KEGG   PATHWAY: ptao04510
Entry
ptao04510                   Pathway                                
Name
Focal adhesion - Phyllopteryx taeniolatus (common seadragon)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
ptao04510  Focal adhesion
ptao04510

Other DBs
GO: 0005925
Organism
Phyllopteryx taeniolatus (common seadragon) [GN:ptao]
Gene
133465043  thbs4b; thrombospondin-4-B [KO:K04659]
133465090  tln1; talin-1 isoform X1 [KO:K06271]
133465148  june; junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
133465313  pip5k1ba; phosphatidylinositol-4-phosphate 5-kinase, type I, beta a isoform X1 [KO:K00889] [EC:2.7.1.68]
133465493  col1a1a; collagen, type I, alpha 1a [KO:K06236]
133465554  actb2; actin, cytoplasmic 2 [KO:K05692]
133465646  ppp1caa; protein phosphatase 1, catalytic subunit, alpha isozyme a [KO:K06269] [EC:3.1.3.16]
133465833  emp2; epithelial membrane protein 2 [KO:K26256]
133465897  [KO:K06493]
133466036  pdgfab; platelet-derived growth factor alpha polypeptide b [KO:K04359]
133466075  [KO:K26255]
133466092  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
133466155  mylk5; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
133466213  prkcab; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
133466239  prkcbb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
133466372  [KO:K04392]
133466481  [KO:K06482]
133466512  grb2b; growth factor receptor-bound protein 2b isoform X1 [KO:K04364]
133466608  ccndx; cyclin Dx [KO:K10151]
133466650  mylpfa; myosin regulatory light chain 2, skeletal muscle [KO:K12758]
133466916  arhgap35b; rho GTPase-activating protein 35 [KO:K05732]
133466921  [KO:K05733] [EC:2.7.11.1]
133467039  [KO:K05089] [EC:2.7.10.1]
133467092  [KO:K17449]
133467404  birc2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
133467408  [KO:K06272] [EC:2.7.11.1]
133467658  vegfd; vascular endothelial growth factor D [KO:K05449]
133467709  [KO:K04438]
133467879  fn1b; fibronectin 1b isoform X1 [KO:K05717]
133467932  itgb6; integrin beta-6 [KO:K06589]
133468003  [KO:K17388] [EC:2.7.11.39]
133468023  lama2; laminin subunit alpha-2 isoform X1 [KO:K05637]
133468221  [KO:K05703] [EC:2.7.10.2]
133468258  pak5; serine/threonine-protein kinase PAK 5 isoform X1 [KO:K05736] [EC:2.7.11.1]
133468282  vegfab; vascular endothelial growth factor Ab isoform X1 [KO:K05448]
133468541  thbs1b; thrombospondin-1 [KO:K16857]
133468658  lama4; laminin subunit alpha-4 isoform X1 [KO:K06241]
133468907  dock1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
133468928  itga3b; integrin alpha-3b [KO:K06482]
133468974  erbb2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
133469052  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
133469055  [KO:K00907] [EC:2.7.11.18]
133469083  ptenb; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
133469086  itgb4; integrin beta-4 isoform X1 [KO:K06525]
133469200  [KO:K05700]
133469308  [KO:K04392]
133469481  pdpk1b; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
133469491  itgb3b; integrin beta-3b [KO:K06493]
133469626  [KO:K07861]
133469661  [KO:K04659]
133469711  col1a1b; collagen, type I, alpha 1b [KO:K06236]
133469796  ppp1cab; protein phosphatase 1, catalytic subunit, alpha isozyme b [KO:K06269] [EC:3.1.3.16]
133469809  mylpfb; myosin regulatory light chain 2, skeletal muscle [KO:K12758]
133470076  myl12.1; myosin, light chain 12, genome duplicate 1 [KO:K12757]
133470077  flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
133470238  lama1; laminin subunit alpha-1 isoform X1 [KO:K05637]
133470254  [KO:K05730]
133470267  [KO:K04361] [EC:2.7.10.1]
133470307  itgb1a; integrin beta-1a isoform X1 [KO:K05719]
133470636  col1a2; collagen alpha-2(I) chain [KO:K06236]
133470736  itgb8; integrin beta-8 isoform X1 [KO:K06591]
133470771  [KO:K02105]
133470797  [KO:K08131]
133471232  itga11a; integrin alpha-11a isoform X1 [KO:K06587]
133471247  col9a2; collagen alpha-2(IX) chain [KO:K08131]
133471262  [KO:K00889] [EC:2.7.1.68]
133471519  [KO:K04393]
