KEGG   PATHWAY: pleu05020
Entry
pleu05020                   Pathway                                
Name
Prion disease - Peromyscus leucopus (white-footed mouse)
Description
Prion diseases, also termed transmissible spongiform encephalopathies (TSEs), are a group of fatal neurodegenerative diseases that affect humans and a number of other animal species. The etiology of these diseases is thought to be associated with the conversion of a normal protein, PrPC, into an infectious, pathogenic form, PrPSc. The conversion is induced by prion infections (for example, variant Creutzfeldt-Jakob disease (vCJD), iatrogenic CJD, Kuru), mutations (familial CJD, Gerstmann-Straussler-Scheinker syndrome, fatal familial insomnia (FFI)) or unknown factors (sporadic CJD (sCJD)), and is thought to occur after PrPC has reached the plasma membrane or is re-internalized for degradation. The PrPSc form shows greater protease resistance than PrPC and accumulates in affected individuals, often in the form of extracellular plaques. Pathways that may lead to neuronal death comprise oxidative stress, regulated activation of complement, ubiquitin-proteasome and endosomal-lysosomal systems, synaptic alterations and dendritic atrophy, corticosteroid response, and endoplasmic reticulum stress. In addition, the conformational transition could lead to the lost of a beneficial activity of the natively folded protein, PrPC.
Class
Human Diseases; Neurodegenerative disease
Pathway map
pleu05020  Prion disease
pleu05020

Disease
H00061  Prion disease
Organism
Peromyscus leucopus (white-footed mouse) [GN:pleu]
Gene
114680676  Bad; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
114680683  Stip1; stress-induced-phosphoprotein 1 [KO:K09553]
114680703  [KO:K02273]
114680800  Ndufb10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
114681169  Ndufs5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
114681332  [KO:K02266]
114681520  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
114681547  Psmc4; 26S proteasome regulatory subunit 6B [KO:K03063]
114681638  [KO:K02270]
114681644  [KO:K02267]
114681741  [KO:K00237]
114681917  Vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
114681926  [KO:K00418]
114682020  Tubb1; tubulin beta-1 chain isoform X1 [KO:K07375]
114682022  Atp5f1e; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
114682357  Tubb6; tubulin beta-6 chain [KO:K07375]
114682732  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
114682782  Psmb7; proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
114683045  [KO:K02135]
114683087  Ryr3; LOW QUALITY PROTEIN: ryanodine receptor 3 [KO:K04963]
114683197  Psmd4; 26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
114683237  Psmb4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
114683255  Ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
114683299  Cacna1s; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
114683312  Psmd2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
114684032  Pik3cd; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
114684041  Psma3; proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
114684093  Grin3b; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 3B [KO:K05214]
114684114  Ndufs7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
114684126  Atp5f1d; ATP synthase subunit delta, mitochondrial [KO:K02134]
114684152  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
114684579  [KO:K03062]
114684640  Bax; apoptosis regulator BAX isoform X1 [KO:K02159]
114684718  Grin2d; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
114684877  Eif2ak3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
114684981  Ryr1; ryanodine receptor 1 isoform X5 [KO:K04961]
114684987  Psmd8; 26S proteasome non-ATPase regulatory subunit 8 isoform X1 [KO:K03031]
114685054  Ryr2; LOW QUALITY PROTEIN: ryanodine receptor 2 [KO:K04962]
114685260  Ncam2; neural cell adhesion molecule 2 isoform X1 [KO:K06491]
114685317  Ndufa7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
114685345  Psma2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
114685415  Sdhc; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
114685431  Ndufs2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
114685872  [KO:K03967]
114686204  Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
114686266  [KO:K07374]
114686525  [KO:K00420]
114686569  Grin3a; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
114686570  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
114686643  Psma8; LOW QUALITY PROTEIN: proteasome subunit alpha-type 8 [KO:K02731] [EC:3.4.25.1]
114686683  Ndufa13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
114686852  [KO:K04741] [EC:3.4.22.-]
114686928  Atp5f1b; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
114686934  [KO:K03283]
