; mitofusin-2 isoform X1 [KO:K06030] [EC:3.6.5.-]
113921493  KIF5B; kinesin-1 heavy chain isoform X1 [KO:K10396]
113922888  KIF5A; kinesin heavy chain isoform X1 [KO:K10396]
113919632  KIF5C; kinesin heavy chain [KO:K10396]
113927199  KLC4; kinesin light chain 4 isoform X1 [KO:K10407]
113936546  KLC3; kinesin light chain 3 isoform X2 [KO:K10407]
113915003  KLC2; kinesin light chain 2 isoform X1 [KO:K10407]
113908627  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
113921668  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
113921728  TUBAL3; tubulin alpha chain-like 3 isoform X1 [KO:K07374]
113931143  tubulin alpha-1C chain-like [KO:K07374]
113920876  tubulin alpha-4A chain isoform X1 [KO:K07374]
118357304  tubulin alpha-8 chain-like [KO:K07374]
113938488  tubulin alpha-8 chain-like [KO:K07374]
118357322  tubulin alpha-1B chain [KO:K07374]
113922330  tubulin alpha-1A chain [KO:K07374]
113922331  tubulin alpha-1C chain [KO:K07374]
113936867  tubulin alpha-1A chain-like [KO:K07374]
113932864  tubulin alpha-8 chain isoform X1 [KO:K07374]
118356158  tubulin alpha-1A chain [KO:K07374]
113935276  tubulin alpha-3 chain [KO:K07374]
118356237  tubulin alpha-3 chain [KO:K07374]
118356266  tubulin alpha-3 chain [KO:K07374]
113935471  tubulin beta-3 chain [KO:K07375]
113913107  TUBB6; tubulin beta-6 chain isoform X1 [KO:K07375]
113934604  TUBB4B; tubulin beta-4B chain [KO:K07375]
113916636  TUBB4A; tubulin beta-4A chain [KO:K07375]
113927996  TUBB; tubulin beta chain isoform X1 [KO:K07375]
113927124  tubulin beta-2B chain [KO:K07375]
113927125  TUBB2A; tubulin beta-2A chain isoform X1 [KO:K07375]
113937669  TUBB1; tubulin beta-1 chain isoform X1 [KO:K07375]
113939587  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
113929802  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
113919460  NFE2L2; nuclear factor erythroid 2-related factor 2 isoform X1 [KO:K05638]
113926562  thioredoxin [KO:K03671]
113921933  TXN2; thioredoxin, mitochondrial [KO:K03671]
113934995  TXN; thioredoxin isoform X1 [KO:K03671]
113927704  DAXX; death domain-associated protein 6 isoform X1 [KO:K02308]
113927218  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
113928769  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
113922602  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
113925863  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
113917990  SOD1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
113927173  superoxide dismutase [Cu-Zn]-like [KO:K04565] [EC:1.15.1.1]
113915830  KEAP1; kelch-like ECH-associated protein 1 [KO:K10456]
Compound
C00002  ATP
C00007  Oxygen
C00008  ADP
C00009  Orthophosphate
C00013  Diphosphate
C00020  AMP
C00027  Hydrogen peroxide
C00034  Manganese
C00076  Calcium cation
C00082  L-Tyrosine
C00165  Diacylglycerol
C00212  Adenosine
C00355  3,4-Dihydroxy-L-phenylalanine
C00575  3',5'-Cyclic AMP
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C03758  Dopamine
C04043  3,4-Dihydroxyphenylacetaldehyde
C04599  1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
C07593  Rotenone
C11310  1-Methyl-4-phenylpyridinium
C14701  Paraquat
C15231  Maneb
C16844  Hydroxyl radical
C17755  Dopamine quinone
C22381  Reactive oxygen species
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Expanding insights of mitochondrial dysfunction in Parkinson's disease.
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Nat Rev Neurosci 7:207-19 (2006)
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Reference
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Molecular mechanisms of neurodegeneration in Parkinson's disease: clues from Mendelian syndromes.
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Molecular pathogenesis of Parkinson disease.
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Calcium signaling and neurodegenerative diseases.
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Mitochondrial calcium imbalance in Parkinson's disease.
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Parkin deficiency disrupts calcium homeostasis by modulating phospholipase C signalling.
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Trends Mol Med 19:165-75 (2013)
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Protective and toxic roles of dopamine in Parkinson's disease.
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Related
pathway
zca00190  Oxidative phosphorylation
zca00350  Tyrosine metabolism
zca03050  Proteasome
zca04020  Calcium signaling pathway
zca04120  Ubiquitin mediated proteolysis
zca04137  Mitophagy - animal
zca04141  Protein processing in endoplasmic reticulum
zca04210  Apoptosis
zca04728  Dopaminergic synapse
KO pathway
ko05012   
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