KEGG   PATHWAY: lcat05012
Entry
lcat05012                   Pathway                                
Name
Parkinson disease - Lemur catta (Ring-tailed lemur)
Description
Parkinson disease (PD) is a progressive neurodegenerative movement disorder that results primarily from the death of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc). Both environmental factors and mutations in familial PD-linked genes such as SNCA, Parkin, DJ-1, PINK1 and LRRK2 are associated with PD pathogenesis. These pathogenic mutations and environmental factors are known to cause disease due to oxidative stress, intracellular Ca2+ homeostasis impairment, mitochondrial dysfunctions and altered protein handling compromising key roles of DA neuronal function and survival. The demise of DA neurons located in the SNc leads to a drop in the dopaminergic input to the striatum, which is hypothesized to impede movement by inducing hypo and hyper activity in striatal spiny projection neurons (SPNs) of the direct (dSPNs) and indirect (iSPNs) pathways in the basal ganglia, respectively.
Class
Human Diseases; Neurodegenerative disease
Pathway map
lcat05012  Parkinson disease
lcat05012

Disease
H00057  Parkinson disease
Organism
Lemur catta (Ring-tailed lemur) [GN:lcat]
Gene
123620171  [KO:K08738]
123620193  SLC39A11; zinc transporter ZIP11 isoform X1 [KO:K14717]
123620321  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
123620478  PSMB5; proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
123620525  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
123620566  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
123620597  PSMC5; 26S proteasome regulatory subunit 8 isoform X1 [KO:K03066]
123620626  UBE2G1; ubiquitin-conjugating enzyme E2 G1 [KO:K10575] [EC:2.3.2.23]
123620754  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
123620810  PSMB3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
123620852  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
123621075  UBB; polyubiquitin-B [KO:K08770]
123621235  PSMB6; proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
123621243  SLC39A2; zinc transporter ZIP2 isoform X1 [KO:K14709]
123621470  [KO:K02138]
123621509  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
123621547  PSMA8; proteasome subunit alpha-type 8 isoform X1 [KO:K02731] [EC:3.4.25.1]
123621590  [KO:K03948]
123621756  SLC39A6; zinc transporter ZIP6 isoform X1 [KO:K14712]
123621799  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
123621824  TUBB6; tubulin beta-6 chain [KO:K07375]
123621827  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
123621881  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
123621919  [KO:K02271]
123622308  [KO:K04632]
123622310  [KO:K04632]
123622324  TUBB1; tubulin beta-1 chain [KO:K07375]
123622325  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
123622513  ADRM1; proteasomal ubiquitin receptor ADRM1 isoform X1 [KO:K06691]
123622686  PSMA7; proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
123622735  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
123622846  BCL2L1; bcl-2-like protein 1 [KO:K04570]
123622847  [KO:K02263]
123623035  CALML3; calmodulin-like protein 3 [KO:K02183]
123623036  CALML5; calmodulin-like protein 5 [KO:K02183]
123623040  TUBAL3; LOW QUALITY PROTEIN: tubulin alpha chain-like 3 [KO:K07374]
123623141  DRD1; D(1A) dopamine receptor [KO:K04144]
123623249  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
123623259  UBA7; ubiquitin-like modifier-activating enzyme 7 isoform X1 [KO:K10698] [EC:6.2.1.45]
123623309  [KO:K00414]
123623513  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
123623574  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
123623846  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
123623919  CALM3; calmodulin-3 [KO:K02183]
123623959  KLC3; kinesin light chain 3 isoform X1 [KO:K10407]
123624121  UCHL1; ubiquitin carboxyl-terminal hydrolase isozyme L1 isoform X1 [KO:K05611] [EC:3.4.19.12]
123624236  [KO:K02128]
123624263  [KO:K02271]
123624276  [KO:K00411] [EC:7.1.1.8]
123624327  PSMC4; 26S proteasome regulatory subunit 6B [KO:K03063]
123624378  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
123624433  [KO:K02270]
123624463  [KO:K02264]
123624466  [KO:K02267]
123624573  [KO:K02738] [EC:3.4.25.1]
123624681  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
123624699  [KO:K02267]
123625148  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
123625340  [KO:K02263]
123625701  ADORA2A; LOW QUALITY PROTEIN: adenosine receptor A2a [KO:K04266]
123625720  SLC39A12; zinc transporter ZIP12 isoform X1 [KO:K14718]
123625801  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
123625824  [KO:K00419]
123625931  [KO:K02266]
123626088  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 [KO:K06693]
123626142  UBC; polyubiquitin-C [KO:K08770]
123626156  [KO:K07374]
