KEGG   PATHWAY: dre04060
Entry
dre04060                    Pathway                                
Name
Cytokine-cytokine receptor interaction - Danio rerio (zebrafish)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
dre04060  Cytokine-cytokine receptor interaction
dre04060

Organism
Danio rerio (zebrafish) [GN:dre]
Gene
100000764  ackr3a; atypical chemokine receptor 3a [KO:K04304]
100001424  ghrA; growth hormone receptor a precursor [KO:K05080]
100001799  il12b2; interleukin-12 subunit beta isoform X2 [KO:K05425]
100002479  epoB; erythropoietin b precursor [KO:K05437]
100002946  cxcl8a; growth-regulated alpha protein isoform X1 [KO:K10030]
100003167  ackr4a; atypical chemokine receptor 4 [KO:K04186]
100003859  cxcl8b.3; interleukin-8b.3 precursor [KO:K10030]
100003911  cxcl19; C-X-C motif chemokine 19 precursor [KO:K10030]
100004224  il19l; interleukin 19 like precursor [KO:K22667]
100004358  zmp:0000001127; interleukin-12 subunit alpha [KO:K05406]
100004455  epoA; erythropoietin isoform L2 precursor [KO:K05437]
100004617  csf1a; macrophage colony-stimulating factor 1a precursor [KO:K05453]
100004625  ccr11.1; LOW QUALITY PROTEIN: C-C chemokine receptor type 5 [KO:K04180]
100004988  ccr2; C-C chemokine receptor type 5 [KO:K04180]
100005027  [KO:K04180]
100005081  [KO:K04180]
100005924  [KO:K05164]
100006078  ccr9b; C-C chemokine receptor type 9 [KO:K04184]
100006301  [KO:K05163]
100006778  il6st; interleukin-6 receptor subunit beta isoform 1 precursor [KO:K05060]
100037357  tnfrsf1b; tumor necrosis factor receptor superfamily member 1B precursor [KO:K05141]
100126803  ifnphi3; interferon phi 3 precursor [KO:K05414]
100134935  csf3r; granulocyte colony-stimulating factor receptor precursor [KO:K05061]
100134971  il12rb2; interleukin-12 receptor subunit beta-2 [KO:K05064]
100134973  il7r; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072]
100134974  ebi3; interleukin-27 subunit beta precursor [KO:K24476]
100134976  il21r.1; interleukin 21 receptor, tandem duplicate 1 precursor [KO:K05075]
100135062  csf2rb; cytokine receptor common subunit beta precursor [KO:K04738]
100135755  il6r; interleukin-6 receptor subunit alpha precursor [KO:K05055]
100144554  il2rgb; interleukin 2 receptor, gamma b precursor [KO:K05070]
100144562  osmR; leukemia inhibitory factor receptor [KO:K05057]
100149404  tnfsf13; tumor necrosis factor ligand superfamily member 13 [KO:K05475]
100150203  il21; interleukin-21 precursor [KO:K05434]
100150233  lepA; leptin a precursor [KO:K05424]
100151629  tnfrsf9b; tumor necrosis factor receptor superfamily member 9b precursor [KO:K05146]
100174902  crfb16; interleukin-20 receptor subunit beta precursor [KO:K05137]
100188894  il4; interleukin-4 precursor [KO:K05430]
100189608  thpO; thrombopoietin precursor [KO:K06854]
100192217  ccl20a.3; C-C motif chemokine 20a.3 precursor [KO:K14625]
100270764  cd40; tumor necrosis factor receptor superfamily member 5 precursor [KO:K03160]
100329171  bmp16; bone morphogenetic protein 16 precursor [KO:K21283]
100329520  [KO:K22687]
100329796  xcr1b.1; chemokine XC receptor 1 [KO:K04193]
100331014  acvr2ab; activin receptor type-2A isoform X1 [KO:K04670] [EC:2.7.11.30]
100331105  acvr1c; activin receptor type-1C isoform X1 [KO:K13568] [EC:2.7.11.30]
100331351  il1rap; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
100331938  acvr2bb; activin receptor type-2B [KO:K13596] [EC:2.7.11.30]
100333821  tnfrsf11a; tumor necrosis factor receptor superfamily member 11A isoform X1 [KO:K05147]
100333914  ccl25a; C-C motif chemokine 25 [KO:K13072]
100334210  gdf5; growth/differentiation factor 5 isoform X1 [KO:K04664]