133471543  ptk2aa; protein tyrosine kinase 2aa isoform X1 [KO:K05725] [EC:2.7.10.2]
133471666  ppp1r12a; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
133471835  [KO:K10151]
133471865  [KO:K05636]
133472083  igf1; insulin-like growth factor I [KO:K05459]
133472086  hgfa; hepatocyte growth factor a isoform X1 [KO:K05460]
133472202  [KO:K07836]
133472286  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
133472328  [KO:K06269] [EC:3.1.3.16]
133472337  zgc:158659; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
133472785  col4a6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
133472786  col4a5; collagen alpha-5(IV) chain [KO:K06237]
133472979  [KO:K02158]
133473425  [KO:K05449]
133474106  igf1rb; insulin-like growth factor 1b receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
133474121  lama5; laminin subunit alpha-5 isoform X1 [KO:K06240]
133474247  [KO:K04349]
133474267  tln2a; talin-2a isoform X1 [KO:K06271]
133474287  lamb2l; laminin subunit beta-2 [KO:K06243]
133474594  tncb; tenascin isoform X1 [KO:K06252]
133474649  pxnb; mucin-2 isoform X1 [KO:K05760]
133474732  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit A [KO:K06269] [EC:3.1.3.16]
133474857  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
133475108  itga2.2; integrin alpha-2 [KO:K06481]
133475117  myl7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
133475343  pip5k1bb; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
133475351  thbs4a; thrombospondin-4a [KO:K04659]
133475742  [KO:K02649]
133475799  [KO:K05692]
133476580  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
133476618  col9a1a; collagen, type IX, alpha 1a isoform X1 [KO:K08131]
133476643  actb1; actin, cytoplasmic 1 [KO:K05692]
133476645  [KO:K05730]
133476693  [KO:K07860]
133476822  pdgfba; platelet-derived growth factor beta polypeptide a isoform X1 [KO:K17386]
133476943  [KO:K03099]
133476952  [KO:K03853] [EC:3.4.22.53]
133477091  emp1; epithelial membrane protein 1 [KO:K26255]
133477257  [KO:K19662] [EC:2.7.11.13]
133477294  [KO:K04359]
133477459  ppp1r12c; protein phosphatase 1 regulatory subunit 12C [KO:K17457]
133477529  [KO:K02677] [EC:2.7.11.13]
133477705  rap1aa; RAP1A, member of RAS oncogene family a isoform X1 [KO:K04353]
133477792  [KO:K02833]
133477824  lamb1a; laminin subunit beta-1a isoform X1 [KO:K05636]
133477861  parvaa; parvin, alpha a [KO:K06275]
133477888  hgfb; hepatocyte growth factor isoform X1 [KO:K05460]
133477984  [KO:K04393]
133477987  bcar1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
133478073  parvb; beta-parvin isoform X1 [KO:K06275]
133478074  parvg; gamma-parvin [KO:K06275]
133478102  [KO:K04513]
133478154  met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
133478155  cav1; caveolin-1 [KO:K06278]
133478156  cav2; caveolin-2 [KO:K12958]
133478285  igf1ra; insulin-like growth factor 1a receptor [KO:K05087] [EC:2.7.10.1]
133478297  vwf; von Willebrand factor isoform X1 [KO:K03900]
133478345  [KO:K04349]
133478376  tln2b; talin-2 isoform X1 [KO:K06271]
133478460  map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
133478505  zmp:0000001167; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K17457]
133478608  reln; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
133478671  ccnd2a; G1/S-specific cyclin-D2a isoform X1 [KO:K10151]
133478707  [KO:K06587]
133479020  col6a4a; collagen alpha-6(VI) chain isoform X1 [KO:K06238]
133479091  shc1; SHC-transforming protein 1 isoform X1 [KO:K06279]
133479196  cdc42l; cell division cycle 42, like [KO:K04393]
133479204  itga8; integrin alpha-8 isoform X1 [KO:K06584]
133479402  [KO:K00889] [EC:2.7.1.68]
133479436  itga10; integrin alpha-10 isoform X1 [KO:K06586]
133479454  ctnnb1; catenin beta-1 [KO:K02105]
133479747  vegfaa; vascular endothelial growth factor A-A [KO:K05448]
133479756  arhgap5; rho GTPase-activating protein 5 isoform X1 [KO:K13709]
133479796  [KO:K05725] [EC:2.7.10.2]
133479984  zyx; zyxin [KO:K06273]
133480010  tnxba; serine-rich adhesin for platelets [KO:K06252]