114686999  Tubb; tubulin beta chain [KO:K07375]
114687555  Psmb6; proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
114687713  [KO:K02267]
114687911  Tubb4a; LOW QUALITY PROTEIN: tubulin beta-4A chain [KO:K07375]
114687991  [KO:K04374]
114688126  Creb3l3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
114688226  Ndufb7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
114688434  Ndufa3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
114688857  Ndufa11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
114688966  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
114689420  [KO:K02727] [EC:3.4.25.1]
114689585  Cav3; caveolin-3 [KO:K12959]
114689726  Creb5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
114689745  [KO:K08738]
114689756  Il6; interleukin-6 [KO:K05405]
114689804  [KO:K00417]
114689841  [KO:K02271]
114690029  Hspa6; LOW QUALITY PROTEIN: heat shock 70 kDa protein 6 [KO:K03283]
114690239  Ncam1; neural cell adhesion molecule 1 isoform X4 [KO:K06491]
114690246  Sdhd; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
114690300  Psma4; proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
114690344  [KO:K02264]
114690413  Psmc5; 26S proteasome regulatory subunit 8 [KO:K03066]
114690433  Psmd12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
114690723  [KO:K02271]
114690777  [KO:K02265]
114690973  [KO:K02264]
114691010  Creb3l2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
114691135  Hspa8; heat shock cognate 71 kDa protein [KO:K03283]
114691328  Psmb1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
114691544  Psmd11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
114691595  Psmd14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
114691777  Mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
114691928  [KO:K05862]
114691978  Itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
114692176  [KO:K00415]
114692200  Ndufab1; acyl carrier protein, mitochondrial [KO:K03955]
114692733  Cacna1b; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
114692767  Tubb4b; tubulin beta-4B chain [KO:K07375]
114692778  Grin1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
114692793  C8g; complement component C8 gamma chain isoform X1 [KO:K03999]
114692821  Notch1; LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 1 [KO:K02599]
114692923  Atp5mc1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
114692965  Psmb3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
114693019  Mapk12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
114693020  Mapk11; mitogen-activated protein kinase 11 isoform X5 [KO:K04441] [EC:2.7.11.24]
114693377  Psma6; proteasome subunit alpha type-6 isoform X1 [KO:K02730] [EC:3.4.25.1]
114693426  Psmd13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
114693469  [KO:K02273]
114693559  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
114693708  Ncf1; neutrophil cytosol factor 1 [KO:K08011]
114693817  Casp3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
114693819  [KO:K08738]
114693920  [KO:K02266]
114694100  [KO:K00419]
114694169  [KO:K00413]
114694222  Ncf4; neutrophil cytosol factor 4 [KO:K08012]
114694231  Rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
114694285  Atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
114694322  Ndufa6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
114694445  [KO:K05863]
114694482  Csnk2a2; casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:2.7.11.1]
114694672  Ndufs8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
114694673  [KO:K02268]
114694722  Cav1; caveolin-1 [KO:K06278]
114694723  Cav2; caveolin-2 [KO:K12958]
114694740  [KO:K03063]
114694751  Ndufv1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
114694791  [KO:K02271]
114694811  Ndufb9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
114694895  Atp5f1a; ATP synthase subunit alpha, mitochondrial [KO:K02132]
114695020  Grin2b; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
114695335  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
114695345  Ndufb5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
114695408  [KO:K08738]
114695532  Grin2a; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
114695599  Ndufa5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
114695621  Kif5b; kinesin-1 heavy chain [KO:K10396]
114695853  Ndufc1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
114696051  Psmc6; 26S proteasome regulatory subunit 10B [KO:K03064]
114696086  Sdha; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
114696107  Ndufs6; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
114696316  Ndufv2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
114696614  Atp5mc2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
114696882  Fyn; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
114697038  [KO:K00417]
