KEGG   PATHWAY: rno04020
Entry
rno04020                    Pathway                                
Name
Calcium signaling pathway - Rattus norvegicus (rat)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
rno04020  Calcium signaling pathway
rno04020

Other DBs
GO: 0019722
Organism
Rattus norvegicus (rat) [GN:rno]
Gene
29715  Slc8a1; sodium/calcium exchanger 1 isoform 6 precursor [KO:K05849]
140447  Slc8a2; sodium/calcium exchanger 2 precursor [KO:K05849]
140448  Slc8a3; sodium/calcium exchanger 3 precursor [KO:K05849]
29600  Atp2b4; plasma membrane calcium-transporting ATPase 4 [KO:K05850] [EC:7.2.2.10]
29599  Atp2b3; plasma membrane calcium-transporting ATPase 3 [KO:K05850] [EC:7.2.2.10]
24215  Atp2b2; plasma membrane calcium-transporting ATPase 2 [KO:K05850] [EC:7.2.2.10]
29598  Atp2b1; plasma membrane calcium-transporting ATPase 1 isoform 3 [KO:K05850] [EC:7.2.2.10]
25229  Chrm1; muscarinic acetylcholine receptor M1 [KO:K04129]
24260  Chrm3; muscarinic acetylcholine receptor M3 [KO:K04131]
53949  Chrm5; muscarinic acetylcholine receptor M5 [KO:K04133]
25369  Adora2a; adenosine receptor A2a A2AR [KO:K04266]
29316  Adora2b; adenosine receptor A2b [KO:K04267]
24925  Adrb1; beta-1 adrenergic receptor [KO:K04141]
24176  Adrb2; beta-2 adrenergic receptor [KO:K04142]
25645  Adrb3; beta-3 adrenergic receptor [KO:K04143]
24316  Drd1; D(1A) dopamine receptor [KO:K04144]
25195  Drd5; D(1B) dopamine receptor [KO:K05840]
25461  Hrh2; histamine H2 receptor [KO:K04150]
25324  Htr4; 5-hydroxytryptamine receptor 4 [KO:K04160]
25689  Htr5a; 5-hydroxytryptamine receptor 5A [KO:K04161]
79247  Htr5b; 5-hydroxytryptamine receptor 5B [KO:K04161]
64354  Htr6; 5-hydroxytryptamine receptor 6 [KO:K04162]
65032  Htr7; 5-hydroxytryptamine receptor 7 [KO:K04163]
24896  Gnas; SCG6 (secretogranin VI) isoform SCG6 precursor [KO:K04632]
24611  Gnal; guanine nucleotide-binding protein G(olf) subunit alpha [KO:K04633]
305509  Adcy1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
81636  Adcy2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
64508  Adcy3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
54223  Adcy4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
84420  Adcy7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
29241  Adcy8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
302950  Adcy9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
25636  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
293508  Prkacb; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
64672  Pln; cardiac phospholamban [KO:K05852]
367086  Sln; sarcolipin [KO:K22642]
100911740  Mrln; myoregulin [KO:K22643]
691807  C2h4orf3; uncharacterized protein C4orf3 homolog [KO:K26467]
102552551  Smim6; small integral membrane protein 6 [KO:K26468]
116601  Atp2a1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
25391  Atp2a3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
29693  Atp2a2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform b [KO:K05853] [EC:7.2.2.10]
292905  Hrc; sarcoplasmic reticulum histidine-rich calcium-binding protein precursor [KO:K23450]
361618  Stim1; stromal interaction molecule 1 precursor [KO:K16059]
117087  Stim2; stromal interaction molecule 2 precursor [KO:K18196]
304496  Orai1; calcium release-activated calcium channel protein 1 [KO:K16056]
304592  Orai2; protein orai-2 [KO:K16057]
309000  Orai3; protein orai-3 [KO:K16058]
24239  Cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
29716  Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
114493  Cacna1f; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
682930  Cacna1s; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
25398  Cacna1a; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
257648  Cacna1b; voltage-dependent N-type calcium channel subunit alpha-1B isoform 1 [KO:K04849]
54234  Cacna1e; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
29717  Cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G isoform 1 [KO:K04854]
114862  Cacna1h; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
56827  Cacna1i; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
25302  Chrna7; neuronal acetylcholine receptor subunit alpha-7 precursor [KO:K04809]
24408  Grin1; glutamate receptor ionotropic, NMDA 1 isoform 1a precursor [KO:K05208]
24409  Grin2a; glutamate receptor ionotropic, NMDA 2A precursor [KO:K05209]
