KEGG   ORTHOLOGY: K04448Help
Entry
K04448                      KO                                     

Name
JUN
Definition
transcription factor AP-1
Pathway
ko01522  Endocrine resistance
ko04010  MAPK signaling pathway
ko04012  ErbB signaling pathway
ko04013  MAPK signaling pathway - fly
ko04024  cAMP signaling pathway
ko04137  Mitophagy - animal
ko04210  Apoptosis
ko04214  Apoptosis - fly
ko04310  Wnt signaling pathway
ko04380  Osteoclast differentiation
ko04510  Focal adhesion
ko04530  Tight junction
ko04620  Toll-like receptor signaling pathway
ko04621  NOD-like receptor signaling pathway
ko04624  Toll and Imd signaling pathway
ko04625  C-type lectin receptor signaling pathway
ko04657  IL-17 signaling pathway
ko04658  Th1 and Th2 cell differentiation
ko04659  Th17 cell differentiation
ko04660  T cell receptor signaling pathway
ko04662  B cell receptor signaling pathway
ko04668  TNF signaling pathway
ko04722  Neurotrophin signaling pathway
ko04912  GnRH signaling pathway
ko04915  Estrogen signaling pathway
ko04921  Oxytocin signaling pathway
ko04926  Relaxin signaling pathway
ko04932  Non-alcoholic fatty liver disease (NAFLD)
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko05030  Cocaine addiction
ko05031  Amphetamine addiction
ko05120  Epithelial cell signaling in Helicobacter pylori infection
ko05130  Pathogenic Escherichia coli infection
ko05132  Salmonella infection
ko05133  Pertussis
ko05135  Yersinia infection
ko05140  Leishmaniasis
ko05142  Chagas disease (American trypanosomiasis)
ko05161  Hepatitis B
ko05162  Measles
ko05166  Human T-cell leukemia virus 1 infection
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05169  Epstein-Barr virus infection
ko05170  Human immunodeficiency virus 1 infection
ko05200  Pathways in cancer
ko05203  Viral carcinogenesis
ko05210  Colorectal cancer
ko05211  Renal cell carcinoma
ko05224  Breast cancer
ko05231  Choline metabolism in cancer
ko05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ko05321  Inflammatory bowel disease (IBD)
ko05323  Rheumatoid arthritis
ko05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04448  JUN; transcription factor AP-1
   04013 MAPK signaling pathway - fly
    K04448  JUN; transcription factor AP-1
   04012 ErbB signaling pathway
    K04448  JUN; transcription factor AP-1
   04310 Wnt signaling pathway
    K04448  JUN; transcription factor AP-1
   04668 TNF signaling pathway
    K04448  JUN; transcription factor AP-1
   04024 cAMP signaling pathway
    K04448  JUN; transcription factor AP-1
 09140 Cellular Processes
  09141 Transport and catabolism
   04137 Mitophagy - animal
    K04448  JUN; transcription factor AP-1
  09143 Cell growth and death
   04210 Apoptosis
    K04448  JUN; transcription factor AP-1
   04214 Apoptosis - fly
    K04448  JUN; transcription factor AP-1
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K04448  JUN; transcription factor AP-1
   04530 Tight junction
    K04448  JUN; transcription factor AP-1
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K04448  JUN; transcription factor AP-1
   04624 Toll and Imd signaling pathway
    K04448  JUN; transcription factor AP-1
   04621 NOD-like receptor signaling pathway
    K04448  JUN; transcription factor AP-1
   04625 C-type lectin receptor signaling pathway
    K04448  JUN; transcription factor AP-1
   04660 T cell receptor signaling pathway
    K04448  JUN; transcription factor AP-1
   04658 Th1 and Th2 cell differentiation
    K04448  JUN; transcription factor AP-1
   04659 Th17 cell differentiation
    K04448  JUN; transcription factor AP-1
   04657 IL-17 signaling pathway
    K04448  JUN; transcription factor AP-1
   04662 B cell receptor signaling pathway
    K04448  JUN; transcription factor AP-1
  09152 Endocrine system