114697210  C1qa; complement C1q subcomponent subunit A [KO:K03986]
114697211  C1qc; complement C1q subcomponent subunit C [KO:K03988]
114697212  C1qb; complement C1q subcomponent subunit B [KO:K03987]
114697334  C6; complement component C6 [KO:K03995]
114697336  C7; LOW QUALITY PROTEIN: complement component C7 [KO:K03996]
114697344  C9; complement component C9 [KO:K04000]
114697603  Psma1; proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
114697686  Atp5pf; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
114697766  Eif2s1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
114697868  Psmd1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
114697928  [KO:K08738]
114698264  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
114698423  Atp5po; ATP synthase subunit O, mitochondrial [KO:K02137]
114698452  Sod1; LOW QUALITY PROTEIN: superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
114698667  Ndufc2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
114698768  Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
114698806  [KO:K04348] [EC:3.1.3.16]
114699348  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
114699521  [KO:K05634]
114699672  Ndufs3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
114699678  Psmc3; 26S proteasome regulatory subunit 6A [KO:K03065]
114699702  Creb3l1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
114699830  [KO:K03937]
114699928  Kif5c; kinesin heavy chain [KO:K10396]
114699980  Psma5; proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
114700198  Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
114700220  Vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
114700271  [KO:K02270]
114700550  Apaf1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
114700572  Ndufa12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
114700676  Ndufa10; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
114700704  [KO:K03064]
114700731  Tuba8; tubulin alpha-8 chain isoform X2 [KO:K07374]
114700762  Cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X8 [KO:K04850]
114700813  [KO:K08738]
114700826  Atp5mc3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
114700827  Atf2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
114700859  Casp9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
114700886  Sdhb; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
114700935  [KO:K07375]
114700949  [KO:K02263]
114700968  [KO:K08009]
114701092  [KO:K00411] [EC:7.1.1.8]
114701179  Slc25a4; ADP/ATP translocase 1 [KO:K05863]
114701281  Cacna1f; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
114701310  [KO:K07375]
114701319  [KO:K21421] [EC:1.-.-.-]
114701331  Tubb2b; tubulin beta-2B chain [KO:K07375]
114701446  Ndufa9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
114701479  Gsk3b; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
114701507  [KO:K02128]
114701855  [KO:K00411] [EC:7.1.1.8]
114701979  [KO:K00417]
114702631  [KO:K03945]
114703061  Klc1; kinesin light chain 1 isoform X1 [KO:K10407]
114703207  Creb3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
114703266  Ndufb6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
114703574  [KO:K08738]
114703635  [KO:K02268]
114703694  [KO:K03944]
114703705  Ndufs4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial isoform X1 [KO:K03937]
114703739  [KO:K07375]
114703831  Ndufb11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
114703850  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
114703999  Ndufv3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial [KO:K03944]
114704190  [KO:K02268]
114704207  Adrm1; proteasomal ubiquitin receptor ADRM1 isoform X1 [KO:K06691]
114704212  Psma7; proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
114704267  Psmb2; proteasome subunit beta type-2 isoform X1 [KO:K02734] [EC:3.4.25.1]
114704332  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
114704407  [KO:K02266]
114704425  [KO:K03957]
114704485  Ndufb3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
114704543  Psmd9; 26S proteasome non-ATPase regulatory subunit 9 isoform X1 [KO:K06693]
114704693  Hspa5; endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
114704700  C5; complement C5 [KO:K03994]
114704715  Ndufa8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
114704795  Ndufa4l2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
114704800  Ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
114704803  Kif5a; kinesin heavy chain [KO:K10396]
114704883  [KO:K02271]
114705017  Psmc1; 26S proteasome regulatory subunit 4 [KO:K03062]
114705057  Creb1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
114705083  Ndufa2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
114705194  [KO:K00414]
114705314  Klc4; kinesin light chain 4 isoform X1 [KO:K10407]
