KEGG    Network variation - Human cytomegalovirus (HCMV)
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ENTRYnt06167
NameHuman cytomegalovirus (HCMV)
CategoryDisease view; Viral infection
Pathwayhsa05163 Human cytomegalovirus infection
GenomeT40080
DiseaseH00368 Cytomegalovirus infection
Display drug-target relation   disease type
ERK signaling
N00001    EGFEGFRGRB2SOSRASRAFMEKERKCCND1
N00392    UL55EGFR
N00386    UL55PDGFRGRB2SOSRASRAFMEKERK
 
PI3K signaling
N00039    PDGFPDGFRPI3KPIP3AKTMTORS6K
N00385    UL55PDGFRA
N00387      (IE1-72,IE2-86)PI3K
N00582    IGF1IGF1RPI3KPIP3AKT(TSC1+TSC2)RHEBMTOREIF4EBP1
N00388            UL38(TSC1+TSC2)
N00390    EGFEGFRPI3KPIP3AKTIKKNFKBIANFKB
N00391    UL55EGFR
 
JAK-STAT signaling
N00415    (IL10,IL19,IL20,IL..((IL10RB+(IL10RA,I..(JAK1+TYK2)STAT3
N00416    vIL10IL10RJAK1STAT3
 
CGAS-STING signaling
N00395    DNACGAScGAMPSTING1TBK1IRF3(IFNA,IFNB)
N00396        UL82STING1
 
TNF signaling
N00151    TNFTNFRSF1A(RIPK1+TRADD+TRAF2..(TAB1/2/3+TAK1)IKKNFKBIANFKB
N00397        UL26IKK
N00398            IE2-86NFKB
N00389            IE1-72NFKB
 
Chemokine signaling
N00401      CXCL12CXCR4GNAQ(PLCB,PLCG)IP3Ca2+CALM=CNNFAT
N00402        US28GNAQ
N00407        UL33(GNAQ,GNA11)
N00410      DADRD1GNASADCY5cAMPPKACREB
N00411        UL33GNAS
N00403      CX3CL1CX3CR1GNAIADCYcAMPPKA
N00404        US28(GNAI,GNAO)
N00412        UL33(GNAI,GNAO)
N00405      CXCL12CXCR4GNA12/13(ARHGEF12,ARHGEF1)RHOAROCK1/2
N00406      (CCL2/3/4/5,CX3CL1..US28GNA12/13
N00408      LPALPARGNB/GRHOA
N00409        UL33GNB/G
N00399      CCL2CCR2GNB/GPI3KPIP3AKTIKKNFKBIANFKB
N00400        US28GNB/G
N00154      CXCL8CXCR2GNB/GPI3KgammaPIP3AKTMTOR
N00427      vCXCL1CXCR2
N00413      CXCL12CXCR4GNB/GPLCB(Ca2+,DAG)PKCPTK2B(PTK2+BCAR1+CRK+PX..
N00414            US27Ca2+PKC
N00428      CCL5CCR5GNB/GPLCB(Ca2+,DAG)PKC
N00429    UL22ACCL5
 
MHC presentation
N00363      TAP1/2=TAPBP=(PDIA3+CALR)(MHCI+B2M)
N00417    US6TAP1/2
N00418          (US2,US11)MHCI
N00419          (US3,US10)MHCI
 
Cell cycle
N00066    CDKN2AMDM2TP53CDKN1A(CCND+CDK4/6)RB1E2F
N00420      IE2-86TP53
N00421        IE2-86CDKN1A
N00422            IE2-86RB1E2F
N00423            IE1-72RB1E2F
N00424            UL82RB1E2F
 
Apoptosis
N00146    (FASLG,TNFSF10)(FAS,TNFRSF10B)FADD(CASP8,CASP10)BID(BAX,BAK1)CYCS=APAF1CASP9(CASP3,CASP7)
N00425        UL36CASP8
N00426            UL37x1BAX
 
Cytoskeletal regulation
N00393    FN1(ITGA+ITGB)SRCARHGAP35RHOA
N00394    UL75(ITGAV+ITGB3)SRCRACRHOA