133480082  prkcg; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
133480405  pdgfra; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
133480430  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
133480513  [KO:K02649]
133480564  pak2b; serine/threonine-protein kinase PAK 2b [KO:K04410] [EC:2.7.11.1]
133480613  comp; cartilage oligomeric matrix protein isoform X1 [KO:K04659]
133480755  mylk4b; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
133480982  pip5k1ca; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
133481114  jun; transcription factor AP-1 [KO:K04448]
133481173  shc2; SHC-transforming protein 2 isoform X1 [KO:K17447]
133481178  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
133481404  kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
133481475  lamb2; laminin subunit beta-2 isoform X1 [KO:K06243]
133481932  [KO:K06272] [EC:2.7.11.1]
133481943  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
133481999  col4a3; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
133482001  col4a4; collagen alpha-4(IV) chain [KO:K06237]
133482017  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
133482042  pak1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
133482165  vaspb; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
133482363  pak4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
133482411  actn4; alpha-actinin-4 isoform X1 [KO:K05699]
133482413  crk; adapter molecule crk isoform X1 [KO:K04438]
133482593  pdgfd; platelet-derived growth factor D [KO:K05450]
133482638  arhgap35a; rho GTPase-activating protein 35 isoform X1 [KO:K05732]
133482768  vtna; vitronectin a [KO:K06251]
133482790  akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
133483015  [KO:K04393]
133483179  itga7; integrin alpha-7 isoform X1 [KO:K06583]
133483214  [KO:K05760]
133483227  [KO:K06244]
133483373  [KO:K04513]
133483430  [KO:K04353]
133483525  [KO:K06484]
133483552  flnbl; filamin-B isoform X1 [KO:K27392]
133483627  [KO:K05704] [EC:2.7.10.2]
133483674  col2a1b; collagen, type II, alpha 1b isoform X1 [KO:K19719]
133483921  cav4a; caveolin-2 [KO:K12958]
133483942  cav3; caveolin-3 [KO:K12959]
133484050  myl9b; myosin regulatory light polypeptide 9b [KO:K12755]
133484071  myl2a; myosin regulatory light chain 2a [KO:K10351]
133484190  [KO:K04513]
133484316  flt4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
133484364  mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
133484417  xiap; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
133484435  pdgfrb; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
133484726  kdrl; vascular endothelial growth factor receptor kdr-like isoform X1 [KO:K05096] [EC:2.7.10.1]
133484770  vegfba; vascular endothelial growth factor A isoform X1 [KO:K05448]
133484834  pdgfc; platelet-derived growth factor C [KO:K05450]
133485125  egf; pro-epidermal growth factor isoform X1 [KO:K04357]
133485270  elk1; ETS domain-containing protein Elk-3 isoform X1 [KO:K04375]
133485601  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
133485661  ptena; phosphatase and tensin homolog A isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
133485663  itga5; integrin alpha-5 isoform X1 [KO:K06484]
133485740  [KO:K03853] [EC:3.4.22.53]
133485741  [KO:K03853] [EC:3.4.22.53]
133485756  itga9; integrin alpha-9 [KO:K06585]
133485855  thbs2a; thrombospondin-2 isoform X1 [KO:K04659]
133485868  src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
133486078  col9a1b; collagen, type IX, alpha 1b [KO:K08131]
133486191  [KO:K05700]
133486243  akt3a; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
133486352  itgav; integrin alpha-V isoform X1 [KO:K06487]
133486415  [KO:K06238]
133486482  itgb5; integrin beta-5 isoform X1 [KO:K06588]
133486503  fn1a; fibronectin 1a [KO:K05717]
133486541  [KO:K00907] [EC:2.7.11.18]
133486622  col4a2; collagen alpha-2(IV) chain isoform X1 [KO:K06237]
133486623  col4a1; collagen alpha-1(IV) chain [KO:K06237]