114705416  Slc25a5; ADP/ATP translocase 2 [KO:K05863]
114705437  Ndufa1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
114705519  Ppp3r1; calcineurin subunit B type 1 isoform X2 [KO:K06268]
114705570  [KO:K02263]
114705599  Csnk2a1; LOW QUALITY PROTEIN: casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
114705743  Vdac3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
114705806  C8b; complement component C8 beta chain [KO:K03998]
114705811  C8a; LOW QUALITY PROTEIN: complement component C8 alpha chain [KO:K03997]
114705817  Tnf; tumor necrosis factor [KO:K03156]
114705847  Atf6b; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
114705867  Hspa1a; heat shock 70 kDa protein 1A [KO:K03283]
114705868  [KO:K03283]
114705870  Hspa1l; heat shock 70 kDa protein 1-like [KO:K03283]
114705884  Csnk2b; casein kinase II subunit beta isoform X1 [KO:K03115]
114705971  [KO:K00417]
114706041  Ndufb1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
114706046  [KO:K02273]
114706123  Itpr3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
114706162  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
114706165  Mapk14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
114706728  Psmd7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
114706832  Ndufb2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
114706860  [KO:K00416]
114706920  Psmd3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
114706924  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
114707044  Grin2c; glutamate receptor ionotropic, NMDA 2C isoform X2 [KO:K05211]
114707050  Atp5pd; ATP synthase subunit d, mitochondrial [KO:K02138]
114707249  Atp5pb; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
114707535  Rac1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
114707747  Ccl5; C-C motif chemokine 5 [KO:K12499]
114707771  [KO:K02127]
114707907  Creb3l4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
114707943  [KO:K03097] [EC:2.7.11.1]
114707978  Psmc2; 26S proteasome regulatory subunit 7 [KO:K03061]
114708122  Ndufb8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
114708186  Prkcd; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
114708203  Ndufs1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
114708306  Atp5f1c; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
114708393  Itpr2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
114708408  [KO:K02272]
114708475  [KO:K07374]
114708557  [KO:K07374]
114708577  [KO:K07374]
114708578  Tuba1b; tubulin alpha-1B chain [KO:K07374]
114708599  [KO:K03941] [EC:7.1.1.2]
114708619  [KO:K02268]
114708722  Psmb5; proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
114708754  Tubal3; tubulin alpha chain-like 3 [KO:K07374]
114708793  [KO:K07374]
114708890  Mcu; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
114708910  [KO:K02270]
114709020  [KO:K08738]
114709194  Klc2; kinesin light chain 2 [KO:K10407]
114709335  Tuba4a; LOW QUALITY PROTEIN: tubulin alpha-4A chain [KO:K07374]
114709520  Il1b; interleukin-1 beta [KO:K04519]
114709525  Il1a; interleukin-1 alpha [KO:K04383]
114709626  Ppif; peptidyl-prolyl cis-trans isomerase F, mitochondrial isoform X1 [KO:K09565] [EC:5.2.1.8]
114709796  [KO:K00417]
114709863  Klc3; kinesin light chain 3 isoform X1 [KO:K10407]
114710174  [KO:K00417]
114710215  [KO:K02138]
114710287  [KO:K08738]
114710373  Psmd6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
114710475  Ndufa4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
114710523  [KO:K04371] [EC:2.7.11.24]
114710722  Ndufb4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
114710781  Slc25a31; ADP/ATP translocase 4 [KO:K05863]
114711016  [KO:K05863]
119087871  [KO:K04962]
119087872  [KO:K04962]
119088668  [KO:K02272]
36275531  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
36275532  COX3; cytochrome c oxidase subunit III [KO:K02262]
36275535  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
36275537  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
36275544  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
36275547  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
36275552  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
36275554  COX2; cytochrome c oxidase subunit II [KO:K02261]
36275555  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
36275556  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
36275557  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
36275560  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
36275561  CYTB; cytochrome b [KO:K00412]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00575  3',5'-Cyclic AMP
C00704  Superoxide
C02140  Corticosterone
Reference
PMID:27055367
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Saa P, Harris DA, Cervenakova L
  Title
Mechanisms of prion-induced neurodegeneration.
