KEGG   PATHWAY: phyp04110
Entry
phyp04110                   Pathway                                
Name
Cell cycle - Pangasianodon hypophthalmus (striped catfish)
Description
Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. Downstream targets of CDKs include transcription factor E2F and its regulator Rb. Precise activation and inactivation of CDKs at specific points in the cell cycle are required for orderly cell division. Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated.
 Eukaryotic cells respond to DNA damage by activating signaling pathways that promote cell cycle arrest and DNA repair. In response to DNA damage, the checkpoint kinase ATM phosphorylates and activates Chk2, which in turn directly phosphorylates and activates p53 tumor suppressor protein. p53 and its transcriptional targets play an important role in both G1 and G2 checkpoints. ATR-Chk1-mediated protein degradation of Cdc25A protein phosphatase is also a mechanism conferring intra-S-phase checkpoint activation.
Class
Cellular Processes; Cell growth and death
Pathway map
phyp04110  Cell cycle
phyp04110

Other DBs
GO: 0000278
Organism
Pangasianodon hypophthalmus (striped catfish) [GN:phyp]
Gene
113536429  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
113528462  G1/S-specific cyclin-D1-like [KO:K04503]
113546664  G1/S-specific cyclin-D2-like [KO:K10151]
113531710  G1/S-specific cyclin-D2-like [KO:K10151]
113539684  ccnd3; G1/S-specific cyclin-D3 [KO:K10152]
113525662  cyclin-dependent kinase 4-like [KO:K02089] [EC:2.7.11.22]
113528439  cyclin-dependent kinase 6-like [KO:K02091] [EC:2.7.11.22]
113536004  cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
113541559  rb1; retinoblastoma-associated protein [KO:K06618]
113526544  rbl1; retinoblastoma-like protein 1 [KO:K04681]
113529961  rbl2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
113531133  abl1; tyrosine-protein kinase ABL1 [KO:K06619] [EC:2.7.10.2]
113543718  hdac1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
113530396  e2f1; transcription factor E2F1 [KO:K17454]
113544992  e2f2; transcription factor E2F2 isoform X1 [KO:K09389]
113543874  transcription factor E2F3-like [KO:K06620]
113533712  e2f3; transcription factor E2F3 [KO:K06620]
113546652  e2f4; transcription factor E2F4 isoform X1 [KO:K04682]
113540007  transcription factor E2F5-like [KO:K04682]
113537277  tfdp1; transcription factor Dp-1 [KO:K04683]
113526271  transcription factor Dp-1-like [KO:K04683]
113539262  transcription factor Dp-2-like [KO:K09392]
113537726  glycogen synthase kinase-3 beta-like [KO:K03083] [EC:2.7.11.26]
113526065  glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
113543081  transforming growth factor beta-1 proprotein-like isoform X1 [KO:K13375]
113541584  transforming growth factor beta-1 proprotein-like [KO:K13375]
113526787  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
113528823  transforming growth factor beta-2 proprotein-like [KO:K13376]
113538920  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
113544066  smad2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
113534580  smad3; mothers against decapentaplegic homolog 3 [KO:K23605]
113540926  mothers against decapentaplegic homolog 3 [KO:K23605]
113543707  mothers against decapentaplegic homolog 4-like [KO:K04501]
113542418  mothers against decapentaplegic homolog 4-like [KO:K04501]
113544828  smad4; mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
113540692  transcriptional regulator Myc-B-like [KO:K04377]
113541047  transcriptional regulator Myc-2-like [KO:K04377]
113530640  zbtb17; zinc finger and BTB domain-containing protein 17 [KO:K10500]
113524623  cyclin-dependent kinase 4 inhibitor B-like [KO:K04685]
113527280  cdkn2c; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
113538316  cdkn2d; cyclin-dependent kinase 4 inhibitor D [KO:K06623]
113531770  cdkn1b; cyclin-dependent kinase inhibitor 1B [KO:K06624]
113529947  cyclin-dependent kinase inhibitor 1C-like [KO:K09993]
113540972  cyclin-dependent kinase inhibitor 1B-like [KO:K09993]
113539506  cyclin-dependent kinase inhibitor 1-like isoform X1 [KO:K06625]
113532400  cyclin-dependent kinase inhibitor 1-like [KO:K06625]
113536206  G1/S-specific cyclin-E2-like isoform X1 [KO:K06626]