100534674  il16; pro-interleukin-16 isoform X2 [KO:K22628]
100535003  ngfra; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
100535903  tnfrsf14; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K05152]
100537421  cxcr5; LOW QUALITY PROTEIN: C-X-C chemokine receptor type 5 [KO:K04190]
100538314  il17rc; uncharacterized protein il17rc [KO:K05166]
100885851  il6; interleukin-6 precursor [KO:K05405]
101883301  il12rb1; interleukin-6 receptor subunit beta isoform X1 [KO:K05063]
101883597  xcr1b.2; chemokine XC receptor 1 [KO:K04193]
101883679  cxcl11.7; C-X-C motif chemokine 11-6 [KO:K12672]
101883994  cxcl-c13b; growth-regulated alpha protein [KO:K05416]
101884175  ccl20l; C-C motif chemokine 20 [KO:K14625]
101886252  il17rb; interleukin-17 receptor B [KO:K05165]
101886665  gdf15; growth/differentiation factor 15 [KO:K05504]
101886937  cxcl13; C-X-C motif chemokine 13 [KO:K10032]
101887111  [KO:K22687]
103911891  tnfrsf13b; tumor necrosis factor receptor superfamily member 13B [KO:K05150]
103911910  tnfrsf17; tumor necrosis factor receptor superfamily member 17 [KO:K05153]
108190761  [KO:K05477]
110438942  si:rp71-1c10.7; uncharacterized protein si:rp71-1c10.7 [KO:K05149]
110440027  [KO:K05168]
114447  cxcr4b; C-X-C chemokine receptor type 4b [KO:K04189]
137496783  [KO:K21283]
140619  admP; anti-dorsalizing morphogenic protein precursor [KO:K21283]
140747  cxcr4a; C-X-C chemokine receptor type 4a [KO:K04189]
30072  inhbaa; inhibin subunit beta Aa [KO:K04667]
30125  gdf3; protein DVR-1 precursor [KO:K22672]
30180  gdf6b; growth/differentiation factor 6-B precursor [KO:K20012]
30183  acvr1ba; activin A receptor type 1Ba precursor [KO:K13567] [EC:2.7.11.30]
30268  ccl27a; C-C motif chemokine 27a isoform 2 precursor [KO:K05513]
30270  ngfA; neurotrophin-7 precursor [KO:K02582]
30275  inhbb; inhibin beta B chain precursor [KO:K22687]
30457  acvr2ba; activin receptor type-2B precursor [KO:K13596] [EC:2.7.11.30]
30584  bmp7a; bone morphogenetic protein 7a precursor [KO:K16621]
30612  bmp4; bone morphogenetic protein 4 precursor [KO:K04662]
30615  acvr1l; activin receptor type-1 precursor [KO:K04675] [EC:2.7.11.30]
30631  bmp2a; bone morphogenetic protein 2 precursor [KO:K21283]
30632  bmp2b; bone morphogenetic protein 2b precursor [KO:K21283]
30642  gdf7; growth/differentiation factor 6-A [KO:K20013]
30739  tgfbr2b; TGF-beta receptor type-2 precursor [KO:K04388] [EC:2.7.11.30]
30742  bmpr1ba; bone morphogenetic protein receptor type-1B precursor [KO:K13578] [EC:2.7.11.30]
334010  il11ra; interleukin-11 receptor subunit alpha precursor [KO:K05056]
334183  bmp15; bone morphogenetic protein 15 precursor [KO:K05498]
336944  ccr6b; C-C chemokine receptor type 6 [KO:K04181]
338101  spaW; southpaw precursor [KO:K04666]
352944  cxcl12a; chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1) precursor [KO:K10031]
359834  tgfb1a; transforming growth factor, beta 1a isoform X1 [KO:K13375]
360134  ifnphi1; interferon phi 1 precursor [KO:K05414]
368326  il13ra2; interleukin-13 receptor subunit alpha-2 precursor [KO:K05077]
368438  cntfr; ciliary neurotrophic factor receptor subunit alpha precursor [KO:K05059]
369194  tgfb2; transforming growth factor beta-2 proprotein precursor [KO:K13376]
369195  tgfb3; transforming growth factor beta-3 proprotein precursor [KO:K13377]
373093  hdr; hematopoietic death receptor precursor [KO:K04722]
394026  bmp5; bone morphogenetic protein 5 precursor [KO:K04663]
404605  relT; tumor necrosis factor receptor superfamily member 19L precursor [KO:K05156]
405770  il1b; interleukin-1 beta isoform X2 [KO:K04519]