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Expert Rev Mol Med 18:e5 (2016)
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Reference
PMID:25584786
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Goold R, McKinnon C, Tabrizi SJ
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Mol Cell Neurosci 66:12-20 (2015)
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Reference
PMID:20889378
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Trends Mol Med 17:14-24 (2011)
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Reference
PMID:27060771
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Brain Res 1648:553-560 (2016)
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Reference
PMID:32565065
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Reference
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Reference
PMID:15695097
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Trends Cell Biol 15:102-11 (2005)
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Reference
PMID:17051207
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Nature 443:803-10 (2006)
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Reference
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Neurobiol Dis 8:743-63 (2001)
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Reference
PMID:17085779
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Prions: protein only or something more? Overview of potential prion cofactors.
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Reference
PMID:14705136
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J Neurosci Res 75:153-61 (2004)
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Reference
PMID:10398674
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Cellular biology of prion diseases.
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Reference
PMID:15890824
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Prion biology relevant to bovine spongiform encephalopathy.
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J Anim Sci 83:1455-76 (2005)
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Reference
PMID:27581199
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Peggion C, Bertoli A, Sorgato MC
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Almost a century of prion protein(s): From pathology to physiology, and back to pathology.
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Biochem Biophys Res Commun 483:1148-1155 (2017)
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Reference
PMID:31618844
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Ryskalin L, Busceti CL, Biagioni F, Limanaqi F, Familiari P, Frati A, Fornai F
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Int J Mol Sci 20:E5107 (2019)
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Reference
PMID:31795242
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The Interplay between Ca(2+) Signaling Pathways and Neurodegeneration.
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Int J Mol Sci 20:E6004 (2019)
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Reference
PMID:30710214
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Meneghetti E, Gasperini L, Virgilio T, Moda F, Tagliavini F, Benetti F, Legname G
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Prions Strongly Reduce NMDA Receptor S-Nitrosylation Levels at Pre-symptomatic and Terminal Stages of Prion Diseases.
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Mol Neurobiol 56:6035-6045 (2019)
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Reference
PMID:23439666
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Song Z, Zhao D, Yang L
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Molecular mechanisms of neurodegeneration mediated by dysfunctional subcellular organelles in transmissible spongiform encephalopathies.
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Acta Biochim Biophys Sin (Shanghai) 45:452-64 (2013)
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Reference
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Fine-tuning PERK signaling for neuroprotection.
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J Neurochem 142:812-826 (2017)
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Reference
PMID:29194372
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What Is Our Current Understanding of PrP(Sc)-Associated Neurotoxicity and Its Molecular Underpinnings?
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Pathogens 6:63 (2017)
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Reference
PMID:24619348
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Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases.
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Nat Rev Neurosci 15:233-49 (2014)
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Reference
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Hughes D, Mallucci GR
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The unfolded protein response in neurodegenerative disorders - therapeutic modulation of the PERK pathway.
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FEBS J 286:342-355 (2019)
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Reference
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Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders.
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J Cell Mol Med 15:2025-39 (2011)
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Reference
PMID:18420416
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The release of calcium from the endoplasmic reticulum induced by amyloid-beta and prion peptides activates the mitochondrial apoptotic pathway.
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Neurobiol Dis 30:331-42 (2008)
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Reference
PMID:16844381
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An endoplasmic-reticulum-specific apoptotic pathway is involved in prion and amyloid-beta peptides neurotoxicity.
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Neurobiol Dis 23:669-78 (2006)
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Reference
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Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies.
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Exp Mol Med 47:e147 (2015)
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Disease-associated prion protein oligomers inhibit the 26S proteasome.
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Reference
PMID:10195903
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Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD.
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Reference
PMID:14532116
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Caspase-12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein.
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EMBO J 22:5435-45 (2003)
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Reference
PMID:31417367
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Protein Misfolding, Signaling Abnormalities and Altered Fast Axonal Transport: Implications for Alzheimer and Prion Diseases.