113525127  ccne1; G1/S-specific cyclin-E1 [KO:K06626]
113526749  G1/S-specific cyclin-E2-like [KO:K06626]
113537787  cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
113535613  skp1; S-phase kinase-associated protein 1 [KO:K03094]
113541255  cullin-1-like [KO:K03347]
113546382  cullin-1 [KO:K03347]
113524074  rbx1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
113541502  skp2; S-phase kinase-associated protein 2 [KO:K03875]
113542701  ccna2; cyclin-A2 [KO:K06627]
113543585  ccna1; cyclin-A1 [KO:K06627]
113523649  cdc6; cell division control protein 6 homolog [KO:K02213]
113546741  cdt1; DNA replication factor Cdt1 isoform X1 [KO:K10727]
113538196  orc1; origin recognition complex subunit 1 isoform X1 [KO:K02603]
113536713  orc2; origin recognition complex subunit 2 [KO:K02604]
113539004  orc3; origin recognition complex subunit 3 isoform X1 [KO:K02605]
113538181  orc4; origin recognition complex subunit 4 [KO:K02606]
113523881  orc5; LOW QUALITY PROTEIN: origin recognition complex subunit 5 [KO:K02607]
113540975  orc6; origin recognition complex subunit 6 [KO:K02608]
113538074  mcm2; DNA replication licensing factor MCM2 [KO:K02540] [EC:5.6.2.3]
113545359  maternal DNA replication licensing factor mcm3-like [KO:K02541] [EC:5.6.2.3]
113546781  zygotic DNA replication licensing factor mcm3-like [KO:K02541] [EC:5.6.2.3]
113533801  mcm4; DNA replication licensing factor MCM4 [KO:K02212] [EC:5.6.2.3]
113528247  mcm5; DNA replication licensing factor MCM5 [KO:K02209] [EC:5.6.2.3]
113546349  maternal DNA replication licensing factor mcm6-like [KO:K02542] [EC:5.6.2.3]
113538152  DNA replication licensing factor MCM6-like [KO:K02542] [EC:5.6.2.3]
113528420  mcm7; DNA replication licensing factor MCM7 [KO:K02210] [EC:5.6.2.3]
113524471  cdc45; cell division control protein 45 homolog [KO:K06628]
113530131  ticrr; treslin [KO:K26117]
113542236  mtbp; mdm2-binding protein isoform X1 [KO:K26116]
113546440  cdc7; cell division cycle 7-related protein kinase [KO:K02214] [EC:2.7.11.1]
113532997  dbf4; protein DBF4 homolog A isoform X1 [KO:K06629]
113535266  protein DBF4 homolog A-like [KO:K06629]
113534242  cdk1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
113531034  ccnb1; G2/mitotic-specific cyclin-B1 isoform X1 [KO:K05868]
113540823  ccnb2; G2/mitotic-specific cyclin-B2 isoform X1 [KO:K21770]
113540442  G2/mitotic-specific cyclin-B3-like [KO:K21771]
113541596  G2/mitotic-specific cyclin-B3-like [KO:K21771]
113546062  cdc25b; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
113526464  14-3-3 protein beta/alpha-A-like [KO:K16197]
113532025  14-3-3 protein beta/alpha-A-like [KO:K16197]
113546188  14-3-3 protein zeta/delta-like [KO:K16197]
113538832  14-3-3 protein beta/alpha-like [KO:K16197]
113533564  14-3-3 protein beta/alpha-A-like [KO:K16197]
113530957  14-3-3 protein beta/alpha-A [KO:K16197]
113532817  ywhae; 14-3-3 protein epsilon isoform X1 [KO:K06630]
113531346  14-3-3 protein epsilon-like isoform X1 [KO:K06630]
113531345  14-3-3 protein gamma-1 [KO:K16198]
113533105  14-3-3 protein gamma-2 [KO:K16198]
113544144  14-3-3 protein gamma-like [KO:K16198]
113535688  plk1; serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
113534810  wee1-like protein kinase 1-A [KO:K06632] [EC:2.7.11.1]
113534325  wee1-like protein kinase 2 [KO:K06632] [EC:2.7.11.1]
113536768  wee1-like protein kinase [KO:K06632] [EC:2.7.11.1]
113547506  pkmyt1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase [KO:K06633] [EC:2.7.11.1]
113536995  ccnh; cyclin-H isoform X1 [KO:K06634]
113536819  cdk7; cyclin-dependent kinase 7 [KO:K02202] [EC:2.7.11.22 2.7.11.23]
113542029  anapc1; anaphase-promoting complex subunit 1 [KO:K03348]
113531155  anapc2; anaphase-promoting complex subunit 2 [KO:K03349]
113534685  cdc27; cell division cycle protein 27 homolog [KO:K03350]
113546875  anapc4; anaphase-promoting complex subunit 4 [KO:K03351]
113546765  cdc16; cell division cycle protein 16 homolog [KO:K03353]
113543095  cdc23; cell division cycle protein 23 homolog [KO:K03355]
113530273  anapc10; anaphase-promoting complex subunit 10 isoform X1 [KO:K03357]
113523704  anapc11; anaphase-promoting complex subunit 11 isoform X1 [KO:K03358]
113531023  cdc26; anaphase-promoting complex subunit CDC26 [KO:K03359]
