KEGG   PATHWAY: mmur04714
Entry
mmur04714                   Pathway                                
Name
Thermogenesis - Microcebus murinus (gray mouse lemur)
Description
Thermogenesis is essential for warm-blooded animals, ensuring normal cellular and physiological function under conditions of environmental challenge. Thermogenesis in brown and beige adipose tissue is mainly controlled by norepinephrine, which is released from sympathetic nervous system in response to cold or dietary stimuli. The mitochondrial uncoupling protein 1 (UCP1) is responsible for the process whereby chemical energy is converted into heat in these adipocytes. Activation of these adipocytes leads to an increase in calorie consumption and is expected to improve overweight conditions, providing a potential strategy for treating obesity and its related metabolic disorders.
Class
Organismal Systems; Environmental adaptation
Pathway map
mmur04714  Thermogenesis
mmur04714

Other DBs
GO: 1990845
Organism
Microcebus murinus (gray mouse lemur) [GN:mmur]
Gene
105854855  [KO:K02264]
105855129  [KO:K09047]
105855815  ACTL6A; actin-like protein 6A isoform X1 [KO:K11340]
105855817  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
105855983  SMARCA2; probable global transcription activator SNF2L2 isoform X2 [KO:K11647] [EC:5.6.2.-]
105856056  PPARGC1A; peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1 [KO:K07202]
105856231  ZNF516; zinc finger protein 516 [KO:K22411]
105856318  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
105856473  [KO:K18179]
105856555  [KO:K02132]
105856794  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
105856893  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
105856967  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
105857182  [KO:K00419]
105857227  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
105857286  KRAS; GTPase KRas isoform X1 [KO:K07827]
105857636  [KO:K02138]
105857701  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 isoform X1 [KO:K07200]
105857797  MGLL; monoglyceride lipase isoform X1 [KO:K01054] [EC:3.1.1.23]
105858124  DPF3; zinc finger protein DPF3 isoform X1 [KO:K22198]
105858234  ATP5C1; LOW QUALITY PROTEIN: ATP synthase subunit gamma, mitochondrial [KO:K02136]
105858346  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
105858410  [KO:K18173]
105858589  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
105858646  ACSL3; long-chain-fatty-acid--CoA ligase 3 [KO:K01897] [EC:6.2.1.3]
105858681  [KO:K02264]
105859108  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
105859339  [KO:K02271]
105859388  [KO:K02270]
105859447  [KO:K18175]
105859584  TSC2; tuberin isoform X1 [KO:K07207]
105859618  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
105859640  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
105859653  ADCY9; adenylate cyclase type 9 isoform X2 [KO:K08049] [EC:4.6.1.1]
105859868  TSC1; hamartin isoform X1 [KO:K07206]
105859934  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
105860083  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
105860331  [KO:K17797]
105860383  [KO:K18177]
105860777  [KO:K00420]
105860785  ATP5D; ATP synthase subunit delta, mitochondrial [KO:K02134]
105860789  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940] [EC:7.1.1.2]
105860911  NDUFV2; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
105861389  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
105861390  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
105861500  ATP5O; ATP synthase subunit O, mitochondrial [KO:K02137]
105861554  SLC25A29; mitochondrial basic amino acids transporter isoform X1 [KO:K15109]
105861621  SMARCD2; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 isoform X1 [KO:K11650]
105861780  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X2 [KO:K04345] [EC:2.7.11.11]
105861972  [KO:K02257] [EC:2.5.1.141]
105862566  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 isoform X1 [KO:K03946]
105862588  KDM3B; lysine-specific demethylase 3B isoform X3 [KO:K15601] [EC:1.14.11.65]
105862787  [KO:K03965]
105862943  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
105862994  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
105863187  [KO:K00237]
105863327  [KO:K02267]
105863329  ACSL4; long-chain-fatty-acid--CoA ligase 4 isoform X1 [KO:K01897] [EC:6.2.1.3]
105863485  ARID1A; AT-rich interactive domain-containing protein 1A isoform X1 [KO:K11653]
105863495  KDM1A; LOW QUALITY PROTEIN: lysine-specific histone demethylase 1A [KO:K11450] [EC:1.14.99.66]
105863518  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