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Front Cell Neurosci 13:350 (2019)
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Reference
PMID:29261664
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Zamponi E, Buratti F, Cataldi G, Caicedo HH, Song Y, Jungbauer LM, LaDu MJ, Bisbal M, Lorenzo A, Ma J, Helguera PR, Morfini GA, Brady ST, Pigino GF
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Prion protein inhibits fast axonal transport through a mechanism involving casein kinase 2.
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PLoS One 12:e0188340 (2017)
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Reference
PMID:21196165
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Schneider B, Pietri M, Pradines E, Loubet D, Launay JM, Kellermann O, Mouillet-Richard S
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Understanding the neurospecificity of Prion protein signaling.
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Front Biosci (Landmark Ed) 16:169-86 (2011)
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Reference
PMID:23479001
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Didonna A
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Prion protein and its role in signal transduction.
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Cell Mol Biol Lett 18:209-30 (2013)
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Reference
PMID:28507517
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Shah SZA, Zhao D, Hussain T, Yang L
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The Role of Unfolded Protein Response and Mitogen-Activated Protein Kinase Signaling in Neurodegenerative Diseases with Special Focus on Prion Diseases.
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Front Aging Neurosci 9:120 (2017)
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Reference
PMID:15528202
  Authors
Marella M, Gaggioli C, Batoz M, Deckert M, Tartare-Deckert S, Chabry J
  Title
Pathological prion protein exposure switches on neuronal mitogen-activated protein kinase pathway resulting in microglia recruitment.
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J Biol Chem 280:1529-34 (2005)
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Reference
PMID:15640354
  Authors
Ishikura N, Clever JL, Bouzamondo-Bernstein E, Samayoa E, Prusiner SB, Huang EJ, DeArmond SJ
  Title
Notch-1 activation and dendritic atrophy in prion disease.
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Proc Natl Acad Sci U S A 102:886-91 (2005)
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Reference
PMID:20205843
  Authors
Dearmond SJ, Bajsarowicz K
  Title
PrPSc accumulation in neuronal plasma membranes links Notch-1 activation to dendritic degeneration in prion diseases.
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Mol Neurodegener 5:6 (2010)
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Reference
PMID:29998397
  Authors
Hirsch TZ, Martin-Lanneree S, Reine F, Hernandez-Rapp J, Herzog L, Dron M, Privat N, Passet B, Halliez S, Villa-Diaz A, Lacroux C, Klein V, Haik S, Andreoletti O, Torres JM, Vilotte JL, Beringue V, Mouillet-Richard S
  Title
Epigenetic Control of the Notch and Eph Signaling Pathways by the Prion Protein: Implications for Prion Diseases.
  Journal
Mol Neurobiol 56:2159-2173 (2019)
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Reference
PMID:28714865
  Authors
Aguzzi A, Zhu C
  Title
Microglia in prion diseases.
  Journal
J Clin Invest 127:3230-3239 (2017)
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Reference
PMID:15342004
  Authors
Mabbott NA
  Title
The complement system in prion diseases.
  Journal
Curr Opin Immunol 16:587-93 (2004)
DOI:10.1016/j.coi.2004.07.002
Reference
PMID:15611724
  Authors
Mallucci G, Collinge J
  Title
Rational targeting for prion therapeutics.
  Journal
Nat Rev Neurosci 6:23-34 (2005)
DOI:10.1038/nrn1584
Related
pathway
pleu00190  Oxidative phosphorylation
pleu03050  Proteasome
pleu04020  Calcium signaling pathway
pleu04140  Autophagy - animal
pleu04141  Protein processing in endoplasmic reticulum
pleu04142  Lysosome biogenesis
pleu04144  Endocytosis
pleu04210  Apoptosis
pleu04330  Notch signaling pathway
pleu04610  Complement and coagulation cascades
pleu04668  TNF signaling pathway
KO pathway
ko05020   

DBGET integrated database retrieval system