123626236  UBE2L3; ubiquitin-conjugating enzyme E2 L3 isoform X1 [KO:K04552] [EC:2.3.2.23]
123626246  [KO:K07374]
123626259  SEPTIN5; septin-5 isoform X1 [KO:K04557]
123626307  [KO:K03940] [EC:7.1.1.2]
123626346  SLC18A1; chromaffin granule amine transporter isoform X1 [KO:K08155]
123626478  SLC39A14; metal cation symporter ZIP14 isoform X1 [KO:K14720]
123626606  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
123626873  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
123626964  [KO:K07374]
123627044  [KO:K00415]
123627205  SLC39A8; metal cation symporter ZIP8 isoform X1 [KO:K14714]
123627295  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
123627330  SNCA; alpha-synuclein [KO:K04528]
123627700  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
123627957  [KO:K02268]
123628005  [KO:K02977]
123628071  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
123628096  [KO:K02977]
123628647  UBA1; ubiquitin-like modifier-activating enzyme 1 [KO:K03178] [EC:6.2.1.45]
123628649  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
123628780  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
123628789  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
123629090  [KO:K03178] [EC:6.2.1.45]
123629091  [KO:K03178] [EC:6.2.1.45]
123629092  [KO:K03178] [EC:6.2.1.45]
123629093  [KO:K03178] [EC:6.2.1.45]
123630171  [KO:K02127]
123630283  MFN1; mitofusin-1 [KO:K21356] [EC:3.6.5.-]
123630288  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
123630330  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
123630472  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
123630502  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
123630658  ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
123630679  SOD1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
123630707  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
123630777  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
123630815  UBE2G2; ubiquitin-conjugating enzyme E2 G2 [KO:K04555] [EC:2.3.2.23]
123631474  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
123631545  [KO:K03938]
123631550  [KO:K03671]
123631697  TUBB; tubulin beta chain [KO:K07375]
123631742  [KO:K03947]
123631755  CALML4; calmodulin-like protein 4 [KO:K02183]
123631818  SLC39A7; zinc transporter SLC39A7 [KO:K14713]
123631832  DAXX; death domain-associated protein 6 [KO:K02308]
123631901  KLC4; kinesin light chain 4 isoform X1 [KO:K10407]
123631926  PSMA4; proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
123632315  TRAP1; heat shock protein 75 kDa, mitochondrial [KO:K09488]
123632466  [KO:K00415]
123632485  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
123632685  [KO:K02266]
123632797  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940] [EC:7.1.1.2]
123632820  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
123632845  ATP5F1D; ATP synthase subunit delta, mitochondrial [KO:K02134]
123632873  [KO:K00420]
123632875  RYR3; ryanodine receptor 3 [KO:K04963]
123633005  [KO:K02270]
123633065  UBE2J1; ubiquitin-conjugating enzyme E2 J1 isoform X1 [KO:K10578] [EC:2.3.2.23]
123633202  SLC39A3; zinc transporter ZIP3 [KO:K14709]
123633303  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
123633420  [KO:K03960]
123633441  PRKN; E3 ubiquitin-protein ligase parkin [KO:K04556] [EC:2.3.2.31]
123633473  PSMB1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
123633935  [KO:K02977]
123633966  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
123633975  PSMB4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
123634007  SLC39A1; zinc transporter ZIP1 [KO:K14709]
123634125  [KO:K03963]
123634180  [KO:K00416]
123634265  KEAP1; kelch-like ECH-associated protein 1 [KO:K10456]
123634464  MFN2; mitofusin-2 [KO:K06030] [EC:3.6.5.-]
123634530  PARK7; Parkinson disease protein 7 [KO:K05687] [EC:3.5.1.124]
123634820  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha [KO:K09054]
123634905  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
123634994  PSMA5; proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
123635002  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
123635033  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial isoform X1 [KO:K02127]
123635220  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
123635226  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
123635431  [KO:K02927]
123635476  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
123635558  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 isoform X1 [KO:K03951]
123635659  [KO:K03948]
123635724  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
123635781  PSMB2; proteasome subunit beta type-2 [KO:K02734] [EC:3.4.25.1]
123635888  PINK1; serine/threonine-protein kinase PINK1, mitochondrial [KO:K05688] [EC:2.7.11.1]
123635928  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
123635958  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
