KEGG   PATHWAY: mcc05146
Entry
mcc05146                    Pathway                                
Name
Amoebiasis - Macaca mulatta (rhesus monkey)
Description
Entamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis of amoebiasis begins with parasite attachment and disruption of the intestinal mucus layer, followed by apoptosis of host epithelial cells. Intestinal tissue destruction causes severe dysentery and ulcerations in amoebic colitis. Several amoebic proteins such as lectins, cysteine proteineases, and amoebapores are associated with the invasion process. The parasite can cause extraintestinal infection like amoebic liver abscess by evading immune response.
Class
Human Diseases; Infectious disease: parasitic
Pathway map
mcc05146  Amoebiasis
mcc05146

Disease
H00360  Amoebiasis
Organism
Macaca mulatta (rhesus monkey) [GN:mcc]
Gene
100424064  [KO:K05505]
100424899  [KO:K04632]
100429807  COL4A2; collagen alpha-2(IV) chain isoform X1 [KO:K06237]
100430164  SERPINB10; serpin B10 [KO:K13963]
100430603  LAMA5; laminin subunit alpha-5 [KO:K06240]
106992315  TGFB1; transforming growth factor beta-1 proprotein isoform X2 [KO:K13375]
106994543  [KO:K13963]
106996003  [KO:K06856]
106999628  [KO:K06856]
114673005  [KO:K13241] [EC:1.14.13.39]
114673806  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
114675805  [KO:K06856]
114679736  [KO:K06856]
574131  COL3A1; collagen alpha-1(III) chain precursor [KO:K19720]
574201  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
574222  CXCL1; growth-regulated alpha protein precursor [KO:K05505]
574223  CXCL3; C-X-C motif chemokine 3 precursor [KO:K05505]
574282  IFNG; interferon gamma precursor [KO:K04687]
574290  TLR2; toll-like receptor 2 precursor [KO:K10159]
574360  TLR4; toll-like receptor 4 precursor [KO:K10160]
574371  CSF2; granulocyte-macrophage colony-stimulating factor precursor [KO:K05427]
613028  CXCL8; interleukin-8 precursor [KO:K10030]
613268  CD1D; antigen-presenting glycoprotein CD1d precursor [KO:K06448]
613269  FN1; fibronectin isoform X1 [KO:K05717]
693666  ACTN4; alpha-actinin-4 [KO:K05699]
694223  C9; complement component C9 [KO:K04000]
694289  [KO:K04632]
694473  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
694747  IL12B; interleukin-12 subunit beta precursor [KO:K05425]
694931  IL10; interleukin-10 precursor [KO:K05443]
696685  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
697230  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
697383  RAB7B; ras-related protein Rab-7b [KO:K07898]
697482  CD14; monocyte differentiation antigen CD14 precursor [KO:K04391]
697712  RAB5A; ras-related protein Rab-5A [KO:K07887]
698438  CD1A; T-cell surface glycoprotein CD1a precursor [KO:K06448]
698996  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
700281  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
700359  COL1A2; collagen alpha-2(I) chain precursor [KO:K06236]
700634  PTK2; focal adhesion kinase 1 isoform X8 [KO:K05725] [EC:2.7.10.2]
700652  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
701078  SERPINB13; serpin B13 isoform X1 [KO:K13963]
701195  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
701313  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
701315  [KO:K13963]
701951  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
702046  [KO:K13963]
702067  [KO:K05505]
702111  LAMB1; laminin subunit beta-1 isoform X2 [KO:K05636]
702225  LAMB4; laminin subunit beta-4 isoform X1 [KO:K06245]
703205  IL12A; interleukin-12 subunit alpha [KO:K05406]
703239  TGFB3; transforming growth factor beta-3 precursor [KO:K13377]
703390  [KO:K05505]
703707  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
703814  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
704701  IL1B; interleukin-1 beta precursor [KO:K04519]
705448  GNA14; guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
705680  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
705819  IL6; interleukin-6 precursor [KO:K05405]
706142  PRDX1; peroxiredoxin-1 [KO:K13279] [EC:1.11.1.24]
706921  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
707280  RAB7A; ras-related protein Rab-7a [KO:K07897]
707310  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
707540  TGFB2; transforming growth factor beta-2 precursor [KO:K13376]
707580  SERPINB9; serpin B9 [KO:K13963]
707892  LAMB2; laminin subunit beta-2 precursor [KO:K06243]