405785  tnfA; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
405790  ifng1; interferon gamma 1 precursor [KO:K04687]
406247  gdf11; growth/differentiation factor 11 precursor [KO:K22679]
406471  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A precursor [KO:K03158]
407639  gh1; somatotropin precursor [KO:K05438]
407649  il1rl1; interleukin-1 receptor-like 1 isoform X1 [KO:K05171]
407651  prlra; prolactin receptor a precursor [KO:K05081]
436866  tnfsf10; tumor necrosis factor ligand superfamily member 10 isoform 2 [KO:K04721]
445373  il12ba; interleukin 12Ba precursor isoform X1 [KO:K05425]
445381  mpl; thrombopoietin receptor precursor [KO:K05082]
445410  il12a; interleukin-12 subunit alpha precursor [KO:K05406]
445816  mstna; myostatin a precursor [KO:K05497]
447846  bmpr1ab; bone morphogenetic protein receptor, type IAb precursor [KO:K04673] [EC:2.7.11.30]
493624  amh; muellerian-inhibiting factor precursor [KO:K04665]
497643  gdf9; growth/differentiatio precursor [KO:K22673]
503761  bmp6; bone morphogenetic protein 6 precursor [KO:K16620]
541493  lifra; LIF receptor subunit alpha a precursor [KO:K05058]
553359  acvr2aa; activin receptor type-2A precursor [KO:K04670] [EC:2.7.11.30]
553366  ccr9a; C-C chemokine receptor type 9a isoform X1 [KO:K04184]
553500  xcr1a.1; chemokine (C motif) receptor 1a, duplicate 1 [KO:K04193]
553816  inhbab; inhibin subunit beta Ab precursor [KO:K04667]
553957  il10; interleukin-10 precursor [KO:K05443]
553959  il17a; interleukin 17a/f1 precursor [KO:K05494]
553960  il17c; interleukin-17C precursor [KO:K05491]
553961  il17d; interleukin-17D isoform X1 [KO:K05492]
553962  il17a; interleukin 17a/f3 precursor [KO:K05494]
553964  il22; interleukin-22 [KO:K05445]
554167  tnfB; tumor necrosis factor b (TNF superfamily, member 2) [KO:K05468]
555655  bmpr2b; bone morphogenetic protein receptor type-2 precursor [KO:K04671] [EC:2.7.11.30]
555717  m17; IL-6 subfamily cytokine M17 precursor [KO:K05420]
556728  il20ra; interleukin-20 receptor subunit alpha precursor [KO:K05136]
557567  bmp7b; bone morphogenetic protein 7b precursor [KO:K16621]
558616  ccr6a; C-C chemokine receptor type 6a [KO:K04181]
559222  acvr1bb; activin receptor type-1B isoform X2 [KO:K13567] [EC:2.7.11.30]
559723  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
559725  tnfrsf19; tumor necrosis factor receptor superfamily member 19 precursor [KO:K05155]
560193  il34; interleukin-34 precursor [KO:K22633]
560446  tgfbr2l; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
560578  tgfbr1a; TGF-beta receptor type-1a precursor [KO:K04674] [EC:2.7.11.30]
561050  ackr3b; atypical chemokine receptor 3b [KO:K04304]
561268  tnfsf13b; tumor necrosis factor ligand superfamily member 13B [KO:K05476]
561494  il17ra1a; interleukin 17 receptor A1a precursor [KO:K05164]
561963  bmp8a; bone morphogenetic protein 8A precursor [KO:K16622]
562247  clcf1; cardiotrophin-like cytokine factor 1 [KO:K05421]
562533  bmp10; bone morphogenetic protein 10 [KO:K22670]
562822  bmpr2a; bone morphogenetic protein receptor type-2a precursor [KO:K04671] [EC:2.7.11.30]
563003  gdf10a; growth/differentiation factor 10 [KO:K22674]
563152  ccl20b; C-C motif chemokine 20b precursor [KO:K14625]
563287  gdf2; growth/differentiation factor 2 preproprotein [KO:K05503]
563674  il4r.2; LOW QUALITY PROTEIN: uncharacterized protein il4r.2 [KO:K05071]
563884  tgfb1b; transforming growth factor beta-1 proprotein [KO:K13375]
563964  cxcl11.8; chemokine (C-X-C motif) ligand 11, duplicate 8 precursor [KO:K12672]
564338  ngfrb; nerve growth factor receptor b precursor [KO:K02583]