123635959  TUBB4A; tubulin beta-4A chain [KO:K07375]
123636026  UBE2J2; ubiquitin-conjugating enzyme E2 J2 isoform X1 [KO:K04554] [EC:2.3.2.23]
123636458  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
123636681  [KO:K02183]
123636840  [KO:K02270]
123636893  CALM2; calmodulin-2 [KO:K02183]
123636925  RPS27A; ubiquitin-40S ribosomal protein S27a [KO:K02977]
123636997  [KO:K03963]
123637092  HTRA2; serine protease HTRA2, mitochondrial [KO:K08669] [EC:3.4.21.108]
123637156  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
123637222  [KO:K02265]
123637477  [KO:K00274] [EC:1.4.3.4]
123637707  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
123637748  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
123637759  [KO:K00418]
123637772  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
123637866  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
123637869  [KO:K03963]
123637948  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
123638028  [KO:K08738]
123638072  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
123638078  [KO:K00416]
123638178  TUBB2A; tubulin beta-2A chain [KO:K07375]
123638179  [KO:K07375]
123638197  [KO:K08738]
123638210  [KO:K03948]
123638412  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
123638560  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
123638639  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
123638644  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
123638661  UBA52; ubiquitin-60S ribosomal protein L40 [KO:K02927]
123638764  [KO:K07375]
123639308  TXN2; thioredoxin, mitochondrial [KO:K03671]
123639404  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
123639435  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
123639600  KIF5A; kinesin heavy chain isoform X1 [KO:K10396] [EC:5.6.1.3]
123639606  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
123639613  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
123639636  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
123639645  [KO:K03957]
123639654  SLC39A5; zinc transporter ZIP5 isoform X1 [KO:K14711]
123639755  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
123639854  LRRK2; leucine-rich repeat serine/threonine-protein kinase 2 [KO:K08844] [EC:2.7.11.1]
123639891  KIF5B; kinesin-1 heavy chain [KO:K10396] [EC:5.6.1.3]
123639915  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
123639916  [KO:K08738]
123640141  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
123640169  TUBA8; tubulin alpha-8 chain [KO:K07374]
123640204  [KO:K02268]
123640284  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
123640339  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
123640372  [KO:K21398]
123640373  [KO:K21398]
123640420  TUBA1C; tubulin alpha-1C chain [KO:K07374]
123640422  [KO:K07374]
123640424  [KO:K07374]
123640642  [KO:K02268]
123640722  [KO:K05687] [EC:3.5.1.124]
123641447  [KO:K02273]
123641584  [KO:K02268]
123641670  DRD2; D(2) dopamine receptor isoform X1 [KO:K04145]
123641691  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
123642293  [KO:K03968]
123642474  PSMA1; proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
123642676  SLC39A13; zinc transporter ZIP13 [KO:K14719]
123642678  PSMC3; LOW QUALITY PROTEIN: 26S proteasome regulatory subunit 6A [KO:K03065]
123642684  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
123642703  UBE2L6; ubiquitin/ISG15-conjugating enzyme E2 L6 [KO:K04553] [EC:2.3.2.23]
123642737  [KO:K03945]
123642823  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
123642832  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
123642897  KLC2; kinesin light chain 2 isoform X1 [KO:K10407]
123642916  TH; tyrosine 3-monooxygenase isoform X1 [KO:K00501] [EC:1.14.16.2]
123642988  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
123643282  [KO:K00274] [EC:1.4.3.4]
123643313  KIF5C; kinesin heavy chain [KO:K10396] [EC:5.6.1.3]
123643440  SLC39A10; zinc transporter ZIP10 [KO:K14716]
123643524  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
123643576  [KO:K00417]
123643690  [KO:K08738]
123643743  NFE2L2; nuclear factor erythroid 2-related factor 2 isoform X1 [KO:K05638]
123643857  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
123643900  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
123643954  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
123643962  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
123643981  TUBA4A; tubulin alpha-4A chain [KO:K07374]
123644027  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
123644088  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
123644332  [KO:K02268]
123644357  [KO:K03959]
123644439  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
123644528  [KO:K00417]
123644587  [KO:K00417]
123644675  [KO:K02268]
123644856  SLC39A4; zinc transporter ZIP4 isoform X1 [KO:K14710]
123644875  [KO:K00413]