708287  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
708347  RAB5B; ras-related protein Rab-5B [KO:K07888]
709286  [KO:K06448]
709308  RAB5C; ras-related protein Rab-5C [KO:K07889]
709728  PRKACB; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
709959  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
710324  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
710410  ARG1; arginase-1 [KO:K01476] [EC:3.5.3.1]
710552  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
710577  ITGB2; integrin beta-2 isoform X1 [KO:K06464]
711033  ARG2; arginase-2, mitochondrial [KO:K01476] [EC:3.5.3.1]
711638  IL1R2; interleukin-1 receptor type 2 precursor [KO:K04387]
711726  IL1R1; interleukin-1 receptor type 1 [KO:K04386]
711994  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
712444  COL4A3; collagen alpha-3(IV) chain isoform X1 [KO:K06237]
714419  [KO:K06856]
714832  ITGAM; integrin alpha-M isoform X3 [KO:K06461]
715212  LAMC2; laminin subunit gamma-2 [KO:K06246]
715265  LAMC1; laminin subunit gamma-1 [KO:K05635]
715394  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
715467  TNF; tumor necrosis factor [KO:K03156]
715615  HSPB1; heat shock protein beta-1 [KO:K04455]
715919  RELA; transcription factor p65 isoform X1 [KO:K04735]
716098  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
716114  C8A; complement component C8 alpha chain [KO:K03997]
716155  C8B; complement component C8 beta chain isoform X1 [KO:K03998]
716411  SERPINB6; serpin B6 [KO:K13963]
716440  CTSG; cathepsin G [KO:K01319] [EC:3.4.21.20]
717148  CD1C; T-cell surface glycoprotein CD1c precursor [KO:K06448]
717764  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
718387  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
718412  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
718418  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X3 [KO:K05858] [EC:3.1.4.11]
718632  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
718955  CD1B; T-cell surface glycoprotein CD1b precursor [KO:K06448]
718968  CD1E; T-cell surface glycoprotein CD1e, membrane-associated precursor [KO:K06448]
719367  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
720263  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
720452  [KO:K06856]
720903  MUC2; mucin-2 [KO:K10955]
720904  [KO:K06856]
720935  [KO:K06856]
720945  LAMB3; laminin subunit beta-3 isoform X1 [KO:K06244]
720985  [KO:K06856]
721002  [KO:K06856]
721083  [KO:K06856]
721647  C8G; complement component C8 gamma chain [KO:K03999]
721649  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
721669  GNA15; guanine nucleotide-binding protein subunit alpha-15 [KO:K04637]
721921  VCL; vinculin isoform X1 [KO:K05700]
722278  [KO:K06856]
722430  LAMC3; laminin subunit gamma-3 [KO:K06247]
722472  LAMA1; LOW QUALITY PROTEIN: laminin subunit alpha-1 [KO:K05637]
Compound
C00027  Hydrogen peroxide
C00062  L-Arginine
C00076  Calcium cation
C00165  Diacylglycerol
C00219  Arachidonate
C00533  Nitric oxide
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C01074  N-Acetylgalactosamine
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01498  Gelatine
C02737  Phosphatidylserine
C18287  Monocyte locomotion inhibitory factor
Reference
PMID:11378035
  Authors
Stanley SL
  Title
Pathophysiology of amoebiasis.
  Journal
Trends Parasitol 17:280-5 (2001)
DOI:10.1016/S1471-4922(01)01903-1
Reference
PMID:10756002
  Authors
Espinosa-Cantellano M, Martinez-Palomo A
  Title
Pathogenesis of intestinal amebiasis: from molecules to disease.
  Journal
Clin Microbiol Rev 13:318-31 (2000)
DOI:10.1128/CMR.13.2.318-331.2000
Reference
PMID:9832261
  Authors
Huston CD, Petri WA Jr
  Title
Host-pathogen interaction in amebiasis and progress in vaccine development.
  Journal
Eur J Clin Microbiol Infect Dis 17:601-14 (1998)
DOI:10.1007/BF01708342
Reference
PMID:14700586
  Authors
Huston CD
  Title
Parasite and host contributions to the pathogenesis of amebic colitis.
  Journal
Trends Parasitol 20:23-6 (2004)
DOI:10.1016/j.pt.2003.10.013
Reference
PMID:15813717
  Authors
Campos-Rodriguezp R, Jarillo-Luna A
  Title
The pathogenicity of Entamoeba histolytica is related to the capacity of evading innate immunity.
  Journal
Parasite Immunol 27:1-8 (2005)
DOI:10.1111/j.1365-3024.2005.00743.x
Reference
PMID:19207103
  Authors
Lejeune M, Rybicka JM, Chadee K
  Title
Recent discoveries in the pathogenesis and immune response toward Entamoeba histolytica.