564348  lepB; leptin b precursor [KO:K05424]
564874  tnfrsf21; tumor necrosis factor receptor superfamily member 21 precursor [KO:K05157]
565104  lifrb; LIF receptor subunit alpha b precursor [KO:K05058]
565958  ccr7; C-C chemokine receptor type 7 precursor [KO:K04182]
566470  gdf6a; growth/differentiation factor 6-A precursor [KO:K20012]
567241  lepR; leptin receptor isoform X2 [KO:K05062]
567472  [KO:K22629]
567542  tnfsf12; tumor necrosis factor ligand superfamily member 12 [KO:K05474]
568405  csf1rb; macrophage colony-stimulating factor 1 receptor 1 isoform X1 [KO:K05090] [EC:2.7.10.1]
570404  il11a; interleukin-11 [KO:K05417]
570520  inhA; inhibin alpha chain precursor [KO:K05500]
571217  tnfrsf18; tumor necrosis factor receptor superfamily member 18 precursor [KO:K05154]
571368  ifngr1; interferon gamma receptor 1 precursor [KO:K05132]
571601  bmp10l; bone morphogenetic protein 10-like [KO:K22670]
572204  nradd; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
572522  smtla; somatolactin alpha precursor [KO:K05438]
58133  ngfB; nerve growth factor isoform 2 [KO:K02582]
58145  bmpr1aa; bone morphogenetic protein receptor, type IAa isoform X1 [KO:K04673] [EC:2.7.11.30]
58151  cxcl14; C-X-C motif chemokine 14 precursor [KO:K10033]
641390  ackr4b; atypical chemokine receptor 4b [KO:K04186]
64274  csf1ra; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
654692  cxcr3.1; C-X-C chemokine receptor type 3.1 [KO:K04188]
654826  il15; interleukin-15 [KO:K05433]
678542  rell2; RELT-like protein 2 isoform X1 [KO:K26541]
678622  tnfrsf9a; tumor necrosis factor receptor superfamily member 9a precursor [KO:K05146]
735295  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
751109  epoR; erythropoietin receptor precursor [KO:K05079]
751714  zgc:153631; uncharacterized protein LOC751714 isoform 1 [KO:K05152]
768248  fas; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
777653  crfb2; cytokine receptor family member b2 precursor [KO:K05131]
777717  bmp3; bone morphogenetic protein 3 precursor [KO:K05496]
791704  zgc:153759; uncharacterized protein LOC791704 precursor [KO:K05152]
791973  cxcr3.2; C-X-C chemokine receptor type 3-2 [KO:K04188]
792928  tgfbr1b; TGF-beta receptor type-1b precursor [KO:K04674] [EC:2.7.11.30]
793148  [KO:K04193]
793479  [KO:K04193]
793819  cd40lg; CD40 ligand [KO:K03161]
793920  il2rb; interleukin-2 receptor subunit beta precursor [KO:K05069]
794493  ifngr1l; growth/differentiation factor 10b precursor [KO:K05132]
794616  ccl27b; C-C motif chemokine 27b precursor [KO:K05513]
795469  ccl19b; C-C motif chemokine 19b precursor [KO:K05512]
795788  ccl25b; C-C motif chemokine 25b precursor [KO:K13072]
796370  edaR; tumor necrosis factor receptor superfamily member EDAR precursor [KO:K05162]
796604  il2rga; interleukin 2 receptor, gamma a precursor [KO:K05070]
796724  cxcr2; C-X-C chemokine receptor type 1 [KO:K05050]
797181  cxcr1; C-X-C chemokine receptor type 1 [KO:K05050]
797527  crfb4; cytokine receptor family member b4 precursor [KO:K05135]
797669  ccl39.6; C-C motif chemokine 22-like [KO:K12499]
798119  tnfsf14; tumor necrosis factor ligand superfamily member 14 [KO:K05477]
798191  [KO:K05152]
798441  mstnb; growth/differentiation factor 8 preproprotein [KO:K05497]
798740  eda; ectodysplasin-A [KO:K05480]
798892  cxcl11.1; C-X-C motif chemokine 11-1 precursor [KO:K12672]
799204  zmp:0000000936; interleukin-1 receptor type 1 [KO:K04386]
799279  il1rl2; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
799352  ndr1; nodal-related 1 precursor [KO:K04666]
