Entry Name Toll-like receptor signaling pathway - Macaca mulatta (rhesus monkey)
Description Specific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors identified as homologs of Toll in Drosophila. Mammalian TLRs are expressed on innate immune cells, such as macrophages and dendritic cells, and respond to the membrane components of Gram-positive or Gram-negative bacteria. Pathogen recognition by TLRs provokes rapid activation of innate immunity by inducing production of proinflammatory cytokines and upregulation of costimulatory molecules. TLR signaling pathways are separated into two groups: a MyD88-dependent pathway that leads to the production of proinflammatory cytokines with quick activation of NF-{kappa}B and MAPK, and a MyD88-independent pathway associated with the induction of IFN-beta and IFN-inducible genes, and maturation of dendritic cells with slow activation of NF-{kappa}B and MAPK.
Class Organismal Systems; Immune systemBRITE hierarchy
Pathway map mcc04620 Toll-like receptor signaling pathway
Organism Macaca mulatta (rhesus monkey) [GN:
mcc ]
Gene 574243 CXCL10; C-X-C motif chemokine 10 precursor [KO:K12671 ]
574294 TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842 ]
574372 CXCL11; C-X-C motif chemokine 11 precursor [KO:K12672 ]
693650 STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220 ]
693961 TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174 ]
694747 IL12B; interleukin-12 subunit beta precursor [KO:K05425 ]
696494 MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729 ]
696875 TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404 ]
697482 CD14; monocyte differentiation antigen CD14 precursor [KO:K04391 ]
698996 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649 ]
699604 IFNAR1; interferon alpha/beta receptor 1 precursor [KO:K05130 ]
699726 IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131 ]
700725 IRF5; interferon regulatory factor 5 isoform X3 [KO:K09446 ]
701237 IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210 ]
703409 TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403 ]
707310 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
707749 CD40; tumor necrosis factor receptor superfamily member 5 precursor [KO:K03160 ]
708013 RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X2 [KO:K02861 ] [EC:2.7.11.1 ]
708606 FADD; FAS-associated death domain protein [KO:K02373 ]
709511 CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X3 [KO:K04467 ] [EC:2.7.11.10 ]
709959 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
710077 MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431 ] [EC:2.7.12.2 ]
710324 NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580 ]
710552 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
712694 STAT2; signal transducer and activator of transcription 2 [KO:K11221 ]
714377 TIRAP; toll/interleukin-1 receptor domain-containing adapter protein [KO:K05403 ]
714390 CD86; T-lymphocyte activation antigen CD86 precursor [KO:K05413 ]
715919 RELA; transcription factor p65 isoform X1 [KO:K04735 ]
716098 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
717755 RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392 ]
718155 MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430 ] [EC:2.7.12.2 ]
719367 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
721821 MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369 ] [EC:2.7.12.2 ]
732518 CD80; T-lymphocyte activation antigen CD80 precursor [KO:K05412 ]
Reference Authors Kawai T, Akira S.
Title TLR signaling.
Journal Reference Authors O'Neill LA, Bowie AG.
Title The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling.
Journal Reference Authors Honda K, Taniguchi T.
Title IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors.
Journal Reference Authors Uematsu S, Akira S.
Title Toll-like receptors and Type I interferons.
Journal Reference Authors Akira S, Uematsu S, Takeuchi O.
Title Pathogen recognition and innate immunity.
Journal Reference Authors Yamamoto M, Takeda K, Akira S.
Title TIR domain-containing adaptors define the specificity of TLR signaling.
Journal Reference Authors Means TK, Hayashi F, Smith KD, Aderem A, Luster AD.
Title The Toll-like receptor 5 stimulus bacterial flagellin induces maturation and chemokine production in human dendritic cells.
Journal Reference Authors Aderem A, Smith KD.
Title A systems approach to dissecting immunity and inflammation.
Journal Reference Authors Banerjee A, Gerondakis S.
Title Coordinating TLR-activated signaling pathways in cells of the immune system.
Journal Reference Authors Loniewski KJ, Patial S, Parameswaran N.
Title Sensitivity of TLR4- and -7-induced NF kappa B1 p105-TPL2-ERK pathway to TNF-receptor-associated-factor-6 revealed by RNAi in mouse macrophages.
Journal Reference Authors Arbibe L, Mira JP, Teusch N, Kline L, Guha M, Mackman N, Godowski PJ, Ulevitch RJ, Knaus UG.
Title Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathway.
Journal Reference Authors Uematsu S, Akira S.
Title Toll-like receptors and innate immunity.
Journal Related mcc04060 Cytokine-cytokine receptor interaction
mcc04610 Complement and coagulation cascades
KO pathway