113541423  anapc13; anaphase-promoting complex subunit 13 [KO:K12456]
113544640  anapc15; anaphase-promoting complex subunit 15 isoform X1 [KO:K25228]
113527593  anapc16; anaphase-promoting complex subunit 16 [KO:K25229]
113546462  cdc20; cell division cycle protein 20 homolog [KO:K03363]
113529244  securin-like [KO:K06635]
113545840  espl1; separin [KO:K02365] [EC:3.4.22.49]
113545567  structural maintenance of chromosomes protein 1A-like [KO:K06636]
113546496  structural maintenance of chromosomes protein 1B-like [KO:K06636]
113530715  smc1a; structural maintenance of chromosomes protein 1A [KO:K06636]
113533044  double-strand-break repair protein rad21 homolog [KO:K06670]
113533515  double-strand-break repair protein rad21 homolog [KO:K06670]
113536064  rad21; double-strand-break repair protein rad21 homolog isoform X1 [KO:K06670]
113525876  cohesin subunit SA-2-like isoform X1 [KO:K06671]
113541203  stag1; cohesin subunit SA-1 [KO:K06671]
113528852  stag2; cohesin subunit SA-2 isoform X1 [KO:K06671]
113527852  stag3; cohesin subunit SA-3 isoform X1 [KO:K06671]
113524235  transcriptional regulator ATRX-like isoform X1 [KO:K10779]
113542728  atrx; transcriptional regulator ATRX [KO:K10779]
113526817  ddx11; ATP-dependent DNA helicase DDX11 isoform X1 [KO:K11273] [EC:5.6.2.7]
113544757  nipbl; nipped-B-like protein [KO:K06672]
113533402  mau2; MAU2 chromatid cohesion factor homolog [KO:K11266]
113540227  hdac8; histone deacetylase 8 isoform X1 [KO:K11405] [EC:3.5.1.98]
113532277  esco2; N-acetyltransferase ESCO2 [KO:K11268] [EC:2.3.1.-]
113534109  N-acetyltransferase ESCO1-like [KO:K11268] [EC:2.3.1.-]
113539207  pds5b; sister chromatid cohesion protein PDS5 homolog B [KO:K11267]
113544425  pds5a; sister chromatid cohesion protein PDS5 homolog A isoform X1 [KO:K11267]
113535272  wings apart-like protein homolog [KO:K25163]
113547727  wings apart-like protein homolog [KO:K25163]
113531516  cdca5; sororin [KO:K17390]
113527955  aurora kinase B [KO:K11479] [EC:2.7.11.1]
113523778  shugoshin 1-like [KO:K11580]
113547123  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like [KO:K04382] [EC:3.1.3.16]
113543531  ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
113532845  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform-like [KO:K03456]
113531393  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
113540588  ppp2r5b; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
113541942  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform-like [KO:K11584]
113532013  ppp2r5a; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
113531888  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
113540748  ppp2r5d; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
113545157  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584]
113538581  ndc80; kinetochore protein NDC80 homolog [KO:K11547]
113535754  knl1; kinetochore scaffold 1 [KO:K11542]
113526358  ttk; dual specificity protein kinase TTK [KO:K08866] [EC:2.7.12.1]
113535786  mad1l1; mitotic spindle assembly checkpoint protein MAD1 [KO:K06679]
113540481  mad2l1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
113538618  bub1b; mitotic checkpoint serine/threonine-protein kinase BUB1 beta [KO:K06637] [EC:2.7.11.1]
113527708  bub3; mitotic checkpoint protein BUB3 [KO:K02180]
113525631  mitotic checkpoint serine/threonine-protein kinase BUB1-like [KO:K02178] [EC:2.7.11.1]
113532913  trip13; pachytene checkpoint protein 2 homolog [KO:K22399]
113542050  mad2l1bp; MAD2L1-binding protein isoform X1 [KO:K26093]
113533546  fizzy-related protein homolog isoform X1 [KO:K03364]
113540102  fizzy-related protein homolog [KO:K03364]
113535016  fzr1; fizzy-related protein homolog isoform X1 [KO:K03364]
113539909  dual specificity protein phosphatase CDC14AB-like [KO:K06639] [EC:3.1.3.16 3.1.3.48]
113536482  cdc14a; dual specificity protein phosphatase CDC14A isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
113530968  dual specificity protein phosphatase CDC14C-like isoform X1 [KO:K06639] [EC:3.1.3.16 3.1.3.48]
113527906  crebbp; CREB-binding protein [KO:K04498] [EC:2.3.1.48]
113524058  histone acetyltransferase p300-like [KO:K04498] [EC:2.3.1.48]
113527092  ep300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
113547574  CREB-binding protein-like isoform X1 [KO:K04498] [EC:2.3.1.48]