799354  cxcl12b; chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1) precursor [KO:K10031]
799475  il13ra1; interleukin-13 receptor subunit alpha-1 precursor [KO:K05076]
799527  cxcr3.3; C-X-C chemokine receptor type 3.3 [KO:K04188]
799556  rell1; RELT-like protein 1 [KO:K26541]
799612  prl2; prolactin 2 precursor [KO:K05439]
799982  cd4-1; CD4-1 molecule precursor [KO:K06454]
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Reference
PMID:21106488
  Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
  Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
  Journal
Hum Genomics 5:30-55 (2010)
DOI:10.1186/1479-7364-5-1-30
Reference
PMID:27577879
  Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
  Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
  Journal
J Allergy Clin Immunol 138:984-1010 (2016)
DOI:10.1016/j.jaci.2016.06.033
Reference
PMID:15500860
  Authors
Boulanger MJ, Garcia KC
  Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
  Journal
Adv Protein Chem 68:107-46 (2004)
DOI:10.1016/S0065-3233(04)68004-1
Reference
PMID:16034365
  Authors
Allan SM, Tyrrell PJ, Rothwell NJ
  Title
Interleukin-1 and neuronal injury.
  Journal
Nat Rev Immunol 5:629-40 (2005)
DOI:10.1038/nri1664
Reference
PMID:23847622
  Authors
Lopetuso LR, Chowdhry S, Pizarro TT
  Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
  Journal
Front Immunol 4:181 (2013)
DOI:10.3389/fimmu.2013.00181
Reference
PMID:21349428
  Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
  Title
Functional specialization of interleukin-17 family members.
  Journal
Immunity 34:149-62 (2011)
DOI:10.1016/j.immuni.2011.02.012
Reference
PMID:17530315
  Authors
Fischer P, Hilfiker-Kleiner D
  Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
  Journal
Basic Res Cardiol 102:279-97 (2007)
DOI:10.1007/s00395-007-0658-z
Reference
PMID:24381786
  Authors
Richards CD
  Title
The enigmatic cytokine oncostatin m and roles in disease.
  Journal
ISRN Inflamm 2013:512103 (2013)
DOI:10.1155/2013/512103
Reference
PMID:18926762
  Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
  Title
Structures and biological functions of IL-31 and IL-31 receptors.
  Journal
Cytokine Growth Factor Rev 19:347-56 (2008)
DOI:10.1016/j.cytogfr.2008.08.003
Reference
PMID:21155715
  Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
  Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
  Journal
Biochem J 434:343-51 (2011)
DOI:10.1042/BJ20101628
Reference
PMID:22410872
  Authors
de Weerd NA, Nguyen T
  Title
The interferons and their receptors--distribution and regulation.
  Journal
Immunol Cell Biol 90:483-91 (2012)
DOI:10.1038/icb.2012.9
Reference
PMID:12949498
  Authors
Aggarwal BB
  Title
Signalling pathways of the TNF superfamily: a double-edged sword.
  Journal
Nat Rev Immunol 3:745-56 (2003)
DOI:10.1038/nri1184
Reference
PMID:12189384
  Authors
Ashkenazi A
  Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
  Journal
Nat Rev Cancer 2:420-30 (2002)
DOI:10.1038/nrc821
Reference
PMID:26115564
  Authors
Seeger P, Musso T, Sozzani S
  Title
The TGF-beta superfamily in dendritic cell biology.
  Journal
Cytokine Growth Factor Rev 26:647-57 (2015)
DOI:10.1016/j.cytogfr.2015.06.002
Reference
PMID:23612460
  Authors
Wakefield LM, Hill CS
  Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
  Journal
Nat Rev Cancer 13:328-41 (2013)
DOI:10.1038/nrc3500
Reference
PMID:22710174
  Authors
Mueller TD, Nickel J
  Title
Promiscuity and specificity in BMP receptor activation.
  Journal
FEBS Lett 586:1846-59 (2012)
DOI:10.1016/j.febslet.2012.02.043
KO pathway
ko04060   

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