123645117  [KO:K02273]
123645245  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 isoform X1 [KO:K03957]
123645426  [KO:K08738]
123645611  CALM1; calmodulin-1 [KO:K02183]
123645645  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
123645738  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
123645993  TUBB4B; tubulin beta-4B chain [KO:K07375]
123646230  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
123646300  PSMB7; proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
123646315  HSPA5; endoplasmic reticulum chaperone BiP [KO:K09490] [EC:5.6.1.10]
123646445  [KO:K03945]
123646605  TXN; thioredoxin [KO:K03671]
123646853  SEM1; 26S proteasome complex subunit SEM1 isoform X1 [KO:K10881]
123647075  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
123647112  [KO:K04555] [EC:2.3.2.23]
123647150  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
123647253  [KO:K02272]
123647359  [KO:K08738]
123647432  SLC39A9; zinc transporter ZIP9 [KO:K14715]
123647452  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
123647466  PSMA2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
123647608  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
123647646  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
123647696  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
123647735  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
123647781  GPR37; prosaposin receptor GPR37 [KO:K04243]
123648018  SLC6A3; sodium-dependent dopamine transporter [KO:K05036]
123648042  [KO:K04558]
123648206  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial isoform X1 [KO:K03939]
123648345  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
123648626  PSMA3; proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
123648630  [KO:K02272]
123648644  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
123648852  [KO:K00274] [EC:1.4.3.4]
123649129  PSMC6; 26S proteasome regulatory subunit 10B [KO:K03064]
123649674  [KO:K02927]
123649962  [KO:K02135]
123650126  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial isoform X1 [KO:K03964]
123650135  PSMA6; proteasome subunit alpha type-6 [KO:K02730] [EC:3.4.25.1]
123650270  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
123650285  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
123650352  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
123650367  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
123650462  SLC18A2; synaptic vesicular amine transporter [KO:K08155]
123650465  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
123650585  [KO:K08738]
123650594  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
123650775  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
123650900  TP53; cellular tumor antigen p53 [KO:K04451]
68929161  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
68929162  COX3; cytochrome c oxidase subunit III [KO:K02262]
68929165  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
68929167  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
68929174  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
68929177  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
68929182  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
68929184  COX2; cytochrome c oxidase subunit II [KO:K02261]
68929185  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
68929186  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
68929187  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
68929190  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
68929191  CYTB; cytochrome b [KO:K00412]
Compound
C00002  ATP
C00007  Oxygen
C00008  ADP
C00009  Orthophosphate
C00013  Diphosphate
C00020  AMP
C00027  Hydrogen peroxide
C00034  Manganese
C00076  Calcium cation
C00082  L-Tyrosine
C00165  Diacylglycerol
C00212  Adenosine
C00355  3,4-Dihydroxy-L-phenylalanine
C00575  3',5'-Cyclic AMP
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C03758  Dopamine
C04043  3,4-Dihydroxyphenylacetaldehyde
C04599  1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
C07593  Rotenone
C11310  1-Methyl-4-phenylpyridinium
C14701  Paraquat
C15231  Maneb
C16844  Hydroxyl radical
C17755  Dopamine quinone
C22381  Reactive oxygen species
Reference
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  Title
Expanding insights of mitochondrial dysfunction in Parkinson's disease.
  Journal
Nat Rev Neurosci 7:207-19 (2006)
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Reference
PMID:12938733
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Lim KL, Lim TM
  Title
Molecular mechanisms of neurodegeneration in Parkinson's disease: clues from Mendelian syndromes.
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Reference
PMID:26501339
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Bobela W, Aebischer P, Schneider BL
  Title
Alphalpha-Synuclein as a Mediator in the Interplay between Aging and Parkinson's Disease.