133486640  itga4; integrin alpha-4 isoform X1 [KO:K06483]
133486751  [KO:K06238]
133486779  [KO:K04513]
133486846  igf3; insulin-like growth factor 3 [KO:K05459]
133486885  itga6a; integrin alpha-6 isoform X1 [KO:K06485]
133486974  flna; filamin-A isoform X1 [KO:K04437]
133487061  gsk3ba; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
133487316  sos2; son of sevenless homolog 2 [KO:K03099]
133487385  akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
133487409  thbs3a; thrombospondin-3a isoform X1 [KO:K04659]
133487473  actn1; alpha-actinin-1 isoform X1 [KO:K05699]
133487624  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
133487668  rock2a; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
133487734  [KO:K06269] [EC:3.1.3.16]
133487799  col9a3; collagen alpha-3(IX) chain [KO:K08131]
133487857  [KO:K04410] [EC:2.7.11.1]
133487934  fyna; tyrosine-protein kinase fyna [KO:K05703] [EC:2.7.10.2]
133487979  [KO:K16857]
133488013  [KO:K05735] [EC:2.7.11.1]
133488044  [KO:K19719]
133488236  pgfb; vascular endothelial growth factor A [KO:K16859]
133488429  [KO:K02649]
133488463  [KO:K06240]
133488470  bcl2b; apoptosis regulator Bcl-2 [KO:K02161]
133488509  rock1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
133488582  [KO:K04448]
133488628  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
133488632  col6a1; collagen alpha-1(VI) chain [KO:K06238]
133488664  [KO:K06485]
133488681  [KO:K00922] [EC:2.7.1.153]
133488730  [KO:K05730]
133488776  [KO:K06237]
133488777  [KO:K06237]
133488875  lamc1; laminin subunit gamma-1 [KO:K05635]
133488879  lamc2; laminin subunit gamma-2 isoform X1 [KO:K06246]
133488931  col6a2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
133488957  egfra; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
133489052  mylk4a; myosin light chain kinase 2, skeletal/cardiac muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
133489154  myl12.2; myosin, light chain 12, genome duplicate 2 [KO:K12757]
133489160  tnr; tenascin-R isoform X1 [KO:K06252]
133489275  [KO:K00889] [EC:2.7.1.68]
133489321  tnn; tenascin-N [KO:K06252]
133490019  rapgef1b; rap guanine nucleotide exchange factor 1b isoform X1 [KO:K06277]
133490095  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
133490215  vav2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
133490229  lamc3; laminin subunit gamma-3 [KO:K06247]
133490325  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
133490342  [KO:K06252]
133490346  shc3; SHC-transforming protein 3 isoform X1 [KO:K17448]
133490357  itga1; integrin alpha-1 isoform X1 [KO:K06480]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
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J Cell Sci 116:1409-16 (2003)
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Mitra SK, Hanson DA, Schlaepfer DD.
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Nat Rev Mol Cell Biol 6:56-68 (2005)
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Curr Opin Cell Biol 15:565-71 (2003)
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Schlaepfer DD, Mitra SK.
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Curr Opin Genet Dev 14:92-101 (2004)
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Cell 116:167-79 (2004)
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Biochem J 346 Pt 3:561-76 (2000)
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Cell Signal 14:381-95 (2002)
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Biochim Biophys Acta 1691:1-15 (2004)
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Nat Cell Biol 2:E231-6 (2000)
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Related
pathway
ptao04010  MAPK signaling pathway
ptao04060  Cytokine-cytokine receptor interaction
ptao04070  Phosphatidylinositol signaling system
ptao04110  Cell cycle
ptao04310  Wnt signaling pathway
ptao04512  ECM-receptor interaction
ptao04810  Regulation of actin cytoskeleton
KO pathway
ko04510   

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