105863632  CNR1; cannabinoid receptor 1 [KO:K04277]
105863646  [KO:K02136]
105863786  [KO:K18184]
105863924  [KO:K02136]
105864015  ATP5F1; ATP synthase F(0) complex subunit B1, mitochondrial isoform X1 [KO:K02127]
105864152  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
105864304  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
105865052  ATF2; LOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
105865065  SMARCC2; SWI/SNF complex subunit SMARCC2 isoform X1 [KO:K11649]
105865079  ATP5G3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
105865392  KLB; LOW QUALITY PROTEIN: beta-klotho [KO:K22404]
105865518  [KO:K02133] [EC:7.1.2.2]
105865626  AKT1S1; proline-rich AKT1 substrate 1 isoform X1 [KO:K16184]
105865647  CPT1C; LOW QUALITY PROTEIN: carnitine O-palmitoyltransferase 1, brain isoform [KO:K19524] [EC:2.3.1.21]
105865679  FGF21; fibroblast growth factor 21 [KO:K22429]
105865739  [KO:K02133] [EC:7.1.2.2]
105866063  [KO:K02263]
105866363  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
105866617  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
105866904  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
105866929  [KO:K02266]
105866963  [KO:K02270]
105867019  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial isoform X1 [KO:K03937]
105867259  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
105867420  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
105867432  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1 [KO:K03941] [EC:7.1.1.2]
105867475  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
105867480  CPT1A; carnitine O-palmitoyltransferase 1, liver isoform [KO:K08765] [EC:2.3.1.21]
105867497  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
105867678  SOS2; son of sevenless homolog 2 [KO:K03099]
105867920  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
105867963  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
105868011  LIPE; hormone-sensitive lipase isoform X1 [KO:K07188] [EC:3.1.1.79]
105868294  ACTB; actin, cytoplasmic 1 [KO:K05692]
105868356  [KO:K18183]
105868493  ACTL6B; actin-like protein 6B isoform X1 [KO:K11652]
105868570  ARID1B; AT-rich interactive domain-containing protein 1B isoform X1 [KO:K11653]
105868860  [KO:K00413]
105868958  GCG; glucagon isoform X1 [KO:K05259]
105869145  [KO:K11265] [EC:4.6.1.1]
105869461  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
105869653  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
105869807  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 isoform X1 [KO:K07199]
105869838  SMARCD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 isoform X1 [KO:K11650]
105869867  [KO:K18181]
105869963  [KO:K00418]
105870006  ACSL6; long-chain-fatty-acid--CoA ligase 6 [KO:K01897] [EC:6.2.1.3]
105870333  [KO:K02133] [EC:7.1.2.2]
105870362  PRKG1; cGMP-dependent protein kinase 1 isoform X1 [KO:K07376] [EC:2.7.11.12]
105870388  ADRB3; beta-3 adrenergic receptor isoform X1 [KO:K04143]
105870403  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
105870472  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
105870617  [KO:K08768]
105870668  ADCY1; LOW QUALITY PROTEIN: adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
105870914  [KO:K00419]
105870975  ATP5G2; ATP synthase F(0) complex subunit C2, mitochondrial isoform X1 [KO:K02128]
105871035  [KO:K02266]
105871186  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
105871213  ATP5J; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
105871362  [KO:K02263]
105871783  [KO:K02128]
105872074  SMARCE1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 isoform X1 [KO:K11651]
105872357  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
105872473  NDUFAF1; complex I intermediate-associated protein 30, mitochondrial [KO:K18159]
105872845  [KO:K02130]
105873243  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
105873394  [KO:K02259] [EC:1.17.99.9]
105873549  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
105873557  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
105873650  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial isoform X1 [KO:K03964]
105873935  SIRT6; NAD-dependent protein deacetylase sirtuin-6 [KO:K11416] [EC:2.3.1.286]
105873936  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
105874016  NDUFAF4; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 [KO:K18161]
105874032  HRAS; GTPase HRas [KO:K02833]
105874051  PNPLA2; patatin-like phospholipase domain-containing protein 2 isoform X1 [KO:K16816] [EC:3.1.1.3]
105874134  RPS6; 40S ribosomal protein S6 [KO:K02991]