   04912 GnRH signaling pathway
    K04448  JUN; transcription factor AP-1
   04915 Estrogen signaling pathway
    K04448  JUN; transcription factor AP-1
   04921 Oxytocin signaling pathway
    K04448  JUN; transcription factor AP-1
   04926 Relaxin signaling pathway
    K04448  JUN; transcription factor AP-1
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K04448  JUN; transcription factor AP-1
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K04448  JUN; transcription factor AP-1
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04448  JUN; transcription factor AP-1
   05203 Viral carcinogenesis
    K04448  JUN; transcription factor AP-1
   05231 Choline metabolism in cancer
    K04448  JUN; transcription factor AP-1
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K04448  JUN; transcription factor AP-1
  09162 Cancer: specific types
   05210 Colorectal cancer
    K04448  JUN; transcription factor AP-1
   05211 Renal cell carcinoma
    K04448  JUN; transcription factor AP-1
   05224 Breast cancer
    K04448  JUN; transcription factor AP-1
  09163 Immune disease
   05323 Rheumatoid arthritis
    K04448  JUN; transcription factor AP-1
   05321 Inflammatory bowel disease (IBD)
    K04448  JUN; transcription factor AP-1
  09165 Substance dependence
   05030 Cocaine addiction
    K04448  JUN; transcription factor AP-1
   05031 Amphetamine addiction
    K04448  JUN; transcription factor AP-1
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    K04448  JUN; transcription factor AP-1
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease (NAFLD)
    K04448  JUN; transcription factor AP-1
   04933 AGE-RAGE signaling pathway in diabetic complications
    K04448  JUN; transcription factor AP-1
  09171 Infectious disease: bacterial
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K04448  JUN; transcription factor AP-1
   05130 Pathogenic Escherichia coli infection
    K04448  JUN; transcription factor AP-1
   05132 Salmonella infection
    K04448  JUN; transcription factor AP-1
   05135 Yersinia infection
    K04448  JUN; transcription factor AP-1
   05133 Pertussis
    K04448  JUN; transcription factor AP-1
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K04448  JUN; transcription factor AP-1
   05170 Human immunodeficiency virus 1 infection
    K04448  JUN; transcription factor AP-1
   05162 Measles
    K04448  JUN; transcription factor AP-1
   05161 Hepatitis B
    K04448  JUN; transcription factor AP-1
   05167 Kaposi sarcoma-associated herpesvirus infection
    K04448  JUN; transcription factor AP-1
   05169 Epstein-Barr virus infection
    K04448  JUN; transcription factor AP-1
  09174 Infectious disease: parasitic
   05140 Leishmaniasis
    K04448  JUN; transcription factor AP-1
   05142 Chagas disease (American trypanosomiasis)
    K04448  JUN; transcription factor AP-1
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    K04448  JUN; transcription factor AP-1
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K04448  JUN; transcription factor AP-1
Transcription factors [BR:ko03000]
 Eukaryotic type
  Basic leucine zipper (bZIP)
   AP-1(-like) components, Jun
    K04448  JUN; transcription factor AP-1
BRITE hierarchy
Genes
HSA: 3725(JUN)
PTR: 456893(JUN)
PPS: 100980908(JUN)
GGO: 101145729(JUN)
PON: 100450292(JUN)
NLE: 100586501(JUN)
MCC: 716452(JUN)
MCF: 102126446(JUN)
CSAB: 103224726(JUN)
RRO: 104664278(JUN)
RBB: 108532921(JUN)
CJC: 100400411(JUN)
SBQ: 101043809(JUN)
MMU: 16476(Jun)
MCAL: 110292423(Jun)
MPAH: 110323252(Jun)
RNO: 24516(Jun)
CGE: 113834001
NGI: 103737138(Jun)
HGL: 101722197(Jun)
CCAN: 109700777(Jun)
OCU: 100008856(JUN) 100338341(EIF5A)
TUP: 102496870(JUN)
CFA: 609429(JUN)
VVP: 112926091(JUN)
AML: 100483834(JUN)
UMR: 103670861(JUN)
UAH: 113254611(JUN)