113540485  prkdc; DNA-dependent protein kinase catalytic subunit isoform X1 [KO:K06642] [EC:2.7.11.1]
113543379  atm; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
113523888  mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
113525266  E3 ubiquitin-protein ligase Mdm2-like [KO:K06643] [EC:2.3.2.27]
113540585  cellular tumor antigen p53-like [KO:K04451]
113546111  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
113528947  growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402]
113546337  growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402]
113540525  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
113533900  gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
113543337  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
113543338  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
113543926  pcna; proliferating cell nuclear antigen [KO:K04802]
113541633  chek1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
113525110  chek2; serine/threonine-protein kinase Chk2 isoform X1 [KO:K06641] [EC:2.7.11.1]
Reference
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Nat Rev Cancer 7:495-507 (2007)
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Cell 113:685-700 (2003)
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Kamura T, Hara T, Kotoshiba S, Yada M, Ishida N, Imaki H, Hatakeyama S, Nakayama K, Nakayama KI
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Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation.
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Proc Natl Acad Sci U S A 100:10231-6 (2003)
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The p53 pathway: positive and negative feedback loops.
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Oncogene 24:2899-908 (2005)
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Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization.
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EMBO J 18:396-410 (1999)
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Cdc7-Dbf4 phosphorylates MCM proteins via a docking site-mediated mechanism to promote S phase progression.
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Mol Cell 24:101-13 (2006)
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Reference
PMID:9029154
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Dual phosphorylation of the T-loop in cdk7: its role in controlling cyclin H binding and CAK activity.
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EMBO J 16:343-54 (1997)
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CAK-Cyclin-dependent Activating Kinase: a key kinase in cell cycle control and a target for drugs?
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Reference
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The spindle-assembly checkpoint in space and time.
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Curr Biol 13:R104-14 (2003)
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PMID:15568976
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  Title
Closing mitosis: the functions of the Cdc14 phosphatase and its regulation.
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Annu Rev Genet 38:203-32 (2004)
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PMID:9618481
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Moustakas A, Kardassis D
  Title
Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members.
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Proc Natl Acad Sci U S A 95:6733-8 (1998)
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Reference
PMID:26650195
  Authors
de Boer HR, Guerrero Llobet S, van Vugt MA
  Title
Controlling the response to DNA damage by the APC/C-Cdh1.
  Journal
Cell Mol Life Sci 73:949-60 (2016)
DOI:10.1007/s00018-015-2096-7
Reference
PMID:20935501
  Authors
Qiao X, Zhang L, Gamper AM, Fujita T, Wan Y
  Title
APC/C-Cdh1: from cell cycle to cellular differentiation and genomic integrity.
  Journal
Cell Cycle 9:3904-12 (2010)
DOI:10.4161/cc.9.19.13585
Related
pathway
phyp03030  DNA replication
phyp04010  MAPK signaling pathway
phyp04120  Ubiquitin mediated proteolysis
phyp04210  Apoptosis
KO pathway
ko04110   
LinkDB

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