105874305  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
105874518  [KO:K04632]
105874520  [KO:K04632]
105874527  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
105874716  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
105874841  [KO:K02132]
105874931  [KO:K00414]
105874942  SLC25A20; mitochondrial carnitine/acylcarnitine carrier protein [KO:K15109]
105874946  NDUFAF3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 isoform X1 [KO:K09008]
105875073  ACSL5; long-chain-fatty-acid--CoA ligase 5 isoform X1 [KO:K01897] [EC:6.2.1.3]
105875089  SMARCC1; SWI/SNF complex subunit SMARCC1 [KO:K11649]
105875144  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
105875650  [KO:K00417]
105875660  NDUFAF6; NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 isoform X1 [KO:K18163]
105875822  [KO:K18178]
105875873  [KO:K02130]
105876051  ATP5L; ATP synthase subunit g, mitochondrial [KO:K02140]
105876415  [KO:K02258]
105876445  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
105876466  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
105876617  KDM3A; lysine-specific demethylase 3A [KO:K15601] [EC:1.14.11.65]
105876842  DPF1; zinc finger protein neuro-d4 isoform X1 [KO:K22198]
105876884  [KO:K02270]
105876919  [KO:K02267]
105877012  [KO:K00411] [EC:7.1.1.8]
105877076  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
105877215  [KO:K02267]
105877260  NDUFAF2; mimitin, mitochondrial [KO:K18160]
105877367  PRDM16; PR domain zinc finger protein 16 isoform X1 [KO:K22410] [EC:2.1.1.367]
105877497  [KO:K00416]
105877563  [KO:K18180]
105877579  CPT2; carnitine O-palmitoyltransferase 2, mitochondrial [KO:K08766] [EC:2.3.1.21]
105877816  SMARCB1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 isoform X1 [KO:K11648]
105877858  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
105877970  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 isoform X1 [KO:K03948]
105878394  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X2 [KO:K07198] [EC:2.7.11.31]
105878710  NRAS; GTPase NRas [KO:K07828]
105878936  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
105879121  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X5 [KO:K03944]
105879533  [KO:K16622]
105879547  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
105879726  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
105879870  ADCY5; LOW QUALITY PROTEIN: adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
105879883  [KO:K03945]
105879910  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
105879919  [KO:K02260]
105880070  NDUFAF5; arginine-hydroxylase NDUFAF5, mitochondrial isoform X1 [KO:K18162] [EC:2.1.1.-]
105880279  [KO:K18182]
105880962  PRKG2; LOW QUALITY PROTEIN: cGMP-dependent protein kinase 2 [KO:K19477] [EC:2.7.11.12]
105881169  [KO:K03938]
105881452  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
105881873  UCP1; mitochondrial brown fat uncoupling protein 1 [KO:K08769]
105881883  ADCY10; LOW QUALITY PROTEIN: adenylate cyclase type 10 [KO:K11265] [EC:4.6.1.1]
105882171  [KO:K00236]
105882326  [KO:K03955]
105882367  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
105882498  ACSL1; long-chain-fatty-acid--CoA ligase 1 isoform X1 [KO:K01897] [EC:6.2.1.3]
105882576  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
105882670  PPARG; peroxisome proliferator-activated receptor gamma isoform X2 [KO:K08530]
105882697  NPPB; natriuretic peptides B [KO:K12335]
105882715  NPPA; natriuretic peptides A [KO:K12334]
105882731  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
105883187  SMARCD3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 isoform X1 [KO:K11650]
105883192  RHEB; GTP-binding protein Rheb isoform X1 [KO:K07208]
105883193  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
105883659  [KO:K02265]
105883673  [KO:K18178]
105884349  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
105884392  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform X1 [KO:K03965]
105884501  NDUFAF7; protein arginine methyltransferase NDUFAF7, mitochondrial isoform X1 [KO:K18164]
105884529  SOS1; son of sevenless homolog 1 [KO:K03099]
105884600  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
105884632  FRS2; fibroblast growth factor receptor substrate 2 isoform X1 [KO:K12461]
105884745  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
105884969  ACTG1; actin, cytoplasmic 2 [KO:K05692]
105884974  NDUFAF8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8 isoform X1 [KO:K24726]
105884979  RPTOR; LOW QUALITY PROTEIN: regulatory-associated protein of mTOR [KO:K07204]
