Entry Name NF-kappa B signaling pathway - Rattus norvegicus (rat)
Description Nuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are several pathways leading to NF-kappa B-activation. The canonical pathway is induced by tumour necrosis factor-alpha (TNF-alpha), interleukin-1 (IL-1) or byproducts of bacterial and viral infections. This pathway relies on IKK- mediated IkappaB-alpha phosphorylation on Ser32 and 36, leading to its degradation, which allows the p50/p65 NF-kappa B dimer to enter the nucleus and activate gene transcription. Atypical pathways are IKK-independent and rely on phosphorylation of IkappaB-alpha on Tyr42 or on Ser residues in IkappaB-alpha PEST domain. The non-canonical pathway is triggered by particular members of the TNFR superfamily, such as lymphotoxin-beta (LT-beta) or BAFF. It involves NIK and IKK-alpha-mediated p100 phosphorylation and processing to p52, resulting in nuclear translocation of p52/RelB heterodimers.
Class Environmental Information Processing; Signal transductionBRITE hierarchy
Pathway map Organism Rattus norvegicus (rat) [GN:
rno ]
Gene 100363332 Card11; caspase recruitment domain-containing protein 11 [KO:K07367 ]
117279 Cflar; CASP8 and FADD-like apoptosis regulator isoform 1 [KO:K04724 ]
117516 Tnfsf11; tumor necrosis factor ligand superfamily member 11 [KO:K05473 ]
171369 Cd40; tumor necrosis factor receptor superfamily member 5 precursor [KO:K03160 ]
246756 Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171 ]
24772 Cxcl12; stromal cell-derived factor 1 isoform beta precursor [KO:K10031 ]
24888 Bcl2l1; bcl-2-like protein 1 isoform 2 [KO:K04570 ]
25112 Gadd45a; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402 ]
25361 Vcam1; vascular cell adhesion protein 1 precursor [KO:K06527 ]
25464 Icam1; intercellular adhesion molecule 1 precursor [KO:K06490 ]
25591 Parp1; poly [ADP-ribose] polymerase 1 [KO:K24070 ]
25625 Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A precursor [KO:K03158 ]
25663 Il1r1; interleukin-1 receptor type 1 precursor [KO:K04386 ]
25738 Plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116 ] [EC:3.1.4.11 ]
266806 Erc1; ELKS/Rab6-interacting/CAST family member 1 isoform 1 [KO:K16072 ]
291005 Gadd45g; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402 ]
29337 Plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859 ] [EC:3.1.4.11 ]
293625 Pidd1; p53-induced death domain-containing protein 1 [KO:K10130 ]
29469 Lbp; lipopolysaccharide-binding protein precursor [KO:K05399 ]
296872 Eda2r; tumor necrosis factor receptor superfamily member 27 [KO:K05163 ]
297604 Ltbr; tumor necrosis factor receptor superfamily member 3 precursor [KO:K03159 ]
299626 Gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402 ]
301059 Myd88; myeloid differentiation primary response protein MyD88 [KO:K04729 ]
301133 Tnfsf14; tumor necrosis factor ligand superfamily member 14 [KO:K05477 ]
307366 Malt1; mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform 1 [KO:K07369 ] [EC:3.4.22.-]
308267 Tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404 ]
309452 Nfkb2; nuclear factor NF-kappa-B p100 subunit [KO:K04469 ]
315120 Card10; caspase recruitment domain-containing protein 10 [KO:K20912 ]
315139 Tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403 ]
317546 Tab3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1 [KO:K12793 ]
363328 Ticam1; TIR domain-containing adapter molecule 1 [KO:K05842 ]
364867 Ticam2; TIR domain-containing adapter molecule 2 [KO:K05409 ]
365581 Edar; tumor necrosis factor receptor superfamily member EDAR precursor [KO:K05162 ]
498206 Tnfrsf11a; tumor necrosis factor receptor superfamily member 11A precursor [KO:K05147 ]
498666 Tnfsf13b; tumor necrosis factor ligand superfamily member 13B [KO:K05476 ]
498769 Edaradd; ectodysplasin-A receptor-associated adapter protein [KO:K23324 ]
500910 Tnfrsf13c; tumor necrosis factor receptor superfamily member 13C [KO:K05151 ]
60350 Cd14; monocyte differentiation antigen CD14 precursor [KO:K04391 ]
60371 Birc2; baculoviral IAP repeat-containing protein 2 [KO:K16060 ]
680127 Tirap; toll/interleukin-1 receptor domain-containing adapter protein [KO:K05403 ]
686781 Ppp1r13l; protein phosphatase 1, regulatory subunit 13 like [KO:K27356 ]
688292 Card14; caspase recruitment domain family, member 14 [KO:K20913 ]
78971 Birc3; baculoviral IAP repeat-containing protein 3 [KO:K16060 ]
81503 Cxcl1; growth-regulated alpha protein precursor [KO:K05505 ]
81511 Lat; linker for activation of T-cells family member 1 [KO:K07362 ]
81650 Csnk2b; casein kinase II subunit beta [KO:K03115 ]
81736 Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform 2 [KO:K02580 ]
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
Reference Authors Oeckinghaus A, Hayden MS, Ghosh S
Title Crosstalk in NF-kappaB signaling pathways.
Journal Reference Authors Gloire G, Piette J
Title Redox regulation of nuclear post-translational modifications during NF-kappaB activation.
Journal Reference Authors Perkins ND
Title Integrating cell-signalling pathways with NF-kappaB and IKK function.
