KEGG   PATHWAY: cvf04148
Entry
cvf04148                    Pathway                                
Name
Efferocytosis - Charadrius vociferus (killdeer)
Class
Cellular Processes; Transport and catabolism
Pathway map
cvf04148  Efferocytosis
cvf04148

Organism
Charadrius vociferus (killdeer) [GN:cvf]
Gene
104281514  VPS11; vacuolar protein sorting-associated protein 11 homolog [KO:K20179]
104281692  DUSP16; LOW QUALITY PROTEIN: dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
104282001  ELMO1; engulfment and cell motility protein 1 isoform X1 [KO:K12366]
104282104  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
104282202  ATP2A2; LOW QUALITY PROTEIN: sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
104282270  VPS33A; vacuolar protein sorting-associated protein 33A [KO:K20182]
104282286  PTPN11; tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
104282484  ANO9; anoctamin-9 [KO:K19503]
104282756  ANO6; anoctamin-6 [KO:K19500]
104282773  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
104282792  VPS41; vacuolar protein sorting-associated protein 41 homolog isoform X1 [KO:K20184]
104282830  XKR4; XK-related protein 4 [KO:K26811]
104283089  PANX1; pannexin-1 [KO:K03443]
104283390  [KO:K01052] [EC:3.1.1.13]
104283399  CASP7; caspase-7 [KO:K04397] [EC:3.4.22.60]
104283454  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
104283588  ATP11C; phospholipid-transporting ATPase IG [KO:K26934]
104283631  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 [KO:K16343] [EC:3.1.1.4]
104284576  CD36; platelet glycoprotein 4 isoform X1 [KO:K06259]
104284706  TGFBRAP1; transforming growth factor-beta receptor-associated protein 1 [KO:K20177]
104285061  [KO:K04397] [EC:3.4.22.60]
104285071  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
104285096  THBS1; thrombospondin-1 [KO:K16857]
104285106  ARG2; LOW QUALITY PROTEIN: arginase-2, mitochondrial [KO:K01476] [EC:3.5.3.1]
104285227  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
104285259  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
104285374  ITGB3; integrin beta-3 [KO:K06493]
104285438  ARNT; aryl hydrocarbon receptor nuclear translocator isoform X1 [KO:K09097]
104285478  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta [KO:K04515] [EC:2.7.11.17]
104285913  PTGS2; prostaglandin G/H synthase 2 isoform X1 [KO:K11987] [EC:1.14.99.1]
104285956  PQLC2L; putative uncharacterized protein C3orf55 homolog [KO:K23678]
104286204  S1PR1; sphingosine 1-phosphate receptor 1 [KO:K04288]
104286373  ATP8A1; phospholipid-transporting ATPase IA [KO:K14802] [EC:7.6.2.1]
104286509  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
104286554  CRK; adapter molecule crk isoform X1 [KO:K04438]
104286606  SCARF1; LOW QUALITY PROTEIN: scavenger receptor class F member 1 [KO:K24318]
104286984  VPS16; vacuolar protein sorting-associated protein 16 homolog [KO:K20180]
104287112  ADAM10; disintegrin and metalloproteinase domain-containing protein 10 [KO:K06704] [EC:3.4.24.81]
104287309  MERTK; LOW QUALITY PROTEIN: tyrosine-protein kinase Mer [KO:K05117] [EC:2.7.10.1]
104287544  ANO3; anoctamin-3 [KO:K19498]
104287582  ANO5; anoctamin-5 [KO:K19480]
104287708  CD47; leukocyte surface antigen CD47 [KO:K06266]
104287787  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
104287808  PLA2G15; group XV phospholipase A2 [KO:K06129] [EC:3.1.1.5]
104288073  MEGF11; multiple epidermal growth factor-like domains protein 11 [KO:K24068]
104288405  ABCA1; ATP-binding cassette sub-family A member 1 [KO:K05641]
104288458  ITGB5; LOW QUALITY PROTEIN: integrin beta-5 [KO:K06588]
104288536  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