105884997  CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform [KO:K19523] [EC:2.3.1.21]
105885016  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
105885017  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
105885081  ATP5G1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
105885209  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
105885296  [KO:K00415]
105885383  ATP5A1; LOW QUALITY PROTEIN: ATP synthase subunit alpha, mitochondrial [KO:K02132]
105885571  SMARCA4; transcription activator BRG1 isoform X1 [KO:K11647] [EC:5.6.2.-]
105885663  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
105885913  NPR1; atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
105885942  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
105886039  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
109729199  ATP5J2; ATP synthase subunit f, mitochondrial [KO:K02130]
109729268  [KO:K03945]
109729274  [KO:K02267]
109729382  [KO:K02268]
109729580  [KO:K02268]
109729584  [KO:K02271]
109729674  ATP5I; ATP synthase subunit e, mitochondrial [KO:K02129]
109729710  ATP5E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
109729728  [KO:K02268]
109730235  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
109730255  [KO:K02271]
109730487  [KO:K03967]
109730635  [KO:K02273]
109730662  [KO:K02268]
109730744  [KO:K02268]
109730745  [KO:K02268]
109730976  [KO:K02268]
109730981  [KO:K02268]
109731042  BMP8B; LOW QUALITY PROTEIN: bone morphogenetic protein 8B [KO:K16622]
109731077  [KO:K02268]
109731090  [KO:K02268]
109731103  [KO:K02268]
109731114  [KO:K03945]
109731122  [KO:K02129]
109731316  [KO:K02268]
109731319  [KO:K02272]
26823973  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
26823976  COX2; cytochrome c oxidase subunit II [KO:K02261]
26823978  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
26823979  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
26823980  COX3; cytochrome c oxidase subunit III [KO:K02262]
26823982  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
26823983  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
26823987  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
26823990  CYTB; cytochrome b [KO:K00412]
26823993  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
26823994  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
26823995  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
26823996  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
Compound
C00002  ATP
C00004  NADH
C00008  ADP
C00010  CoA
C00024  Acetyl-CoA
C00040  Acyl-CoA
C00080  H+
C00116  Glycerol
C00162  Fatty acid
C00165  Diacylglycerol
C00318  L-Carnitine
C00422  Triacylglycerol
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00745  Nicotine
C00942  3',5'-Cyclic GMP
C00951  Estradiol-17beta
C01352  FADH2
C01885  1-Acylglycerol
C02301  O-Acylcarnitine
C02465  Triiodothyronine
C11695  Anandamide
C13856  2-Arachidonoylglycerol
Reference
  Authors
Inagaki T, Sakai J, Kajimura S
  Title
Transcriptional and epigenetic control of brown and beige adipose cell fate and function.
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Nat Rev Mol Cell Biol 17:480-95 (2016)
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Brown and beige fat: development, function and therapeutic potential.
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Nat Med 19:1252-63 (2013)
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  Title
Peripheral cannabinoid 1 receptor blockade activates brown adipose tissue and diminishes dyslipidemia and obesity.
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FASEB J 28:5361-75 (2014)
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Merlin J, Evans BA, Dehvari N, Sato M, Bengtsson T, Hutchinson DS
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Could burning fat start with a brite spark? Pharmacological and nutritional ways to promote thermogenesis.
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Mol Nutr Food Res 60:18-42 (2016)
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van Dam AD, Kooijman S, Schilperoort M, Rensen PC, Boon MR
  Title
Regulation of brown fat by AMP-activated protein kinase.
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Trends Mol Med 21:571-9 (2015)
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  Title
Neuronal Control of Brown Fat Activity.
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Trends Endocrinol Metab 26:657-68 (2015)
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Redox Biol 12:854-863 (2017)
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Regulation of adipocyte lipolysis.