Journal Reference Authors Lindstrom TM, Bennett PR
Title The role of nuclear factor kappa B in human labour.
Journal Reference Authors Razani B, Reichardt AD, Cheng G
Title Non-canonical NF-kappaB signaling activation and regulation: principles and perspectives.
Journal Reference Authors Sun SC
Title Non-canonical NF-kappaB signaling pathway.
Journal Reference Authors Neumann M, Naumann M
Title Beyond IkappaBs: alternative regulation of NF-kappaB activity.
Journal Reference Authors Verhelst K, Carpentier I, Beyaert R
Title Regulation of TNF-induced NF-kappaB activation by different cytoplasmic ubiquitination events.
Journal Reference Authors Rickert RC, Jellusova J, Miletic AV
Title Signaling by the tumor necrosis factor receptor superfamily in B-cell biology and disease.
Journal Reference Authors Naude PJ, den Boer JA, Luiten PG, Eisel UL
Title Tumor necrosis factor receptor cross-talk.
Journal Reference Authors Grivennikov SI, Kuprash DV, Liu ZG, Nedospasov SA
Title Intracellular signals and events activated by cytokines of the tumor necrosis factor superfamily: From simple paradigms to complex mechanisms.
Journal Reference Authors Wada T, Nakashima T, Hiroshi N, Penninger JM
Title RANKL-RANK signaling in osteoclastogenesis and bone disease.
Journal Reference Authors Schulze-Luehrmann J, Ghosh S
Title Antigen-receptor signaling to nuclear factor kappa B.
Journal Reference Authors Weil R, Israel A
Title T-cell-receptor- and B-cell-receptor-mediated activation of NF-kappaB in lymphocytes.
Journal Reference Authors Siebenlist U, Brown K, Claudio E
Title Control of lymphocyte development by nuclear factor-kappaB.
Journal Reference Authors Lucas PC, McAllister-Lucas LM, Nunez G
Title NF-kappaB signaling in lymphocytes: a new cast of characters.
Journal Reference Authors Khan WN
Title B cell receptor and BAFF receptor signaling regulation of B cell homeostasis.
Journal Reference Authors Vallabhapurapu S, Karin M
Title Regulation and function of NF-kappaB transcription factors in the immune system.
Journal Reference Authors Hacker H, Karin M
Title Regulation and function of IKK and IKK-related kinases.
Journal Reference Authors Sabatel H, Pirlot C, Piette J, Habraken Y
Title Importance of PIKKs in NF-kappaB activation by genotoxic stress.
Journal Reference Authors Miyamoto S
Title Nuclear initiated NF-kappaB signaling: NEMO and ATM take center stage.
Journal Reference Authors Brzoska K, Szumiel I
Title Signalling loops and linear pathways: NF-kappaB activation in response to genotoxic stress.
Journal Reference Authors Wu ZH, Miyamoto S
Title Many faces of NF-kappaB signaling induced by genotoxic stress.
Journal Reference Authors Maelfait J, Beyaert R
Title Emerging role of ubiquitination in antiviral RIG-I signaling.
Journal Reference Authors Ware CF
Title Targeting lymphocyte activation through the lymphotoxin and LIGHT pathways.
Journal Reference Authors Schneider K, Potter KG, Ware CF
Title Lymphotoxin and LIGHT signaling pathways and target genes.
Journal Reference Authors Remouchamps C, Boutaffala L, Ganeff C, Dejardin E
Title Biology and signal transduction pathways of the Lymphotoxin-alphabeta/LTbetaR system.
Journal Reference Authors Liu S, Chen ZJ
Title Expanding role of ubiquitination in NF-kappaB signaling.
Journal Reference Authors Skaug B, Jiang X, Chen ZJ
Title The role of ubiquitin in NF-kappaB regulatory pathways.
Journal Reference Authors Wertz IE, Dixit VM
Title Signaling to NF-kappaB: regulation by ubiquitination.
Journal Reference Authors Karin M, Lin A
Title NF-kappaB at the crossroads of life and death.
Journal Reference Authors Lin A, Karin M
Title NF-kappaB in cancer: a marked target.
Journal Reference Authors Morlon A, Munnich A, Smahi A
Title TAB2, TRAF6 and TAK1 are involved in NF-kappaB activation induced by the TNF-receptor, Edar and its adaptator Edaradd.
Journal Reference Authors Sadier A, Viriot L, Pantalacci S, Laudet V
Title The ectodysplasin pathway: from diseases to adaptations.
Journal Reference Authors Verhelst K, Gardam S, Borghi A, Kreike M, Carpentier I, Beyaert R
Title XEDAR activates the non-canonical NF-kappaB pathway.
Journal Reference Authors McDaniel DK, Eden K, Ringel VM, Allen IC
Title Emerging Roles for Noncanonical NF-kappaB Signaling in the Modulation of Inflammatory Bowel Disease Pathobiology.
Journal Reference Authors Mikkola ML, Thesleff I
Title Ectodysplasin signaling in development.
Journal Reference Authors Hu Y, Ge W, Wang X, Sutendra G, Zhao K, Dedeic Z, Slee EA, Baer C, Lu X
Title Caspase cleavage of iASPP potentiates its ability to inhibit p53 and NF-kappaB.
Journal Related rno04060 Cytokine-cytokine receptor interaction
rno04620 Toll-like receptor signaling pathway
rno04622 RIG-I-like receptor signaling pathway
rno04660 T cell receptor signaling pathway
rno04662 B cell receptor signaling pathway
KO pathway