24410  Grin2b; glutamate receptor ionotropic, NMDA 2B precursor [KO:K05210]
24411  Grin2c; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
24412  Grin2d; glutamate receptor ionotropic, NMDA 2D precursor [KO:K05212]
191573  Grin3a; glutamate receptor ionotropic, NMDA 3A isoform 1 precursor [KO:K05213]
170796  Grin3b; glutamate receptor ionotropic, NMDA 3B precursor [KO:K05214]
25505  P2rx1; P2X purinoceptor 1 isoform 1 [KO:K05215]
114115  P2rx2; P2X purinoceptor 2 [KO:K05216]
81739  P2rx3; P2X purinoceptor 3 isoform 1 [KO:K05217]
29659  P2rx4; P2X purinoceptor 4 [KO:K05218]
113995  P2rx5; P2X purinoceptor 5 [KO:K05219]
25041  P2rx6; P2X purinoceptor 6 [KO:K05221]
29665  P2rx7; P2X purinoceptor 7 [KO:K05220]
114207  Ryr1; ryanodine receptor 1 [KO:K04961]
689560  Ryr2; ryanodine receptor 2 isoform 1 [KO:K04962]
170546  Ryr3; ryanodine receptor 3 isoform X1 [KO:K04963]
59299  Trdn; triadin [KO:K23449]
686019  Casq1; calsequestrin-1 precursor [KO:K23468]
29209  Casq2; calsequestrin-2 precursor [KO:K23445]
312981  Asph; aspartyl/asparaginyl beta-hydroxylase isoform 2 [KO:K00476] [EC:1.14.11.16]
114099  Cysltr1; cysteinyl leukotriene receptor 1 [KO:K04322]
170926  Cysltr2; cysteinyl leukotriene receptor 2 [KO:K04323]
81645  Chrm2; muscarinic acetylcholine receptor M2 [KO:K04130]
29412  Adra1a; alpha-1A adrenergic receptor [KO:K04135]
24173  Adra1b; alpha-1B adrenergic receptor [KO:K04136]
29413  Adra1d; alpha-1D adrenergic receptor [KO:K04137]
24180  Agtr1a; type-1 angiotensin II receptor A [KO:K04166]
81638  Agtr1b; type-1 angiotensin II receptor B [KO:K04166]
24326  Ednra; endothelin-1 receptor precursor [KO:K04197]
50672  Ednrb; endothelin receptor type B precursor [KO:K04198]
25439  F2r; proteinase-activated receptor 1 precursor [KO:K03914]
24414  Grm1; metabotropic glutamate receptor 1 isoform alpha precursor [KO:K04603]
24418  Grm5; metabotropic glutamate receptor 5 precursor [KO:K04604]
24938  Grpr; gastrin-releasing peptide receptor [KO:K04169]
24448  Hrh1; histamine H1 receptor [KO:K04149]
29595  Htr2a; 5-hydroxytryptamine receptor 2A [KO:K04157]
29581  Htr2b; 5-hydroxytryptamine receptor 2B [KO:K04157]
25187  Htr2c; 5-hydroxytryptamine receptor 2C precursor [KO:K04157]
25477  Lhcgr; lutropin-choriogonadotropic hormone receptor precursor [KO:K04248]
366274  Ntsr1; neurotensin receptor type 1 [KO:K04211]
25342  Oxtr; oxytocin receptor [KO:K04229]
25107  Avpr1a; vasopressin V1a receptor [KO:K04226]
100909648  Avpr1b; vasopressin V1b receptor [KO:K04227]
114098  Ltb4r2; leukotriene B4 receptor 2 [KO:K04297]
58949  Ptafr; platelet-activating factor receptor [KO:K04279]
25637  Ptger1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
24929  Ptger3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
25652  Ptgfr; prostaglandin F2-alpha receptor [KO:K04262]
81509  Bdkrb1; B1 bradykinin receptor [KO:K03915]
25245  Bdkrb2; B2 bradykinin receptor isoform 2 [KO:K03916]
24807  Tacr1; substance-P receptor [KO:K04222]
25007  Tacr2; substance-K receptor [KO:K04223]
24808  Tacr3; neuromedin-K receptor [KO:K04224]
24816  Tbxa2r; thromboxane A2 receptor [KO:K04264]
25570  Trhr; thyrotropin-releasing hormone receptor [KO:K04282]
252859  Mlnr; motilin receptor [KO:K04282]
24889  Cckar; cholecystokinin receptor type A [KO:K04194]
25706  Cckbr; gastrin/cholecystokinin type B receptor [KO:K04195]
60628  Cxcr4; C-X-C chemokine receptor type 4 [KO:K04189]
81666  Gnaq; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
81662  Gna11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
309242  Gna14; guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
89788  Gna15; guanine nucleotide-binding protein subunit alpha-15 [KO:K04637]
25313  Egf; pro-epidermal growth factor precursor [KO:K04357]
24827  Tgfa; protransforming growth factor alpha preproprotein [KO:K08774]
25266  Pdgfa; platelet-derived growth factor subunit A precursor [KO:K04359]
24628  Pdgfb; platelet-derived growth factor subunit B precursor [KO:K17386]
79429  Pdgfc; platelet-derived growth factor C precursor [KO:K05450]
66018  Pdgfd; platelet-derived growth factor D precursor [KO:K05450]
25317  Fgf1; fibroblast growth factor 1 [KO:K18496]
54250  Fgf2; fibroblast growth factor 2 [KO:K18497]
170633  Fgf3; fibroblast growth factor 3 precursor [KO:K04358]
116499  Fgf4; fibroblast growth factor 4 precursor [KO:K04358]