  Journal
Future Microbiol 4:105-18 (2009)
DOI:10.2217/17460913.4.1.105
Reference
PMID:17576362
  Authors
Carrero JC, Cervantes-Rebolledo C, Aguilar-Diaz H, Diaz-Gallardo MY, Laclette JP, Morales-Montor J
  Title
The role of the secretory immune response in the infection by Entamoeba histolytica.
  Journal
Parasite Immunol 29:331-8 (2007)
DOI:10.1111/j.1365-3024.2007.00955.x
Reference
PMID:12660071
  Authors
Stanley SL Jr
  Title
Amoebiasis.
  Journal
Lancet 361:1025-34 (2003)
DOI:10.1016/S0140-6736(03)12830-9
Reference
PMID:14502002
  Authors
Stauffer W, Ravdin JI
  Title
Entamoeba histolytica: an update.
  Journal
Curr Opin Infect Dis 16:479-85 (2003)
DOI:10.1097/01.qco.0000092821.42392.ca
Reference
PMID:12142490
  Authors
Petri WA Jr, Haque R, Mann BJ
  Title
The bittersweet interface of parasite and host: lectin-carbohydrate interactions during human invasion by the parasite Entamoeba histolytica.
  Journal
Annu Rev Microbiol 56:39-64 (2002)
DOI:10.1146/annurev.micro.56.012302.160959
Reference
PMID:18725798
  Authors
Baxt LA, Singh U
  Title
New insights into Entamoeba histolytica pathogenesis.
  Journal
Curr Opin Infect Dis 21:489-94 (2008)
DOI:10.1097/QCO.0b013e32830ce75f
Reference
PMID:12160867
  Authors
Petri WA Jr
  Title
Pathogenesis of amebiasis.
  Journal
Curr Opin Microbiol 5:443-7 (2002)
DOI:10.1016/S1369-5274(02)00335-1
Reference
PMID:17702556
  Authors
Guo X, Houpt E, Petri WA Jr
  Title
Crosstalk at the initial encounter: interplay between host defense and ameba survival strategies.
  Journal
Curr Opin Immunol 19:376-84 (2007)
DOI:10.1016/j.coi.2007.07.005
Reference
PMID:20303955
  Authors
Mortimer L, Chadee K
  Title
The immunopathogenesis of Entamoeba histolytica.
  Journal
Exp Parasitol 126:366-80 (2010)
DOI:10.1016/j.exppara.2010.03.005
Reference
PMID:16380324
  Authors
Meza I, Talamas-Rohana P, Vargas MA
  Title
The cytoskeleton of Entamoeba histolytica: structure, function, and regulation by signaling pathways.
  Journal
Arch Med Res 37:234-43 (2006)
DOI:10.1016/j.arcmed.2005.09.008
Reference
PMID:10637584
  Authors
Meza I
  Title
Extracellular matrix-induced signaling in Entamoeba histolytica: its role in invasiveness.
  Journal
Parasitol Today 16:23-8 (2000)
DOI:10.1016/S0169-4758(99)01586-0
Reference
PMID:11352795
  Authors
Stanley SL Jr, Reed SL
  Title
Microbes and microbial toxins: paradigms for microbial-mucosal interactions. VI. Entamoeba histolytica: parasite-host interactions.
  Journal
Am J Physiol Gastrointest Liver Physiol 280:G1049-54 (2001)
DOI:10.1152/ajpgi.2001.280.6.G1049
Reference
PMID:20145703
  Authors
Wong-Baeza I, Alcantara-Hernandez M, Mancilla-Herrera I, Ramirez-Saldivar I, Arriaga-Pizano L, Ferat-Osorio E, Lopez-Macias C, Isibasi A
  Title
The role of lipopeptidophosphoglycan in the immune response to Entamoeba histolytica.
  Journal
J Biomed Biotechnol 2010:254521 (2010)
DOI:10.1155/2010/254521
Related
pathway
mcc00330  Arginine and proline metabolism
mcc00590  Arachidonic acid metabolism
mcc04144  Endocytosis
mcc04210  Apoptosis
mcc04510  Focal adhesion
mcc04610  Complement and coagulation cascades
mcc04612  Antigen processing and presentation
mcc04620  Toll-like receptor signaling pathway
mcc04672  Intestinal immune network for IgA production
mcc04810  Regulation of actin cytoskeleton
KO pathway
ko05146   

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