Entry Name Axon guidance - Peromyscus leucopus (white-footed mouse)
Description Axon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are read by growth cone receptors, and signal transduction pathways downstream of these receptors converge onto the Rho GTPases to elicit changes in cytoskeletal organization that determine which way the growth cone will turn.
Class Organismal Systems; Development and regenerationBRITE hierarchy
Pathway map Other DBs Organism Peromyscus leucopus (white-footed mouse) [GN:
pleu ]
Gene 114680645 Rac3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861 ]
114681035 Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333 ]
114681065 Pard6a; partitioning defective 6 homolog alpha isoform X1 [KO:K06093 ]
114682227 Camk2d; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
114683255 Ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
114684032 Pik3cd; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
114684433 Nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332 ]
114688966 Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649 ]
114689590 Srgap3; SLIT-ROBO Rho GTPase-activating protein 3 isoform X1 [KO:K07526 ]
114690966 Trpc1; short transient receptor potential channel 1 isoform X1 [KO:K04964 ]
114691150 Arhgef12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532 ]
114693290 Srgap1; SLIT-ROBO Rho GTPase-activating protein 1 isoform X2 [KO:K07526 ]
114693559 Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
114693978 Camk2b; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X7 [KO:K04515 ] [EC:2.7.11.17 ]
114695335 Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
114695867 Trpc4; short transient receptor potential channel 4 isoform X1 [KO:K04967 ]
114697206 Cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393 ]
114698058 Srgap2; SLIT-ROBO Rho GTPase-activating protein 2 isoform X1 [KO:K07526 ]
114698768 Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348 ] [EC:3.1.3.16 ]
114699988 Gnai3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630 ]
114700198 Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
114700207 Camk2g; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
114703850 Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
114706924 Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
114707171 Trpc3; short transient receptor potential channel 3 isoform X1 [KO:K04966 ]
114707239 Lrig2; leucine-rich repeats and immunoglobulin-like domains protein 2 isoform X1 [KO:K24609 ]
114707312 Dpysl2; dihydropyrimidinase-related protein 2 isoform X1 [KO:K07528 ]
114707396 Camk2a; LOW QUALITY PROTEIN: calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515 ] [EC:2.7.11.17 ]
114707535 Rac1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392 ]
114707998 Trpc6; short transient receptor potential channel 6 isoform X1 [KO:K04969 ]
114708228 Gnai1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630 ]
114708726 Nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334 ]
114710969 Gnai2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630 ]
Compound Reference Authors Guan KL, Rao Y.
Title Signalling mechanisms mediating neuronal responses to guidance cues.
Journal Reference Authors Govek EE, Newey SE, Van Aelst L.
Title The role of the Rho GTPases in neuronal development.
Journal Reference Authors Huber AB, Kolodkin AL, Ginty DD, Cloutier JF.
Title Signaling at the growth cone: ligand-receptor complexes and the control of axon growth and guidance.
Journal Reference Authors Negishi M, Oinuma I, Katoh H.
Title Plexins: axon guidance and signal transduction.
Journal Reference Authors Huot J.
Title Ephrin signaling in axon guidance.
Journal Reference Authors Patel BN, Van Vactor DL.
Title Axon guidance: the cytoplasmic tail.
Journal Reference Authors Yu TW, Bargmann CI.
Title Dynamic regulation of axon guidance.
Journal Reference Authors Dickson BJ.
Title Molecular mechanisms of axon guidance.
Journal Reference Authors Barallobre MJ, Pascual M, Del Rio JA, Soriano E.
Title The Netrin family of guidance factors: emphasis on Netrin-1 signalling.
Journal Reference Authors Sabatier C, Plump AS, Le Ma, Brose K, Tamada A, Murakami F, Lee EY, Tessier-Lavigne M.
Title The divergent Robo family protein rig-1/Robo3 is a negative regulator of slit responsiveness required for midline crossing by commissural axons.
Journal Reference Authors Fujita Y, Yamashita T
Title Axon growth inhibition by RhoA/ROCK in the central nervous system.
Journal Reference Authors Yamashita T, Mueller BK, Hata K
Title Neogenin and repulsive guidance molecule signaling in the central nervous system.
Journal Reference Authors van Erp S, van den Heuvel DMA, Fujita Y, Robinson RA, Hellemons AJCGM, Adolfs Y, Van Battum EY, Blokhuis AM, Kuijpers M, Demmers JAA, Hedman H, Hoogenraad CC, Siebold C, Yamashita T, Pasterkamp RJ
Title Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases.
Journal Related pleu04060 Cytokine-cytokine receptor interaction
KO pathway