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Biomolecules 5:2675-700 (2015)
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Reference
PMID:15767499
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Reference
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Mov Disord 21:1806-23 (2006)
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Reference
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Lim KL, Tan JM
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BMC Biochem 8 Suppl 1:S13 (2007)
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Reference
PMID:29090092
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  Title
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Transl Neurodegener 6:28 (2017)
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Reference
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  Title
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Neuropharmacology 45:1-13 (2003)
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Reference
PMID:20495568
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  Journal
Nat Med 16:653-61 (2010)
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Reference
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Reference
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  Authors
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Trends Mol Med 15:89-100 (2009)
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Reference
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  Title
The role of Ca(2+) signaling in Parkinson's disease.
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Dis Model Mech 10:519-535 (2017)
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Reference
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  Title
Mitochondrial calcium imbalance in Parkinson's disease.
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Neurosci Lett 663:86-90 (2018)
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Reference
PMID:19663908
  Authors
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  Title
Parkin deficiency disrupts calcium homeostasis by modulating phospholipase C signalling.
  Journal
FEBS J 276:5041-52 (2009)
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Reference
PMID:23352769
  Authors
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  Title
An ERcentric view of Parkinson's disease.
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Trends Mol Med 19:165-75 (2013)
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Reference
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  Authors
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  Title
ER stress and Parkinson's disease: Pathological inputs that converge into the secretory pathway.
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Brain Res 1648:626-632 (2016)
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Reference
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  Title
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Eur J Pharmacol 765:154-6 (2015)
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Reference
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Shah A, Chao J, Legido-Quigley C, Chang RC
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Oxyresveratrol exerts ATF4- and Grp78-mediated neuroprotection against endoplasmic reticulum stress in experimental Parkinson's disease.
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Nutr Neurosci 1-16 (2019)
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Reference
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Protective and toxic roles of dopamine in Parkinson's disease.
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J Neurochem 129:898-915 (2014)
DOI:10.1111/jnc.12686
Reference
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  Authors
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  Title
The interplay between parkin and alpha-synuclein; possible implications for the pathogenesis of Parkinson's disease.
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Reference
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A new mechanism for protection of dopaminergic neurons mediated by astrocytes.
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Neural Regen Res 10:1225-7 (2015)
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Reference
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Reference
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Melatoninergic System in Parkinson's Disease: From Neuroprotection to the Management of Motor and Nonmotor Symptoms.
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Oxid Med Cell Longev 2016:3472032 (2016)
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Reference
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The Parkinson Disease Mitochondrial Hypothesis: Where Are We at?
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Reference
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Mol Cell Neurosci 55:37-43 (2013)
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Reference
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Biochim Biophys Acta 1813:623-33 (2011)
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Reference
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Neuron 85:257-73 (2015)
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Reference
PMID:27911343
  Authors
Truban D, Hou X, Caulfield TR, Fiesel FC, Springer W
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PINK1, Parkin, and Mitochondrial Quality Control: What can we Learn about Parkinson's Disease Pathobiology?
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J Parkinsons Dis 7:13-29 (2017)
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Reference
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Biosa A, Sandrelli F, Beltramini M, Greggio E, Bubacco L, Bisaglia M
  Title
Recent findings on the physiological function of DJ-1: Beyond Parkinson's disease.
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Neurobiol Dis 108:65-72 (2017)
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Reference
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Reference
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Role of DJ-1 in the mechanism of pathogenesis of Parkinson's disease.
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J Bioenerg Biomembr 51:175-188 (2019)
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Reference
PMID:30370500
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Melo TQ, Copray SJCVM, Ferrari MFR
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Alpha-Synuclein Toxicity on Protein Quality Control, Mitochondria and Endoplasmic Reticulum.
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Neurochem Res 43:2212-2223 (2018)
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Reference
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J Neural Transm (Vienna) 126:411-422 (2019)
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Reference
PMID:29720658
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Diametric neural ensemble dynamics in parkinsonian and dyskinetic states.
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Nature 557:177-182 (2018)
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Related
pathway
lcat00190  Oxidative phosphorylation
lcat00350  Tyrosine metabolism
lcat03050  Proteasome
lcat04020  Calcium signaling pathway
lcat04120  Ubiquitin mediated proteolysis
lcat04137  Mitophagy - animal
lcat04141  Protein processing in endoplasmic reticulum
lcat04210  Apoptosis
lcat04728  Dopaminergic synapse
KO pathway
ko05012   

DBGET integrated database retrieval system