ORO: 101368207(JUN)
FCA: 101097261(JUN)
PTG: 102958666(JUN)
PPAD: 109266785(JUN)
AJU: 106974986(JUN)
BTA: 280831(JUN)
BOM: 102267895(JUN)
BIU: 109556235(JUN)
BBUB: 102405224(JUN)
CHX: 102185423(JUN)
OAS: 443219(JUN)
SSC: 396913(JUN)
CFR: 102516943
CDK: 105092850(JUN)
LVE: 103071861(JUN)
OOR: 101288913(JUN)
DLE: 111175871(JUN)
PCAD: 102975458(JUN)
ECB: 100067469(JUN)
EAI: 106833477(JUN)
MYB: 102260808(JUN)
MYD: 102752693(JUN)
MNA: 107536966(JUN)
HAI: 109371251(JUN) 109371257
DRO: 112314642(JUN)
PALE: 102896121(JUN)
RAY: 107518352(JUN)
MJV: 108386817(JUN)
LAV: 100670432(JUN)
TMU: 101361653
MDO: 100018774(JUN)
PCW: 110212948(JUN)
GGA: 424673(JUN)
MGP: 100548501(JUN)
CJO: 107317693(JUN)
NMEL: 110402812(JUN)
APLA: 101796626(JUN)
ACYG: 106032923(JUN)
TGU: 100229914(JUN)
LSR: 110476957(JUN)
SCAN: 103815057(JUN)
GFR: 102039078(JUN)
FAB: 101816255(JUN)
PHI: 102112236(JUN)
PMAJ: 107208073(JUN)
CCAE: 111932998(JUN)
CCW: 104695158(JUN)
ETL: 114055179(JUN)
FPG: 101918818(JUN)
FCH: 102050406(JUN)
CLV: 102092209(JUN)
EGZ: 104123944(JUN)
NNI: 104009262(JUN)
ACUN: 113482645(JUN)
PADL: 103913320(JUN)
AAM: 106494500(JUN)
ASN: 102374896(JUN)
AMJ: 102566064(JUN)
PSS: 102455008(JUN)
CMY: 102937264(JUN)
CPIC: 101930786(JUN) 103306405
ACS: 100567718(jun)
PVT: 110077124(JUN)
PBI: 103057921(JUN)
PMUR: 107302456(JUN)
TSR: 106545185(JUN)
PMUA: 114598927(JUN)
GJA: 107111867(JUN)
XLA: 108700666 379050(jun.S) 399400(jun.L)
XTR: 100493911(jun)
NPR: 108788164(JUN)
DRE: 335916(jun)
IPU: 108258130(jun) 108260086 108267848(JUN)
AMEX: 103021920 103026868(jun)
TRU: 101064806(jun) 101077059
XMA: 102230050(jun) 102234665
XCO: 114145916(jun) 114151264
PRET: 103463760 103478989(jun)
CVG: 107083648(jun) 107095895
NFU: 107384375(jun) 107396464
KMR: 108230559 108238338(jun)
ALIM: 106521291(jun) 106534447
AOCE: 111577530 111587627(jun)
CSEM: 103376719(jun) 103398819
POV: 109625845 109643961(jun)
LCF: 108879142 108883834(jun)
SDU: 111228982(jun) 111231968
BPEC: 110154702(jun) 110173458
MALB: 109952420 109970646(jun)
LCM: 102350279(JUN) 102358101
CMK: 103185297(jun) 103187587
CIN: 778972(jun)
SPU: 588294
APLC: 110977802
SKO: 100313553
DME: Dmel_CG2275(Jra)
DER: 6541513
DSI: Dsimw501_GD15385(Dsim_GD15385)
DSR: 110178000
DPE: 6592569
DMN: 108160413
DWI: 6640122
DAZ: 108617394
DNV: 108654006
MDE: 101896731
LCQ: 111685493
AAG: 5578266
AALB: 109408179
AME: 726289
BIM: 100750048
BTER: 100645950
CCAL: 108627361
OBB: 114875381
SOC: 105200133
MPHA: 105830524
AEC: 105155106
ACEP: 105621323
PBAR: 105428867
VEM: 105565543
HST: 105190515
DQU: 106744297
CFO: 105253340
LHU: 105671646
PGC: 109856529
OBO: 105277703
NVI: 100123087
CSOL: 105368040
MDL: 103568136
TCA: 663937(Jra)
DPA: 109542182
ATD: 109593897
NVL: 108557779
BMOR: 101736835
PMAC: 106715838
PRAP: 110996297
HAW: 110381290
TNL: 113505301
PXY: 105388607
DNX: 107166782
AGS: 114122336
RMD: 113557503
BTAB: 109035563
ZNE: 110827968
FCD: 110859845
PVM: 113800779
TUT: 107364868
DPTE: 113799532
BMY: Bm1_43340
PCAN: 112574619
CRG: 105341654
OBI: 106868153
LAK: 106165046
HMG: 100204820(jun)
AQU: 100640297
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Liu J, Han Q, Peng T, Peng M, Wei B, Li D, Wang X, Yu S, Yang J, Cao S, Huang K, Hutchins AP, Liu H, Kuang J, Zhou Z, Chen J, Wu H, Guo L, Chen Y, Chen Y, Li X, Wu H, Liao B, He W, Song H, Yao H, Pan G, Chen J, Pei D
  Title
The oncogene c-Jun impedes somatic cell reprogramming.
  Journal
Nat Cell Biol 17:856-67 (2015)
DOI:10.1038/ncb3193
Reference
PMID:3194415
  Authors
Hattori K, Angel P, Le Beau MM, Karin M
  Title
Structure and chromosomal localization of the functional intronless human JUN protooncogene.
  Journal
Proc Natl Acad Sci U S A 85:9148-52 (1988)
DOI:10.1073/pnas.85.23.9148
  Sequence
[hsa:3725]
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