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Nutr Res Rev 27:63-93 (2014)
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Tansey JT, Sztalryd C, Hlavin EM, Kimmel AR, Londos C
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The central role of perilipin a in lipid metabolism and adipocyte lipolysis.
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IUBMB Life 56:379-85 (2004)
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Collins S, Yehuda-Shnaidman E, Wang H
  Title
Positive and negative control of Ucp1 gene transcription and the role of beta-adrenergic signaling networks.
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Int J Obes (Lond) 34 Suppl 1:S28-33 (2010)
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  Title
Selective activation of mitogen-activated protein (MAP) kinase kinase 3 and p38alpha MAP kinase is essential for cyclic AMP-dependent UCP1 expression in adipocytes.
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Mol Cell Biol 25:5466-79 (2005)
DOI:10.1128/MCB.25.13.5466-5479.2005
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Hattori K, Naguro I, Okabe K, Funatsu T, Furutani S, Takeda K, Ichijo H
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ASK1 signalling regulates brown and beige adipocyte function.
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Nat Commun 7:11158 (2016)
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Abe Y, Rozqie R, Matsumura Y, Kawamura T, Nakaki R, Tsurutani Y, Tanimura-Inagaki K, Shiono A, Magoori K, Nakamura K, Ogi S, Kajimura S, Kimura H, Tanaka T, Fukami K, Osborne TF, Kodama T, Aburatani H, Inagaki T, Sakai J
  Title
JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis.
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Nat Commun 6:7052 (2015)
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Cold-inducible Zfp516 activates UCP1 transcription to promote browning of white fat and development of brown fat.
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Mol Cell 57:235-46 (2015)
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LSD1 Interacts with Zfp516 to Promote UCP1 Transcription and Brown Fat Program.
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Cell Rep 15:2536-49 (2016)
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Biochimie 134:86-92 (2017)
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Thermogenic activation induces FGF21 expression and release in brown adipose tissue.
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Yao L, Cui X, Chen Q, Yang X, Fang F, Zhang J, Liu G, Jin W, Chang Y
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Cold-Inducible SIRT6 Regulates Thermogenesis of Brown and Beige Fat.
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Cell Rep 20:641-654 (2017)
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Klingenberg M
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UCP1 - A sophisticated energy valve.
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Biochimie 134:19-27 (2017)
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Targeting thermogenesis in brown fat and muscle to treat obesity and metabolic disease.
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Nat Rev Endocrinol 14:77-87 (2018)
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mTORC1 Is a Major Regulatory Node in the FGF21 Signaling Network in Adipocytes.
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Cell Rep 17:29-36 (2016)
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FGF21 regulates PGC-1alpha and browning of white adipose tissues in adaptive thermogenesis.
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Natriuretic peptides in cardiometabolic regulation and disease.
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Nat Rev Cardiol 11:403-12 (2014)
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Indiveri C, Iacobazzi V, Tonazzi A, Giangregorio N, Infantino V, Convertini P, Console L, Palmieri F
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The mitochondrial carnitine/acylcarnitine carrier: function, structure and physiopathology.
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Mol Aspects Med 32:223-33 (2011)
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McCoin CS, Knotts TA, Adams SH
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Acylcarnitines--old actors auditioning for new roles in metabolic physiology.
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Nat Rev Endocrinol 11:617-25 (2015)
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Ohtomo T, Ino K, Miyashita R, Chigira M, Nakamura M, Someya K, Inaba N, Fujita M, Takagi M, Yamada J
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Chronic high-fat feeding impairs adaptive induction of mitochondrial fatty acid combustion-associated proteins in brown adipose tissue of mice.
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Biochem Biophys Rep 10:32-38 (2017)
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Related
pathway
mmur00020  Citrate cycle (TCA cycle)
mmur00190  Oxidative phosphorylation
mmur04010  MAPK signaling pathway
mmur04022  cGMP-PKG signaling pathway
mmur04024  cAMP signaling pathway
mmur04150  mTOR signaling pathway
mmur04923  Regulation of lipolysis in adipocytes
KO pathway
ko04714   

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