104288563  VPS8; vacuolar protein sorting-associated protein 8 homolog [KO:K20178]
104288617  STAB2; stabilin-2 [KO:K19013]
104288732  RAB17; ras-related protein Rab-17 [KO:K07909]
104288821  MFGE8; lactadherin [KO:K17253]
104289053  XKR6; XK-related protein 6 [KO:K26811]
104289083  VPS39; vam6/Vps39-like protein [KO:K20183]
104289233  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
104289254  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
104289282  IL10; interleukin-10 [KO:K05443]
104289289  RAB7B; ras-related protein Rab-7b [KO:K07898]
104289341  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
104289488  SLC16A1; monocarboxylate transporter 1 [KO:K08179]
104289554  PROS1; vitamin K-dependent protein S [KO:K03908]
104289713  CH25H; cholesterol 25-hydroxylase [KO:K10223] [EC:1.14.99.38]
104289796  LIPA; lysosomal acid lipase/cholesteryl ester hydrolase [KO:K01052] [EC:3.1.1.13]
104289798  [KO:K01052] [EC:3.1.1.13]
104289812  ALOX5; arachidonate 5-lipoxygenase [KO:K00461] [EC:1.13.11.34]
104289827  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
104289860  [KO:K01370] [EC:3.4.22.36]
104289902  RAB5A; ras-related protein Rab-5A isoform X1 [KO:K07887]
104290185  PPARD; peroxisome proliferator-activated receptor delta isoform X1 [KO:K04504]
104290293  CPT1A; carnitine O-palmitoyltransferase 1, liver isoform [KO:K08765] [EC:2.3.1.21]
104290372  [KO:K07299]
104290548  [KO:K07293] [EC:3.1.3.48]
104290593  MEGF10; multiple epidermal growth factor-like domains protein 10 isoform X1 [KO:K24068]
104290698  C1QC; complement C1q subcomponent subunit C [KO:K03988]
104290699  C1QB; complement C1q subcomponent subunit B [KO:K03987]
104290708  C1QA; complement C1q subcomponent subunit A [KO:K03986]
104290774  PPARG; peroxisome proliferator-activated receptor gamma [KO:K08530]
104290811  PQLC2; lysosomal amino acid transporter 1 homolog [KO:K23678]
104290947  GULP1; PTB domain-containing engulfment adapter protein 1 isoform X1 [KO:K23285]
104291002  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
104291018  ITGAV; integrin alpha-V [KO:K06487]
104291205  RAB7A; ras-related protein Rab-7a isoform X1 [KO:K07897]
104291384  ATP8A2; phospholipid-transporting ATPase IB [KO:K14802] [EC:7.6.2.1]
104291422  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
104291474  GPR132; probable G-protein coupled receptor 132 [KO:K08426]
104291718  P2RY2; P2Y purinoceptor 2 [KO:K04269]
104291719  P2RY6; P2Y purinoceptor 6 [KO:K04272]
104291916  HIF1A; LOW QUALITY PROTEIN: hypoxia-inducible factor 1-alpha [KO:K08268]
104291971  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
104291973  STAB1; stabilin-1 [KO:K19020]
104292272  [KO:K26935]
104292348  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
104292365  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
104292396  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
104292582  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
104292731  GAS6; growth arrest-specific protein 6 [KO:K05464]
104292739  ATP11A; probable phospholipid-transporting ATPase IH [KO:K26934]
104292831  RXRA; LOW QUALITY PROTEIN: retinoic acid receptor RXR-alpha [KO:K08524]
104292843  RAB14; ras-related protein Rab-14 [KO:K07881]
104292944  PTPN6; tyrosine-protein phosphatase non-receptor type 6 [KO:K05697] [EC:3.1.3.48]
104293120  CAMK2A; LOW QUALITY PROTEIN: calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
104293258  DOCK1; dedicator of cytokinesis protein 1 [KO:K13708]
104293271  [KO:K06834] [EC:3.4.24.-]
104293302  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
104293411  PBX1; pre-B-cell leukemia transcription factor 1 [KO:K09355]
104293456  BCAR1; breast cancer anti-estrogen resistance protein 1 [KO:K05726]