60662  Fgf5; fibroblast growth factor 5 isoform 1 precursor [KO:K04358]
170700  Fgf6; fibroblast growth factor 6 [KO:K04358]
29348  Fgf7; fibroblast growth factor 7 precursor [KO:K04358]
25444  Fgf9; fibroblast growth factor 9 [KO:K04358]
25443  Fgf10; fibroblast growth factor 10 precursor [KO:K04358]
60464  Fgf16; fibroblast growth factor 16 [KO:K04358]
29368  Fgf17; fibroblast growth factor 17 isoform 1 precursor [KO:K04358]
29369  Fgf18; fibroblast growth factor 18 precursor [KO:K04358]
66017  Fgf20; fibroblast growth factor 20 [KO:K04358]
170579  Fgf22; fibroblast growth factor 22 precursor [KO:K04358]
170582  Fgf19; fibroblast growth factor 19 precursor [KO:K22603]
170580  Fgf21; fibroblast growth factor 21 precursor [KO:K22429]
170583  Fgf23; fibroblast growth factor 23 precursor [KO:K22428]
83785  Vegfa; vascular endothelial growth factor A isoform 6 precursor [KO:K05448]
89811  Vegfb; vascular endothelial growth factor B precursor [KO:K16858]
114111  Vegfc; vascular endothelial growth factor C precursor [KO:K05449]
360457  Vegfd; vascular endothelial growth factor D precursor [KO:K05449]
310738  Ngf; beta-nerve growth factor precursor [KO:K02582]
24446  Hgf; hepatocyte growth factor preproprotein [KO:K05460]
24566  Mst1; hepatocyte growth factor-like protein precursor [KO:K23441]
25453  Gdnf; glial cell line-derived neurotrophic factor isoform 1 [KO:K05452]
24329  Egfr; epidermal growth factor receptor isoform 2 precursor [KO:K04361] [EC:2.7.10.1]
24337  Erbb2; receptor tyrosine-protein kinase erbB-2 precursor [KO:K05083] [EC:2.7.10.1]
29496  Erbb3; receptor tyrosine-protein kinase erbB-3 precursor [KO:K05084] [EC:2.7.10.1]
59323  Erbb4; receptor tyrosine-protein kinase erbB-4 precursor [KO:K05085] [EC:2.7.10.1]
25267  Pdgfra; platelet-derived growth factor receptor alpha precursor [KO:K04363] [EC:2.7.10.1]
24629  Pdgfrb; platelet-derived growth factor receptor beta precursor [KO:K05089] [EC:2.7.10.1]
79114  Fgfr1; fibroblast growth factor receptor 1 precursor [KO:K04362] [EC:2.7.10.1]
25022  Fgfr2; fibroblast growth factor receptor 2 isoform b [KO:K05093] [EC:2.7.10.1]
84489  Fgfr3; fibroblast growth factor receptor 3 precursor [KO:K05094] [EC:2.7.10.1]
25114  Fgfr4; fibroblast growth factor receptor 4 precursor [KO:K05095] [EC:2.7.10.1]
54251  Flt1; vascular endothelial growth factor receptor 1 isoform 2 precursor [KO:K05096] [EC:2.7.10.1]
114110  Flt4; vascular endothelial growth factor receptor 3 precursor [KO:K05097] [EC:2.7.10.1]
25589  Kdr; vascular endothelial growth factor receptor 2 precursor [KO:K05098] [EC:2.7.10.1]
59109  Ntrk1; high affinity nerve growth factor receptor precursor [KO:K03176] [EC:2.7.10.1]
25054  Ntrk2; BDNF/NT-3 growth factors receptor isoform 1 precursor [KO:K04360] [EC:2.7.10.1]
29613  Ntrk3; NT-3 growth factor receptor isoform 1 precursor [KO:K05101] [EC:2.7.10.1]
24553  Met; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
300999  Mst1r; macrophage-stimulating protein receptor isoform 2 precursor [KO:K05100] [EC:2.7.10.1]
24716  Ret; proto-oncogene tyrosine-protein kinase receptor Ret isoform a precursor [KO:K05126] [EC:2.7.10.1]
24655  Plcd1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 [KO:K05857] [EC:3.1.4.11]
287745  Plcd3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 [KO:K05857] [EC:3.1.4.11]
140693  Plcd4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 [KO:K05857] [EC:3.1.4.11]
24654  Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
29322  Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
85240  Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
25031  Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
25738  Plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
29337  Plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
114633  Plce1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
497197  Plcz1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 [KO:K05861] [EC:3.1.4.11]
25262  Itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform 3 [KO:K04958]
81678  Itpr2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
25679  Itpr3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
25668  Cd38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
246215  Tpcn1; two pore calcium channel protein 1 [KO:K16896]
309139  Tpcn2; two pore channel protein 2 [KO:K14077]
288371  Mcoln1; mucolipin-1 [KO:K04992]
292168  Mcoln2; mucolipin-2 [KO:K04993]
308022  Mcoln3; mucolipin-3 [KO:K04994]
308589  Sphk2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
170897  Sphk1; sphingosine kinase 1 isoform b [KO:K04718] [EC:2.7.1.91]
294560  Mcu; calcium uniporter protein, mitochondrial precursor [KO:K20858]
83529  Vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
83531  Vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
83532  Vdac3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
25176  Slc25a5; ADP/ATP translocase 2 [KO:K05863]
85333  Slc25a4; ADP/ATP translocase 1 [KO:K05863]
689108  Slc25a31; ADP/ATP translocase 4 [KO:K05863]
498885  Slc25a6; solute carrier family 25 member 6 [KO:K05863]
500871  Slc25a5l1; ADP/ATP translocase 2-like [KO:K05863]
282819  Ppif; peptidyl-prolyl cis-trans isomerase F, mitochondrial precursor [KO:K09565] [EC:5.2.1.8]
290561  Tnnc1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
296369  Tnnc2; troponin C, skeletal muscle [KO:K12042]
364774  Calml5; calmodulin-like protein 5 [KO:K02183]
307100  Calml3; calmodulin-like protein 3 [KO:K02183]
691455  Calml4; calmodulin-like protein 4 [KO:K02183]
24242  Calm1; calmodulin-1 [KO:K02183]
24244  Calm3; calmodulin-3 [KO:K02183]
50663  Calm2; calmodulin-2 [KO:K02183]
140671  Phkg2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
29353  Phkg1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [KO:K00871] [EC:2.7.11.19]
64561  Phka1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform [KO:K07190]
361377  Phkb; phosphorylase b kinase regulatory subunit beta isoform 1 [KO:K07190]
678739  Phka2; phosphorylase b kinase regulatory subunit alpha, liver isoform [KO:K07190]
288057  Mylk; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
117558  Mylk2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
291926  Mylk3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
100911165  Mylk4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
171358  Camk1g; calcium/calmodulin-dependent protein kinase type 1G [KO:K08794] [EC:2.7.11.17]
171503  Camk1; calcium/calmodulin-dependent protein kinase type 1 [KO:K08794] [EC:2.7.11.17]
25400  Camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
24246  Camk2d; calcium/calmodulin-dependent protein kinase type II subunit delta [KO:K04515] [EC:2.7.11.17]
24245  Camk2b; calcium/calmodulin-dependent protein kinase type II subunit beta isoform 2 [KO:K04515] [EC:2.7.11.17]
171140  Camk2g; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
25050  Camk4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
24674  Ppp3ca; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
24675  Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform [KO:K04348] [EC:3.1.3.16]
171378  Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
29748  Ppp3r1; calcineurin subunit B type 1 [KO:K06268]
29749  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
316214  Tfeb; transcription factor EB [KO:K15590]
100361818  Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform 1 [KO:K04446]
311658  Nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
361400  Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
305897  Nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
24598  Nos1; nitric oxide synthase 1 [KO:K13240] [EC:1.14.13.39]
24599  Nos2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
24600  Nos3; nitric oxide synthase 3 [KO:K13242] [EC:1.14.13.39]
81529  Pde1a; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A [KO:K13755] [EC:3.1.4.17]
29691  Pde1b; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B [KO:K13755] [EC:3.1.4.17]
81742  Pde1c; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C [KO:K13755] [EC:3.1.4.17]
50646  Ptk2b; protein-tyrosine kinase 2-beta [KO:K05871] [EC:2.7.10.2]
81677  Itpka; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
54260  Itpkb; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
308451  Itpkc; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
24680  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
25023  Prkcb; protein kinase C beta type isoform 2 [KO:K19662] [EC:2.7.11.13]
24681  Prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
rno04010  MAPK signaling pathway
rno04070  Phosphatidylinositol signaling system
rno04210  Apoptosis
rno04720  Long-term potentiation
rno04730  Long-term depression
KO pathway
ko04020   
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