104293506  XKR8; XK-related protein 8 [KO:K26813]
104293572  ANO7; anoctamin-7 [KO:K19501]
104293690  CRKL; crk-like protein [KO:K04438]
104293738  ODC1; ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
104293745  ADAM17; disintegrin and metalloproteinase domain-containing protein 17 [KO:K06059] [EC:3.4.24.86]
104293871  [KO:K26936]
104293938  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
104293984  XKR7; LOW QUALITY PROTEIN: XK-related protein 7 [KO:K26811]
104294006  [KO:K06551]
104294007  [KO:K06551]
104294175  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
104294350  PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
104294389  BSG; basigin [KO:K06535]
104294417  SIRT1; LOW QUALITY PROTEIN: NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
104294480  [KO:K00411] [EC:7.1.1.8]
104294731  LRP1; LOW QUALITY PROTEIN: prolow-density lipoprotein receptor-related protein 1 [KO:K04550]
104294768  ANO4; anoctamin-4 [KO:K19499]
104294771  RAB5C; ras-related protein Rab-5C isoform X1 [KO:K07889]
104294828  CX3CL1; fractalkine [KO:K05508]
104294893  XKR9; XK-related protein 9 [KO:K26814]
104294973  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
104295083  PECAM1; LOW QUALITY PROTEIN: platelet endothelial cell adhesion molecule [KO:K06471]
104295299  CX3CR1; CX3C chemokine receptor 1 [KO:K04192]
104295380  [KO:K05853] [EC:7.2.2.10]
104295537  ATP11B; probable phospholipid-transporting ATPase IF [KO:K26934]
104295646  [KO:K06834] [EC:3.4.24.-]
104295852  NR1H3; oxysterols receptor LXR-alpha [KO:K08536]
104295880  TYRO3; tyrosine-protein kinase receptor TYRO3 [KO:K05116] [EC:2.7.10.1]
104295903  VPS18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
104295947  TMEM30A; cell cycle control protein 50A [KO:K26935]
Compound
C00002  ATP
C00003  NAD+
C00019  S-Adenosyl-L-methionine
C00031  D-Glucose
C00062  L-Arginine
C00073  L-Methionine
C00075  UTP
C00077  L-Ornithine
C00134  Putrescine
C00162  Fatty acid
C00186  (S)-Lactate
C00187  Cholesterol
C00584  Prostaglandin E2
C02530  Cholesterol ester
C02737  Phosphatidylserine
C04230  1-Acyl-sn-glycero-3-phosphocholine
C06124  Sphingosine 1-phosphate
C06314  Lipoxin A4
C15519  25-Hydroxycholesterol
C15610  Cholest-5-ene-3beta,26-diol
C18178  Resolvin D1
Reference
PMID:31822793
  Authors
Doran AC, Yurdagul A Jr, Tabas I
  Title
Efferocytosis in health and disease.
  Journal
Nat Rev Immunol 20:254-267 (2020)
DOI:10.1038/s41577-019-0240-6
Reference
PMID:36028471
  Authors
Zhang J, Ding W, Zhao M, Liu J, Xu Y, Wan J, Wang M
  Title
Mechanisms of efferocytosis in determining inflammation resolution: Therapeutic potential and the association with cardiovascular disease.
  Journal
Br J Pharmacol 179:5151-5171 (2022)
DOI:10.1111/bph.15939
Reference
PMID:30165442
  Authors
Kawano M, Nagata S
  Title
Efferocytosis and autoimmune disease.
  Journal
Int Immunol 30:551-558 (2018)
DOI:10.1093/intimm/dxy055
Reference
PMID:35650427
  Authors
Mehrotra P, Ravichandran KS
  Title
Drugging the efferocytosis process: concepts and opportunities.
  Journal
Nat Rev Drug Discov 21:601-620 (2022)
DOI:10.1038/s41573-022-00470-y
Reference
PMID:28496201
  Authors
Park SY, Kim IS
  Title
Engulfment signals and the phagocytic machinery for apoptotic cell clearance.
  Journal
Exp Mol Med 49:e331 (2017)
DOI:10.1038/emm.2017.52
Reference
PMID:28137963
  Authors
Kojima Y, Weissman IL, Leeper NJ
  Title
The Role of Efferocytosis in Atherosclerosis.
  Journal
Circulation 135:476-489 (2017)
DOI:10.1161/CIRCULATIONAHA.116.025684
Related
pathway
cvf00010  Glycolysis / Gluconeogenesis
cvf04140  Autophagy - animal
cvf04145  Phagosome
KO pathway
ko04148   

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